Andreas Neu- University of Tübingen
Andreas Neu
- University of Tübingen
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137
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Introduction
Current institution
Publications
Publications (137)
Zusammenfassung
Prädiktion und Prävention des Typ-1-Diabetes bilden den Rahmen für die Diskussion, ob ein Antikörperscreening Teil der Regelversorgung werden sollte. Der Inselautoantikörpertest charakterisiert nicht die Stoffwechselsituation, sondern ist eine Momentaufnahme von Autoimmunität und ermöglicht eine Prognose des künftigen Typ-1-Diabetes...
Aims:
Transition from pediatric to adult care is difficult for patients with chronic diseases. We sought to analyze factors associated with metabolic control in childhood-onset Type 1 diabetes (T1D) after transfer to adult care.
Methods:
Overall, 224 persons with T1D were contacted yearly from 1998 to 2019. They voluntarily answered a questionna...
Aims:
To determine whether the incidence of type 1 diabetes mellitus (T1D), autoantibody-negative diabetes, and diabetic ketoacidosis (DKA) at diabetes onset in 2020 and 2021 changed when compared to long-standing trends.
Methods:
Our study is based on diabetes manifestation data of the 0.5-<18-year-old children/adolescents from the German multi...
Zusammenfassung
Der Einsatz von Insulin zur Therapie des Diabetes mellitus Typ 1 beim Menschen hat vor 100 Jahren erstmals zum Überleben betroffener Patienten nach Manifestation der Erkrankung geführt. War zuvor die Diagnose mit der Gewissheit verknüpft, dass es sich um eine unmittelbar lebensbedrohliche Erkrankung handelt, wurde mit dem Einsatz de...
Aims:
To investigate (1) daily, emotional, and physical caregiving burdens in parents of children with type 1 diabetes, (2) the sociodemographic and clinical predictors of three burdens, and (3) support measures that parents wish to receive.
Methods:
The study was a multicenter cross-sectional survey conducted in nine German pediatric diabetes c...
AimsSpecific patterns in incidence may reveal environmental explanations for type 1 diabetes incidence. We aimed to study type 1 diabetes incidence in European childhood populations to assess whether an increase could be attributed to either period or cohort effects.Methods
Nineteen EURODIAB centres provided single year incidence data for ages 0–14...
Objective:
To investigate the occupational and financial consequences for parents following the onset of type 1 diabetes in their child.
Research design and methods:
A questionnaire assessing occupational and financial situations before and in the first year after the onset of diabetes was distributed to all families with a child ≤14 years of ag...
Background:
Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches to reduce the inciden...
Objective:
The aim of this study was to investigate the frequency of newly diagnosed type 1 diabetes without evidence of autoimmunity and the respective frequencies of ketoacidosis in children, adolescents, and young adults during the coronavirus disease 2019 (COVID-19) pandemic in Germany compared with the previous decade.
Research design and me...
In pediatric diabetes, insulin pump therapy is associated with less acute complications but inpatient pump education may lead to more hospital days. We investigated the number of hospital days associated with pump vs. injection therapy between 2009 and 2018 in 48,756 patients with type 1 diabetes < 20 years of age from the German Diabetes Prospecti...
Background
To investigate longitudinal trends of admissions with diabetic ketoacidosis (DKA) in new-onset type 1 diabetes (T1D) and subsequent duration of hospitalization in association with structural health care properties, such as size of treatment facility, population density and linear distance between home and treatment centers.
Methods
Data...
Objective Dietary proteins raise blood glucose levels; dietary fats delay this rise. We sought to assess the insulin amount required to normalize glucose levels after a fat- and protein-rich meal (FPRM).
Methods Sixteen adolescents (5 female) with type 1 diabetes (median age: 18.2 years; range: 15.2–24.0; duration: 7.1 years; 2.3–14.3; HbA1c: 7.2%;...
Vor dem Hintergrund steigender Inzidenz und Prävalenz des Diabetes im Kindes- und Jugendalter, vielseitiger Innovationen in der Diabetestechnologie und neuer Kommunikationsmöglichkeiten sowie in Anbetracht sich verändernder Arbeitsbedingungen im stationären und im ambulanten Versorgungssystem fragen die Autorinnen und Autoren nach zukünftigen Verso...
Elliot Proctor Joslin (1869–1962) war der Überzeugung, dass mit der Entdeckung des Insulins der Diabetes mellitus seinen Schrecken verloren habe und formulierte sinngemäß in den 1920er-Jahren „today it is not allowed to die of diabetic coma“. Dass sich diese Hoffnung nicht erfüllte, kann man in den ISPAD-Guidelines nachlesen: Die Mortalitätsrate be...
Introduction Regarding pediatric diabetes, hospital admission for acute complications of type 1 diabetes (T1D) has often been investigated, but little is known about other causes of hospitalization. This study aimed to explore the total burden of hospitalization in individuals with diabetes<20 years of age in Germany.
Methods Using the German Diagn...
