Andrew Newberg

Andrew Newberg
Thomas Jefferson University | Jefferson · Department of Radiology

MD

About

322
Publications
121,610
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
10,988
Citations

Publications

Publications (322)
Article
Positron emission tomography (PET) has been a key component in the diagnostic armamentarium for assessing neurodegenerative diseases such as Alzheimer or Parkinson disease. PET imaging has been useful for diagnosing these disorders, identifying their pathophysiology, and following their treatment. Further, PET imaging has been extensively used for...
Article
Introduction Breast cancer is one of the most commonly diagnosed cancers in women in the US, and its treatments have significant physical and psychological side effects and long-term complications causing significant morbidity and decreased quality of life. Integrative medicine modalities, such as Yoga, have been found to reduce side effects of con...
Article
Full-text available
There is a growing interest in the potential beneficial effects of mindfulness meditation training in protecting against age-related physical, emotional, and cognitive decline. The current prospective, single-center, single-arm study investigated if functional magnetic resonance imaging-based changes in cerebral blood flow and brain functional conn...
Article
Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design. Objective:...
Chapter
The term “complementary and alternative medicine” (CAM) refers to the broad range of health systems, modalities, and practices that are not part of the conventional and politically dominant health system [1, 2]. We would also suggest that “integrative medicine” incorporates conventional medical approaches with evidence-based complementary approache...
Article
Full-text available
Mild traumatic brain injury (mTBI) accounts for more than 80% of people experiencing brain injuries. Symptoms of mTBI include short-term and long-term adverse clinical outcomes. In this study, resting-state functional magnetic resonance imaging (rs-fMRI) was conducted to measure voxel-based indices including fractional amplitude of low-frequency fl...
Article
Full-text available
Background: The diagnosis of attention deficit hyperactivity disorder (ADHD) relies on history and observation, as no reliable biomarkers have been identified. In this study, we compared a large single diagnosis group of patients with ADHD (combined, inattentive, and hyperactive) to healthy controls using brain perfusion single-photon emission comp...
Chapter
The purpose of this chapter is to review the potential functional and structural effects on the brain of long-term habitation of human beings on the moon. Using current knowledge about long-term effects of space flight on the central nervous system, we can extrapolate to the potential effects of the moon environment. However, it must be realized th...
Article
Full-text available
Background: We measured changes in resting brain functional connectivity, with blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI), associated with a creative meditation practice that is augmented by clitoral stimulation and is designed to not only achieve a spiritual experience but to help individuals manage their most...
Preprint
Full-text available
We hypothesised that unilateral leg pain following surgical treatment of lumbar disc herniation (LDH) is associated with an increase in the glucose metabolism of the contralateral thalamus. Patients scheduled for surgery due to LDH underwent ¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) less than two weeks pr...
Article
Full-text available
Background The purpose of this study was to explore if administration of N-acetyl-cysteine (NAC) in patients with multiple sclerosis (MS) resulted in altered cerebral blood flow (CBF) based on Arterial Spin Labeling (ASL) magnetic resonance imaging (MRI). Methods Twenty-three patients with mild to moderate MS, (17 relapsing remitting and 6 primary...
Article
Taking an integrative approach toward developmental psychology and neurophysiology, this review selects findings from the psychological and medical literature on guilt and bereavement that are relevant to considering whether and how guilt contributes to the development of prolonged grief disorder (PGD) in bereaved persons. Mention of guilt is ubiqu...
Article
Full-text available
In reviewing this literature, there are several apparent takeaways. There are variations in the binding patterns between different tau radiotracers. Nevertheless, there is consistently uptake in certain regions across studies; aberrant binding is expected given the variation in small studies and potential off-site radiotracer binding. However, the...
Article
Full-text available
The detection and association of in vivo biomarkers in white matter (WM) pathology after acute and chronic mild traumatic brain injury (mTBI) are needed to improve care and develop therapies. In this study, we used the diffusion MRI method of hybrid diffusion imaging (HYDI) to detect white matter alterations in patients with chronic TBI (cTBI). 40...
