Andreas Santamaria

Andreas Santamaria
Institut Laue-Langevin · Large Scale Structures

PhD

About

10
Publications
1,177
Reads
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57
Citations
Citations since 2017
10 Research Items
57 Citations
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Introduction
Andreas Santamaria currently works at the Institut Laue-Langevin as PhD student. The project is focused on the study of the interaction between proteins and model membranes. The proteins involved can be divided in two main branches: endocytic proteins from Clathrin Mediated Endocytosis and proteins from SARS-CoV19.
Additional affiliations
October 2017 - October 2018
University of Naples Federico II
Position
  • Master's Student
Description
  • Investigation and modulation of aptamer functionality by a combined use of click-chemistry and X-ray crystallography. This research project was developed in collaboration with prof. Mayer of LIMES Institute (Bonn University).
Education
September 2016 - October 2018
University of Naples Federico II
Field of study
  • Chemical Sciences

Publications

Publications (10)
Article
Full-text available
Hypothesis: Inositol phospholipids are well known to form clusters in the cytoplasmic leaflet of the plasma membrane that are responsible for the interaction and recruitment of proteins involved in key biological processes like endocytosis, ion channel activation and secondary messenger production. Although their phosphorylated inositol ring headgr...
Article
Full-text available
Reversible control of the 3D structure of polyelectrolyte/surfactant films at the air/water interface is showcased. A recently discovered mechanism is exploited to form highly efficient, stable and biocompatible films by spreading aggregates composed of poly-L-lysine and sodium dodecyl sulfate on the surface of water. Reversible control of: (1) the...
Preprint
Unravelling the structural diversity of cellular membranes is a paramount challenge in life sciences. In particular, lipid composition affects the membrane collective behaviour, and its interactions with other biological molecules. Here, the relationship between membrane composition and resultant structural features was investigated by surface pres...
Article
Full-text available
Coronavirus disease-2019 (COVID-19), a potentially lethal respiratory illness caused by the coronavirus SARS-CoV-2, emerged in the end of 2019 and has since spread aggressively across the globe. A thorough understanding of the molecular mechanisms of cellular infection by coronaviruses is therefore of utmost importance. A critical stage in infectio...
Preprint
Full-text available
Coronavirus disease-2019 (COVID-19), a lethal respiratory illness caused by the coronavirus SARS-CoV-2, emerged in the end of 2019 and has since spread aggressively across the globe. A thorough understanding of the molecular mechanisms of cellular infection by coronaviruses is therefore of utmost importance. A critical stage in infection is the fus...
Article
Full-text available
SARS-CoV-2 spike proteins are responsible for the membrane fusion event, which allows the virus to enter the host cell and cause infection. This process starts with the binding of the spike extramembrane domain to the angiotensin-converting enzyme 2 (ACE2), a membrane receptor highly abundant in the lungs. In this study, the extramembrane domain of...
Article
Full-text available
Particle-laden fluid/fluid interfaces are ubiquituos in academia and industry, which has fostered extensive research efforts trying to disentangle the physico-chemical bases underlying the trapping of particles to fluid/fluid interfaces as well as the properties of the obtained layers. The understanding of such aspects is essential for exploiting t...
Preprint
Full-text available
SARS-CoV-2 spike proteins are responsible for the membrane fusion event, which allows the virus to enter the host cell and cause infection. This process starts with the binding of the spike extramembrane domain to the angiotensin-converting enzyme 2 (ACE2), a membrane receptor highly abundant in the lungs. In this study, the extramembrane domain of...
Article
The long-range communication between the two exosites of human α-thrombin (thrombin) tightly modulates the protein-effector interactions. Duplex/quadruplex aptamers represent an emerging class of very effective binders of thrombin. Among them, NU172 and HD22 aptamers are at the forefront of exosite I and II recognition, respectively. The present st...
Article
Full-text available
Langmuir monolayers of 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine, known as DPPC, at the air/water interface are extensively used as model systems of biomembranes and pulmonary surfactant. The properties of these monolayers have been mainly investigated by surface pressure–area isotherms coupled with different complementary techniques such as Bre...

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Projects

Project (1)
Project
Sudy of protein-lipid interaction through interfacial techniques.