Andrew Newberg

• MD
• Professor at Thomas Jefferson University

Background Chronic pelvic pain is a substantial clinical challenge that profoundly impacts quality of life for many women. The Neuro Emotional Technique (NET) is a novel mind-body intervention designed to attenuate emotional arousal of distressing thoughts and pain. This study evaluated functional connectivity changes in key areas of the brain in p...

Purpose A growing number of research studies have explored the potential effects of vagus nerve stimulation (VNS) on brain physiology as well as clinical effects particularly related to stress and anxiety. However, there currently are limited studies showing functional changes during different frequencies of stimulation and laterality effects trans...

Purpose of Review Neurotheology is a nascent field of research and scholarship that seeks to understand the relationship between the brain and religious and spiritual phenomena. In the context of integrative psychiatry, neurotheology offers an intriguing intermediary between understanding how spirituality and religion affect brain function, and how...

Objective Concussion accounts for more than 80% of people experiencing traumatic brain injury. Acute concussion is associated with characteristic cognitive and functional deficits that may persist for weeks to months. A subgroup of these patients (from 10% to 50%) have persistent symptoms referred to as chronic post-concussion syndrome (PCS). There...

PET has become a cornerstone in the molecular exploration of brain function. This special issue of PET Clinics seeks to present the major indications and breakthrough prospects of cerebral PET imaging, highlighting its growing importance in both clinical and research settings, driven by several paradigm shifts. First, considering developments in in...

Background: Cardiovascular disease is a leading cause of illness and death globally, primarily due to atherosclerosis. This disease reduces blood flow and oxygen delivery to organs, and when it affects the carotid arteries, it can lead to cognitive impairment and dementia. In a population of 104 individuals, comprising both healthy controls and ind...

Background: Religious and spiritual interventions may have an effect on Alzheimer’s disease prevention. Kirtan Kriya meditation has been shown to mitigate the deleterious effects of chronic stress on cognition, reverse memory loss, and create psychological and spiritual wellbeing, which may reduce multiple drivers of Alzheimer’s disease risk. Objec...

Mild traumatic brain injury (mTBI) is a public health concern. The present study aimed to develop an automatic classifier to distinguish between patients with chronic mTBI (n = 83) and healthy controls (HCs) (n = 40). Resting-state functional MRI (rs-fMRI) and positron emission tomography (PET) imaging were acquired from the subjects. We proposed a...

Mild traumatic brain injury (mTBI) is a significant public health concern, specially characterized by a complex pattern of abnormal neural activity and functional connectivity. It is often associated with a broad spectrum of short-term and long-term cognitive and behavioral symptoms including memory dysfunction, headache, and balance difficulties....

Background The relationship between sexuality, or the libido, and spirituality or religion has long been debated in psychiatry. Recent studies have explored the neurophysiology of both sexual experiences and spiritual practices such as meditation or prayer. In the present study, we report changes in cerebral glucose metabolism in a unique meditatio...

Background and purpose Traumatic brain injury (TBI) can cause progressive neuropathology that leads to chronic impairments, creating a need for biomarkers to detect and monitor this condition to improve outcomes. This study aimed to analyze the ability of data-driven analysis of diffusion tensor imaging (DTI) and neurite orientation dispersion imag...

This article reviews the neuroscientific understanding of the self and personal identity, focusing on various elements of inclusivity and exclusivity as well as engaging religious and spiritual perspectives. We will also consider how the identity is comprised of biological, social, and ideological or spiritual aspects, and how they are interconnect...

This paper revisits the proposal for the classification of meditation methods which we introduced in our initial 2013 publication, “Toward a Universal Taxonomy and Definition of Meditation”. At that time, we advanced the thesis that meditation methods could be effectively segregated into three orthogonal categories by integrating the taxonomic prin...

Mild traumatic brain injury (mTBI) is a major public health concern that can result in a broad spectrum of short-term and long-term symptoms. Recently, machine learning (ML) algorithms have been used in neuroscience research for diagnostics and prognostic assessment of brain disorders. The present study aimed to develop an automatic classifier to d...

Introduction: We have recently recorded, processed, and published preliminary research (Part I) on brain activity by quantitative electroencephalography (EEG) tomography (QEEGt), comparing separate subjects remembering their near-death experiences (NDEs) and mystical experiences (SCE). Several reports have affirmed that NDE and SCE are related to i...

