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Introduction
Publications
Publications (169)
Alterations within the tryptophan–kynurenine metabolic pathway have been linked to the etiology of colorectal cancer (CRC), but the relevance of this pathway for prognostic outcomes in CRC patients needs further elucidation. Therefore, we investigated associations between circulating concentrations of tryptophan–kynurenine pathway metabolites and a...
Background
The colorectal cancer (CRC) screening program B-PREDICT is a population based invited two stage screening project using a faecal immunochemical test (FIT) for initial screening followed by a colonoscopy for those with a positive FIT. B-PREDICT was compared with the opportunistic screening colonoscopy (OPP-COL), performed in course of the...
Über 400 Führungskräfte in Österreich wurden mittels Online-Erhebung gebeten, Karenz- und Teilzeitwünsche fiktiver männlicher Mitarbeiter mit Hilfe eines faktoriellen Surveys zu bewerten. Es zeigt sich ein hohes Potenzial für väterunterstützende Maßnahmen und große Offenheit gegenüber den Anliegen männlicher Mitarbeiter. Ansatzpunkte zur Realisieru...
Background
Stent thrombosis is a rare but deleterious event. Routine coronary angiography with percutaneous coronary intervention (PCI) is often deferred in the presence of laboratory markers of acute inflammation to prevent complications. The aim of this study was to investigate whether an acute inflammatory state is associated with an increased r...
Although work is increasingly globalized and mediated by technology, little research has accumulated on the role of culture in shaping individuals' preferences regarding the segmentation or integration of their work and family roles. This study examines the relationships between gender egalitarianism (the extent a culture has a fluid understanding...
Simple Summary
Colorectal cancer is increasingly recognized as two separate diseases: colon cancer and rectal cancer, each with its own causes and outcomes. We included 674 patients with colorectal cancer, with pre-surgery collected blood samples, and patient follow up for an average of 4.4 years. Ninety-three patients (14%) died from various cause...
The association between intravenous iron substitution therapy and hypophosphatemia was previously reported in patients with iron deficiency anemia. However, the extent of hypophosphatemia is thought to depend on the type of iron supplementation. We hypothesized that the intravenous application of ferric carboxymaltose and iron sucrose leads to a di...
Although cross-national work–family research has made great strides in recent decades, knowledge accumulation on the impact of culture on the work–family interface has been hampered by a limited geographical and cultural scope that has excluded countries where cultural expectations regarding work, family, and support may differ. We advance this lit...
Background:
Anterior cruciate ligament (ACL) reconstruction with bone-patellar-tendon-bone (BPTB) autograft has the potential biological advantage of direct bone-to-bone healing over soft tissue grafts. The primary aim of this study was to investigate possible graft slippage and therefore fixation strength in a modified BPTB autograft technique wi...
Objectives
To compare multiparametric magnetic resonance imaging (mpMRI) findings, US-MR fusion prostate biopsy results and whole-mount thin-section histopathology after radical prostatectomy.
Patients and methods
Overall 259 patients, who had undergone mpMRI with lesions reported as PI-RADS 3-5, underwent a MR-US fusion biopsy between 2018 and 20...
![A: [gray box] Boxplot of distances between samples of different...](publication/368573258/figure/fig3/AS:11431281257145369@1719591041460/A-gray-box-Boxplot-of-distances-between-samples-of-different-subjects-regardless-of_Q320.jpg)
The colorectal cancer (CRC) screening program B-PREDICT is an invited two-stage screening project using a fecal immunochemical test (FIT) for initial screening followed by a colonoscopy for those with a positive FIT. Since the gut microbiome likely plays a role in the etiology of CRC, microbiome-based biomarkers in combination with FIT could be a p...
Purpose
The overarching goal of the FOCUS (biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer (CRC) recurrence and survival) Consortium is to unravel the effect of folate and folate-mediated one-carbon metabolism (FOCM) biomarkers on CRC prognosis to provide clinically relevant advice on folate intake to cancer patien...
