Andrew Mathews

King's College London | KCL · Department of Psychology

Objective: Generalized anxiety disorder (GAD) is a debilitating condition, characterized by negative interpretations about ambiguous situations. This study tested whether entirely internet-delivered interpretation training [cognitive bias modification (CBM)] versus control promotes positive interpretations and reduces worry and anxiety in individua...

Objective: Repetitive negative thinking (RNT; e.g., worry and rumination) is common across emotional disorders, as is the tendency to generate negative interpretations (interpretation bias). Ameliorating negative interpretations via cognitive bias modification of interpretations (CBM-I) reduces worry/rumination, and improves mood in people diagnos...

Objective: Repetitive negative thinking (RNT) for example, worry in generalized anxiety disorder (GAD) and rumination in depression, is often targeted during psychological treatments. To test the hypothesis that negative interpretation bias contributes to worry and rumination, we assessed the effects of inducing more positive interpretations in re...

Individuals with high levels of worry are more likely than others to attend to possible threats, although the extent of top-down attentional control processes on this bias is unknown. We compared the performance of high (n = 26) and low worriers (n = 26) on a probe discrimination task designed to assess attention to threat cues, under cognitive loa...

Pathological worry, as in Generalized Anxiety Disorder (GAD), takes a predominantly verbal form, as if talking to oneself about possible negative outcomes. The current study aimed to examine alternative approaches in reducing pathological worry by allocating volunteers meeting diagnostic criteria for GAD to either a condition in which they practice...

Experimental research suggests that dysfunctional forms of cognitive processing help to cause and maintain emotional disorders (Clark & Beck, 2010; Williams, Watts, MacLeod, & Mathews, 1997). Successful cognitive thera-pies involve identifying and challenging these dysfunc-tional cognitions. One example is biased attentional processing of emotional...

Depression has been widely associated with a cognitive deficit leading to the negative interpretation of ambiguous information. Recently, cognitive bias modification (CBM) procedures have shown that such negative biases are causally related to emotional vulnerability. However, research using CBM has been notably lacking in depression. This is the f...

Worry is predominantly a verbal-linguistic process with relatively little imagery. This study investigated whether the verbal nature of worry contributes to the maintenance of worry by enhancing attention to threat. It was hypothesised that verbal worry would lead to greater attentional bias to threat than imagery-based worry. Fifty high-worriers w...

Background & objectives Groups of clients and community volunteers with Generalized Anxiety Disorder (GAD) and clients with Panic Disorder were compared to a group with elevated worry but without GAD on a range of measures, to identify individual differences beyond a high propensity to worry. Method Participants completed standardised questionnair...

There are now a number of experimental studies showing that modification of interpretation biases can influence later emotional vulnerability. We present a series of three experiments in which the first two studies showed no such effects, apparently due to the content of training differing in certain critical respects from that of the intended targ...

Objective: Computerized cognitive behavioral therapy (cCBT) and cognitive bias modification for interpretation (CBM-I) both have demonstrated efficacy in alleviating social anxiety, but how they compare with each other has not been investigated. The present study tested the prediction that both interventions would reduce anxiety relative to a no-i...

The production of mental images involves processes that overlap with perception and the extent of this overlap may contribute to reality monitoring errors (i.e., images misremembered as actual events). We hypothesised that mental images would be more confused with having actually seen a pictured object than would alternative representations, such a...

We present an evidence-based model of pathological worry in which worry arises from an interaction between involuntary (bottom-up) processes, such as habitual biases in attention and interpretation favouring threat content, and voluntary (top-down) processes, such as attentional control. At a pre-conscious level, these processes influence the compe...

Experimental evidence using picture-word cues has shown that generating mental imagery has a causal impact on emotion, at least for images prompted by negative or benign stimuli. It remains unclear whether this finding extends to overtly positive stimuli and whether generating positive imagery can increase positive affect in people with dysphoria....

Cognitive Bias Modification (CBM) procedures have been used to train individuals to interpret ambiguous information in a negative or benign direction and have provided evidence that negative biases causally contribute to emotional vulnerability. Here we present the development and validation of a new form of CBM designed to manipulate the cognitive...

