Andrei Mihai Măluțan

Andrei Mihai Măluțan
Iuliu Haţieganu University of Medicine and Pharmacy | UMF Cluj · IInd Obstetrics and Gynecology

MD, PhD

About

71
Publications
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486
Citations
Citations since 2017
28 Research Items
420 Citations
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2017201820192020202120222023020406080

Publications

Publications (71)
Article
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Citation: Bucuri, C.; Mihu, D.; Malutan, A.; Oprea, V.; Berceanu, C.; Nati, I.; Rada, M.; Ormindean, C.; Blaga, L.; Ciortea, R. Fetal Ovarian Cyst-A Scoping Review of the Data from the Last 10 Years. Medicina 2023, 59, 186. https://doi. Abstract: Abdominal cystic masses are diagnosed during the intrauterine period and have a relatively low incidenc...
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Unlabelled: A fetus identified to be at risk for chromosomal abnormalities may benefit from identification of genetic defects through amniocentesis. Although the risks associated with amniocentesis are considered to be minimal, being an invasive procedure it is not completely without complications. Background and objectives: The current study ai...
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Cervical cancer is one of the most common malignancies in women in terms of prevalence and mortality. Cervical cancer has some particularities that distinguish it from any other oncologic pathology: first, it is completely preventable by prompt detection of its precursor, cervical intraepithelial neoplasia (CIN); second, the Human Papillomavirus (H...
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Background: The etiology of embryonic demise is multifactorial, with chromosomal abnormalities being the most common (60%). The purpose of this study is to evaluate the correlation between a serum biomarker, Placental Growth Factor (PlGF) and an ultrasonographic parameter, the distance between Yolk Sac (YS) and embryo (DYSE), in assessing the progn...
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Objectives: Late first-stage or second-stage cesarean section is commonly associated with fetal head impaction, leading to maternal and neonatal complications. This situation requires safe delivery techniques, but the optimal management remains controversial. The aim of this meta-analysis was to compare maternal and neonatal outcomes associated wi...
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The ultrasonographic (US) features of endometriomas and hemorrhagic ovarian cysts (HOCs) are often overlapping. With the emergence of new computer-aided diagnosis techniques, this is the first study to investigate whether texture analysis (TA) could improve the discrimination between the two lesions in comparison with classic US evaluation. Fifty-s...
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Aims: To analyse the intra- and interobserver variability of two elastographic methods of quantification available on the same machine, the technical factors that may influence variability as well as the intra- and interobserver variability for the same indices between two different ultrasound machines in an in vitro experimental setting. Materia...
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Background and Objectives: To assess ovarian cysts with texture analysis (TA) in magnetic resonance (MRI) images for establishing a differentiation criterion for endometriomas and functional hemorrhagic cysts (HCs) that could potentially outperform their classic MRI diagnostic features. Materials and Methods: Forty-three patients with known ovarian...
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Aims: To revise the current literature about the usefulness of elastography in cervical cancer (CC) and cervical intraepithelial neoplasia (CIN), from methods and technical limitations, to diagnosis, staging and the ability of predicting the response to oncologic treatment. Methods: An electronic database search was performed (PubMed, EMBASE, We...
Article
Aims In overactive bladder (OAB) research, different biomarkers have been proposed as diagnostic tools and may be used to create individual patient profiles. Assessing the diagnostic performance of biomarkers would better outline their utility. Therefore, our aim was to investigate the diagnostic value of four urinary biomarkers: human brain derive...
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Background and aims. The microscopic description of the nerve fibers responsible for micturition is useful when planning minimally invasive interventions for refractory overactive bladder such as intravesical botulinum toxin injections. The purpose of this study was to investigate the density of nerves and ganglia within the bladder trigone, with a...
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Aims: To assess the usefulness of real time elastography (RTE) strain ratio (SR) in diagnosing cervical cancer (CC) and cervical intraepithelial neoplasia (CIN), using a synthetic experimental device (ED) as reference material. Material and methods: Seventy-nine participants were enrolled, divided in three groups: Group 1 - benign cervix (n=39);...
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Background and objectives: As pelvic floor disorders are often difficult to assess thoroughly based on clinical examination alone, the use of imaging as a complementary technique is helpful. This study’s aim was to investigate by transperineal ultrasound (US) if there was any significant difference in the mobility of the bladder neck in women with...
