Andrew Defries

Andrew Defries
Sangre AgroTech · Cannbis Science

Doctor of Philosophy

About

5
Publications
1,233
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276
Citations
Citations since 2016
1 Research Item
211 Citations
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2016201720182019202020212022010203040
Introduction
Doctoral botantist with a interdisciplinary skill set in plant genomic sciences, chemistry and cheminformatics. Experience setting up scientific laboratories for cannabis genetics, breeding, and molecular engineering. Poised to manage a team of scientists and technicians. Lifelong learner with equal parts tenacity, creativity and gusto. http://tinyurl.com/AndrewGoogleScholar

Publications

Publications (5)
Article
Full-text available
The critical role of veins in transporting water, nutrients and signals suggests that some key regulators of vein formation may be genetically redundant and thus undetectable by forward genetic screens. To identify such regulators, we screened over 5,000 structurally diverse small molecules for compounds that alter Arabidopsis thaliana leaf vein pa...
Article
Full-text available
Small molecules (xenobiotics) that inhibit cell-wall-localised enzymes are valuable for elucidating the enzymes' biological roles. We applied a high-throughput fluorescent dot-blot screen to search for inhibitors of Petroselinum xyloglucan endotransglucosylase (XET) activity in vitro. Of 4216 xenobiotics tested, with cellulose-bound xyloglucan as d...
Article
Full-text available
Abscisic acid (ABA) is an essential molecule in plant abiotic stress responses. It binds to soluble pyrabactin resistance1/PYR1-like/regulatory component of ABA receptor receptors and stabilizes them in a conformation that inhibits clade A type II C protein phosphatases; this leads to downstream SnRK2 kinase activation and numerous cellular outputs...
Article
Full-text available
Background DNA methylation ensures genome integrity and regulates gene expression in diverse eukaryotes. In Arabidopsis, methylation occurs in three sequence contexts: CG, CHG and CHH. The initial establishment of DNA methylation at all three sequence contexts occurs through a process known as RNA-directed DNA methylation (RdDM), in which small RNA...

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