Article
Background: Many patients who have traumatic brain injury experience a wide range of psychiatric and neurological symptoms (including impairment in functional status, cognition, and mood), and if persistent are referred to as persistent postconcussion syndrome (PCS). To our knowledge, this is the first study to broadly evaluate metabolic dysregula...
Article
Full-text available
Development, whether motor, language, social, or spiritual, is the functional expression of complex brain processes throughout one’s life span, the foundations of which are laid in childhood. The effects of cancer, chemotherapy, radiation, and surgical procedures on early brain development have been measured using neuroimaging and developmental ass...
Article
Full-text available
PurposePositron emission tomography (PET) has been widely utilized in the study of traumatic brain injury (TBI) for decades. While most applications of PET have attempted to assess neuronal function after TBI, more recently, novel radiotracers have sought to image biomarkers in the context of TBI and chronic traumatic encephalopathy (CTE).Methods T...
Article
Full-text available
Background: Religious and spiritual interventions may have an effect on Alzheimer's disease prevention. Kirtan Kriya meditation has been shown to mitigate the deleterious effects of chronic stress on cognition, reverse memory loss, and create psychological and spiritual wellbeing, which may reduce multiple drivers of Alzheimer's disease risk. Obj...
Article
Full-text available
Background: Many individuals participate in spiritual retreats to enhance their sense of spirituality or to improve their overall mental and spiritual well-being. We are not aware of any studies specifically evaluating changes in functional connectivity using functional magnetic resonance imaging (fMRI) in individuals undergoing an intense spiritua...
Article
The lengthy debate on the validity of the amyloid hypothesis and the usefulness of amyloid imaging and anti-amyloid therapeutic interventions in dementia continues unabated, even though none of them have been able to convince the medical world of their correctness and clinical value. There are huge financial interests associated with promoting both...
Chapter
The purpose of this chapter is to review the potential metabolic, neurotransmitter, and morphological changes that may occur in the human central nervous system (CNS) during long-duration habitation of Earth’s Moon. When there are either permanent space habitats or long-duration interplanetary missions, we must determine if there will be any detrim...
Article
Full-text available
Background: While obesity has been shown to be a risk factor for Alzheimer's disease, the potential mechanisms underlying this risk may be clarified with better understanding of underlying physiology in obese persons. Objective: To identify patterns of cerebral perfusion abnormality in adults as a function of body mass index (BMI) defined weight...
Article
PET with 18F-fluorodeoxyglucose (FDG) is used to assess a wide array of inflammatory and neoplastic disorders. FDG-PET has shown particular utility in the evaluation of disorders of the central nervous system (CNS). Although fused PET/computed tomography (CT) is frequently used across the globe for these diseases, recent evidence has pointed to PET...
Article
This article reviews and synthesizes the current data on the relationship between the brain and religion and spirituality, with regard to aging and neurodegenerative diseases. Specifically, we consider how religious and spiritual beliefs, attitudes, and practices might be affected by the aging process on the brain, particularly when neurodegenerati...
Article
Full-text available
An influential model of the neural mechanisms of creative thought suggests that creativity is manifested in the joint contributions of the Default Mode Network (DMN; a set of regions in the medial PFC, lateral and medial parietal cortex, and the medial temporal lobes) and the executive networks within the dorsolateral PFC. Several empirical reports...
Conference Paper
Full-text available
Purpose: To assess the value of FDG-PET/CT for predicting survival in non-small cell lung cancer (NSCLC) patients measuring global disease activity. Methods: This study included 16 patients with NSCLC (9 females, 7 males) aged 56-86 years (mean: 70 ±9) with FDG-PET/CT performed prior to initiation of nivolumab and after the end of the treatment. Th...
