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Andreas Dr. Werner

Andreas Dr. Werner
German Air Force Centre for Aerospace Medicine / Center for Space Medicine and Extreme Environments Berlin · Aviation Physiology - Diagnostics and Research

MD, PhD, Assistent Scientist

About

81
Publications
14,893
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407
Citations
Introduction
As a member of the military services of GAF, I studied human medicine and became a general practitioner. Sent to the Charité Berlin I completed my education as a specialist in physiology. Under supervision of Prof. Gunga, I brought Thermolab on ISS. I´m working for the Center of Aerospace Medicine (Aviation Physiology Training Center) as a specialist in aviation physiology and flight surgeon. I´m a visiting scientist at Center for Space Medicine Berlin. Current research is the mobPhysioLab(R).
Additional affiliations
July 2007 - present
Charité Universitätsmedizin Berlin
Position
  • Researcher

Publications

Publications (81)
Article
During gravitational changes or changes in the direction of action in relation to the body, fluid displacements can be observed. In special cases different breathing maneuvers (e. g., exhaling on exertion; Ex-Ex) are used to counteract acute fluid shifts. Both factors have a significant impact on cardiovascular regulation. Eight healthy male subjec...
Article
Full-text available
Background Indirect core body temperature (CBT) monitoring from skin sensors is gaining attention for in-field applications thanks to non-invasivity, portability, and easy probe positioning. Among skin sensors, heat-flux devices, such as the so-called Double Sensor (DS), have demonstrated reliability under various experimental and clinical conditio...
Article
Full-text available
Spaceflight can be associated with sleep loss and circadian misalignment as a result of non-24 h light-dark cycles, operational shifts in work/rest cycles, high workload under pressure, and psychological factors. Head-down tilt bed rest (HDBR) is an established model to mimic some of the physiological and psychological adaptions observed in spacefl...
Article
Highlight This study was able to show in a crossover design that neither at resting conditions nor during a simulated 80 minutes flight wearing the examined FFP2 face mask leads to changes in the SpO2, the heart rate or the parameters of the capillary blood gas analysis.
Conference Paper
Full-text available
Remote Health Monitoring (RHM) has the potential to increase operational safety in extreme environments. Negative stress exposure influences mission success or the short-and long-term health conditions of deployed personnel. To quantify negative stress, we introduce a washable smart textile with integrated sensors. Analyzing the transmitted sensor...
Article
Remotely piloted aircraft (RPA; also called drones) constitute a new dimension in aviation. In the past, the military used RPAs extensively in the conflicts in Iraq and Afghanistan. Meanwhile, they are employed worldwide, which illustrates the new way of future complementary military warfare. It is well known that military personnel develops mental...
Chapter
Humans have an endothermic metabolism which regulates core body temperature autonomously with a median of 36.7°C and in a circadian rhythm of 24.5 h with a range of ±0.5 °C. In the past, the possibilities of measuring core body temperature in humans to assess stress-dependent changes in the thermal regulation and to thereby monitor changes in circa...
Article
ZUSAMMENFASSUNG Telemedizin (eHealth) ist aus der heutigen Welt nicht mehr wegzudenken. In manchen Bereichen geht es ohne diese Übertragung gar nicht – im Weltraum. Die modernsten und neuesten Informations- und Kommunikationssysteme werden im Gesundheitssystem eingesetzt; in Kliniken schon lange zum Monitoring von Patienten verwendet. Beim US-ameri...
Article
Introduction: We have used our human centrifuge to simulate the parabolic flight environment. Tests were carried out on four candidates taking part in a parabolic flight program. The main idea behind the project was to test the possibility of simulation of a near zero Gz environment with the centrifuge as a cheaper and simpler alternative to parabo...
Article
INTRODUCTION: Changes in gravity or body position provoke changes in hydrostatic pressure in the arterial system and in venous return. Potential asymmetries between left (QLV) and right ventricular (QRV) cardiac output during transient gravity changes were investigated. It was hypothesized that blood volume is temporarily stored in the pulmonary ve...
Article
It was hypothesized that faster cardiorespiratory kinetics during exercise are associated with higher orthostatic tolerance. Cardiorespiratory kinetics of 14 healthy male subjects (30 ± 4 years, 179 ± 8 cm, 79 ± 8 kg) were tested on a cycle ergometer during exercise with changing work rates of 30 and 80 W. Pulmonary oxygen uptake ( ) was measured b...