This study compares the critical neural correlates of two altered states of consciousness: near-death experience (NDE) and spiritual contemplative experience (SCE), a.k.a. mystical experience. For Centuries NDE and SCE have been reported by all faiths, including Abrahamic religious contemplatives: Christian mystics, Muslim Sufis, and Jewish Kabbali...

PurposeWe hypothesized that unilateral leg pain following surgical treatment of lumbar disc herniation (LDH) is associated with an increase in the glucose metabolism of the contralateral thalamus.Methods Patients scheduled for surgery due to LDH underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography less than two weeks pr...

We recently recorded, processed, and published brain activity by quantitative electroencephalography (EEG) tomography (QEEGt), comparing separate subjects remembering their near-death experience (NDE) and mystical experience. Our studies refer to a mystical experience as a spiritual contemplative experience (SCE). We found neural and Greyson Scale...

Spirituality and Psychiatry addresses the crucial but often overlooked relevance of spirituality to mental well-being and psychiatric care. This updated and expanded second edition explores the nature of spirituality, its relationship to religion, and the reasons for its importance in clinical practice. Contributors discuss the prevention and manag...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Integrative medicine includes a combination of current medical therapies in conjunction with evidence-based diet and nutrition support, mind-body practices, and additional practices, sometimes referred to as complementary or alternative. Patients with hepatobiliary or pancreatic cancer often seek integrative therapies to help manage the cancer itse...

Objectives: While there are researches on the neural processes of some religious/spiritual practices like mindfulness meditation, no fMRI research on brain functions of mindfulness in Islam is available. Methods: In this study, by using a 3T MRI machine and recruiting 31 (16F) mentally and physically healthy and highly religious individuals, we per...

Background: The relationship between sexuality, or the libido, and spirituality or religion has long been debated in psychiatry. Recent studies have explored the neurophysiology of both sexual experiences and spiritual practices such as meditation or prayer. In the present study, we report changes in cerebral glucose metabolism in a unique meditati...

Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report...

Introduction Glycaemic variability and other metrics are not well characterised in subjects without diabetes. More comprehensive sampling as obtained with continuous glucose monitoring (CGM) may improve diagnostic accuracy of the transition from health to pre-diabetes. Our goal is to investigate the glycaemic system as it shifts from health to pre-...

[This corrects the article DOI: 10.2196/34995.].

UNSTRUCTURED This is a corrigendum for MS 34995.

Positron emission tomography (PET) has been a key component in the diagnostic armamentarium for assessing neurodegenerative diseases such as Alzheimer or Parkinson disease. PET imaging has been useful for diagnosing these disorders, identifying their pathophysiology, and following their treatment. Further, PET imaging has been extensively used for...

Background: Estrogen receptor-positive breast cancer is the most common type of breast cancer in postmenopausal women. Aromatase inhibitors (AIs) are the endocrine therapy of choice recommended for these patients. Up to 50% of those treated with an AI develop arthralgia, often resulting in poor adherence and decreased quality of life. Objective:...

e12523 Background: Estrogen receptor positive breast cancer (BC) is the most common type of breast cancer in postmenopausal women and aromatase inhibitors (AI) are the endocrine therapy of choice recommended for these patients. Up to 50% of those treated with an AI develop Arthralgia often resulting in poor adherence and decreased quality of life....

Introduction Breast cancer is one of the most commonly diagnosed cancers in women in the US, and its treatments have significant physical and psychological side effects and long-term complications causing significant morbidity and decreased quality of life. Integrative medicine modalities, such as Yoga, have been found to reduce side effects of con...

There is a growing interest in the potential beneficial effects of mindfulness meditation training in protecting against age-related physical, emotional, and cognitive decline. The current prospective, single-center, single-arm study investigated if functional magnetic resonance imaging-based changes in cerebral blood flow and brain functional conn...

Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design. Objective:...

The term “complementary and alternative medicine” (CAM) refers to the broad range of health systems, modalities, and practices that are not part of the conventional and politically dominant health system [1, 2]. We would also suggest that “integrative medicine” incorporates conventional medical approaches with evidence-based complementary approache...

Mild traumatic brain injury (mTBI) accounts for more than 80% of people experiencing brain injuries. Symptoms of mTBI include short-term and long-term adverse clinical outcomes. In this study, resting-state functional magnetic resonance imaging (rs-fMRI) was conducted to measure voxel-based indices including fractional amplitude of low-frequency fl...

Background: The diagnosis of attention deficit hyperactivity disorder (ADHD) relies on history and observation, as no reliable biomarkers have been identified. In this study, we compared a large single diagnosis group of patients with ADHD (combined, inattentive, and hyperactive) to healthy controls using brain perfusion single-photon emission comp...

