Andreas Lundh

Andreas Lundh
University of Southern Denmark | SDU · Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark

MD, MSc, PhD

About

58
Publications
34,166
Reads
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9,119
Citations
Additional affiliations
March 2017 - present
Copenhagen University Hospital Hvidovre
Position
  • Fellow
September 2016 - present
Odense University Hospital
Position
  • Senior Researcher
June 2016 - February 2017
Zealand University Hospital Roskilde
Position
  • Fellow

Publications

Publications (58)
Article
Full-text available
transparency in reporting of conflict of interest is an increasingly important aspect of publication in medical journals. Publication of large industry-supported trials may generate many citations and journal income through reprint sales and thereby be a source of conflicts of interest for journals. We investigated industry-supported trials' influe...
Article
Full-text available
To investigate the effect of including unpublished trial outcome data obtained from the Food and Drug Administration (FDA) on the results of meta-analyses of drug trials. Reanalysis of meta-analyses. Drug trials with unpublished outcome data for new molecular entities that were approved by the FDA between 2001 and 2002 were identified. For each dru...
Article
Background: Clinical research affecting how doctors practice medicine is increasingly sponsored by companies that make drugs and medical devices. Previous systematic reviews have found that pharmaceutical-industry sponsored studies are more often favorable to the sponsor's product compared with studies with other sources of sponsorship. A similar...
Article
Full-text available
Objectives To determine the role of academic authors, funders, and contract research organisations in industry funded trials of vaccines, drugs, and devices and to determine lead academic authors’ experiences with industry funder collaborations. Design Cross sectional analysis of trial publications and survey of lead academic authors. Eligibility...
Article
Full-text available
Background The growing access to mobile phones in Africa has led to an increase in mobile health interventions, including an increasing number of two-way text message interventions. However, their effect on healthcare outcomes in an African context is uncertain. This systematic review aims to landscape randomized trials involving two-way text messa...
Article
Background : Chronic hepatitis B virus (HBV) treatment consists of nucleos(t)ide analogues to suppress viral replication. The HBV inhibitor tenofovir has a high barrier to resistance, however, evidence of virus-escape is emerging. This study investigates HBV evolution in patients undergoing tenofovir treatment with the primary aim to assess the eme...
Article
Full-text available
Background Effective drug treatments for Covid-19 are needed to decrease morbidity and mortality for the individual and to alleviate pressure on health care systems. Remdesivir showed promising results in early randomised trials but subsequently a large publicly funded trial has shown less favourable results and the evidence is interpreted differen...
Article
Introduction Randomised trials are often funded by commercial companies and methodological studies support a widely held suspicion that commercial funding may influence trial results and conclusions. However, these studies often have a risk of confounding and reporting bias. The risk of confounding is markedly reduced in meta-epidemiological studie...
Article
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Background and aims Proton pump inhibitor (PPI) use has been associated with increased risk of SARS-CoV-2 infection and severe outcomes. However, meta-analyses show unclear results leading to uncertainty regarding the safety of PPI use during the ongoing COVID-19 pandemic. Methods We conducted a nationwide observational study including all SARS-Co...
Article
Full-text available
Background: This systematic review aims to estimate the proportion of medical schools and teaching hospitals with conflicts of interest (COI) policies for health research and education, to describe the provisions included in the policies and their impact on research outputs and educational quality or content. Methods: Experimental and observational...
Article
Full-text available
Background: Intimate partner violence (IPV) is a major public health concern. eHealth interventions may reduce exposure to violence and health-related consequences as the technology provides a safe and flexible space for the target population. However, the evidence is unclear. Objective: The goal of the review is to examine the effect of eHealth i...
Article
Objective: To investigate the association between conflicts of interest and favourable recommendations in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews. Design: Systematic review. Eligibility criteria: Studies that compared the association between conflicts of interest and favourable recommendations of...
Article
Background Treatment and diagnostic recommendations are often made in clinical guidelines, reports from advisory committee meetings, opinion pieces such as editorials, and narrative reviews. Quite often, the authors or members of advisory committees have industry ties or particular specialty interests which may impact on which interventions are rec...
Article
Full-text available
Objective To characterise and analyse the experiences of trial researchers of if and how conflicts of interest had unduly influenced clinical trials they had worked on, what management strategies they had used to minimise any potential influence, and their experiences and views on conflicts of interest more generally. Design Qualitative interview...
Preprint