Article
Full-text available
Humans’ core body temperature (CBT) is strictly controlled within a narrow range. Various studies dealt with the impact of physical activity, clothing, and environmental factors on CBT regulation under terrestrial conditions. However, the effects of weightlessness on human thermoregulation are not well understood. Specifically, studies, investigati...
Poster
Full-text available
Introduction: Remote Health monitoring in hazardous environments has the potential to improve operational safety. It can identify exposures that influence short and long-term health conditions and thus save lives of professionals such as firefighters or military personnel. While professionals operate, medical advisors lack insights of exposures and...
Poster
Full-text available
Einleitung: Seitdem Tätigkeiten in großen Höhen stattfinden, werden über Veränderungen der Sehleistung durch den eintretenden Sauerstoff(O 2)mangel in der internationalen Literatur berichtet. Es liegen hierzu zum Teil konträre Ergebnisse für das Farbsehen vor. Brandl geht von einer Verringerung des Sehens aller Farben aus und empfiehlt das Verstärk...
Article
Purpose: The goal of the study was to compare the kinetics responses of heart rate (HR) and pulmonary (V’O2pulm) and muscular (V’O2musc) oxygen uptake during dynamic leg exercise across different acute ambient temperature conditions in a climatic chamber. Methods: Thirteen physically healthy, active male volunteers performed pseudo-random binary se...
Chapter
Microgravity is an extreme environment Astronauts are exposed to when they escape Earth’s gravitational field. A different set of stimuli experienced during spaceflight seriously affects all parts of the body. Instantly, the body starts to adapt to the new gravity-free environment; different organs and organ systems do so in different ways and at d...
Chapter
The cardiovascular system and the contained red blood cells are the backbone of oxygen transportation in the human body. From an evolutionary point of view, this system is rather ancient and originated approximately 500 million years ago when multicellular organisms had grown so much that transportation of oxygen and nutrients by diffusion had beco...
Chapter
The changes and adaptations to microgravity and its implications for the return to Earth have not yet been fully understood. Hence, the development of countermeasures is important, but have only been partly successful in reducing, for example, orthostatic intolerance experienced by returning astronauts, especially after long-duration flights. This...
Chapter
The lung is directly affected by weightlessness: the disappearance of weight forces on the lung tissue itself and surrounding tissues, and hydrostatic pressure gradient changes lung shape and the distribution of gas-filled space. However, inhomogeneous ventilation and aeration of alveolar volumes can also be detected in weightlessness. In the trans...
Chapter
In space the human body and, in particular, the cardiovascular system are exposed to an altered and unfamiliar environment. The new set of stimuli imposes novel challenges on the cardiovascular system. More precisely, a lack of the impeding gravitational force makes some cardiovascular functions more facile. Upon injection to space, extensive mecha...
Article
Ferngesteuerte, unbemannte Luftfahrtsysteme (UAV), auch Drohnen genannt, sind die neue Dimension des Fliegens. Militarisch wurden sie in der Vergangenheit intensiv in den Konflikten im Irak und in Afghanistan eingesetzt, mittlerweile jedoch auch weltweit und stellen den erganzenden, zukunftigen Weg in der Kriegsfuhrung dar. Es ist seit Langem bekan...
Poster
Full-text available
PROBLEM STATEMENT: This case report describes a military jet pilot with a hemodynamic relevant atrial septal defect (ASD). During his flight medical he was declared unfit for flying. After successful implantation of a septal occluding device he regained his medical certificate after thorough testing in the long-arm human centrifuge (laHC) and high...
Book
This book comprehensively describes the physiological changes and consequences that occur in humans during spaceflight. It specifically explains the adaptations of the cardiovascular and the respiratory system. Specific changes occurring after 10, 20 or more days in space are presented. Furthermore, the book explains various effective countermeasur...
Article
Full-text available
Zusammenfassung Nachtsichtgeräte bieten die einzigartige Möglichkeit, Gren-zen der menschlichen Sensorik beim Flug unter reduzierten Sichtbedingungen zu überwinden. Allerdings beginnen sich die Bildverstärker und Thermosensoren in dem Maß, in dem sich der technologische Fortschritt in Bezug auf Avionik und integrierte Systeme vollzieht, zu hochansp...