Based on data from the national diabetes registry DPV (Diabetes patient documentation), the diabetes registry of North Rhine-Westphalia and surveys conducted at hospitals and practices in Baden-Württemberg and Saxony, this study estimates the incidence and prevalence of type 1 diabetes in over-18-year-old adults and type 2 diabetes in 11- to 18-yea...
Aims/hypothesis:
Against a background of a near-universally increasing incidence of childhood type 1 diabetes, recent reports from some countries suggest a slowing in this increase. Occasional reports also describe cyclical variations in incidence, with periodicities of between 4 and 6 years.
Methods:
Age/sex-standardised incidence rates for the...
Background:
The incidence of type 1 diabetes mellitus in childhood and adolescence is steadily rising and now stands at 22.9 new cases per year per 100 000 persons up to age 15.
Methods:
This review is based on pertinent publications retrieved by a selective literature search, with special attention to the current German S3 guideline on diabetes...
Objective of this study was to analyze prevalence changes in type 2 diabetes (T2D) among children and adolescents over the last 10 years. We performed a cross-sectional survey in Baden-Württemberg (BW), Germany, by using a written questionnaire and comparing these results with T2D prevalence data from the same area retrieved in 2004/2005. In 2016,...
Objective:
The reason for center differences in metabolic control of childhood diabetes is still unknown. We sought to determine to what extent the targets, expectations, and goals that diabetes care professionals have for their patients is a determinant of center differences in metabolic outcomes.
Research design and methods:
Children, under th...
Background:
Diabetes and prediabetes are defined based on different methods such as fasting glucose, glucose at 2-hour in oral glucose tolerance test (OGTT), and glycated hemoglobin A1c (HbA1c). These parameters probably describe different deteriorations in glucose metabolism limiting the exchange between each other in definitions of diabetes.
Ob...
Aims:
To estimate the national incidence rate and trend of type 1 diabetes (T1DM) in Germany from 1999 to 2008 and the national prevalence in 2008 in the age group 0-14 years.
Methods:
Data were taken from a nationwide registry for incident cases of T1DM in the ages 0-4 years and 3 regional registries (North-Rhine-Westphalia, Baden-Wuerttemberg...
To investigate rates and risk factors of hospital admission for diabetic ketoacidosis (DKA) or severe hypoglycemia in young patients with established type 1 diabetes.
31,330 patients with type 1 diabetes (median age 12.7 years) from the DPV Prospective Diabetes Registry treated between 2011 and 2013 in Germany were included.
Admission rates for DKA...
Modern insulin regimens for the treatment of type 1 diabetes are highly individualized. The concept of an individually tailored medicine accounts for a broad variety of different insulin regimens applied. Despite clear recommendations for insulin management in children and adolescents with type 1 diabetes there is little distinctiveness about conce...
Background
The month of diagnosis in childhood type 1 diabetes shows seasonal variation.Objective
We describe the pattern and investigate if year-to-year irregularities are associated with meteorological factors using data from 50 000 children diagnosed under the age of 15 yr in 23 population-based European registries during 1989–2008.Methods
Tests...
Hintergrund: Neben Kohlenhydraten haben auch Proteine und Fett Einfluss auf den Blutzuckerverlauf. Therapeutische Empfehlungen zum Umgang mit Fett und Protein bei der Insulindosierung fehlen weitestgehend. Fragestellung: Wie verandert sich der Blutzucker nach einer fett- und proteinreichen Mahlzeit (FPRM) im Vergleich zu einer Standardmahlzeit (SM)...
OBJECTIVE: To investigate whether center differences in glycemic control are present in prepubertal children <11 yr with type 1 diabetes mellitus.
RESEARCH DESIGN AND METHODS: This cross-sectional study involved 18 pediatric centers worldwide. All children, <11 y with a diabetes duration ≥12 months were invited to participate. Case Record Forms inc...
The aim of the study was to describe 20-year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989-1998) and second (1999-2008) halves of the period.
All registers operate in geographically defined regions and are based on a clinical diagnosis. Completeness of registration is assessed...
Objective:
To examine the impact of rapidly changing environmental factors on the incidence of type 1 diabetes mellitus (T1D).
Method:
We compared the frequency of T1D in children before and after the reunification of Germany by means of the registries of the German Democratic Republic (GDR, 1960–1989) and of Baden-Wuerttemberg (BW, 1987–2006). Th...
The 65-kD isoform of glutamic acid decarboxylase (GAD65) is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 (GAD-alum) can preserve beta-cell function in patients with recent-onset type 1 diabetes.
We studied 334 patients, 10 to 20 years of age, with type 1 diabetes, fasting C-peptide levels of more than 0.3 ng pe...
To provide data on type 1 diabetes (T1D) epidemiology in childhood over a period of 20 years and to predict prevalence and cohort-age-specific incidence rates (IRs) for the next two decades in Germany.
The Baden-Wuerttemberg Diabetes Incidence Registry (DIARY) includes children and adolescents below 15 years of age with new onset of T1D (period 198...
Diabetic ketoacidosis (DKA) remains a major cause of hospitalization and death in children and adolescents with established type 1 diabetes despite DKA preventing strategies. The aim of the study was to determine incidence and risk factors for DKA in a large cohort of young diabetic patients.