CIREL, a prospective, Europe-wide, observational study aimed to assess the real-world feasibility and tolerability of irinotecan-based transarterial chemoembolization (LP-irinotecan TACE) for unresectable colorectal cancer liver metastases with regard to the treatment plan and adverse events (AEs). CIREL enrolled 152 eligible patients (≥18 years) w...
Background
Extracorporeal membrane oxygenation, with an inherent requirement for anticoagulation to avoid circuit thrombosis, is a key element in the treatment of respiratory failure associated with COVID-19. Anticoagulation remains challenging, the standard of care being intravenous continuous administration of unfractionated heparin. Yet regimens...
Background:
Common skin conditions, such as irritated, dry, aging and oily skin or dark eye circles with periorbital edema, usually do not require pharmaceutical therapy in form of dermatological drugs. They can, however, still affect the quality of life significantly. With the advent of newer cosmetics, a more targeted treatment of these dermatol...
Background:
Anti-factor Xa activity has been suggested as a surrogate parameter for judging the effectiveness of pharmacological thromboprophylaxis with low molecular weight heparins in critically ill patients. However, this practice is not supported by evidence associating low anti-factor Xa activity with venous thromboembolism.
Methods:
We per...
Background
Folate-mediated one-carbon metabolism requires several nutrients, including vitamin B6. Circulating levels of biomarkers indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients.
Objectives
We i...
Background: The colorectal cancer (CRC) screening program B-PREDICT is an invited two stage screening project using a faecal immunochemical test (FIT) for initial screening followed by a colonoscopy for those with a positive FIT. Since the gut microbiome likely plays a role in the etiology of CRC, microbiome-based biomarkers in combination with FIT...
Hintergrund: Bei Eisenmangelanämie besteht ein Zusammenhang zwischen intravenöser Eisensubstitutionstherapie und Hypophosphatämie. Es wird vermutet, dass das Ausmaß der Hypophosphatämie von dem verabreichten Eisenpräparat abhängt. Bisher gibt es keine Studie, welche die Veränderung des Serum-Phosphatspiegels in Abhängigkeit von Eisen(III)-Carboxyma...
Background:
Current guidelines recommend the monitoring of anti-factor Xa (anti-Xa) levels to avoid an accumulation of low-molecular-weight heparins in patients with acute kidney injury, but there is no evidence on how to proceed with such monitoring during continuous renal replacement therapy. Against this background, we investigated the potentia...
The COloRectal cancer Study of Austria (CORSA) is comprised more than 13,500 newly diagnosed colorectal cancer (CRC) patients, patients with high- and low-risk adenomas as well as population-based controls. The recruitment for the CORSA biobank is performed in close cooperation with the invited two-stage CRC screening project “Burgenland PREvention...
Dysregulation of tryptophan metabolism has been linked to colorectal tumorigenesis; however, epidemiological studies investigating tryptophan metabolites in relation to colorectal cancer risk are limited. We studied associations of plasma tryptophan, serotonin and kynurenine with colon cancer risk in two studies with cancer patients and controls, a...
Background: To investigate pro- and anticoagulant alterations in uremic critically ill patients prior to and during continuous renal replacement therapy. In addition to the conventional thrombin generation assay (TGA), we performed a thrombomodulin-modified variant to better elucidate procoagulant imbalances. Platelet function was determined via mu...
The 3-year overall survival (OS) rate of patients with previously treated or untreated stage III or IV melanoma has by now reached 63% using ipilimumab and nivolumab therapy. However, immune-related adverse events (irAEs) of grade 3 or 4 occurred in 59% of patients leading to discontinuation of therapy in 24.5% of patients and one death. Therapy wi...
Background:
B vitamins have been associated with the risk and progression of colorectal cancer (CRC), given their central roles in nucleotide synthesis and methylation, yet their association with quality of life in established CRC is unclear.
Objectives:
To investigate whether quality of life 6 months postdiagnosis is associated with: 1) circula...
