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Introduction
Doctor and surgeon of the Universidad Pontificia Bolivariana, specialist in
Gynecology of the same University. Fellow in Breast Cancer Surgery
(Mastology) at the National Institute of Cancerology, Bogotá Colombia. Fellow
Observer MD Anderson Cancer Center Houston Texas, Master in Oncology
Molecular CNIO Madrid Spain.2013-2015
Member of the Colombian Society of Mastology and Active Member of the
American Society Breast Surgeons. I participate in the elaboration of the
Breast Cancer Guidelines 2011 and Updating In 2017 , has been an exhibitor in several National Congresses.
More than 12 Scientific Publications in Indexed International journals And pair
Evaluator of international journals in Breast Cancer. PUBLONS
Current institution
Additional affiliations
January 2020 - present
Position
- Chief Breast Cancer Department
Description
- Public hospital. With 400 beds and about 1,500 health workers, it started its breast cancer unit in January 2020, aimed at the poor and vulnerable population of the country. seeking to be a center of reference in breast pathology for the next 5 years
June 2009 - June 2011
June 2011 - March 2016
Position
- Breast Surgeon, Member Research Unit IDC And Oncogenetic Unit
Education
August 2013 - August 2015
June 2009 - August 2011
Publications
Publications (56)
Background
Our previous study reported higher mRNA levels of the human epidermal growth factor receptor 2 (HER2)-amplicon genes ERBB2 and GRB7 in estrogen receptor (ER)-positive breast cancer patients with relatively high Indigenous American (IA) ancestry from Colombia. Even though the protein expression of HER2 and GRB7 is highly correlated, they...
Background
Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America.
Methods
We investigated the associations between serum bi...
PURPOSE
To report on pathogenic germline variants detected among individuals undergoing genetic testing for hereditary breast and/or ovarian cancer (HBOC) from Latin America and compare them with self-reported Hispanic individuals from the United States.
METHODS
In this cross-sectional study, unrelated individuals with a personal/family history su...
Objectives: This study examined the association between reproductive factors and risk of breast cancer (BC) according to the expression of hormone receptors (HR) in women from three Colombian cities. Methodology: 316 cases were recruited between 2012 and 2019 from major general or cancer-dedicated hospitals were women diagnosed with first primary i...
Introduction: Breast cancer is the most prevalent cancer in women worldwide. It is a heterogeneous disease that has been classified into intrinsic subtypes based on gene expression analyses. Previous studies have reported a higher proportion of HER2-positive (HER2+) tumors in Hispanics/Latinas, compared to Non-Hispanic White women, characterized by...
Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer...
Abstract
Background:
An estimated 43,390 breast augmentation surgeries (86,780 implants) and 1486 breast implant reconstructions are performed annually in Colombia, representing the second-most breast surgery destination in South America, the fourth in the western hemisphere, and the fifth country worldwide. No previous reports have evaluated the...
Objetivo: establecer la asociación entre el retraso en el diagnóstico de cáncer de mama con un estadio clínico avanzado y explorar factores que influyen en dicho retraso. Materiales y métodos: estudio de corte transversal con mujeres mayores de 18 años con cáncer de mama que consultaron en cuatro centros oncológicos de Medellín, Colombia, en 2017....
Objective:
To describe the rationale and the methodology of a multicenter project to study the etiology of breast cancer in young Latin American women.
Materials and methods:
The International Agency for Research on Cancer has established an international collaborative population-based case-control study in four countries in Latin America: Chile...
The study aimed to estimate the effect of health insurance on overall survival and disease-free survival in breast cancer patients undergoing surgery at the Las Américas Oncology Institute in Medellín, Colombia, with data from the institutional registry. The variables were compared between subsidized coverage and contributive coverage with chi-squa...
Etiological differences among breast cancer (BC) subtypes have not been clearly established, especially among young women in Latin America. This study examined the relationship between reproductive factors and BC subtypes among 288 BC cases (20-45 years) and population-based matched controls in four Latin American countries. Immunohistochemistry wa...
El objetivo fue estimar el efecto del aseguramiento en salud sobre la supervivencia global y libre de enfermedad en pacientes con cáncer de mama. La muestra se compuso de mujeres operadas en el Instituto de Cancerología (Medellín-Colombia) con datos del Registro Institucional. Las variables se compararon entre Régimen Subsidiado y Contributivo con...
Colombia is a country with high socioeconomic inequalities and important barriers for health care. Genomic medicine has been slowly introduced into standard clinical care, mainly in oncology, but it is still inadequate because of limited health care resources, deficiency in laws and regulations in genetics, an insufficient number of trained health...
Background: Mastectomy is associated with acute and chronic postoperative pain. This study investigated the efficacy of thoracic paravertebral block (TPB) compared to local anesthetic of surgical wound (LASW) in breast cancer patients undergoing mastectomy.
