Andreas Baierl

Andreas Baierl
University of Vienna | UniWien · Institut für Statistik und Operations Research

PhD

About

153
Publications
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1,576
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Publications

Publications (153)
Article
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Background Extracorporeal membrane oxygenation, with an inherent requirement for anticoagulation to avoid circuit thrombosis, is a key element in the treatment of respiratory failure associated with COVID-19. Anticoagulation remains challenging, the standard of care being intravenous continuous administration of unfractionated heparin. Yet regimens...
Article
Background Folate-mediated one-carbon metabolism requires several nutrients, including vitamin B6. Circulating levels of biomarkers indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients. Objectives We i...
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Background: Anti-factor Xa activity has been suggested as a surrogate parameter for judging the effectiveness of pharmacological thromboprophylaxis with low molecular weight heparins in critically ill patients. However, this practice is not supported by evidence associating low anti-factor Xa activity with venous thromboembolism. Methods: We per...
Preprint
Background: The colorectal cancer (CRC) screening program B-PREDICT is an invited two stage screening project using a faecal immunochemical test (FIT) for initial screening followed by a colonoscopy for those with a positive FIT. Since the gut microbiome likely plays a role in the etiology of CRC, microbiome-based biomarkers in combination with FIT...
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Background: Current guidelines recommend the monitoring of anti-factor Xa (anti-Xa) levels to avoid an accumulation of low-molecular-weight heparins in patients with acute kidney injury, but there is no evidence on how to proceed with such monitoring during continuous renal replacement therapy. Against this background, we investigated the potentia...
Article
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The COloRectal cancer Study of Austria (CORSA) is comprised more than 13,500 newly diagnosed colorectal cancer (CRC) patients, patients with high- and low-risk adenomas as well as population-based controls. The recruitment for the CORSA biobank is performed in close cooperation with the invited two-stage CRC screening project “Burgenland PREvention...
Article
Dysregulation of tryptophan metabolism has been linked to colorectal tumorigenesis, however, epidemiological studies investigating tryptophan metabolites in relation to colorectal cancer risk are limited. We studied associations of plasma tryptophan, serotonin, and kynurenine with colon cancer risk in two studies with cancer patients and controls,...
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Background: To investigate pro- and anticoagulant alterations in uremic critically ill patients prior to and during continuous renal replacement therapy. In addition to the conventional thrombin generation assay (TGA), we performed a thrombomodulin-modified variant to better elucidate procoagulant imbalances. Platelet function was determined via mu...
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The 3-year overall survival (OS) rate of patients with previously treated or untreated stage III or IV melanoma has by now reached 63% using ipilimumab and nivolumab therapy. However, immune-related adverse events (irAEs) of grade 3 or 4 occurred in 59% of patients leading to discontinuation of therapy in 24.5% of patients and one death. Therapy wi...
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Background: B vitamins have been associated with the risk and progression of colorectal cancer (CRC), given their central roles in nucleotide synthesis and methylation, yet their association with quality of life in established CRC is unclear. Objectives: To investigate whether quality of life 6 months postdiagnosis is associated with: 1) circula...
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The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samp...
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Sporadic colorectal cancer is characterized by a multistep progression from normal epithelium to precancerous low-risk and high-risk adenomas to invasive cancer. Yet, the underlying molecular mechanisms of colorectal carcinogenesis are not completely understood. Within the “Metabolomic profiles throughout the continuum of colorectal cancer” (Metabo...
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Dort wollen wir in diesem Kapitel hin: erste Grafiken erstellen und einfache Grafikeinstellungen kennenlernendie Welt der Streudiagramme erkundenGrafikelemente hinzufügen: Punkte, Linien, Texte, Boxen, Gitter, Achsen, Legenden, Polygone, intelligente Linien, Pfeile und Beschriftungen erste Grafiken erstellen und einfache Grafikeinstellungen kennenl...
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Im Folgenden wird eine Auswahl von R-Paketen aufgelistet und kurz beschrieben. Pakete stellen in R Erweiterungen zu den vorhandenen Funktionen dar. Standardmäßig werden beim Start von R die folgenden sieben Pakete geladen.