The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samp...
Sporadic colorectal cancer is characterized by a multistep progression from normal epithelium to precancerous low-risk and high-risk adenomas to invasive cancer. Yet, the underlying molecular mechanisms of colorectal carcinogenesis are not completely understood. Within the “Metabolomic profiles throughout the continuum of colorectal cancer” (Metabo...
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Dort wollen wir in diesem Kapitel hin: erste Grafiken erstellen und einfache Grafikeinstellungen kennenlernendie Welt der Streudiagramme erkundenGrafikelemente hinzufügen: Punkte, Linien, Texte, Boxen, Gitter, Achsen, Legenden, Polygone, intelligente Linien, Pfeile und Beschriftungen erste Grafiken erstellen und einfache Grafikeinstellungen kennenl...
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Im Folgenden wird eine Auswahl von R-Paketen aufgelistet und kurz beschrieben. Pakete stellen in R Erweiterungen zu den vorhandenen Funktionen dar. Standardmäßig werden beim Start von R die folgenden sieben Pakete geladen.
Bereits in den einzelnen Kapiteln haben wir weiterführende Informationen erwähnt. Hier möchten wir noch einmal eine Auswahl an R-Ressourcen zusammenstellen.
Dort wollen wir in diesem Kapitel hin:
Dort wollen wir in diesem Kapitel hin:
Thrombelastometry, allowing timely assessment of global hemostatic function, is increasingly used to guide hemostatic interventions in bleeding patients. Reference values are available for adults and children, including infants but not neonates immediately after birth.
Neonates were grouped as preterm (30 + 0 to 36 + 6 weeks/days) and term (37 + 0...
Introduction:
Multiple fractures are of high clinical relevance, as a significant increase in mortality rate has been described. The purpose of this study was to evaluate differences in age and gender distribution in multiple fractures dependent on severity of trauma. Furthermore, affected anatomic regions and frequently associated fracture regions...
Background
Bone mineral density at the humeral head is reduced in patients with chronic rotator cuff tears. Bone loss in the humeral head is associated with repair failure after rotator cuff reconstruction. Bisphosphonates (eg, zoledronic acid) increase bone mineral density.
Hypothesis
Zoledronic acid improves bone mineral density of the humeral h...
Food cues modulate hunger and dictate nutritional choices. The omnipresent stimulus of palatable food promotes the epidemics of obesity and metabolic diseases. The aim of our study was to investigate the impact of visual stimulation with food pictures on appetite-related hormones as well as the functionality of the secreted hormones and its impact...
Food cues affect hunger and nutritional choices. Omnipresent stimulation with palatable food contributes to the epidemics of obesity. The objective of the study was to investigate the impact of food cues on appetite-related hormones and to assess the functionality of the secreted hormones on macronutrient uptake in healthy subjects. Additionally, w...
Prostate cancer is a major health burden, being the second most commonly diagnosed malignancy in men worldwide. Overtreatment represents a major problem in prostate cancer therapy, leading to significant long-term quality-of-life effects for patients and a broad socio-ecological burden. Biomarkers that could facilitate risk stratification of prosta...
The original version of this article unfortunately contained a mistake. The last sentence should read: Patients with ALD had significantly lower sclerostin levels, compared to controls. The authors apologize for the mistake.
Extracorporeal membrane oxygenation (ECMO) is gaining importance in the perioperative management of lung transplant patients. To date, the ideal substance for anticoagulation of ECMO patients is still a matter of debate. In this study, we describe our experience with the use of low molecular weight heparin (LMWH) in comparison with unfractioned hep...
We analyzed volumetric bone mineral density (vBMD) and bone microstructure using HR-pQCT in subjects with normouricemia (NU) and subjects with hyperuricemia (HU) with and without psoriasis (PSO). HU was associated with higher cortical vBMD and thickness. Differences in average and trabecular vBMD were found between patients with PSO + HU and NU.
I...