Clients in treatment for Generalized Anxiety Disorder (GAD) were compared to a control group to assess the extent and nature of imagery during worry or while thinking about a personally relevant positive future event. Two methods were used to assess mentation and were completed in counter balanced order within the worry and positive conditions. One...

Clinical anxiety disorders and elevated levels of anxiety vulnerability are characterized by cognitive biases, and this processing selectivity has been implicated in theoretical accounts of these conditions. We review research that has sought to evaluate the causal contributions such biases make to anxiety dysfunction and to therapeutically allevia...

This study investigated the effect on worry of biased attentional engagement and disengagement. Variants of a novel attention modification paradigm were developed, designed to induce a group difference either in participants' tendency to selectively engage with, or disengage from, threatening meanings. An index of threat bias, reflecting relative s...

In this study we assessed the cognitive mechanisms underlying the affective consequences of modifying emotional processing biases. During ‘active’ training participants selected either threatening or non-threatening meanings of emotionally ambiguous words, in contrast to ‘passive’ conditions in which participants read unambiguous words with equival...

Mental imagery has been considered relevant to psychopathology due to its supposed special relationship with emotion, although evidence for this assumption has been conspicuously lacking. The present review is divided into four main sections: (1) First, we review evidence that imagery can evoke emotion in at least three ways: a direct influence on...

Training participants to select threat or nonthreat interpretations of emotionally ambiguous stimuli or passively exposing them to valenced scenarios can modify later interpretation of ambiguity. However, only when encouraged to actively select meanings do congruent changes in emotional response occur during training itself (Mathews & Mackintosh, 2...

The causal role of biased attention in worry was investigated in an experiment in which high worriers were assigned either to a condition requiring attention to nonthreatening words and text while ignoring worry-related material or to a mixed-attention control condition. The former procedure led to fewer negative thought intrusions in a worry test...

This study investigated whether facilitating a benign interpretive bias decreases negative thought intrusions in generalized anxiety disorder (GAD). Clients were randomly allocated to an interpretation modification condition in which they repeatedly accessed benign meanings of emotionally ambiguous homographs and scenarios, or to a control conditio...

In this experiment we investigated the effect of different instructions on the modification of attentional biases, and subsequently on worry persistence. Participants without excessive worry completed a modified dot-probe task, designed to train attention either to threat or neutral words. Half of each group was given explicit instructions regardin...

We tested the hypothesis that people with a high fear of cancer would be more likely to interpret ambiguous information about cancer in a negative manner compared with people low on cancer fear. Adults (n=47) aged 50–70, who scored either high (n=16) or low (n=31) on cancer fear, took part in a laboratory-based ambiguous sentences task. Participant...

This research investigated whether increasing access to benign outcomes of ambiguous events decreases excessive worry. Participants reporting high levels of worry were assigned either to practice in accessing benign meanings of threat-related homographs and emotionally ambiguous scenarios or to a control condition in which threatening or benign mea...

The implicit control of emotion processing was investigated by varying encoding instructions for both negative and neutral pictures while measuring psychophysiological responses. Participants made comparative judgments about consecutive pictures for blocks of neutral or negative content. The highly specified judgment task was designed to minimize v...

The authors report the first direct assessment of working memory capacity when people engage in worry. High and low worriers performed a random key-press task while thinking about a current worry or a positive personally relevant topic. High (but not low) worriers showed more evidence of restricted capacity during worry than when thinking about a p...

The hypothesis that mental imagery is more likely to elicit emotion than verbal processing of the same material was investigated in two studies. Participants saw a series of pictures, each accompanied by a word, designed to yield a negative or benign meaning when combined. Participants were either free to combine the picture and word as they wished...

Up until recently, it had been assumed that attentional biases for negative information do not exist in depression. However studies using post-conscious exposure durations have produced contradictory results. The limitations of common attentional tasks, suitability of stimulus materials and differences in stimulus duration times may have contribute...

Prior work suggests that variations in self-imagery can influence the emotional interpretations people make about social situations. The current experiment investigated the converse possibility: that inducing an inferential bias can change the content of self-related images. The effects of repeated practice in accessing either negative or positive...

This study investigated the role of neutral, happy, fearful, and angry facial expressions in enhancing orienting to the direction of eye gaze. Photographs of faces with either direct or averted gaze were presented. A target letter (T or L) appeared unpredictably to the left or the right of the face, either 300 ms or 700 ms after gaze direction chan...