Conference Paper
Full-text available
Objectives: Evaluate the efficacy of 5-HT1A/5-HT1B in the assessment of MDD Methods: Major Depressive Disorder (MDD) is a mood disorder that is diagnosed clinically by a constellation of 5 or more symptoms, including at least 1 of either depressed affect or anhedonia, over 2 or more weeks that leads to significant distress in occupational or socia...
Article
Full-text available
Nearly everyone has the ability for creative thought. Yet, certain individuals create works that propel their fields, challenge paradigms, and advance the world. What are the neurobiological factors that might underlie such prominent creative achievement? In this study, we focus on morphometric differences in brain structure between high creative a...
Conference Paper
Purpose: The applications of PET/MRI in neuroimaging have improved the use of functional imaging in the brain. Nonetheless, the complex structures within the brain can make quantitative assessment difficult given the partial volume effect. This study develops a novel methodology that segments white matter and grey matter so as to minimize the parti...
Article
Elevated blood pressure (BP) is a major avoidable cause of premature morbidity and mortality in the United States (US) and worldwide, due primarily to increased risks of stroke as well as myocardial infarction. While there are therapeutic lifestyle changes and adjunctive pharmacologic medications of proven benefit, recent interest has increasingly...
Article
Full-text available
Background: Multiple Sclerosis (MS) is an autoimmune disease marked by progressive neurocognitive injury. Treatment options affording neuroprotective effects remain largely experimental. The purpose of this proof of concept study was to explore the effects of N-acetyl-cysteine (NAC) on cerebral glucose metabolism (CMRGlu) and symptoms in patients w...
Chapter
The basis of this chapter is to provide a phenomenological and scholarly foundation for understanding the rituals and practices associated with various religious and spiritual systems. Thus, we hope to provide scholars, clinicians, and researchers with valuable descriptions of different rituals with a focus on cognitive, emotional, behavioral, and...
Article
Full-text available
Background: It is well known that vibratory and auditory stimuli from vehicles such as cars and trains can help induce sleep. More recent literature suggests that specific types of vibratory and acoustic stimulation might help promote sleep, but this has not been tested with neuroimaging. Thus, the purpose of this study was to observe the effects...
Book
This book codifies, describes, and contextualizes group rituals and individual practices from world religious traditions. At the interface of religious studies, psychology, and medicine, it elucidates the cultural richness of practices and rituals from numerous world religions. The book begins by discussing the role that religious rituals and pract...
Article
Full-text available
The neuroscientific study of religious and spiritual phenomena requires the development of methodologies that can target both the biological as well as the subjective dimensions of such phenomena. The purpose of the current study was to compare various subjective questionnaires evaluating neuropsychological dimensions of religiosity. Many scales an...
Article
Full-text available
Importance Evidence shows that sleep dysfunction and β-amyloid (Aβ) deposition work synergistically to impair brain function in individuals with normal cognition, increasing the risk of developing dementia later in life. However, whether Aβ continues to play an integral role in sleep dysfunction after the onset of cognitive decline in individuals w...
Article
Full-text available
[This corrects the article DOI: 10.3389/fpsyg.2013.00806.].
Article
Background: 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and 18F-florbetapir PET are approved neuroimaging biomarkers for the Alzheimer's disease (AD) and mild cognitive impairment (MCI). Objectives: This study aims to compare the efficacy of 18F-FDG and 18F-florbetapir PET at evaluating the cognitive performance of patien...
Article
This study assessed the biological and clinical effects in patients with Parkinson's disease (PD) of N‐acetyl‐cysteine (NAC), the prodrug to L‐cysteine, a precursor to the natural biological antioxidant glutathione. Forty‐two patients with PD were randomized to either weekly intravenous infusions of NAC (50mg/kg) plus oral doses (500mg twice per da...
Article
PET has been a key component in the diagnostic armamentarium for evaluating neurodegenerative diseases such as Alzheimer's or Parkinson's disease. PET imaging has been used for the diagnosis of these disorders, for identification of their pathophysiology, and for following treatment of these disorders. Further, PET imaging has been extensively used...