Methods: This phase 3, randomized controlled, single blind, parallel arms and superiority cl...
Germline mutations in BRCA1 and BRCA2 account for approximately 50% of inherited breast and ovarian cancers. Three founder mutations in BRCA1/2 have been reported in Colombia, but the pattern of mutations in other cancer susceptibility genes is unknown. This study describes the frequency and type of germline mutations in hereditary breast and/or ov...
Objetive: evaluate the efficacy of Thoracic Paravertebral Block compared to Local Anesthetic of Surgical Woundon acute pain at rest and with movement at 24 hours post-mastectomy, measured by a visual analog scale
BACKGROUND: Study Z0011 showed that patients with early breast cancer cT1-2N0 and 1 to 2 Sentinel Nodes (SN) Committed to conservative surgery there was no difference in DFS or OS after SN Only vs Axillary Clearance (AC). In the last 6 years, this strategy has been adopted in our practice in Latin America without knowing the behavior in our populat...
Ductal Carcinoma In Situ (DCIS) constituted less than 5% of malignant breast lesions before mammographic screening era. Currently in developed countries, DCIS corresponds to 20-25% of all breast carcinomas diagnoses. Scarce evidence exist about DCIS behavior in Hispanics People outside United States. Objectives: evaluate overall survival (OS) and d...
Introducción: el 70% de las mujeres tratadas por cáncer de mama experimentan problemas de función sexual; 77% síntomas vasomotores, las cuales tienen el doble de probabilidad de experimentar problemas de función sexual; las que toman inhibidores de aromatasa son más propensas a reportar disfunciones sexuales; y las que tienen problemas de imagen co...
NAC it´s the standard procedure when handling non-surgical tumors and inflammatory breast carcinomas, increases the possibility of conservative surgery and must be considered an evaluative tool in designing a therapeutic strategy. NAC improves Disease-Free Survival (DFS) and Overall Survival (OS) in patients achieving pathological complete response...
Objectives: to investigate the pathological response to NAC and its correlation with IMS, as well as its correlation with DFS and OS in a Hispanic cohort of breast cancer patients treated with NAC
Efecto del aseguramiento en salud sobre la supervivencia global y libre de enfermedad en pacientes operadas por cáncer de mama en un centro oncológico de Medellín: estudio de cohorte histórica
Background:
Numerous epidemiological factors affect the probability of developing breast or ovarian cancer, but no predictor is as determinant as inheriting a mutation in BRCA1 or BRCA2. The concept of the founder effect explains the reduced genetic variability in some populations, according to the theory that new populations can be formed from a...
The Li-Fraumeni syndrome is characterized clinically by the appearance of tumors in multiple organs generally at an early age. This hereditary condition is caused by germinal mutations in the TP53 gene, which codifies for the tumoural suppressor gene p53. We present the case of a patient aged 31 with clinical and molecular diagnosis of Li-Fraumeni...
Li-Fraumeni syndrome is clinically characterized by the development of tumors in multiple organs, often at a young age. This hereditary condition is caused by germline mutations in the gene TP53, which encodes the tumor suppressor gene p53.
We present the case of a 31 year-old woman, with clinical and molecular diagnosis of Li-Fraumeni syndrome, wh...
Abstract
Introduction: Breast Phyllodes tumors are rare breast tumors present in less than 1% of new cases of breast cancer, usually occurring among middle-aged women (40-50 yrs).
Objective: This study shows diagnostic experience, surgical management and follows up of patients with this disease during a period of ten years in a oncology referral ce...
Introduction: the survival of patients with breast cancer varied depending on the timing of the diagnosis,
the biological characteristics of the tumor, racial disparities and the therapies received. There are no
Colombian reports on survival based on molecular subtypes. Objective: to describe the Overall Survival and
Disease-Free Survival according...
Neoadjuvant chemotherapy (NAC) is the standard treatment for patients with locally advanced breast cancer, showing improvement in disease-free survival (DFS) and overall survival (OS) rates in patients achieving pathological complete response (pCR). The relationship between immunohistochemistry-based molecular subtyping (IMS), chemo sensitivity and...
Summary
Li-Fraumeni syndrome (LFS) is clinically characterized by the development of tumors in multiple organs, often at a young age. This hereditary condition is caused by germline mutations in the gene TP53 which encodes the tumor suppressor gene p53.
We present the case of a 31 year-old woman, with clinical and molecular diagnosis of LFS, who wa...
Disclosures Abstract e17553 Background: Breast cancer mortality rates in Colombia remain high in part due to unequal access to quality programs within the country's health care system. Patient navigation Program (PNP) is an intervention that aims at improving health care by providing coordination from diagnosis to treatment. The patient population...
