Andrea Sanchini

Andrea Sanchini
Freelance

Ph.D. in Biomedical Sciences

About

32
Publications
9,385
Reads
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637
Citations
Introduction
Andrea is a trainer in scientific writing and publishing. In July 2017, he completed his Ph.D. in Biomedical Sciences. Since May 2018, he is a certified writing trainer and coach. He has more than ten years of experience in the field of Life Sciences. As a researcher, he experienced the challenges of writing and publishing journal articles with limited time and limited funding. Andrea worked in Public Health institutions and universities in Italy, France, Germany, and India.
Additional affiliations
April 2017 - July 2019
Robert Koch Institut
Position
  • Researcher
Description
  • Researcher responsible for the molecular epidemiology of Tuberculosis in Germany
January 2017 - present
Freelance
Position
  • Trainer in Scientific Writing and Publishing
Description
  • Organization of Workshops in Scientific Writing and Publishing
January 2015 - March 2015
University of Hyderabad
Position
  • Research stay abroad
Description
  • Research stay in the frame of the International PhD Graduate School IRTG1673. Collaboration in a project analyzing the genetic diversity of Mycobacterium avium isolates
Education
August 2017 - May 2018
Technische Universität Darmstadt
Field of study
  • Writing Center
March 2006 - May 2008
October 2002 - February 2006
Università Degli Studi Roma Tre
Field of study
  • Biological Sciences