Conference Paper
Full-text available
Introduction: Pilots in high-performance aircrafts undergo high physical strain. Anatomically, the dislocation and elongation of the heart could increase the development of arrhythmias during high-G-acceleration. From literature, arrhythmias during high-posGz-acceleration is described, but mostly analyzed in small numbers of subjects and their clin...
Article
Background: Cholinergic urticaria (CholU) is a common condition in which active or passive warming leads to development of pinpoint wheals, flares and itch. Objective: To develop a standardized protocol for diagnosing CholU and measuring trigger thresholds, independent of patients’ fitness levels. Method: Ten CholU patients and matched healthy cont...
Article
A growing body of research indicates that a misalignment of circadian rhythms can be detrimental to mental and physical health. Long duration space missions may also potentially alter circadian rhythms, and pose a critical risk to crew health and safety. We here assessed the impact of the Mars500 study on the circadian phase of core body temperatur...
Article
Full-text available
Immobility plus preexisting chronic disease or acute trauma can activate the coagulation system, thus increasing the risk for thromboembolic events. The effects of long-term bed-rest immobility and microgravity on the coagulation system of healthy persons (e.g., during crewed Mars missions) have not yet been studied. The main objective of the secon...
Article
Humans have an endothermic metabolism which is regulated autonomously with a body core temperature in median of 36.7°C and a circadian rhythm in a range of ±0.5°C. In the past, the possibilities of measuring body core temperature in humans to assess stress-dependent changes in the thermal regulation and to thereby monitor also changes in circadian...
Article
Full-text available
Hintergrund: Im Labor ermittelten Daten sind in die reale Umwelt nur schwer übertragbar, weil häufig differente Ergebnisse gefunden werden. Insbesondere sind die Umwelteinflüsse in die physiologische Gesamtbetrachtung einzubeziehen. Messungen im Feld sind sehr schwierig, weil bisherige Systeme invasiv, zu schwer oder singuläre Parameter erfassen oh...
Article
Full-text available
/st>Clinical temperature management remains challenging. Choosing the right sensor location to determine the core body temperature is a particular matter of academic and clinical debate. This study aimed to investigate the relationship of measured temperatures at different sites during surgery in deep hypothermic patients. /st>In this prospective s...
Conference Paper
Full-text available
The body core temperature (BCT) alters lightly during the 24-hour cycle, and BCT profiles are used as an indicator for the “quality” of the circadian rhythm (CR) in humans. Sleep and the regulation of biochemical pathways are synchronized to this 24-hour light/dark cycle. Previous research suggests that isolated crew members are influenced from dis...
Article
Full-text available
Long-haul flights (LHF) are known to be connected with an increased risk of deep vein thrombosis. There is still some lack of clarity about the impact of hypoxia and lower levels of air pressure and humidity on passengers during flight. This cross-over study researched interstitial fluid shifts traced by measurements of tissue thickness (TT) under...
Data
A new non-invasive device to monitor core temperature on earth and in space Vortrag am 8. März 2012 im Plenum der Leibniz-Sozietät anlässlich des 75. Geburtstages des Ehrenmitgliedes der Sozietät, Sigmund Jähn ("Weltraumforschung – bemannter Raumflug vom erdnahen zum interplanetaren kosmischen Raum") 3 Abstract Accurate measurement of the core body...
Conference Paper
Background Cholinergic urticaria (CholU) is a common condition in which active or passive warming leads to development of pinpoint wheals, flares and itch. Objective To develop a standardized protocol for diagnosing CholU and measuring trigger thresholds, independent of patients’ fitness levels. Method Ten CholU patients and matched healthy contr...
Article
HealthLab, ein modulares, flexibles und intelligentes System, das zugleich eine Vielzahl physiologischer und umweltbezogener Daten verarbeiten kann, ermöglicht das Monitoring von Soldaten während realer Einsätze. Besser als mit bisheriger Methodik kann mit diesem System die Weiterentwicklung von Ausrüstung und Ausbildung auf eine solide wissenschaf...
Conference Paper
Full-text available
Introduction: Studies on thermoregulatory adaptations in Astronauts during long-term Space Flight have been very limited to date or are even missing. First measurements have been done nearly 40 years ago (Spacelab); moreover only in animals up to date. But those studies could not answer questions to body core temperature (BCT) due to methodological...