Introducción. Las tasas de mortalidad por cáncer de mama en Colombia siguen siendo altas, entre otras causas por el acceso desigual a los programas de prevención temprana, al tratamiento
oportuno y al seguimiento adecuado. El tipo de afiliación a la seguridad social se ha asociado a la desigualdad en el acceso a estos programas. Los regímenes contr...
Introducción: La supervivencia en las pacientes con cáncer de
mama varía según momento del diagnóstico, características biológicas
del tumor y tratamientos administrados. No hay reportes
colombianos sobre la supervivencia según subtipos moleculares.
Objetivo: Describir SG y SLE según subtipos por inmunohistoquímica
y características clínicas de las...
Resumen: Las recomendaciones para la biopsia por aspiración con aguja fina de mama se desarrollaron y aprobaron en 1997 por el Instituto Nacional de Cáncer en Bethesda, Estados Unidos y fueron adap-tadas a nuestro país en 2007, sin embargo, en los últimos años no se han realizado cambios formales en estas indicaciones. El objetivo de este módulo es...
Disclosures Abstract e11548 Background: in developing countries, there is a need to evaluate the correlation between basic immunohistochemistry (IHC) and OncotypeDX recurrence score (RS) in breast cancer patients. Our primary aim was to determine if RS is predicted by estrogen receptor (ER), progesterone receptor (PR) and Ki67 levels in HER2-negati...
Breast imaging diagnostic have become an indispensable tool for the specialist in breast disease.
Currently, the diagnostic tools are: mammography, breast ultrasound and magnetic resonance;
but they are under study new technologies such as elastography and tomosynthesis (3D digital mammography).
This article presented the most important elements in...
N= 87 Edad Media 53.5 años Mediana 52 años Histología Ductal Infiltrante = 82 (94%) Lobular Infiltrante = 5 (6%) Estado clínico T1= 43 (49%) T2 = 44 (51%) Tipo cirugía Mastectomía=14 (16%) Cuadrantectomía=73 (84%) Rastreador utilizado y detección Tc99=87 /87 (100%) Azul = 85/85 (100%) Intervalo = aplicación/biopsia 1.5 horas Inmediato= Intraoperato...
La quimioterapia neoadyuvante (QTxN) es el estandar de manejo en pacientes con cancer de mama localmente avanzado demostrando mejoría en la supervivencia libre de enfermedad (DFS) y en la supervivencia global (OS) en el grupo de pacientes que alcanzan respuesta patológica completa (PCR). Se realizó un estudio de supervivencia retrospectivo con paci...
Introduction: Breast Phyllodes tumors are rare breast tumors present in less than 1% of new cases of breast cancer, usually occurring among middle-aged women (40 – 50 years) the phyllodes tumors need to be distinguished from the fibroadenoma because of their risk of relapse and possible metastatatic disease. Objective: This study shows diagnostic e...
El presente estudio describe las características clínicas y epidemiológicas de las pacientes con cáncer de mama a quienes se les aplicó la técnica del ganglio centinela en el Servicio de Seno y Tejidos Blandos del Instituto Nacional de Cancerología (INC), en 10 años de experiencia.
Establecer la prevalencia y describir las características clínico-patológicas de las pacientes con cáncer de mama triple-negativo subtipo (basal-like y no basal-like) mediante técnicas de inmunohistoquímica que fueron atendidas en el Instituto Nacional de Cancerología (INC) y el Hospital San José (HSJ) durante el periodo 2006- 2008.
Descripción de una cohorte de pacientes con cáncer de mama triple-negativo subtipo basal-like, atendidas en el Instituto Nacional de Cancerología y en el Hospital de San José durante el periodo 2006-2008 Resumen Objetivos: Establecer la prevalencia y describir las características clínico-patológicas de las pacientes con cáncer de mama triple-negati...
Artículo original Ganglio centinela en cáncer de mama: experiencia 2000-2010 en el Resumen Objetivos: El presente estudio describe las características clínicas y epidemiológicas de las pacientes con cáncer de mama a quienes se les aplicó la técnica del ganglio centinela en el Servicio de Seno y Tejidos Blandos del Instituto Nacional de Cancerología...
92 Artículo original Ganglio centinela en cáncer de mama: experiencia 2000-2010 en el Resumen Objetivos: El presente estudio describe las características clínicas y epidemiológicas de las pacientes con cáncer de mama a quienes se les aplicó la técnica del ganglio centinela en el Servicio de Seno y Tejidos Blandos del Instituto Nacional de Cancerolo...
92 Artículo original Ganglio centinela en cáncer de mama: experiencia 2000-2010 en el Resumen Objetivos: El presente estudio describe las características clínicas y epidemiológicas de las pacientes con cáncer de mama a quienes se les aplicó la técnica del ganglio centinela en el Servicio de Seno y Tejidos Blandos del Instituto Nacional de Cancerolo...