Article
Full-text available
Background: Intravenous ascorbic acid (IV AA) has been used extensively in cancer patients throughout the United States. Currently, there are limited data on the safety and clinical effects of IV AA. The purpose of this study was to expand the current literature using a retrospective analysis of adverse events and symptomatic changes of IV AA in a...
Conference Paper
Objectives: Neurofibrillary tangles (NFTs) composed of aggregated hyper-phosphorylated tau along with the deposition of β-amyloid plaques are one of the pathological hallmarks of Alzheimer’s disease (AD) and other neuro-degenerative disorders. Up till now, our understanding about the natural history and topography of tau deposition has only been ba...
Conference Paper
Multiple Sclerosis (MS) is a complex disease of the brain and spinal cord characterized by neuro-inflammation, demyelination, gliosis, axonal degeneration, and neuronal loss. As such, several pathologic processes can be selected as a marker for diagnosis and follow-up of MS. Today, the diagnosis and follow-up of MS is usually based on clinical asse...
Conference Paper
Traumatic brain injury (TBI) due to contact sports is the cause of more than 200,000 emergency room visits and 1.7 million reported new cases each year in the United States, which contributes to one third of all deaths due to injury. Almost 75% of all reported TBIs are mild traumatic brain injury (mTBI) or concussion, although the number of unrepor...
Article
Full-text available
Purpose: A growing number of research studies have implicated the cerebellum in emotional processing and regulation, especially with regard to negative emotional memories. However, there currently are no studies showing functional changes in the cerebellum as a result of treatment for traumatic stress symptoms. The Neuro Emotional Technique (NET)...
Article
Full-text available
Psychology and neuroscience can benefit from inter-disciplinary insights and cross-cultural concepts. While this statement should be uncontroversial, some in the humanities and the sciences remain unconvinced. In contrast, we suggest that this kind of exchange is already occurring in some quarters of academia and that both the sciences and the huma...
Chapter
Meditation is a complex mental process that involves changes in cognition, sensory perception, emotions, hormones, and autonomic activity. Many different neurotransmitter systems, including dopamine, serotonin, glutamate, and opiates are likely affected by meditation practices. Meditation has also become widely used, either alone or combined with o...
Chapter
In this chapter, we review what is currently known about the clinical effects of religious and spiritual practices. We also discuss some of the challenges that researchers and healthcare practitioners may face in designing appropriate studies and translating results to clinical practice. Finally, we outline some future directions for research regar...
Article
Full-text available
This article reviews the most recent information and data regarding brain processes associated with altered states of consciousness. It takes a neurotheological approach, seeking to blend what is known about these states, particularly as they relate to religious and spiritual experiences, in terms of brain processes and subjective elements of the e...
Chapter
Single photon emission computed tomography (SPECT) is a widely available and flexible imaging technique that is capable of visualizing and quantifying changes in cerebral blood flow and neurotransmitter systems. SPECT, in addition to newer SPECT-CT, scanners are an important tool in the differential diagnosis of both neurological and psychiatric di...
Chapter
Until the late eighteenth century, religions, particularly in the West, were defined by their sacred texts and dogmatic formulations. Friedrich Schleiermacher, in the late eighteenth century, was one of the first scholars that attempted to define “religion” by switching from a doctrinal emphasis to a more cognitive, visceral, or intuitive one. Schl...
Article
Full-text available
Importance: Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials. Objective: To investigate whether amyloid-β...
Article
Context: Intravenous ascorbic acid (IVAA) has been used extensively as part of the management plan for cancer patients in various medical clinics throughout the United States. The current research team has evaluated its effectiveness in patients with cancer as part of an ongoing research program. However, no data are available that support the che...
