Andrés Valentí Azcárate

• MD,PhD
• Universidad de Navarra

Background: Bone marrow mesenchymal stem cell (BM-MSC) therapy has emerged as a safe and feasible treatment option for patients with knee osteoarthritis (OA). However, the role of adjuvants remains unclear. Our aim was to evaluate the clinical and radiological effects of hyaluronic acid (HA) in comparison to platelet-rich plasma (PRP) as adjuvants...

Objective This study was conducted to assess the effect of osteochondroplasty on osteoarthritis (OA) prevention, comparing radiological evolution between identical hips from the same patient who had undergone unilateral surgery. Design We retrospectively reviewed radiological evolution between hips with similar shape from the same patient who had...

Purpose A question still remains as to whether constrictive toe-box shoes (TBS) cause disability only due to pain on pressure points or if they can cause permanent changes in the hallux anatomy. The aim of this study is to compare the hallux morphology in 3 groups classified according to their use of constrictive or open TBS. Methods 424 patients...

Objective To evaluate the clinical effectiveness, tolerability, and impact on quality of life of Hymovis in the conservative treatment of overuse cartilage lesions due to osteoarthritis and/or meniscus tears. Patients and methods Non-interventional, prospective, descriptive, observational, multicenter study of 165 patients aged over 18 years with...

Background: Knee osteoarthritis (KOA) and meniscal tears (MT) are the two most common types of knee injuries having an important impact on the quality of life of patients (QoL). The objective is to evaluate the impact on the QoL, physical activity and satisfaction degree of patients with KOA, MT or both conditions after intraarticular Hymovis infil...

Background: Knee osteoarthritis (KOA) and meniscal tears (MT) are the two most common types of knee injuries having an important impact on the quality of life of patients (QoL). The objective is to evaluate the impact on the QoL, physical activity, and satisfaction degree of patients with KOA, MT, or both conditions after intra-articular Hymovis in...

The purpose of this study was to determine if driving ability 6 weeks after anterior cruciate ligament (ACL) reconstruction is affected by the addition of a meniscal suture. It was also hypothesized that no differences in the driving performance would be found between right or left knee surgery subgroups. A total of 82 people participated in this p...

Several studies have shown that double mobility (DM) cups reduce postoperative dislocations. Does the cemented dual mobility cup reduce dislocations in a specific cohort of elder patients with a high dislocation risk? Our hypothesis is that this implant is optimal for elder patients because it reduces early dislocation. We have retrospectively revi...

Introduction The knee in Parkinson’s disease (PD) patients is a problematic joint due to pain, stiffness and gait instability. The aim of this study is to evaluate the functional outcome and degree of pain relief achieved after total knee arthroplasty (TKA) in PD patients. Materials and methods This is a retrospective review of 26 PD patients (32...

Background There is some controversy about how the proximal tibiofibular joint (PTFJ) capsulotomy changes PTFJ anatomy in closed-wedge high tibial osteotomy (CW-HTO) and about how this affects ankle and knee mobility and the onset of lateral knee pain. The aim of this study is to evaluate changes in PTFJ after CW-HTO, and its possible clinical sign...

Background: Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants must be determined. Here, we evaluated the clinical effects of a dose of 100 × 106 bone marrow mesenchymal stromal cells (BM-MSCs...

Background and objective Currently, there is no stablished pre-operative model that helps the orthopaedic surgeon predict the final graft diameter in anterior cruciate ligament reconstruction (ACLR). The purpose of this study was to determine whether there is a correlation between semitendinosus (ST) and gracilis (GT) cross-sectional area (CSA) eva...

Background During the last century, total hip arthroplasties have become more popular. They have had a huge impact on the quality of life, pain, range of motion, social interaction, and psychological well-being. A number of studies have emphasized the importance of using templates to choose the appropriate implant size when planning the surgery. Ou...

Background and objectives There are no randomized prospective studies that evaluate sports activity after total hip arthroplasty (THA). The objective of this study is to assess the level and type of sports activity in patients undergoing THA and to assess the recommendations given by physicians. Materials and methods We performed a descriptive stu...

Resumen Antecedentes y objetivo Actualmente no existe un modelo establecido en la práctica clínica que permita predecir de forma fiable este parámetro. El objetivo del estudio fue valorar si existe correlación entre el área total sumada de los tendones recto interno (TRI) y semitendinoso (ST) en estudios preoperatorios de resonancia magnética (RM)...