BACKGROUND Intimate partner violence (IPV) is a major public health concern. Electronic health (eHealth) interventions may reduce exposure to violence and health-related consequences as the technology provides a safe and flexible space for the target population. However, the evidence is unclear. OBJECTIVE To examine the effect of eHealth intervent...
Article
Background Intimate partner violence (IPV) is a major public health concern. eHealth interventions may reduce exposure to violence and health-related consequences as the technology provides a safe and flexible space for the target population. However, the evidence is unclear. Objective The goal of the review is to examine the effect of eHealth int...
Article
Objective: To identify and summarise 1) appraisal tools and other guides which address conflicts of interest in medical research studies; and 2) top journals with policies on managing conflicts of interest in journal papers. Study design and setting: Systematic review. We searched bibliographic databases, other sources and websites of 30 top med...
Book
Full-text available
The revised edition of the Handbook offers the only guide on how to conduct, report and maintain a Cochrane Review. The second edition of The Cochrane Handbook for Systematic Reviews of Interventions contains essential guidance for preparing and maintaining Cochrane Reviews of the effects of health interventions. Designed to be an accessible resou...
Article
Background Financial conflicts of interest in systematic reviews (e.g. funding by drug or device companies or authors’ collaboration with such companies) may impact on how the reviews are conducted and reported. Objectives To investigate the degree to which financial conflicts of interest related to drug and device companies are associated with re...
Article
Full-text available
Background: The impact of one-way SMS on health outcomes in Africa is unclear. We aimed to conduct a systematic review of one-way SMS randomised trials in Africa and a meta-analysis of their effect on healthcare appointments attendance and medicine adherence. Methods: PubMed, Embase, CENTRAL, The Global Health Library, ClinicalTrials.gov, ICTRP,...
Article
Full-text available
Background Early identification of patients with chronic viral hepatitis co-infected with HIV is essential for optimal care. The objectives of this study were to estimate the prevalence of HIV co-infection among patients newly diagnosed with chronic viral hepatitis, HIV testing prevalence and identify factors associated with co-infection. Methods...
Article
Full-text available
Purpose Clinical research is widely sponsored by drug and device companies. We investigated whether industry sponsored drug and device studies have more favorable outcomes and differ in risk of bias, compared with studies having other sources of sponsorship. This review is an update of a previous Cochrane review. Methods In this update we searched...
Article
Full-text available
This is a protocol for a Cochrane Review (Methodology). The objectives are as follows: The primary objectives are to investigate to what degree: funding of systematic reviews by drug, device, and imaging companies and authors' other financial conflicts of interest are associated with effect size estimate; and funding of systematic reviews by drug,...
Article
Authors’ financial ties may be a source of bias in trials and must be disclosed in full Substantial evidence shows that sponsorship or funding of trials of drugs and devices by companies producing the drug or device results in publications that tend to favour the sponsor’s product.1 Personal financial ties—including travel expenses, honorariums, p...
Article
BACKGROUND: Previous studies suggest that non-nucleoside-reverse-transcriptase inhibitors (NNRTI) cause faster virologic suppression while ritonavir-boosted-protease inhibitors (PI/r) recover more CD4 cells. However, individual trials have not been powered to compare clinical outcomes. METHODS: We searched databases (up to February 2016) to identif...
Article
Full-text available
Background Pharmacotherapy in the elderly population is complicated by several factors that increase the risk of drug-related harms and less favourable effectiveness. The concept of medication review is a key element in improving the quality of prescribing and in preventing adverse drug events. Although there is no generally accepted definition of...
Article
Full-text available
Objectives: To determine the prevalence of conflicts of interest (COIs) among Danish physicians who are authors of clinical drug trial reports and determine the extent of undisclosed COIs in trial publications. Design: Cross-sectional study. Setting: The 100 most recent drug trial reports with at least one Danish non-industry employed physicia...
Article
Full-text available
Objective To determine, using research on duloxetine for major depressive disorder as an example, if there are inconsistencies between protocols, clinical study reports, and main publicly available sources (journal articles and trial registries), and within clinical study reports themselves, with respect to benefits and major harms. Design Data on...
Article
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Objective To assess the effects of coding and coding conventions on summaries and tabulations of adverse events data on suicidality within clinical study reports. Design Systematic electronic search for adverse events of suicidality in tables, narratives, and listings of adverse events in individual patients within clinical study reports. Where pos...
Article
Full-text available
The seven roles of the CanMEDS system have been implemented in Danish postgraduate medical training. For each medical specialty, a professional profile describes which elements of the seven roles the specialty deems important for applicants for a specialist training position. We investigated use of professional profiles among the 38 Danish specialt...