This investigation uses the dpv-wiss base containing dat...
Diabetic ketoacidosis (DKA) is a frequent acute complication at onset of type 1 diabetes. It is assumed that increased public awareness about diabetes symptoms may reduce DKA rate at diabetes onset. To investigate the time-dependent trend in DKA prevalence we analysed the frequency and determinants of DKA at disease onset over 15 years in pediatric...
Hintergrund: Das Diabetesinzidenzregister mit dem langsten Erfassungszeitraum aller deutschen Register war das der DDR (1960–1989). Das alteste noch bestehende deutsche Diabetesinzidenzregister wird in Baden-Wurttemberg (BW) gefuhrt (seit 1987). Ziel: Vergleich der Diabeteshaufigkeit im Kindes- und Jugendalter vor und nach der Wende in Deutschland....
Our main objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of long-term treatment after the transition.
A standardized questionnaire was used prospectively to follow 99 patients with type 1 diabet...
Little is known about the use of the hemoglobin A1C (HbA1c) test for the diagnosis of diabetes in childhood and adolescence. The aim is to investigate sensitivity and specificity of HbA1c at onset of childhood type 1 diabetes.
A total of 184 children and adolescents with blood glucose levels above 200 mg/dL (11.1 mmol/L) were included: 84.8% (n = 1...
OBJECTIVE
To investigate if long-acting insulin analogs decrease the risk of diabetic ketoacidosis (DKA) in young individuals with type 1 diabetes.
RESEARCH DESIGN AND METHODS
Of 48,110 type 1 diabetic patients prospectively studied between 2001 and 2008, the incidence of DKA requiring hospitalization was analyzed in 10,682 individuals aged ≤20 ye...
Elliot Proctor Joslin (1869–1962) war der Üerzeugung, dass mit der Entdeckung des Insulins der Diabetes mellitus seinen Schrecken
verloren habe und formulierte sinngemäß in den 1920er Jahren “today it is not allowed to die of diabetic coma”. Dass sich
diese Hoffnung nicht erfüllte, kann man in den ISPAD-(International-Society-for-Pediatric- and -Ad...
To predict the frequency of type 1 diabetes in childhood and adolescence (<15 years of age) in Germany for the next 20 years.
Data on diabetes onset has been collected by means of a registry in the federal German state of Baden-Württemberg (documentation period, 1987-2006; n = 5,108; completeness of data 98.1%).
The current incidence rate (2000-200...
The incidence of type 1 diabetes in children younger than 15 years is increasing. Prediction of future incidence of this disease will enable adequate fund allocation for delivery of care to be planned. We aimed to establish 15-year incidence trends for childhood type 1 diabetes in European centres, and thereby predict the future burden of childhood...
To assess the prevalence of type 2 diabetes mellitus (T2DM) and maturity onset diabetes of the young (MODY) in children and adolescents aged 0-20 yr in Baden-Württemberg (BW), Germany, and to compare our results with those from other European countries.
Our study involved every children's hospital (n = 31), each diabetologist in private practice (n...
We aimed at analyzing the frequency, clinical characteristics, and trends associated with the occurrence of diabetic ketoacidosis (DKA) at the onset of type 1 diabetes on the basis of long-term follow-up data.
A total of 106 pediatric diabetes centers in Germany and Austria participated in this study. Data from 14,664 patients with type 1 diabetes...
Unlabelled:
To investigate the role of genetic and environmental factors in the pathogenesis of type 1 diabetes mellitus (T1D), we carried out a study in Germany aimed at comparing the prevalence and incidence of T1D among children of migrant Italians from high-risk (Sardinia) and low-risk (continental Italy) regions versus German children. Childr...
In Baden-Württemberg werden seit 1987 fortlaufend alle Manifestationen eines Typ-1-Diabetes bei Kindern und Jugendlichen im Alter von 0 bis 14 Jahren erfasst. Alle 31 Kinderkliniken des Landes sowie eine Diabetes-Fachklinik sind an dieser Erhebung beteiligt und bilden die DIARY (diabetes registry) Group Baden-Württemberg. Dieses Netzwerk ist Teil d...
To assess the incidence and the trend in incidence of Type 1 diabetes (T1DM) in children and adolescents < 15 years of age in Baden-Württemberg (BW), Germany.
BW is Germany's third largest federal state. All 31 paediatric departments in BW and one diabetes centre participated in the study. Case registration was done according to the EURODIAB criter...
Objectives: To evaluate 5-slice stack/single-slice MRI approaches and anthropometric measures as pre-dictors for metabolically relevant whole-body adipose tissue (AT) compartments in overweight/obese adolescents. Methods: Forty adolescents (22 males, age 11.4–16.1 years) were included with a BMI above the 90th per-centile. Volumes of whole-body AT...
Patients with type 1 diabetes (T1D) have an increased risk of autoimmune thyroiditis (AIT).
Our objective was to determine whether levothyroxine (l-T(4)) treatment prevents the clinical manifestation of AIT in euthyroid subjects with T1D.
We conducted a prospective, randomized, open, controlled clinical trial at six tertiary care centers for pediat...