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Bereits in den einzelnen Kapiteln haben wir weiterführende Informationen erwähnt. Hier möchten wir noch einmal eine Auswahl an R-Ressourcen zusammenstellen.
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Article
Thrombelastometry, allowing timely assessment of global hemostatic function, is increasingly used to guide hemostatic interventions in bleeding patients. Reference values are available for adults and children, including infants but not neonates immediately after birth. Neonates were grouped as preterm (30 + 0 to 36 + 6 weeks/days) and term (37 + 0...
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Introduction: Multiple fractures are of high clinical relevance, as a significant increase in mortality rate has been described. The purpose of this study was to evaluate differences in age and gender distribution in multiple fractures dependent on severity of trauma. Furthermore, affected anatomic regions and frequently associated fracture regions...
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Background: Bone mineral density at the humeral head is reduced in patients with chronic rotator cuff tears. Bone loss in the humeral head is associated with repair failure after rotator cuff reconstruction. Bisphosphonates (eg, zoledronic acid) increase bone mineral density. Hypothesis: Zoledronic acid improves bone mineral density of the humeral...
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Food cues modulate hunger and dictate nutritional choices. The omnipresent stimulus of palatable food promotes the epidemics of obesity and metabolic diseases. The aim of our study was to investigate the impact of visual stimulation with food pictures on appetite-related hormones as well as the functionality of the secreted hormones and its impact...
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Food cues affect hunger and nutritional choices. Omnipresent stimulation with palatable food contributes to the epidemics of obesity. The objective of the study was to investigate the impact of food cues on appetite-related hormones and to assess the functionality of the secreted hormones on macronutrient uptake in healthy subjects. Additionally, w...
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Prostate cancer is a major health burden, being the second most commonly diagnosed malignancy in men worldwide. Overtreatment represents a major problem in prostate cancer therapy, leading to significant long-term quality-of-life effects for patients and a broad socio-ecological burden. Biomarkers that could facilitate risk stratification of prosta...
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Correction to: Wien Klin Wochenschr 2019 https://doi.org/10.1007/s00508-019-01595-8 The original version of this article unfortunately contained a mistake. The last sentence should read: Patients with ALD had significantly lower sclerostin levels, compared to controls. The authors apologize for the ….
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Extracorporeal membrane oxygenation (ECMO) is gaining importance in the perioperative management of lung transplant patients. To date, the ideal substance for anticoagulation of ECMO patients is still a matter of debate. In this study, we describe our experience with the use of low molecular weight heparin (LMWH) in comparison with unfractioned hep...
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We analyzed volumetric bone mineral density (vBMD) and bone microstructure using HR-pQCT in subjects with normouricemia (NU) and subjects with hyperuricemia (HU) with and without psoriasis (PSO). HU was associated with higher cortical vBMD and thickness. Differences in average and trabecular vBMD were found between patients with PSO + HU and NU. I...
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Background: Patients with hepatic cirrhosis are at increased risk of bone loss. Recent work on areal bone mineral density has reported contradictory findings. As the assessment of bone microarchitecture is complex, a search was made for correlations with new serum markers of bone turnover. Current data on serum sclerostin levels in patients with in...
Book
Dieses Buch gibt eine umfassende, didaktisch erprobte Einführung in die statistische Programmiersprache R. Es vermittelt fundierte Kenntnisse zum sicheren und effizienten Einsatz von R zur Datenaufbereitung, Datenanalyse, Visualisierung, Berichterstellung und Simulation. Sein didaktisches Konzept wurde im Rahmen der mit dem Teaching Award der Unive...
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The present study examines the specific conditions under which part-time (PT) arrangements in managerial jobs allow parents with childcare responsibilities to stay on the career track. By integrating economic signaling theory and gender role congruity theory, a vignette study among German managers revealed that substantial PT hours, flexible workin...
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Colorectal cancer is the second most common cause of cancer‐related death globally, with marked differences in prognosis by disease stage at diagnosis. We studied circulating metabolites in relation to disease stage to improve the understanding of metabolic pathways related to colorectal cancer progression. We investigated plasma concentrations of...