Previous research has shown that high socially anxious individuals lack the benign interpretation bias present in people without social anxiety. The tendency of high socially anxious people to generate more negative interpretations may lead to anticipated anxiety about future social situations. If so, developing a more benign interpretation bias co...

Cognitive theories propose that the resolution of ambiguity is related to the maintenance of social anxiety. A sentence completion task was used to examine how individuals high (n=26) and low (n=23) in social anxiety resolve ambiguous social sentences. Individuals were asked to generate as many responses as came to mind for each sentence, and then...

If negative interpretational bias causes emotional vulnerability, reduction of this bias should reduce proneness to anxiety. High trait-anxious volunteers were trained over four sessions to resolve descriptions of ambiguous events in an increasingly positive manner. This group subsequently made more positive interpretations of novel descriptions th...

Previous research has shown that interpretation biases can be experimentally induced and endure for 24 hours. In two experiments, we show that induced biases not only persist but survive changes in environmental context, including transferring to different rooms with different experimenters. In one experiment, training and testing materials were al...

Cognitive-behavioral models of clinical problems typically postulate a role for the combined effects of different cognitive biases in the maintenance of a given disorder. It is striking therefore that research has tended to examine cognitive biases in isolation rather than assessing how they work together to maintain psychological dysfunction. The...

Therapists often assume a special association between mental imagery and emotion, though empirical evidence has been lacking. Using an interpretation training paradigm, we previously found that imagery had a greater impact on anxiety than did verbal processing of the same material (Holmes & Mathews, 2005). Although the finding of a differential imp...

This study tests the causal role of negative self-imagery in social anxiety. Low public-speaking anxious volunteers rehearsed a negative self-image, a positive self-image or a control image prior to giving a speech. As predicted, the negative image group felt more anxious, believed they performed less well and reported more negative thoughts than t...

Elevated anxiety vulnerability is associated with a tendency to interpret ambiguous stimuli as threatening, but the causal basis of this relationship has not been established. Recently, procedures have been developed to systematically manipulate interpretive bias, but the impact of such manipulation on anxiety reactivity to a subsequent stressor ha...

A special association between imagery and emotion is often assumed, despite little supporting evidence. In Experiment 1, participants imagined unpleasant events or listened to the same descriptions while thinking about their verbal meaning. Those in the imagery condition reported more anxiety and rated new descriptions as more emotional than did th...

Previous research has demonstrated that it is possible to induce biases in the interpretation of ambiguous text passages by training. Participants consistently trained to interpret emotionally ambiguous passages in either a negative or positive direction show training-congruent effects when presented with new ambiguous material. These training effe...

A review of recent research on cognitive processing indicates that biases in attention, memory, and interpretation, as well as repetitive negative thoughts, are common across emotional disorders, although they vary in form according to type of disorder. Current cognitive models emphasize specific forms of biased processing, such as variations in th...

IntroductionA Classification of Inhibitory Phenomena in Cognition and EmotionThe Controlled Inhibition of Emotional FeelingsThe Automatic Inhibition of Emotional FeelingsControlled Inhibition of Emotional InformationAutomatic Inhibition of Emotional InformationDiscussion and Conclusions References

Previous research with an on-line processing task found that individuals without social anxiety generate benign inferences when ambiguous social information is encountered, but people with high social anxiety or social phobia do not (Hirsch and Mathews, 1997, 2000). In the present study, we tested if it is possible to induce a benign (or less negat...

In this article, we consider the extent to which variations in the neural activation associated with fear-related stimuli are obligatory or optional. More specifically, we investigated modulation of activation according to type of encoding operation, and how this relates to individual differences in fearfulness and attentional control. In an fMRI s...

The encoding of emotional events has sometimes been regarded as automatic, because the processing involved can occur outside awareness. However, this does not mean that emotional encoding cannot be controlled, although it may often be the case that people are unaware of how to do so, or even that such control is possible. Evidence is presented to s...

Evidence has accumulated showing that central aspects of negative emotional scenes are remembered better than equivalent aspects of nonemotional scenes. Previous work, and an attentional account of these findings, led the authors to predict that anxiety-prone individuals would remember extremely negative emotional pictures as if seen from a closer...