The purpose of this chapter is to review the potential functional and structural effects on the brain of long-term habitation of human beings on the moon. Using current knowledge about long-term effects of space flight on the central nervous system, we can extrapolate to the potential effects of the moon environment. However, it must be realized th...

BACKGROUND Estrogen receptor–positive breast cancer is the most common type of breast cancer in postmenopausal women. Aromatase inhibitors (AIs) are the endocrine therapy of choice recommended for these patients. Up to 50% of those treated with an AI develop arthralgia, often resulting in poor adherence and decreased quality of life. OBJECTIVE The...

Background: We measured changes in resting brain functional connectivity, with blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI), associated with a creative meditation practice that is augmented by clitoral stimulation and is designed to not only achieve a spiritual experience but to help individuals manage their most...

We hypothesised that unilateral leg pain following surgical treatment of lumbar disc herniation (LDH) is associated with an increase in the glucose metabolism of the contralateral thalamus. Patients scheduled for surgery due to LDH underwent ¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) less than two weeks pr...

Background The purpose of this study was to explore if administration of N-acetyl-cysteine (NAC) in patients with multiple sclerosis (MS) resulted in altered cerebral blood flow (CBF) based on Arterial Spin Labeling (ASL) magnetic resonance imaging (MRI). Methods Twenty-three patients with mild to moderate MS, (17 relapsing remitting and 6 primary...

Taking an integrative approach toward developmental psychology and neurophysiology, this review selects findings from the psychological and medical literature on guilt and bereavement that are relevant to considering whether and how guilt contributes to the development of prolonged grief disorder (PGD) in bereaved persons. Mention of guilt is ubiqu...

In reviewing this literature, there are several apparent takeaways. There are variations in the binding patterns between different tau radiotracers. Nevertheless, there is consistently uptake in certain regions across studies; aberrant binding is expected given the variation in small studies and potential off-site radiotracer binding. However, the...

The detection and association of in vivo biomarkers in white matter (WM) pathology after acute and chronic mild traumatic brain injury (mTBI) are needed to improve care and develop therapies. In this study, we used the diffusion MRI method of hybrid diffusion imaging (HYDI) to detect white matter alterations in patients with chronic TBI (cTBI). 40...

Background: Many patients who have traumatic brain injury experience a wide range of psychiatric and neurological symptoms (including impairment in functional status, cognition, and mood), and if persistent are referred to as persistent postconcussion syndrome (PCS). To our knowledge, this is the first study to broadly evaluate metabolic dysregula...

Development, whether motor, language, social, or spiritual, is the functional expression of complex brain processes throughout one’s life span, the foundations of which are laid in childhood. The effects of cancer, chemotherapy, radiation, and surgical procedures on early brain development have been measured using neuroimaging and developmental ass...

PurposePositron emission tomography (PET) has been widely utilized in the study of traumatic brain injury (TBI) for decades. While most applications of PET have attempted to assess neuronal function after TBI, more recently, novel radiotracers have sought to image biomarkers in the context of TBI and chronic traumatic encephalopathy (CTE).Methods T...

Background Religious and spiritual interventions may have an effect on Alzheimer’s disease prevention. Kirtan Kriya meditation has been shown to mitigate the deleterious effects of chronic stress on cognition, reverse memory loss, and create psychological and spiritual wellbeing, which may reduce multiple drivers of Alzheimer’s disease risk. Objec...

Background: Many individuals participate in spiritual retreats to enhance their sense of spirituality or to improve their overall mental and spiritual well-being. We are not aware of any studies specifically evaluating changes in functional connectivity using functional magnetic resonance imaging (fMRI) in individuals undergoing an intense spiritua...

The lengthy debate on the validity of the amyloid hypothesis and the usefulness of amyloid imaging and anti-amyloid therapeutic interventions in dementia continues unabated, even though none of them have been able to convince the medical world of their correctness and clinical value. There are huge financial interests associated with promoting both...

This study compares the critical neural correlates of two altered states of consciousness: near-death experience (NDE) and spiritual contemplative experience (SCE) a.k.a. mystical experience. For Centuries NDE and SCE have been reported by all faiths including Abrahamic religious contemplatives: Christian mystics, Muslim Sufis, and Jewish Kabbalist...