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Objective The etiology of embryonic demise is multifactorial, with chromosomal abnormalities being the most common (40%). The purpose of the present study is to evaluate the correlation between a serum biomarker, progesterone, and an ultrasonographic parameter, the distance between yolk sac and embryo (DYSE) in assessing the prognosis of pregnancy...
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Background and objectives: Doppler ultrasound of umbilical and fetal vessels is useful for monitoring fetal well-being, fetal anemia, intrauterine growth retardation, and other perinatal outcomes. The adverse perinatal outcome and circulatory changes can be reflected in fetal Doppler studies. The aim of this study was to evaluate the effect of incr...
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Aims: Embryonic demise is a frequent complication of the first trimester pregnancy. The purpose of this study was to evaluate the correlation between a serum biomarker, the soluble form of the vasculo-endothelial growth factor (sFlt-1) and the distance between the yolk sac (YS) and embryo (DYSE), determined by ultrasonography.Material and methods:...
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Twin reversed arterial perfusion (TRAP) sequence is a rare and severe complication specific to monochorionic twin pregnancies, involving the presence of an acardiac twin and a structurally normal co-twin (pump twin). We report on the case of a33-year-old female with a biamniotic monochorionic twin pregnancy complicated with TRAP sequence and polyhy...
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Urinary incontinence (UI) represents a condition that, although not vital, has a significant impact that can interfere with the quality of life in a meaningful way for many women, its overall prevalence being of approximately 40%. Since 1920, urogynecologists showed an increasing interest in imaging techniques of the pelvic floor, ultrasound being...
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Preeclampsia (PE), a pathological entity characterized by hypertension and pregnancy-related proteinuria, is a medical condition of incompletely known etiopathogenesis. Placental defects and placental angiogenesis may be a cause of this condition. The main factor that controls angiogenesis in the early stages of placental development is vascular en...
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Visceral obesity is a risk factor for endometrial cancer (EC). Visceral adipose tissue secretes over 50 inflammatory cytokines that can act centrally to regulate different physiological processes of the body but also remotely involved in communicating messages from the adipose tissue to other target tissues. The purpose of this study is to demonstr...
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Pregnancy is associated with a procoagulant predisposition considered preparatory for the hemostatic challenge of delivery. During pregnancy, deep vein thrombosis (DVT) involves the left leg in 88% of cases. Our patient presents with atypical distribution of DVT. A primipara presented to our service with pain and thrombosed veins of the right calf...
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Preeclampsia is a syndrome that affects approximately 2-8% of all pregnancies [1] and is closely linked to a particularly elevated inflammatory response, its presence resulting in high maternal and neonatal mortality. Several adipokins have been found to be involved in this process. Visfatin is a cytokine that exerts its effects especially on metab...
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Background . Leiomyomas are a known cause of infertility and recurrent pregnancy loss, with a global incidence of 25-30% and 2.7-10.7% during pregnancy. They can have an unpredictable evolution and determine numerous complications during pregnancy, such as preterm delivery and severe postpartum hemorrhage. Case presentation. This case report presen...
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Background and aims. Endometriosis is a commonly found disorder in women of reproductive age, consisting in the presence of active ectopic endometrial tissue outside of the endometrial cavity. Surgical scar endometriosis is a rare condition representing about 2% of all endometriosis cases. The purpose of this study was to assess the main characteri...
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Background and aim. The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. Materials and methods. A total of 160 women were divided in two study groups (Group I – endometriosis; Group 2 – healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eo...
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Purpose Endometriosis has an incidence reaching up to 50% in infertile women. Cytokine-mediated immune responses seem to play an important role in endometriosis pathogenesis, but still the etiology and pathophysiology remain unclear. In the current study we tried to investigate whether there is a relationship between IL-10 genetic polymorphism, ser...
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Holoprosencephaly (HPE), a major congenital abnormality in brain development is characterized by the absence or incomplete cleavage of prosencephalon into separate hemispheres, with cyclopia as the extreme manifestation of HPE, presenting as a failure of embryonic prosencephalon to properly divide the orbits of the eye in two cavities. We report th...
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Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, pro...
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Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, pr...