Publications

Publications (32)
Article
Full-text available
Staphylococcus aureus is an opportunistic pathogen responsible for a wide range of infections in humans, such as skin and soft tissue infections, pneumonia, food poisoning or sepsis. Historically, S. aureus was able to rapidly adapt to anti-staphylococcal antibiotics and become resistant to several classes of antibiotics. Today, methicillin-resista...
Article
Introduction Improving the surveillance of tuberculosis (TB) is especially important for multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. The large amount of publicly available whole genome sequencing (WGS) data for TB gives us the chance to re-use data and to perform additional analyses at a large scale. Aim We assessed the usef...
Preprint
Full-text available
Introduction Improving the surveillance of tuberculosis (TB) is especially important for multidrug-resistant (MDR) and extensively drug-resistant (XDR)-TB. The large amount of publicly available whole-genome sequencing (WGS) data for TB gives us the chance to re-use data and to perform additional analysis at a large scale. Aim We assessed the usef...
Article
Full-text available
Background The implementation of an integrated molecular surveillance (IMS) of tuberculosis (TB) is of high priority for TB control. IMS is defined as the systematic inclusion of molecular typing results in the national TB surveillance system. Although not standardized, an IMS of TB is already implemented in several low TB incidence countries. Germ...
Article
Full-text available
Background Mycobacterium avium subsp. hominissuis (MAH) is an emerging opportunistic human pathogen. It can cause pulmonary infections, lymphadenitis and disseminated infections in immuno-compromised patients. In addition, MAH is widespread in the environment, since it has been isolated from water, soil or dust. In recent years, knowledge on MAH at...
Data
Kinetic curves corresponding to the plates PM1 to PM4 tested without any bacteria In the X-axis time is reported. In the Y-axis Omnilog units are reported. The Omnilog unit is a measurement of dye reduction and therefore a measurement of bacterial respiration. Wells in which the dye reduction is observed usually became positive soon and have a flat...
Data
Kinetic curves corresponding to the plates PM1 to PM4 tested with the ten MAH isolates analyzed in this study In the X-axis time is reported. In the Y-axis Omnilog units are reported. The Omnilog unit is a measurement of dye reduction and therefore a measurement of bacterial respiration. Each color represents a different isolate. For each isolate,...
Data
List of the 23 wells causing abiotic dye reduction The number and letter of each substrate indicate the exact position in the PM plate.
Data
Distribution of the genes associated with the propionic acid and the butyric acid pathways among the ten MAH isolates The three pathways where the propionic acid is involved, and the one pathway where the butirric acid is invovled are shown.
Data
Distribution of the 698 genes specific for the environmental isolates of Mycobacterium avium subsp. hominissuis(MAH) The presence or abscence of the 698 genes in the five clinical MAH isolates is shown. The genes are ordered by frequency. The number of genes specific and unique for each environmental isolate is provided.
Data
The 334 substrates showing negative reaction for all of the ten MAH isolates tested, listed by PM plates
Data
Distribution of the 1,688 genes specific for the clinical isolates of Mycobacterium avium subsp. hominissuis(MAH) The presence or abscence of the 1,688 genes in the five clinical MAH isolates is shown. The genes are ordered by frequency. The number of genes specific and unique for each clinical isolate is provided.
Data
Phylogenetic analysis of each gene associated with the propionic acid and the butyric acid pathways among the ten MAH isolates For each gene we made a phylogenetic tree based on the nucleotide sequences. The gene analyzed are the ones presented in the Table S3. in blue clinical isolates, in orange environmental isolates are shown
Article
Mycobacterium avium subsp. hominissuis (MAH) is an opportunistic human pathogen widespread in the environment. Genomic islands (GI)s represent a part of the accessory genome of bacteria and influence virulence, drug-resistance or fitness and trigger bacterial evolution. We previously identified a novel GI in four MAH genomes. Here, we further explo...
Article
Outbreaks of Staphylococcus aureus are common in neonatal intensive care units (NICUs). Usually they are documented for methicillin-resistant strains, while reports involving methicillin-susceptible S. aureus (MSSA) strains are rare. In this study we report the epidemiological and molecular investigation of an MSSA outbreak in a NICU among preterm...
Article
Mycobacterium avium subsp. hominissuis (MAH) is an environmental bacterium causing opportunistic infections. The objective of this study was to identify flexible genome regions in MAH isolated from different sources. By comparing five complete and draft MAH genomes we identified a genomic island conferring additional flexibility to the MAH genomes....
Article
Cryptococcosis is a fungal infection mostly caused by Cryptococcus neoformans. We identified agents of cryptococcosis diagnosed in Germany from 2004 to 2010. We used multi-locus sequence typing (MLST) to understand the molecular epidemiology of cryptococcosis. Sero- and mating types of individual patient isolates were determined by PCR. MLST was pe...
Article
Panton-Valentine Leukocidin (PVL) is the hallmark of community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) but can also be found in methicillin-susceptible S. aureus (MSSA) sharing pathogenic and epidemiological characteristics of CA-MRSA. PVL is encoded by two co-transcribed genes that are carried by different staphylococcal bac...
Article
Full-text available
Laboratory confirmation of paediatric tuberculosis (TB) is frequently lacking. We reviewed the range of routine laboratory tests and their performance in different biological samples used to diagnose active TB in children. A questionnaire-based survey was conducted among the European Reference Laboratory Network for TB followed by collection of rou...
Article
Full-text available
West Nile virus, genus Flavivirus, is transmitted between birds and occasionally other animals by ornithophilic mosquitoes. This virus also infects humans causing asymptomatic infections in about 85% of cases and <1% of clinical cases progress to severe neuroinvasive disease. The virus also presents a threat since most infections remain unapparent....
Article
Full-text available
Background Livestock-Associated MRSA (LA-MRSA) belonging to ST398 lineage, common among pigs and other animals, emerged in Central and Northern Europe, becoming a new risk factor for MRSA among farm workers. Strains belonging to ST398 can be responsible for human colonization and infection, mainly in areas with high livestock-farming. The aim of th...
Article
Full-text available
Background In recent decades, sporadic cases and outbreaks in humans of West Nile virus (WNV) infection have increased. Serological diagnosis of WNV infection can be performed by enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay (IFA) neutralization test (NT) and by hemagglutination-inhibition assay. The aim of this study is to co...
Article
Background: Community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) is responsible for severe infections in previously healthy people acquired in the community in different areas of the world. Aim: To report an outbreak of CA-MRSA in a hospital newborn nursery in northern Italy in September-October 2010, its investigation and con...
Article
Full-text available
Staphylococcus aureus is a leading cause of community-acquired infections and healthcare-associated infections. Epidemiological data are useful for understanding the dynamics of the diffusion of this pathogen, and to plan control activities and monitor their efficacy. S. aureus isolates were collected in 13 public hospital laboratories of Emilia-Ro...
Article
Objectives: Both MSSA and MRSA PVL-positive strains can cause serious and recurrent infections in subjects without risk factors living in the community. In this work we focus the attention on the characterization of the PVL-positive MSSA strains, responsible for outbreak and sporadic infections in Italy. Methods: During the period 2005–2010, twent...
Article
Full-text available
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates are widespread in many countries, with varying distribution and epidemiology. The aim of this study was to collect and characterise the CA-MRSA isolates circulating in Italy, since only some case reports have been published. Eighteen Panton-Valentine-positive CA-MRSA...
Article
Full-text available
The aim of this study was to characterise invasive methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) strains from Italy and to investigate the presence of heteroresistant vancomycin-intermediate S. aureus (h-VISA). Eighty-two MSSA and 66 MRSA strains obtained from 19 laboratories were submitted to in vi...
Article
Staphylococcus aureus can exemplify better than any other human pathogen the adaptive evolution of bacteria in the antibiotic era, as it has demonstrated a unique ability to quickly respond to each new antibiotic with the development of a resistance mechanism, starting with penicillin and methicillin, until the most recent, linezolid and daptomycin...

Questions

Questions (3)
Question
I practically need to have the Gene ontology (GO) numbers of a certain number of proteins of which I have the sequence.
Question
I have a gene list and I would like to assign them the relative COG category, I would like to know whether there is any "official" tool, or whether people do it just manually.
Question
I am working with genomic island and it is well known that the presence of several close tRNAs represents an hot spot for genomic island insertion due to recombination events. Do you know if this tRNA may have any role in virulence or pathogenesis? Or do you know if a different position of these tRNAs in the Island may have any role? Or any publication regarding that? Many thanks

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