Background: Patients with hepatic cirrhosis are at increased risk of bone loss. Recent work on areal bone mineral density has reported contradictory findings. As the assessment of bone microarchitecture is complex, a search was made for correlations with new serum markers of bone turnover. Current data on serum sclerostin levels in patients with in...
Dieses Buch gibt eine umfassende, didaktisch erprobte Einführung in die statistische Programmiersprache R. Es vermittelt fundierte Kenntnisse zum sicheren und effizienten Einsatz von R zur Datenaufbereitung, Datenanalyse, Visualisierung, Berichterstellung und Simulation.
Sein didaktisches Konzept wurde im Rahmen der mit dem Teaching Award der Unive...
The present study examines the specific conditions under which part-time (PT) arrangements in managerial jobs allow parents with childcare responsibilities to stay on the career track. By integrating economic signaling theory and gender role congruity theory, a vignette study among German managers revealed that substantial PT hours, flexible workin...
Colorectal cancer is the second most common cause of cancer‐related death globally, with marked differences in prognosis by disease stage at diagnosis. We studied circulating metabolites in relation to disease stage to improve the understanding of metabolic pathways related to colorectal cancer progression. We investigated plasma concentrations of...
Objective:
The aim of this study was to determine the clinical role of the systemic immune-inflammation index in patients with resectable adenocarcinoma of the gastroesophageal junction treated with or without neoadjuvant therapy.
Background:
Adenocarcinoma of the gastroesophageal junction is an aggressive disease, with less than 20% of overall...
Background: Bone stress injuries (BSI) occur as inability of bone to withstand repetitive loading resulting in a loss of stiffness leading to microstructural damage. Biopsies of hyperintense bone bruise areas of BSI have revealed microfractures of cancellous bone with a concomitant inflammatory reaction. The incidence of BSI is greatest among soldi...
Colorectal cancer is known to arise from multiple tumorigenic pathways; however, the underlying mechanisms remain not completely understood. Metabolomics is becoming an increasingly popular tool in assessing biological processes. Previous metabolomics research focusing on colorectal cancer is limited by sample size and did not replicate findings in...
Im vorliegenden Artikel wird herausgearbeitet, entlang welcher regelungsstrukturellen Dimensionen sich Bildungssysteme theoretisch klassifizieren lassen und welche dieser Dimensionen empirisch (mit PISA-Daten der Jahre 2000 bis 2015) nachweisbar sind. Es kann gezeigt werden, dass ein großer Teil der regelungsstrukturellen Varianz europäischer Schul...
Background: Stress fractures are commonly due to repetitive-use injuries, often described in competitive athletes or military recruits. An edema inside the bone marrow (“bone bruise”) – assessed by magnetic resonance imaging (MRI) – represents the early sign of a stress fracture. Bone bruise biopsies have revealed microfractures of cancellous bone...
Purpose: Systemic teriparatide (TPTD) enhances callus formation and mechanical strength after fracture in animal models and in humans. Less data exist on three-dimensional (3D) structural effects at the proximal humerus, a specific non weight-bearing cortical and trabecular bone site with high fracture incidence.
Methods: This prospective double-bl...
Part-time work is an increasingly common strategy for handling work and family – but is it an effective strategy everywhere and for everyone? To answer this question, we examine satisfaction with work–life balance (SWLB) of workers in 22 European countries. Our results show that part-time workers have higher SWLB than full-time workers; the more so...
Part-time work is an increasingly common strategy for handling work and family—but is it an effective strategy everywhere and for everyone? To answer this question, we examine the satisfaction with work–life balance of workers in 22 European countries included in round five of the European Social Survey. Our results show that part-time workers are...
The assessment of bone quality and the prediction of fracture risk in idiopathic osteoporosis (IOP) are complex prospects as bone mineral density (BMD) and bone turnover markers (BTM) do not indicate fracture-risk. MicroRNAs (miRNAs) are promising new biomarkers for bone diseases, but the current understanding of the biological information containe...