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Objective: The aim of this study was to determine the clinical role of the systemic immune-inflammation index in patients with resectable adenocarcinoma of the gastroesophageal junction treated with or without neoadjuvant therapy. Background: Adenocarcinoma of the gastroesophageal junction is an aggressive disease, with less than 20% of overall...
Poster
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Background: Bone stress injuries (BSI) occur as inability of bone to withstand repetitive loading resulting in a loss of stiffness leading to microstructural damage. Biopsies of hyperintense bone bruise areas of BSI have revealed microfractures of cancellous bone with a concomitant inflammatory reaction. The incidence of BSI is greatest among soldi...
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Colorectal cancer is known to arise from multiple tumorigenic pathways; however, the underlying mechanisms remain not completely understood. Metabolomics is becoming an increasingly popular tool in assessing biological processes. Previous metabolomics research focusing on colorectal cancer is limited by sample size and did not replicate findings in...
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Im vorliegenden Artikel wird herausgearbeitet, entlang welcher regelungsstrukturellen Dimensionen sich Bildungssysteme theoretisch klassifizieren lassen und welche dieser Dimensionen empirisch (mit PISA-Daten der Jahre 2000 bis 2015) nachweisbar sind. Es kann gezeigt werden, dass ein großer Teil der regelungsstrukturellen Varianz europäischer Schul...
Poster
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Background: Stress fractures are commonly due to repetitive-use injuries, often described in competitive athletes or military recruits. An edema inside the bone marrow (“bone bruise”) – assessed by magnetic resonance imaging (MRI) – represents the early sign of a stress fracture. Bone bruise biopsies have revealed microfractures of cancellous bone...
Conference Paper
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Purpose: Systemic teriparatide (TPTD) enhances callus formation and mechanical strength after fracture in animal models and in humans. Less data exist on three-dimensional (3D) structural effects at the proximal humerus, a specific non weight-bearing cortical and trabecular bone site with high fracture incidence. Methods: This prospective double-bl...
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Part-time work is an increasingly common strategy for handling work and family – but is it an effective strategy everywhere and for everyone? To answer this question, we examine satisfaction with work–life balance (SWLB) of workers in 22 European countries. Our results show that part-time workers have higher SWLB than full-time workers; the more so...
Preprint
Part-time work is an increasingly common strategy for handling work and family—but is it an effective strategy everywhere and for everyone? To answer this question, we examine the satisfaction with work–life balance of workers in 22 European countries included in round five of the European Social Survey. Our results show that part-time workers are...
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The assessment of bone quality and the prediction of fracture risk in idiopathic osteoporosis (IOP) are complex prospects as bone mineral density (BMD) and bone turnover markers (BTM) do not indicate fracture-risk. MicroRNAs (miRNAs) are promising new biomarkers for bone diseases, but the current understanding of the biological information containe...
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Considering the high prevalence of colorectal cancer (CRC) and relatively high mortality there is strong interest in identification of clinically relevant biomarkers. Telomere shortening is supposed to contribute to genomic instability and crucially involved in process of carcinogenesis. Peripheral blood leukocyte (PBL) telomere length was previous...
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Background. The outcome of patients with adenocarcinoma of the esophagogastric junction (AEG) remains poor. The programmed cell-death-protein-1 (PD-1), a co-inhibitory receptor primarily expressed by T-cells, represents a potential new therapeutic target. PD-1, PD-1 ligand 1 (PD-L1), and PD-L2 expression have all been described as prognostic factor...
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The modified Glasgow Prognostic Score (mGPS) combines the indicators of decreased plasma albumin and elevated CRP. In a number of malignancies, elevated mGPS is associated with poor survival. Aim of this study was to investigate the prognostic role of mGPS in patients with neoadjuvantly treated adenocarcinomas of the esophagogastric junction 256 pa...
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Left ventricular hypertrophy (LVH) ultimately leads to heart failure in conditions of increased cardiac pre- or afterload. The bone-derived phosphaturic and sodium-conserving hormone fibroblast growth factor-23 (FGF23) and its co-receptor Klotho have been implicated in the development of uremic LVH. Using transverse aortic constriction (TAC) in gen...