Andrea Slachevsky

Andrea Slachevsky
University of Chile · Instituto de Ciencias Biomédicas (ICBM)

MD, PhD

About

231
Publications
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Publications

Publications (231)
Article
Latin American and Caribbean countries face complex challenges to improve brain health and reduce the impact of dementia. Regional hubs devoted to research, capacity building, implementation science, and education are critically needed. The Latin American Brain Health Institute represent an important step to address many of these needs.
Article
Full-text available
ABSTRACT: The Frontal Assessment Battery (FAB) is a screening test that measures executive functions. Although this instrument has been validated in several countries, its diagnostic utility in a Chilean population has not been studied yet. OBJECTIVES: This study aimed to (1) adapt FAB in a Chilean population; (2) study the psychometric properties...
Article
Background: Processing of linguistic negation has been associated to inhibitory brain mechanisms. However, no study has tapped this link via multimodal measures in patients with core inhibitory alterations, a critical approach to reveal direct neural correlates and potential disease markers. Methods: Here we examined oscillatory, neuroanatomical...
Article
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Introduction: Projected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia-prevention strategies. Methods: We analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk fac...
Article
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Frontotemporal dementia (FTD) is the third most common form of dementia across all age groups and is a leading cause of early-onset dementia. The Frontotemporal dementia (FTD) includes a spectrum of diseases that are classified according to their clinical presentation and patterns of neurodegeneration. There are two main types of FTD: behavioral FT...
Article
Background The predictive coding theory of allostatic interoceptive load states that brain networks mediating autonomic regulation and interoceptive-exteroceptive balance regulate the internal milieu to anticipate future needs and environmental demands. These functions seems to be distinctly compromised in behavioral variant frontotemporal dementia...
Article
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Introduction: Automated speech analysis has emerged as a scalable, cost-effective tool to identify persons with Alzheimer's disease dementia (ADD). Yet, most research is undermined by low interpretability and specificity. Methods: Combining statistical and machine learning analyses of natural speech data, we aimed to discriminate ADD patients fr...
Article
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Background: The cognitive and neuropsychiatric deficits present in patients with behavioral variant frontotemporal dementia (bvFTD) are associated with loss of functionality in the activities of daily living (ADLs). The main purpose of this study was to examine and explore the association between the cognitive and neuropsychiatric features that mig...
Article
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Dementia in Latin America is a crucial public health problem. Identifying brief cognitive screening (BCS) tools for the primary care setting is crucial, particularly for illiterate individuals. We evaluated tool performance characteristics and validated the free and total recall sections of the Free and Cued Selective Reminding Test-Picture version...
Poster
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Novel neuropsychological approaches able to detect subtle deficits in preclinical Alzheimer's Disease (AD) are largely missing. The Visual short-term memory binding task (VSTMBT) and the Free and cued selective reminding test (FCSRT) arise as strong candidates as they have proved effective to identify subjects throughout the AD continuum with high...
Article
Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial...
Article
Individuals tend to accumulate a larger number of losses in old age than in prior stages of life, leading to major consequences for the well-being of older adults. Research has generally focused on a single type of loss, with only a handful of studies exploring the accumulation of losses in old age and examining which and how many losses are experi...
Article
Cognitive assessments able to detect impairments as early as neuropathological changes that occur in neurodegenerative diseases initiate are urgently needed. The Visual Short‐Term Memory Binding Test (VSTMBT) and the Free and Cued Selective Reminding Test (FCRST) have been recently recommended by the Neurodegenerative Diseases Working Group (Costa...
Article
Social cognition impairments have been extensively described in patients with behavioral variant frontotemporal dementia (bvFTD). Moral emotions have recently emerged as a potentially sensitive domain to characterize and discriminate bvFTD patients from other types of dementia. Here, we examined the usefulness of moral emotions measures to characte...
Article
Background Self-stigma is a dimension of stigma concerning how individuals internalize negative attributes and discriminate against their own selves. Dementia is a stigmatizing condition, and there is a paucity of research exploring the manifestations and implications of self- stigma in people living with dementia in various contexts. Aim To exami...