The purpose of this chapter is to review the potential metabolic, neurotransmitter, and morphological changes that may occur in the human central nervous system (CNS) during long-duration habitation of Earth’s Moon. When there are either permanent space habitats or long-duration interplanetary missions, we must determine if there will be any detrim...

Background While obesity has been shown to be a risk factor for Alzheimer’s disease, the potential mechanisms underlying this risk may be clarified with better understanding of underlying physiology in obese persons. Objective To identify patterns of cerebral perfusion abnormality in adults as a function of body mass index (BMI) defined weight cat...

PET with 18F-fluorodeoxyglucose (FDG) is used to assess a wide array of inflammatory and neoplastic disorders. FDG-PET has shown particular utility in the evaluation of disorders of the central nervous system (CNS). Although fused PET/computed tomography (CT) is frequently used across the globe for these diseases, recent evidence has pointed to PET...

This article reviews and synthesizes the current data on the relationship between the brain and religion and spirituality, with regard to aging and neurodegenerative diseases. Specifically, we consider how religious and spiritual beliefs, attitudes, and practices might be affected by the aging process on the brain, particularly when neurodegenerati...

An influential model of the neural mechanisms of creative thought suggests that creativity is manifested in the joint contributions of the Default Mode Network (DMN; a set of regions in the medial PFC, lateral and medial parietal cortex, and the medial temporal lobes) and the executive networks within the dorsolateral PFC. Several empirical reports...

Purpose: To assess the value of FDG-PET/CT for predicting survival in non-small cell lung cancer (NSCLC) patients measuring global disease activity. Methods: This study included 16 patients with NSCLC (9 females, 7 males) aged 56-86 years (mean: 70 ±9) with FDG-PET/CT performed prior to initiation of nivolumab and after the end of the treatment. Th...

Objectives: Evaluate the efficacy of 5-HT1A/5-HT1B in the assessment of MDD Methods: Major Depressive Disorder (MDD) is a mood disorder that is diagnosed clinically by a constellation of 5 or more symptoms, including at least 1 of either depressed affect or anhedonia, over 2 or more weeks that leads to significant distress in occupational or socia...

Nearly everyone has the ability for creative thought. Yet, certain individuals create works that propel their fields, challenge paradigms, and advance the world. What are the neurobiological factors that might underlie such prominent creative achievement? In this study, we focus on morphometric differences in brain structure between high creative a...

Purpose: The applications of PET/MRI in neuroimaging have improved the use of functional imaging in the brain. Nonetheless, the complex structures within the brain can make quantitative assessment difficult given the partial volume effect. This study develops a novel methodology that segments white matter and grey matter so as to minimize the parti...

Elevated blood pressure (BP) is a major avoidable cause of premature morbidity and mortality in the United States (US) and worldwide, due primarily to increased risks of stroke as well as myocardial infarction. While there are therapeutic lifestyle changes and adjunctive pharmacologic medications of proven benefit, recent interest has increasingly...

Background: Multiple Sclerosis (MS) is an autoimmune disease marked by progressive neurocognitive injury. Treatment options affording neuroprotective effects remain largely experimental. The purpose of this proof of concept study was to explore the effects of N-acetyl-cysteine (NAC) on cerebral glucose metabolism (CMRGlu) and symptoms in patients w...

The basis of this chapter is to provide a phenomenological and scholarly foundation for understanding the rituals and practices associated with various religious and spiritual systems. Thus, we hope to provide scholars, clinicians, and researchers with valuable descriptions of different rituals with a focus on cognitive, emotional, behavioral, and...

Background: It is well known that vibratory and auditory stimuli from vehicles such as cars and trains can help induce sleep. More recent literature suggests that specific types of vibratory and acoustic stimulation might help promote sleep, but this has not been tested with neuroimaging. Thus, the purpose of this study was to observe the effects...

This book codifies, describes, and contextualizes group rituals and individual practices from world religious traditions. At the interface of religious studies, psychology, and medicine, it elucidates the cultural richness of practices and rituals from numerous world religions. The book begins by discussing the role that religious rituals and pract...

The neuroscientific study of religious and spiritual phenomena requires the development of methodologies that can target both the biological as well as the subjective dimensions of such phenomena. The purpose of the current study was to compare various subjective questionnaires evaluating neuropsychological dimensions of religiosity. Many scales an...

Importance Evidence shows that sleep dysfunction and β-amyloid (Aβ) deposition work synergistically to impair brain function in individuals with normal cognition, increasing the risk of developing dementia later in life. However, whether Aβ continues to play an integral role in sleep dysfunction after the onset of cognitive decline in individuals w...