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Background: The purpose of this study was to assess the histological changes occurring in the vagina and vulva in ovariectomised female rats, as well as the response to the administration of injectable oestrogens. Material and methods: We used 30 female Wistar white rats, distributed as follows: group 1 - the control group, group 2 - the operate...
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Increased recurrence of pelvic organ prolapse (POP) following reconstructive pelvic surgery entails a careful surgical technique, corroborated with the possibility of using biological or synthetic prostheses to ensure adequate support. Simultaneous correction of pelvic floor disorders and urinary incontinence can be performed using prosthetic mater...
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Aim of the study Aim of the study was to investigate interleukin (IL)-4 serum levels in patients with advanced endometriosis and whether IL-4 promoter region (-590C/T) genetic polymorphism is involved in genetic susceptibility to endometriosis. Material and methods IL-4 serum levels and IL-4 -590C/T genetic polymorphism were determined for 80 pati...
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The purpose of this electrone microscopy study was to identify and specify structural and ultrastructural changes occurring in the vulvar epithelium of ovariectomised female rats, as well as their reactivity to the administration of injectable oestrogens. We used 30 female Wistar white rats, distributed in four groups with 1 control group, to which...
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The purpose of this study has been to identify the reaction occurring at the level of the vulvovaginal epithelium in ovariectomised female rats, after the administration of injectable oestrogens. We have studied 30 female Wistar white rats, with control group. 15 days after surgery, the hormonal substitution therapy with injectable oestrogens was i...
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The purpose of this study has been to identify and emphasise structural and ultrastructural modifications occurring in the vaginal epithelium in ovariectomised female rats, as well as their reactivity to the administration of injectable oestrogens. 30 female Wistar white rats have been used, with an average weight of 200 g, distributed as follows:...
Article
Embryonic demise is the most common event in the lives of women during theirs reproductive time with a rate of about 25%. The aim of this review is to outline the most important paraclinic and biological prognostic parameters. English language articles containing keywords like “embryonic demise”, “predictive factors” which were searched using Med...
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Aims: To characterize the vascularity of endometriotic cysts using color Doppler ultrasound and to differentiate more accurately between endometriotic cysts and other pelvic cyst masses. Methods: Two prospective studies were initiated: the first included 50 patients diagnosed with ovarian endometriotic cysts and 50 patients without gynecological pa...
Article
Full-text available
Embryonic demise is the most common event in the lives of women during theirs reproductive time with a rate of about 25%. The aim of this review is to outline the most important paraclinic and biological prognostic parameters. English language articles containing keywords like "embryonic demise", "predictive factors" which were searched using Medli...
Article
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Context: Endometriosis is a common gynecological disease, characterized by ectopic deposits of endometrial tissue outside of the uterine cavity, and it is associated with pelvic pain and infertility, with an important impact on the quality of life. At this point there is a controversy regarding the etiology and pathophysiology of endometriosis and...
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Introduction. The identification of biological markers that indicate an increased risk for the development or recurrence of endometrial cancer (EC) in obese women might be useful for decreasing EC mortality and morbidity. Glucose-regulated protein 78 (GRP78) is a major protein of the endoplasmic reticulum expressed in all normal cells. Overexpressi...
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Hormonal contraception represents the contraceptive method of choice for the majority of women aged between 15 and 44 from developing countries. The majority of autoimmune diseases, especially rheumatologically ones, as systemic lupus erythematosus (SLE), rheumatoid arthritis, polymyositis or dermatomyositis, scleroderma or Sjogren syndrome, mainly...
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Background: Endometriosis is a frequent gynecologic disease with a severe impact on the quality of life in affected women; its pathogenesis is yet to be fully understood, with an altered immunity as a possible key factor. The present study aimed to investigate the serum anti-inflammatory cytokine profile in patients with endometriosis compared with...
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The aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis. Material and methods: The study included 160 women, who were divided in two study groups (Group I – endometriosis; Group 2 – healthy). We evaluated the serum levels of interleukin (IL)-1β, IL-5, IL-6, IL-7, and IL-12, and o...
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pregnancy. Materials and methods: The following serum parameters were determined in three groups of patients: leukocytes, neutrophils, tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), C-reactive protein (CRP), and certain markers of oxidative stress. Fetal status was assessed based on the gestational age at which birth occurred, on the Apgar...