Resumen Antecedentes y objetivos No hay estudios prospectivos aleatorizados que evalúen la actividad deportiva tras una artroplastia total de cadera (ATC). El objetivo de este estudio es evaluar el nivel y el tipo de actividad deportiva en pacientes intervenidos de ATC y valorar las recomendaciones dadas por los médicos. Materiales y métodos Estu...

Background Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants must be determined. Here, we evaluated the clinical effects of a dose of 100 × 10⁶ bone marrow mesenchymal stromal cells (BM-MSCs)...

Background Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants must be determined. Here, we evaluated the clinical effects of a dose of 100x10 6 bone marrow mesenchymal stromal cells (BM-MSCs) i...

Background: Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants must be determined. Here, we evaluated the clinical effects of a dose of 100x10⁶ bone marrow mesenchymal stromal cells (BM-MSCs) i...

Background: Mesenchymal stromal cells (MSCs) are a promising option to treat knee osteoarthritis (OA). Their safety and usefulness have been reported in several short-term clinical trials but less information is available on the long-term effects of MSC in patients with osteoarthritis. We have evaluated patients included in our previous randomized...

Background: Having had a previous experience of 4 open F2 osteotomies to correct interphalangeal hallux valgus, the aim of this study was to test the efficacy of a percutaneous approach for this correction. Methods: 3 open and 12 percutaneous F2 osteotomies in 15 cadaver feet were performed. Interphalangeal (IPH), F2 asymmetry (AF2) and joint de...

Background: There are no well-established guidelines for safe driving after injury or surgical treatment. The purpose of this study was to assess the aptitude to regain driving skills and brake reaction abilities after anterior cruciate ligament (ACL) surgery. Methods: This study compared the driving abilities and skills at four to six weeks aft...

Background: Mesenchymal stromal cells (MSCs) are a promising option to treat knee osteoarthritis (OA). Their safety and usefulness have been reported in several short-term clinical trials but less information is available on the long-term effects of MSC in patients with osteoarthritis. We have evaluated patients included in our previous randomized...

Background Exostoses at the base of the distal phalanx of the great toe are usually asymptomatic. The literature has not generally considered them as the origin of a possible problem resulting from a pressure conflict between hallux and shoe (medial aspect) or second toe (lateral aspect) nor a potential complication of surgical correction of hallux...

Background Mesenchymal stromal cells are a promising option to treat knee osteoarthritis. Their safety and usefulness must be confirmed and the optimal dose established. We tested increasing doses of bone marrow mesenchymal stromal cells (BM-MSCs) in combination with hyaluronic acid in a randomized clinical trial. MaterialsA phase I/II multicenter...

BACKGROUND: Interphalangeal deformities are not usually included in feet deformity treatment algorithms. There are few studies on the correction of hallux distal phalanx deviation. AIM: The aim of this study is to test efficacy and security of using a percutaneous technique to correct valgus of hallux second phalanx. METHOD After having planned a...

BACKGROUND: Interphalangeal valgus angle of the hallux can be decomposed into obliquity angle (AF1), asymmetry angle (AF2) and joint deviation. There is insufficient evidence to determine the normal range of these angles and how they affect each other, as well as how they adjust in different foot morphologies. AIM The aim of this study is to examin...

Fracture nonunion is a major complication of bone fracture regeneration and repair. The molecular mechanisms that result in fracture nonunion appearance are not fully determined. We hypothesized that fracture nonunion results from the failure of hypoxia and hematoma, the primary signals in response to bone injury, to trigger Bmp2 expression by mese...

Fracture nonunion is a major complication of bone fracture regeneration and repair. The molecular mechanisms that result in fracture nonunion appearance are not fully determined. We hypothesized that fracture nonunion results from the failure of hypoxia and hematoma, the primary signals in response to bone injury, to trigger Bmp2 expression by mese...

Resumen. e inmadurez esquelética suponiendo un reto en el tratamiento. Nuestro objetivo es valorar el resultado clíni-revisado retrospectivamente a los pacientes con síndrome de Down e inmadurez esquelética intervenidos por síndrome de Down. Summary. Down syndrome patients could be enough for patellar instability treatment. Introducción La inestabi...