We investigated whether a fearful expression enhances the effect of another's gaze in directing the attention of an observer. Participants viewed photographs of faces whose gaze was directed ahead, to the left or to the right. Target letters then appeared unpredictably to the left or right. As expected, targets in the location indicated by gaze wer...

Interpretation bias, the tendency to interpret ambiguous situations in a positive or negative fashion, has been implicated in the maintenance of social anxiety. To examine this hypothesis, off-line interpretations of ambiguous social and nonsocial situations were examined separately for positive and negative bias in a sample of 102 participants who...

Patients with social phobia often experience negative self-images in social situations. The current study investigated whether negative self-images have a causal role in maintaining social phobia. Patients with social phobia participated twice in a conversation with a stranger, once whilst holding their usual negative self-image in mind and once wh...

It is often assumed that emotional stimuli receive high priority for processing, and that the distinction between positive and negative valence is fundamental. However, studies of attention to symbolic stimuli, such as words of different valence, have proved inconclusive. In four experiments, control over the emotional attributes of previously neut...

In several recent studies, P. A. MacDonald and colleagues (e.g., P. A. MacDonald & S. Joordens, 2000) reported unusually large negative priming effects and claimed that attention to distractors, counter to expectations, served to enhance the magnitude of the effect. In 3 experiments using their novel comparative judgment task, negative priming was...

After briefly describing the nature of emotional processing biases associated with vulnerability to anxiety, and a model of how they may be produced, we review new data on the experimental induction of attentional and interpretative biases. We show that these biases can be readily induced in the laboratory, in the absence of mood changes. However,...

Three experiments are reported that bridge previous research on evaluative learning and attentional bias for emotional material. Research in the latter area has shown that negatively valenced stimuli selectively capture attention in those prone to anxiety or depression. It remains unclear whether this is due to differences in acquired emotional eva...

In 3 experiments, the authors investigated whether anxiety proneness is associated with impaired inhibitory processing. Participants made speeded decisions requiring inhibition of threatening or neutral meanings of ambiguous words, which were inappropriate in their current context. In Experiment 1 there were no differences found in inhibitory proce...

Anxiety states are associated with increasedattention to threat and a greater likelihood of reachinga pessimistic interpretation of ambiguous events.Existing models of this selective processing possess features that are difficult to reconcile withcurrent experimental findings. In this paper we build onthese earlier ideas to develop a new model,inco...

The existence of cognitive biases in anxiety is now well established, and we summarize evidence demonstrating attentional vigilance to cues associated with threat, pessimistic interpretation of ambiguous items and an increased perception of the likelihood of occurrence of negative events. We explore how these reactions can be understood within an e...

A modified version of the attentional deployment task developed by MacLeod, Mathews and Tata (1986) [Journal of Abnormal Psychology, 95, 15–20] was used to examine two issues: first, whether there was any evidence of attentional bias in depressed subjects, rather than in anxious subjects alone; and second, whether attentional effects would occur in...

Measures of attention and implicit memory for threatening words were obtained from anxious patients before and after psychological treatment, and compared with data from non-anxious control Ss collected over the same period. Findings confirmed the expectation that the presence of threatening distractors would be associated with greater interference...

Investigated selective processing of emotional information in anxiety and depression using a modified Stroop color naming task. 19 anxious, 18 depressed, and 18 normal control Ss were required to name the background colors of anxiety-related, depression-related, positive, categorized, and uncategorized neutral words. Half of the words were presente...

The study investigated selective processing of emotional information in anxiety and depression using a modified Stroop color naming task. Anxious (n = 19), depressed (n = 18), and normal control (n = 18) subjects were required to name the background colors of anxiety-related, depression-related, positive, categorized, and uncategorized neutral word...

Attentional responses to threat stimuli were assessed in anxious patients, normal controls, and subjects who had recovered from a clinical anxiety state. The main aims of the study were: (1) to replicate MacLeod, Mathews, and Tata's (1986) finding of an attentional bias to threat in currently anxious patients compared with normal control subjects;...