Working Paper
This is the protocol for a review and there is no abstract. The objectives are as follows: The objectives are to investigate whether: authors of scientific opinion pieces with personal financial conflicts of interest related to drug, device or medical imaging companies are more likely to recommend the companies' products; authors of clinical practi...
Article
Full-text available
Background Conflicts of interest affect recommendations in clinical guidelines and disclosure of such conflicts is important. However, not all conflicts of interest are disclosed. Using a public available disclosure list we determined the prevalence and underreporting of conflicts of interest among authors of clinical guidelines on drug treatments....
Article
Background: Pharmacotherapy in the elderly population is complicated by several factors that increase the risk of drug related harms and poorer adherence. The concept of medication review is a key element in improving the quality of prescribing and the prevention of adverse drug events. While no generally accepted definition of medication review e...
Article
Clinical research affecting how doctors practice medicine is increasingly sponsored by companies that make drugs and medical devices. Previous systematic reviews have found that pharmaceutical industry sponsored studies are more often favorable to the sponsor's product compared with studies with other sources of sponsorship. This review is an updat...
Article
Full-text available
It is unclear whether Schierbeck and colleagues’ primary composite outcome was defined in the original protocol.1 In other words, is their analysis exploratory or confirmatory? The main question is whether the results should lead to changes in clinical practice. Schierbeck has advocated for the safety of hormone therapy,2, but we believe that the s...
Article
Full-text available
Background Bias in industry-sponsored trials is common and the interpretation of the results can be particularly distorted in favour of the sponsor’s product. We investigated sponsors’ involvement in the conduct and reporting of industry-sponsored trials. Methods We included all industry-sponsored trials published in The Lancet in 2008 and 2009 an...
Article
Full-text available
Although the BMJ and Lancet provided Handel and colleagues access to information on reprint sales,1 the big US journals were unwilling to share this information. Our experience was similar when we investigated reprint sales.2 Much of the previous evidence in this field has been anecdotal, such as the infamous VIGOR trial of rofecoxib, where …
Article
Full-text available
Case reports are often regarded as second-class research, but are an important part of medical science as they often present first evidence of new discoveries. We here describe the type of case reports published in a Danish general medical journal. We included all case reports published in Ugeskrift for Laeger in 2009. For each report, two authors...
Article
Full-text available
To investigate whether substantive criticism in electronic letters to the editor, defined as a problem that could invalidate the research or reduce its reliability, is adequately addressed by the authors. Cohort study. BMJ between October 2005 and September 2007. Inclusion criteria Research papers generating substantive criticism in the rapid respo...
Article
Full-text available
Background: To study whether medical textbooks are sponsored by drug or device companies, and if so, whether they have tried to influence their contents. Methods: Cross-sectional study of the medical textbooks written in Danish for graduate clinical courses at the University of Copenhagen and anonymous web-based survey of editors. For sponsored bo...
Article
To ensure evidence-based decision making in pediatric oncology systematic reviews are necessary. The objective of our study was to evaluate the methodological quality of all currently existing systematic reviews in pediatric oncology. We identified eligible systematic reviews through a systematic search of the literature. Data on clinical and metho...
Article
Full-text available
Assessing the risk of bias in individual studies in a systematic review can be done using individual components or by summarizing the study quality in an overall score. We examined the instructions to authors of the 50 Cochrane Review Groups that focus on clinical interventions for recommendations on methodological quality assessment of studies. Fo...
Article
This sixth article in the series ‘Tips and tricks for understanding and using SR results’ is, like the previous ones, aimed at helping the readers to understand the results of systematic reviews and to use these results in clinical practice. Earlier articles in the Tips and Tricks section of this journal have addressed the sources of evidence, i.e....

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Projects

Projects (3)
Project
The overall aim of this PhD project is to describe and investigate conflicts of interest in peer review of research manuscripts submitted to biomedical journals, biomedical funding applications, higher education institutions and clinical guidelines.
Project
TACIT stands for Tool for Addressing Conflicts of Interest in Trials and is a tool that provides review authors with a framework for addressing conflicts of interest in trials included in Cochrane Reviews and other systematic reviews. We aim to develop a tool that facilitates a systematic and transparent judgement of "notable concern" about conflicts of interest in relation to key trial stakeholders, including funders, investigators and authors of randomised clinical trials included in Cochrane reviews and other systematic reviews. For more info visit: https://tacit.one/