Article
Objective Teleneuropsychology (teleNP) could potentially expand access to services for patients who are confined, have limited personal access to healthcare, or live in remote areas. The emergence of the COVID-19 pandemic has significantly increased the use of teleNP for cognitive assessments. The main objective of these recommendations is to ident...
Article
Objective: To compare social cognition performance between patients with amyotrophic lateral sclerosis (ALS) and those patients with behavioural variant frontotemporal dementia (bvFTD). Methods: We included 21 participants with ALS, 20 with bvFTD and 21 healthy controls who underwent a comprehensive cognitive battery, including the short version o...
Article
Full-text available
Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain measures, can complement standard approaches by revealing direct multidimensional correlates of the pheno...
Article
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The COVID-19 pandemic has revealed existing gaps in policies, systems and services, stressing the need for concerted global action on healthy aging. Similar to the COVID-19 pandemic, dementia is a challenge for health systems on a global scale. Our hypothesis is that translational potential lies in cross-country learning by involving three high-inc...
Article
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The development of healthcare services for dementia is key to improving access to care and post-diagnostic support for people living with dementia. Memory Units have emerged as a new healthcare service composed of multidisciplinary teams with the goal of improving diagnosis and/or management of dementia patients. The main objective of this study wa...
Article
Introducción: Comunicar el diagnóstico de demencia es un importante desafío médico, por lo que tiende a ser una práctica poco frecuente no obstante el derecho de los pacientes a ser informados de sus diagnósticos. En Chile, existe investigación que describe las implicancias del diagnóstico de demencia en el sistema familiar y cuidadores informales,...
Article
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Background: Social cognition is critically compromised across neurodegenerative diseases, including the behavioral variant frontotemporal dementia (bvFTD), Alzheimer's disease (AD), and Parkinson's disease (PD). However, no previous study has used social cognition and other cognitive tasks to predict diagnoses of these conditions, let alone report...
Preprint
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Background: Dysexecutive syndrome is a prominent and functionally significant cognitive feature of schizophrenia. This study assesses and correlates executive function deficits and dysexecutive behavior in first-episode schizophrenia patients and healthy participants. Methods: We evaluated 22 FES patients (aged 17−29 years, history of single episod...
Article
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Frontotemporal dementia (FTD) includes a group of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders, affecting the fronto-insular-temporal regions of the brain. Clinically, FTD is characterized by progressive deficits in behavior, executive function, and language and its diagnosis relies mainly on the clinical ex...
Article
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Background: In the COVID-19 pandemic, older adults from vulnerable ethnoracial groups are at high risk of infection, hospitalization, and death. We aimed to explore the pandemic’s impact on the well-being and cognition of older adults living in the United States (US), Argentina, Chile, Mexico, and Peru. Methods: 1,608 (646 White, 852 Latino, 77 Bla...
Article
Full-text available
Background In the COVID-19 pandemic, older adults from vulnerable ethnoracial groups are at high risk of infection, hospitalization, and death. We aimed to explore the pandemic's impact on the well-being and cognition of older adults living in the United States (US), Argentina, Chile, Mexico, and Peru. Methods 1,608 (646 White, 852 Latino, 77 Blac...
Article
Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that...
Article
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The prevalence of dementia in Latin America and the Caribbean is growing rapidly, increasing the burden placed on caregivers. Exacerbated by fragile health-care systems, unstable economies, and extensive inequalities, caregiver burden in this region is among the highest in the world. We reviewed the major challenges to caregiving in Latin America a...
Article
Background: People with dementia and their family caregivers may face a great burden through social isolation due to the COVID-19 pandemic, which can be manifested as various behavioral and clinical symptoms. Objective: To investigate the impacts of social isolation due to the COVID-19 pandemic on individuals with dementia and their family careg...
Article
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Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and mana...
Article
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Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean...