Economic crisis time gives to efficient procedures an important role in healthy system. Total hip replacement is a common bilateral orthopedic procedure, but there exists an important controversy to perform it in single or two stages. Our aim is to report our clinical and radiological short-term complications of bilateral uncemented total hip arthr...

Introduction: To compare the clinical, analytical and graft maturation effects of two different platelet-rich plasma (PRP) preparations applied during anterior cruciate ligament (ACL) reconstruction. Materials and methods: A total of 150 patients with ACL disruption were included in the study. Arthroscopic ACL reconstruction with patellar tendon...

The purpose of the present study is to translate and validate the “Hip and Knee Outcomes Questionnaire”, developed in English, into Spanish. The ‘Hip and Knee Outcomes Questionnaire is a questionnaire planned to evaluate the impact in quality of life of any problem related to the human musculoskeletal system. 10 scientific associations developed it...

Patellar tendon rupture after total knee replacement is a rare and highly limiting injury with multifactorial aetiology. Many reconstruction techniques have been described with not very predictable results. The use of allografts has been accepted as a suitable solution. A series of seven patients with patellar tendon rupture treated with fresh-froz...

The aim of this study is to compare effectiveness and safety profile of rivaroxaban with bemiparin in 3-week extended prophylaxis after knee arthroscopy. Four hundred and sixty-seven patients were included in this review divided in two groups. One followed prophylaxis with rivaroxaban and the other one with bemiparin. All patients were interviewed...

IntroductionIn clinical practice, we see quite often painful sterno-clavicular prominence, deformity, which is the hallmark of two entities with a low incidence, although well defined hyperostosis cost sterno-clavicular (HECC) and ossification cost inter-sternoclavicular (OIECC). The differential diagnosis of these conditions, you must include ster...

IntroductionIn clinical practice, we see quite often painful sterno-clavicular prominence, deformity, which is the hallmark of two entities with a low incidence, although well defined hyperostosis cost sterno-clavicular (HECC) and ossification cost inter-sterno-clavicular (OIECC). The differential diagnosis of these conditions, you must include ste...

The aim of this study was to evaluate and compare the clinical and inflammatory parameters with the addition of platelet-derived growth factor (PDGF) in primary anterior cruciate ligament (ACL) reconstruction with bone-patellar tendon-bone allograft. We prospectively randomized 100 patients undergoing arthroscopic patellar tendon allograft ACL reco...

Unlabelled: The authors present the case of a 54-year-old female who developed a painful compression lesion localized to the medial aspect of the base of the distal phalanx of the great toe as a complication of hallux valgus surgery. Preoperative radiographic evaluation of the patient's foot revealed the first ray to be longer than the second, a 1...

Introduction The result of total knee replacement (TKR) after proximal tibial osteotomy performed to treat unicompartmental knee osteoarthritis is a highly relevant issue given the widespread use made nowadays of unicompartmental knee prostheses. This is a retrospective comparative study carried out to determine whether the presence of a previous o...

Aim To review our cases of resection arthroplasty in order to determine outcomes and possible complications. Materials and methods We performed a retrospective study of 23 hips that had undergone reconstruction during the last 2.2 years on average. The inclusion criteria were: resection arthroplasty, joint prosthesis reconstruction, and a minimum...

RESUMEN Describimos la metodología del Banco de Huesos y Tejidos blandos desde su extracción y su almacenamiento hasta su utilización. Desde el año 1986 con la creación del Banco de Huesos en la Clínica Universitaria de Navarra, se han utilizado más de 3.000 injertos para cirugías muy diversas. Los injertos óseos se pueden clasificar en corticales...

Describimos la metodología del Banco de Huesos y Tejidos blandos desde su extracción y su almacenamiento hasta su utilización. Desde el año 1986 con la creación del Banco de Huesos en la Clínica Universitaria de Navarra, se han utilizado más de 3.000 injertos para cirugías muy diversas. Los injertos óseos se pueden clasificar en corticales y esponj...

We describe the methodology of the Bone and Soft Tissue Bank, from extraction and storage until use. Since the year 1986, with the creation of the Bone Bank in the University Clinic of Navarra, more than 3,000 grafts have been used for very different types of surgery. Bone grafts can be classified into cortical and spongy; the former are principall...