Existing measures of worry content were designed to ascertain levels of worry in special groups, particularly children and the elderly. In the present study, cluster analysis techniques were employed to develop a measure of worry suitable for use on a nonclinical adult population. The Worry Domains Questionnaire (WDQ) yields a global score which is...

Previous experiments on the recall of threatening and neutral information in clinically anxious subjects have yielded mixed results. The present study assessed autobiographical memory in patients with generalised anxiety disorder (GAD), and normal controls. Subjects were first presented with neutral cue words and asked to respond with any personal...

Work conducted under the auspices of the Pennsylvania State University Worry Project suggests that worriers show retarded responding when attempting to categorise ambiguous figures. Recent research has yielded similar findings. These effects might be attributed to a characteristic elevated evidence requirement in high worriers. In the following, an...

It is suggested that worry has not been given serious academic attention due to problems of definition, and a prevailing belief that it is an unnecessary addition to the theorists vocabulary given the term “anxiety”. However, an increasing awareness of the importance of cognitive factors in emotional disorders makes the study of worry a necessary e...

Three experiments used the “colour perception” task described by Gotlib, McLachlan, and Katz (1988) to examine attentional biases in anxiety and depression. Contrary to expectation, Experiment 1 suggested that neither state nor trait anxiety was associated with an attentional bias favouring threat stimuli. Experiment 2 also failed to show a bias to...

There is considerable evidence that anxiety is associated with a cognitive bias favouring the processing of threat-related information. Bower's (1981) network model attributes this bias to the enhanced availability of mood congruent information from memory. However, certain experimental tasks do not reveal such a bias, when this effect is strongly...

It has been shown that, under certain circumstances, anxiety is associated with a processing bias favouring threatening information. To explain why this bias is apparent only on certain cognitive tasks, it has recently been proposed that the bias operates only when there is competition for processing resources. The present study sought to replicate...

Two experiments extended the work of C. MacLeod and A. Mathews (see record 1989-23867-001) and examined whether a cognitive bias for threat information is a function of state or trait anxiety. Color-naming and attention deployment tasks were used to assess the effects of a stress manipulation procedure on attentional responses in high and low trai...

Previous investigations of recall and recognition for threatening information in clinically anxious subjects have yielded equivocal results. The present study contrasts implicit (word completion) with explicit (cued recall) memory and shows that indices of bias for emotional material derived from the two types of memory are independent of one anoth...

A replication of Mathews and MacLeod's (Behav. Res. Ther.23, 563–569, 1985) study, using a modified Stroop task, confirmed that threat words selectively interfere with the colour-naming performance of generally anxious patients, compared with normal controls. Clearer evidence was obtained of a highly specific interference effect of threat words tha...

Memory bias for negative versus positive adjectives was investigated in 11 recovered primary unipolar depressives, 12 non-psychiatric controls and 9 current depressives. Adjectives were presented in an intentional memory task, in either a self- or unfamiliar other person-referent condition, where a yes/no judgement was made of whether each word des...

Various possible differences in cognitive functioning between those high and low in trait anxiety are considered. Particular emphasis is paid to the hypothesis that individuals high in trait anxiety tend to approach threatening stimuli, whereas those low in trait anxiety tend to avoid such stimuli. The evidence indicates that there are such differe...

Reviews research that used information-processing psychology to investigate the role of cognitive factors in clinical anxiety states. Anxious Ss have been found to be characterized by their tendency to process selectively stimuli related to threat, even when such stimuli are presented outside of awareness. Similarly, anxious Ss tend to select the m...

In the preceding chapter we argued that clinical anxiety may be related to variations in what has been termed trait anxiety. Just as trait anxiety is described as the propensity to experience greater or lesser degrees of fear and anxiety, so particularly high levels of trait anxiety may predispose an individual to develop pathological anxiety state...

This chapter should be read in conjunction with the following chapter by Mathews and Eysenck. The emphasis differs in the two chapters, in that this chapter is concerned with trait anxiety in normals, whereas the chapter by Mathews and Eysenck deals with clinical anxiety. Despite this difference, there is much overlap between the two chapters. As w...

This chapter considers how memory might be influenced by a variety of emotional states and conditions experienced by people with anxiety disorders. It represents a thorough review of research performed with people who describe themselves as generally anxious (without formal diagnosis), as well as with people who have been diagnosed as experiencing...