Article
HealthLab, ein modulares, flexibles und intelligentes System, das zugleich eine Vielzahl physiologischer und umweltbezogener Daten verarbeiten kann, ermöglicht das Monitoring von Soldaten während realer Einsätze. Besser als mit bisheriger methodik kann mit diesem System die Weiterentwicklung von Ausrüstung und Ausbildung auf eine solide wissenschaf...
Article
Background and aim: The majority of avalanche victims who sustain complete burial die within 35min due to asphyxia and injuries. After 35min, survival is possible only in the presence of a patent airway, and an accompanying air pocket around the face may improve survival. At this stage hypothermia is assumed to be an important factor for survival...
Chapter
Humans have an endothermic metabolism which is regulated autonomously with a body core temperature in median of 36.7°C and a circadian rhythm in a range of ± 0.5°C. The past possibilities of measuring body core temperature in humans to assess stress dependent changes in the thermal regulation and to hereby monitor also changes in circadian rhythm w...
Article
Full-text available
Accurate measurement of the core temperature (Tc) is fundamental to the study of human temperature regulation. As standard sites for the placement of Tc measurement sensors have been used: the rectum, the bladder, the esophagus, the nasopharynx and the acoustic meatus. Nevertheless those measurement sites exhibit limited applicability under field c...
Conference Paper
Full-text available
Introduction: The operating areas of the armed forces of any nation have changed drastically during the last years and enclose increasing climatic strain. High heat strains produces reduction in performance and alters cognitive function. Currently used helmets and garments are not or insufficiently conditioned, while the brain plays an important ro...
Conference Paper
Full-text available
Introduction: Studies on thermoregulatory adaptations of humans during Space Flight have been very limited to date or are even missing due to methodological constraints. Body core temperature (BCT) is one of the important parameters which influences several physiological and biochemical key pathways of the organism. With the new heat flux DoubleSen...
Article
Given the increasing duration of space flights problems associated with changes of the circadian rhythm might be increasingly prominent during future exploratory missions. Therefore, technological advances for simple and accurate monitoring of circadian rhythm are clearly needed. Furthermore, such technology would provide the basis for countermeasu...
Article
Purpose of the study: After 35 min of avalanche burial, only persons with a patent airwayare still alive and develop a combination of hypoxia, hypercapnia and hypothermia.1,2 Interactions between these factors are still unknown.3,4 This prospective, randomized study analysed factors relevant to avalanche survival. Materials and methods: After anaes...
Conference Paper
Full-text available
In future space missions and space tourism the administration of pharmaceutical drugs will increase. Assuming that beta-blockers might be taken under stressful circumstances during space missions, we conducted two studies investigating the effects of Nebivolol (Nebilet®), a highly selective beta-1-receptor blocker, on cardiovascular changes. The fi...
Article
Full-text available
Middle ear barotrauma is a condition frequently associated with flying. It is usually caused by Eustachian tube (ET) dysfunction. Pressure-regulating earplugs (PREP) should improve complaints due to pressure equalization problems. There were 21 patients with a history of pressure equalization problems while flying who were examined. ET function was...
Article
The objective of our study was to establish whether rectal temperature recordings in humans could be replaced by a non-invasive skin temperature sensor combined with a heat flux sensor (Double Sensor) located at the forehead to monitor core body temperature changes due to circadian rhythms. Rectal and Double Sensor data were collected continuously...
Chapter
Earth ObservationCommunicationsNavigationSpace Astronomy and Planetary MissionsMaterials ScienceSpace Medicine and BiologyNew Technologies and RoboticsBibliography
Article
Full-text available
Hitzestress ist ein signifikanter Faktor für viele militärische Aktivitäten, die dadurch entstehenden Verluste haben für alle militärischen und nicht-militärischen Organisationen einen hohen Stellenwert. Durch Einsätze in Regionen mit starker klimatischer Belastung (heiß/trocken, warm/feucht) ist die Hitzebelastung ein wichtiger Faktor bei der Durc...
Conference Paper
Background: A solid understanding of thermoregulation in humans under extreme environmental conditions is important for applications in manned spaceflight (e.g. EVA, long-term space missions to Mars) or Special Forces (e.g. fire men). Previous studies have shown that thermoregulation in humans is altered during long- and short-term exposure to micr...