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Publications (67)
Introduction Doppler sonography of the uterine artery (UA) is done to monitor pregnancies, because the detected flow patterns are useful to draw inferences about possible disorders of trophoblast invasion. Increased resistance in the UA is associated with an increased risk of preeclampsia and/or intrauterine growth restriction (IUGR) and perinatal...
Purpose: To assess the prevalence and value of a suspicious prenasal skin thickness-to-nasal bone length ratio (PT/NB ratio) in comparison to other established markers in a large population of Down syndrome (DS) fetuses. Materials and Methods: This was a retrospective study of 139 DS fetuses and 530 normal fetuses scanned after 14 + 0 weeks of gest...
Congenital diaphragmatic hernia (CDH) affects 1:2500-1:4000 newborns and shows additional malformations and chromosomal anomalies in 40%. Secondary lung hypoplasia is an important factor for the prognosis of the newborn. Survival rates of up to 100% published by single institutions are a selection of favourable cases. Population based studies show...
Here we describe the successful application of massively parallel sequencing for noninvasive prenatal detection of trisomy 21. In addition, for the detection of a broader spectrum of fetal aneuploidies, a target enrichment approach was successfully tested.
The circulating cell-free DNA was prepared from 53 maternal blood samples and analysed using...
To evaluate the acceptance of noninvasive screening for trisomy 13, 18, 21 and the impact on invasive testing rates in women at an age≥35 years.
In a retrospective analysis from 2003-2006 including 13 268 women≥35 years old with singleton pregnancies and 3133 invasive procedures, we evaluated the prenatal detection rate of aneuploidies in two cohor...
Fallvorstellung: Bei Hydrops fetalis und einem Nackenodem von 6mm Durchmesser wurde mit 12+2 Schwangerschaftswochen eine linksseitige Zwerchfellhernie aufgrund einer Dextropositio cordis und eines Enterothorax diagnostiziert (Abb. 1). Die Chorionzottenbiopsie ergab einen normalen Karyotyp. Mit 21+3 SSW zeigte sich linksseitig eine grosse echogene L...
Fragestellung: die Zwerchfellhernie ist eine wichtige pranatale Diagnose, weil sie haufig von weiteren Fehlbildungen begleitet wird. Die Prognose hangt aber aufgrund des neonatalen Erstversorgung von der pranatalen Erkennung der Zwerchfellhernie ab. Wie haufig sind im pranatal diagnostizierten Kollektiv Begleitfehlbildungen und wie entscheiden die...
Isolated fetal heart block is considered as an immunological disorder in the majority of cases. Mothers of affected fetuses often suffer from connective tissue disease (Sjögren syndrome or Lupus erythematodes). All of them test positive for anti-SS-A (anti Ro) and/or anti-SS-B (anti La) antibodies. Once established, third-degree congenital heart bl...
Hydrops fetalis is the final common hemodynamic pathway for a variety of pathological states in the fetus, including high output states associated with fetal anemia or arterio-venous fistulas and abnormalities of both cardiac structure and rhythm. Hydrops fetalis secondary to cardiovascular decompensation is usually accompanied by elevations in fet...
In 1:50 000 to 1:100 000 births, conjoined twins occur, caused by incomplete division of the embryonic disc more than 13 days after fertilisation. We present a case of cephalothoracopagus janiceps, a very rare form of conjoined twins, which was diagnosed at 13 weeks of gestation. Three-dimensional and colour Doppler ultrasound enabled precise prena...
Problemstellung: Esophageal atresia (ET) is a malformation, which is difficult to diagnose at prenatal screening, especially in the 2nd trimester of pregnancy. Indicators of ET are an empty or almost empty fetal stomach and polyhydramnios. Visualization of the esophageal fluid filled pouch at the level of ET has been described in recent years, but...
Problemstellung: Softmarkers as indicators of chromosomal abnormalities of the fetus are described for more than 15 years now. The main problems of softmarkers are, that they are usually published as sonographic phenomenon in high risk pregnancies prior to amniocentesis. So the positive predictive value is usually overestimated when applied to a sc...