Article
Background High oxidative stress as defined by hydroxyl and peroxyl activity is often found in the stroma of human breast cancers. Oxidative stress induces stromal catabolism, which promotes cancer aggressiveness. Stromal cells exposed to oxidative stress release catabolites such as lactate, which are up-taken by cancer cells to support mitochondri...
Article
Full-text available
Background: The results of several studies have demonstrated that women and men with a cancer diagnosis benefit from interventions to reduce distress and improve quality of life (QOL). However, little is known about the costs and effectiveness of such interventions. Identifying a stress-reduction program that is low cost and effective is important...
Article
Full-text available
PurposeThe purpose of this study was to characterize the neurophysiological and clinical effects that may result from the neuro emotional technique (NET) in patients with traumatic stress symptoms associated with a cancer-related event. We hypothesized that self-regulatory processing of traumatic memories would be observable as physiological change...
Article
Background: miRNA-21, a well-known onco-miR, has been found to be up-regulated in over 18 major cancer types and is linked to radiation and chemotherapy resistance. It has been widely reported that radiation induces mir-21 expression levels in several different types of cancer and is also associated with cancer recurrence. Our laboratory has demons...
Article
Full-text available
As noninvasive brain stimulation (NIBS) technology advances, these methods may become increasingly capable of influencing complex networks of mental functioning. We suggest that these might include cognitive and affective processes underlying personality and belief systems, which would raise important questions concerning personal identity and auto...
Article
Full-text available
Various forms of self-loss have been described as aspects of mental illness (e.g., depersonalization disorder), but might self-loss also be related to mental health? In this integrative review and proposed organizational framework, we focus on self-transcendent experiences (STEs)—transient mental states marked by decreased self-salience and increas...
Article
Full-text available
Spiritual retreats are a commonly used intensive program of meditation and prayer, along with other elements, designed to provide participants with opportunities for spiritual and psychological growth. While individual elements of such retreats have been studied, there have been no reports in the literature regarding the neurophysiological effects...
Article
Full-text available
Religious, spiritual, and mystical experiences (RSMEs) are often described as having a noetic quality, or the compelling sense that the experience feels “real.” In this exploratory, multimethod study, 701 participants completed questions about the subjective qualities of their RMSEs, reported the impact of their RSMEs on various life domains, and p...
Article
Background: Depression and cognitive disorders (CDs) are two common co-morbid afflictions that commonly present with overlapping symptoms. Objective: To evaluate if perfusion neuroimaging with brain SPECT can distinguish persons with depression from those with CDs or both conditions. Methods: Inclusion criteria were DSM-IV defined depression o...
Chapter
Integrative medicine practice includes a combination of current medical therapies in conjunction with practices sometimes referred to as complementary or alternative. Patients undergoing liver transplantation initially are suffering from some type of liver dysfunction pretransplant and also require increased liver support posttransplant. This chapt...
Article
Objective: To examine neural mechanisms of action in behavioral weight loss treatment (BWL) and explore neural and genetic predictors of BWL. Methods: Neural activation to milkshake receipt and genetics were compared in 17 women with obesity who received 12 weeks of BWL and 17 women who received no intervention. Participants were scanned twice u...
Article
Full-text available
Experiences of profound existential or spiritual significance can be triggered reliably through psychopharmacological means using psychedelic substances. However, little is known about the benefits of religious, spiritual, or mystical experiences (RSMEs) prompted by psychedelic substances, as compared with those that occur through other means. In t...
Chapter
Mind–body practices have existed for hundreds to thousands of years. Within the last century, the medical community has become interested in the effects of these practices. There is encouraging data to suggest that mind–body practices can exert significant beneficial effects on the cardiovascular system. It is probable that the beneficial effects o...
Chapter
Full-text available
This chapter will review religion and spirituality from the perspective of neuroscience. First, it will characterize religion and spirituality and describe how they can be understood through a neuroscientific approach. Next, it will review some of the basics of neuroscience, including methods of study and chemicals of particular importance to the n...