Article
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Introduction The increasing evidence of SARS‐CoV‐2 impact on the central nervous system (CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer's disease (AD), and other dementia. Methods The Alzheimer's Association and representatives from more than 30 countries—with technical guidance from the World Health...
Article
Full-text available
Introduction: The increasing evidence of SARS-CoV-2 impact on the central nervous system (CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer's disease (AD), and other dementia. Methods: The Alzheimer's Association and representatives from more than 30 countries-with technical guidance from the World Healt...
Chapter
Syndromes, defined by a group of symptoms and signs, are the main framework in behavioral neurology. Most of the corpus of knowledge in the discipline is related to the definition of syndromes and underlying diseases. Reviewing primary syndromes and diseases studied in behavioral neurology is crucial to understanding and introducing the field. In t...
Article
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Chile is currently implementing policies addressing dementia care with efforts to translate evidence-based programs towards culturally sensitive models of care. This study describes the cultural adaptation of the Tailored Activity Program (TAP). A complementary mixed-method design was performed following the 4-phase Dynamic Adaptation Process (DAP)...
Article
The prevalence of dementia in Chile is 1.06%, meaning that over 200,000 people are affected. In 2017, the Ministry of Health launched the National Plan of Dementia in Chile which proposed establishing a range of health‐care services from primary care to Memory Units (MU). MUs have emerged as a new health care service composed of multidisciplinary t...
Article
Full-text available
Alzheimer's disease dementia (ADD) and Parkinson's disease (PD) have a significant impairment in social emotion recognition. Most of these studies assess emotional perception as the ability to identify others' facial emotions (Ekman faces). Nevertheless, emotional recognition with information that integrates whole‐body and postural control response...
Article
The Tailored Activity Program (TAP) provides people with dementia with activities tailored to their capabilities and trains caregivers in their use. The TAP has been previously cross‐culturally adapted in different settings and countries. This study was aimed to develop a cultural adaptation of the TAP in Santiago, Chile. Complementary mixed‐method...
Article
New procedures based on attributional methods have not been used to estimate the burden of Dementia in term of loss of Health‐State Utilities (HSU) or Quality‐Adjusted Life Years (QALY) at the populational level. Chile, in recent decades, has presented an accelerated aging process and has few studies on dementia. We analysed data from the Chilean N...
Article
Availability of culture‐free cognitive tests with marker properties for AD has proved a barrier to global harmonization strategies. The European Neurodegenerative Diseases Working Group suggested that the Short‐Term Memory Binding Test (STMBT) and the Free and Cued Selective Reminding Test (FCSRT) are useful tests for the early detection of AD (Cos...
Article
Decades of researches aiming to unveil truths about human neuropsychology may have instead unveil facts appropriate to only a fraction of the world’s population: those living in western educated rich democratic nations (Muthukrishna et al., 2020 Psych Sci). So far, most studies were conducted as if education and cultural assumptions on which neurop...
Article
Dementia is one of the mean causes of disability in elderly. Peripheral inflammatory biomarkers and ApoE‐ε4 allele have been described as important biological risk factors of dementia in Caucasian population. Currently, there is scarce information about the specific age‐related and predisposition factors to develop dementia in Latino populations. T...
Article
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Background With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and the most rapidly growing cause of death in the last 20 years. Cognitive complaint is considered a predictor for cognitive and fu...
Poster
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The enactive approach considers that perception emerges from a sensory-motor coupling between the body and its environment. From an enactive approach, emotions can be understood as a structural coupling intimately related to physiological and experiential attributes, like motor control and lived experience. Recent studies have demonstrated that emo...
Article
Full-text available
The prevalence of dementia in Chile is 1.06 %, meaning that over 200,000 people are affected. In 2017, the Ministry of Health launched the National Plan of Dementia, which proposed establishing a range of health-care services from primary care to Memory Units (MU). MUs have emerged as a new health care service composed of multidisciplinary teams wi...
Article
Objective: To compare social cognition performance between patients with amyotrophic lateral sclerosis (ALS) and those patients with behavioural variant frontotemporal dementia (bvFTD). Methods: We included 21 participants with ALS, 20 with bvFTD and 21 healthy controls who underwent a comprehensive cognitive battery, including the short version...