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In rats with surgically induced primary ovarian failure, melatonin may influence intra-retroperitoneal fat and a number of metabolic factors, which are risk factors for a number of disorders, including endometrial cancer (EC). The aim of this study is to investigate the influence of melatonin treatment in female rats with surgically induced menopau...
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Endometriosis is a benign gynaecological disease with an unclear pathophysiology characterized by ectopic endometrium causing endometrium-like inflammatory lesions outside the uterine cavity. Genetic, endocrine, immunological, and environmental factors have been suggested in its pathogenesis. A great number of studies have investigated genetic p...
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Glucose-regulated protein 78 (GRP78) is a major ubiquitous endoplasmic reticulum (ER) protein expressed in normal cells. It belongs to the heat shock protein (HSP) family and is induced by a variety of stress conditions. In cancer cells, in addition to its location in the ER, GRP78 is also present in the plasma membrane, serving as a receptor for v...
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The aim of the study was to determine menopause-related changes in serum levels of main proinflammatory and anti-inflammatory cytokines. The study included 175 women, who were divided into 5 study groups (group 1 - fertile women; group 2 - pre- and perimenopausal women; group 3 - postmenopausal women; group 4 - surgically induced menopausal women;...
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Background. Osteoporosis has a high incidence after menopause, and at the same time the relationship between menopausal oestrogen deprivation and proinflammatory status is considered to be involved in postmenopausal bone turnover. Objective. The aim of this study was to evaluate the serum levels of IL-1β and of the TNFα in pre and postmenopausal wo...
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The aim of this study was to investigate the plasma level of the degradation products of nitric oxide - which is a potent vasodilator - in relation to the plasma levels of the degradation products of reactive oxygen species and to the plasma levels of antioxidants in preeclampsia. About 240 patients were considered for the study divided into three...
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Aim. The aim of this study was to assess serum levels of the key anti-inflammatory cytokines in women of reproductive age and in pre and postmenopausal women. Material and Method. 175 women were enrolled and were divided into 5 groups (1 – Fertile women; 2 – Pre-and perimenopausal women; 3 – Postmenopausal women; 4 – Surgically-induced menopause; 5...
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Objective. We aimed to assess serum levels of interleukin (IL) -20 in menopausal patients and its relationship to nutritional status. Methods. A number of 175 women were included in the study and divided into five groups, as follow: control group, pre-menopause group, post-menopause group, surgical menopause group and chronic inflammation group. We...
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Ovarian pregnancy is a rare entity. Making a definitive preoperative or even intraoperative diagnosis of ovarian pregnancy is difficult and the diagnosis is usually established by the pathologist. Rupture in the first trimester is the usual rule in ovarian ectopy. Thus, it continues to challenge practicing clinicians. The literature shows an associ...
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Objectives. The aim of this study was to evaluate serum levels of interleukin (IL)-8 in pre- and postmenopausal women and in patients with surgically-induced menopause, and the relationship between IL-8 and vasomotor symptoms. Material and Method. 175 women were enrolled and were divided into 5 groups (I – Fertile women; II – Pre- and perimenopausa...
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Static genital disorders during menopause become clinically apparent when the process of involution and atrophy exceeds the physiological posibility of compensation. Surgery of the pelvic floor is considered an intermediate risk procedure with a perioperative mortality rate below 5%. Surgery for older women should be performed after identifying and...
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To evaluate the intensity of oxidative stress in normal pregnancy and in pregnancy complicated by preeclampsia. To investigate a possible correlation between the intensity of oxidative stress, severity of preeclampsia and the fetal status at birth. A retrospective transversal study was performed in three groups of 80 patients each: Group I--preecla...
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The information provided by Doppler ultrasound examination during labor permits the understanding of the mechanisms regarding the physiology and pathophysiology of feto-placental exchange and the fetal adaptive systems. There are certain technical difficulties related to intrapartum Doppler ultrasound examination. The investigated sites are the ute...
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Introduction: In pregnancies with preeclampsia, there is a generalized inflammatory response, which is much more intense than in normal pregnancy. Aim: To evaluate leukocytes and neutrophils in the serum of pregnant women with preeclampsia and to compare these values to normal pregnancy. To investigate a possible relation between the detected value...