Angeborene oder erworbene arteriovenöse Malformationen (AVM) des Uterus sind selten. Sie können bei prä- und postmenopausalen Frauen auftreten. Gemeinsam sind beiden AVM-Typen die multiplen, chaotischen Gefäßvernetzungen und -anomalien, die alle Schichten des Uterus durchziehen und bis unter das Endometrium reichen können. Das Hauptsymptom ist die...
Premature obstruction of the foramen ovale is a rare but serious clinical entity. Obstruction can be associated with right ventricular failure, fetal hydrops, tricuspid regurgitation, left heart obstructive defects and supraventricular tachycardia. In most cases, the diagnosis is made at the postmortem examination. The etiology is unknown. We discu...
Der pranatale Verschluss des Foramen ovale ist ein seltenes aber schwerwiegendes Ereignis. Er kann einhergehen mit supraventrikularer Tachykardie, Hydrops fetalis, Trikuspidalinsuffizienz oder Rechtsherzversagen. In der Mehrzahl der Falle erfolgt die Diagnosestellung im Rahmen einer postmortalen Untersuchung nach intrauterinem Fruchttod. Die Atiolo...
Einleitung: Etwa 10% aller fetalen Arrhythmien sind anhaltende supraventrikulare Tachykardien, die medikamentos gut zu behandeln sind. Hinsichtlich Therapiebeginn und Applikationsweg bestehen keine einheitlichen Richtlinien. Methode/Ergebnis: Wir berichten uber unsere Therapieerfahrungen anhand zweier exemplarischer Bespiele. - 29jahrige Patientin,...
We report on a case of a fetal epignathus combined with two fetus-like structures resembling acardius acranius. The anomaly was detected at 23 weeks of gestation and led to termination of pregnancy at 24 weeks. This is the first description of epignathus with parasitic fetuses detected prenatally. It shows that the boundary between fetal teratoma a...
On the ''4 optimal chamber view'', we propose to check 4 key points: pulmonary inferior veins attaching the heart to lungs, in a strict axial plane; 4 chambers, mobile, balanced and concordant with a normal offset of the AV valves on the crux of the heart. We also describe the difficulties and the possible traps of the 4 chamber view. We justify ea...
Fragestellung: Beim HELLP-Syndrom wurde bis vor kurzem wegen der vitalen Gefährdung von Mutter und Kind eine rasche Entbindung nach Diagnosestellung empfohlen. Angesichts der hohen Rate hochgradig unreifer Frühgeburten wird zunehmend eine Prolongation wenigstens bis zum Abschluss der Lungenreifeinduktion erwogen. Überprüft wurde die Auswirkung des...
Until recently, delivery immediately after diagnosing HELLP syndrome was recommended due to the life-threatening risk to mother and child. Prolongation at least until lung maturation is being increasingly considered because of the high rate of premature births characterized by extreme immaturity. We investigated the influence of the time of deliver...
Gastric cancer is unusual during pregnancy. The diagnosis may be delayed because specific symptoms are similar to typical pregnancy associated complaints. Our therapeutic management with palliative chemotherapy and later gastrectomy differs from other known cases, where surgical resection has been the treatment of choice. Surgery appears to have no...
Purpose and Design: This is a critical review of the growing body of data, 32 retrospective studies of the outcomes of 9,665 women published since 1989, relevant to the possibility that the timing of primary breast cancer resection within the menstrual cycle impacts breast cancer recurrence and/or spread and patient survival. This article evaluates...
158 patients with endometrial cancer who were treated between 1980-1990 at the Department of Obstetrics and Gynecology, Hospital Berlin-Buch, were reviewed retrospectively with regard to prognostical and therapeutical aspects. The 5-year-survival rate of all patients amounted to 84%. The 5-year-survivals were 92.6% for stage I, 87.5% for stage II a...
In a case-control-study an epidemiological investigation of cancer of the endometrium was carried out. The study included 159 cases and 159 controls. It was shown, that woman in the sixth life decade with overweight, a smaller number of deliveries and a later menopause had a higher risk for endometrial cancer. Other risk factors are diabetes mellit...
In a case-control-study an epidemiological investigation of cancer of the endometrium was carried out. The study included 159 cases and 159 controls. It was shown, that woman in the sixth life decade with overweight, a smaller number of deliveries and a later menopause had a higher risk for endometrial cancer. Other risk factors are diabetes mellit...