Article
Full-text available
Objectives: The aim of this study was to evaluate the validity of brief cognitive screening (BCS) tools designed to diagnose mild cognitive impairment (MCI) or dementia in Spanish-speaking individuals over the age of 50 years from Latin America (LA). Methods: A systematic search of titles and abstracts in Medline, Biomed Central, Embase, Scopus, Sc...
Preprint
Full-text available
Humans have developed specific abilities to interact efficiently with their conspecifics (social cognition). Despite abundant behavioral and neuroscientific research, the influence of cultural factors on these skills remains poorly understood. This issue is of particular importance as most cognitive tasks are developed in highly specific contexts,...
Chapter
Full-text available
Previo a la redacción del presente capítulo, se elaboró una encuesta que fue respondida por distintos referentes clínicos en Argentina, Chile y Uruguay, que trabajan principalmente en grandes urbes, con el fin de poder consensuar qué instrumentos neuropsicológicos son indispensables para realizar una evaluación neurocognitiva adecuada. Los tests fu...
Research Proposal
Full-text available
Geroscience Center for Brain Health and Metabolism seeks motivated post-doctoral researchers To start on May 2020 Topics include: Cytoskeleton dysfunction in aging and neurodegenerative diseases Proteostasis in aging and neurodegenerative diseases Axonal degeneration and regeneration in neurodegenerative diseases Age-dependent microbiome changes...
Article
Full-text available
Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are the most common neurodegenerative early-onset dementias. Despite the fact that both conditions have a very distinctive clinical pattern, they present with an overlap in their cognitive and behavioral features that may lead to misdiagnosis or delay in diagnosis. The current review intend...
Article
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Accurate early diagnosis of neurodegenerative diseases represents a growing challenge for current clinical practice. Promisingly, current tools can be complemented by computational decision-support methods to objectively analyze multidimensional measures and increase diagnostic confidence. Yet, widespread application of these tools cannot be recomm...
Article
Apathy is a common neuropsychiatric syndrome observed across many neurocognitive and psychiatric disorders. Although there are currently no definitive standard therapies for the treatment of apathy, nonpharmacological treatment (NPT) is often considered to be at the forefront of clinical management. However, guidelines on how to select, prescribe,...
Article
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Background Impairments in activities of daily living (ADL) are a criterion for Alzheimer’s disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social functioning), instrumental (IADL, maintaining life in community), and finally basic functions (BADL, activities related to physiological...
Article
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Background The needs of people with dementia (PWD) have not been assessed in any Latin American country. Several European countries have already related unmet needs with quality of life, caregiver’s age, burden, stress, anxiety and depression. The aim of this study was to identify met and unmet needs in Chilean older adults with dementia and to det...
Article
Background: The needs of people with the dementia (PWD) have not been assessed in any Latin American country. Several European countries have already related unmet needs with quality of life, caregiver's age, burden, stress, anxiety and depression. The aim of this study was to identify met and unmet needs in Chilean older adults with dementia and t...
Article
Full-text available
Background: The needs of people with dementia (PWD) have not been assessed in any Latin American country. Several European countries have already related unmet needs with quality of life, caregiver’s age, burden, stress, anxiety and depression. The aim of this study was to identify met and unmet needs in Chilean older adults with dementia and to de...
Article
Full-text available
Background The Addenbrooke's Cognitive Examination III (ACE-III), an adaptation of the ACE cognitive screening test, has been demonstrated to have high sensitivity and specificity in detecting cognitive impairment in patients with dementia and other neurological and psychiatric disorders. Although the Spanish-language version of the ACE-III has alr...
Article
Full-text available
In humans and non-humans primates, extensive evidence supports the existence of subcortico-cortical circuits for cognition and behavior. Lesions studies are critical to understand the clinical significance of these functionally segregated circuits. Mapping these circuits from lesion studies is difficult given the heterogeneous etiology of the lesio...