Andrea Kroeker

Andrea Kroeker
Canadian Food Inspection Agency · Special Pathogens

Doctor of Philosophy, Virology and Pathophysiology

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31
Publications
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778
Citations

Publications

Publications (31)
Article
Full-text available
Rift Valley fever virus (RVFV) is a zoonotic arbovirus of the Phenuiviridae family. Infection causes abortions in pregnant animals, high mortality in neonate animals, and mild to severe symptoms in both people and animals. There is currently an ongoing effort to produce safe and efficacious veterinary vaccines against RVFV in livestock to protect a...
Article
Full-text available
All cellular functions, ranging from regular cell maintenance and homeostasis, specialized functions specific to cellular types, or generating responses due to external stimulus, are mediated by proteins within the cell. Regulation of these proteins allows the cell to alter its behavior under different circumstances. A major mechanism of protein re...
Chapter
Mouse models of Ebola virus (EBOV) have demonstrated their utility as important tools for screening the efficacy of candidate therapeutics and vaccines. In this chapter we explain the various mouse models that utilize either wild-type or mouse-adapted EBOV variants.
Article
Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. Non-human primates (NHP) remain the gold standard for modeling filovirus disease, but they are not conducive to screening large numbers of experimental c...
Article
Objective: To determine if the problem list (health conditions) in primary care electronic medical records (EMRs) accurately reflects the conditions for which chronic medications are prescribed in the EMR. Design: A retrospective analysis of EMR data. Setting: Eighteen primary care clinics across rural and urban Manitoba using the Accuro EMR....
Article
Enhanced virulence and/or transmission of West African Ebola virus (EBOV) variants, which are divergent from their Central African counterparts, are suspected to have contributed to the sizable toll of the recent Ebola virus disease (EVD) outbreak. This study evaluated the pathogenicity and shedding in rhesus macaques infected with 1 of 2 West Afri...
Article
A licensed vaccine against Ebola virus (EBOV) remains unavailable, despite >11 000 deaths from the 2014–2016 outbreak of EBOV disease in West Africa. Past studies have shown that recombinant vaccine viruses expressing EBOV glycoprotein (GP) are able to protect nonhuman primates (NHPs) from a lethal EBOV challenge. However, these vaccines express th...
Article
Importance: The 2013-2016 outbreak of Ebola virus in West Africa has highlighted the threat posed by filoviruses to global public health. Bundibugyo virus (BDBV) is a member of the genus Ebolavirus, and has caused outbreaks in the past, but is relatively understudied, likely due to the lack of a suitable small animal model. Such a model for BDBV i...
Article
Ebola outbreaks occur on a frequent basis, with the 2014-15 outbreak in West Africa being the largest ever recorded. It has resulted in over 11 000 deaths in four African countries and has received international attention and intervention. Although currently, there are no approved therapies or vaccines, many promising candidates are undergoing clin...
Article
Full-text available
Ebola virus infections cause a deadly hemorrhagic disease for which no vaccines or therapeutics has received regulatory approval. Here we show isolation of three (Q206, Q314 and Q411) neutralizing monoclonal antibodies (mAbs) against the surface glycoprotein (GP) of Ebola virus identified in West Africa in 2014 through sequential immunization of Ch...
Article
Full-text available
Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM04) that targets a uniquely exposed epitope within the RBS; cross-neutralizes Ebola (EBOV), Sudan (SUDV), and,...
Article
Objective: To determine problem list completeness related to chronic diseases in electronic medical records (EMRs) and explore clinic and physician factors influencing completeness. Methods: A retrospective analysis of primary care EMR data quality related to seven chronic diseases (hypertension, diabetes, asthma, congestive heart failure, coron...
Article
Full-text available
The 2014-2015 Ebola virus (EBOV) outbreak in West Africa highlighted the urgent need for specific therapeutic interventions for infected patients. The human-mouse chimeric monoclonal antibody (mAb) cocktail ZMapp, previously shown to be efficacious in EBOV (variant Kikwit) lethally infected nonhuman primates (NHPs) when administration was initiated...
Article
Full-text available
Importance: A disease outbreak due to Ebola virus (EBOV), suspected to have emerged during December 2013 in Guinea, is finally winding down with over 11,000 dead and 28,000 infected. Experimental EBOV vaccines and treatments were administered to patients under compassionate circumstances with promising results, and an approved countermeasure appea...
Article
Full-text available
Subcellular trafficking within host cells plays a critical role in viral life cycles, including influenza A virus (IAV). Thus, targeting relevant subcellular compartments holds promise for effective intervention to control the impact of influenza infection. Bafilomycin A1 (Baf-A1), when used at relative high concentrations (≥10 nM) inhibits vacuola...
Article
Interferon production is an important defence against viral replication and its activation is an attractive therapeutic target. However, it has long been known that viruses perpetually evolve a multitude of strategies to evade these host immune responses. In recent years there has been an explosion of information on virus-induced alterations of the...
Article
Full-text available
Cell death is a characteristic consequence of cellular infection by influenza virus. Mounting evidence indicates the critical involvement of host-mediated cellular death pathways in promoting efficient influenza virus replication. Furthermore, it appears that many signaling pathways, such as NF-κB, formerly suspected to solely promote cell survival...
Article
Virus-host interactions are important determinants of virus replication and immune responses but they are not well defined. In this study we analyzed quantitative host protein alterations in nuclei-enriched fractions from multiple primary human bronchial airway epithelial (HBAE) cells infected by an H1N1 influenza A virus (A/PR/8/34). We first deve...
Article
Viral proteins and their roles in virus replication are typically well understood. However, their interactions with host proteins are currently not as well defined, and a better understanding may lead to novel findings involving virus replication, pathogenicity, host immune responses and antiviral therapies. With recent advances in 'omic' technolog...
Article
Influenza A virus exerts a large health burden during both yearly epidemics and global pandemics. However, designing effective vaccine and treatment options has proven difficult since the virus evolves rapidly. Therefore, it may be beneficial to identify host proteins associated with viral infection and replication to establish potential new antivi...
Article
Full-text available
Fishing Beyond the Peer: Future Omic Analyses of Virus-Host Interactions There has been considerable progress made in the study of viruses and how they infect, replicate and spread inside hosts and host cells. Much is known about how viruses change their genome and proteins throughout their life cycles. However, our understanding of how the host ce...
Article
Full-text available
Smooth muscle cells promote fibroproliferative airway remodeling in asthma, and transforming growth factor β1 (TGFβ1) is a key inductive signal. Statins are widely used to treat hyperlipidemia. Growing evidence indicates they also exert a positive impact on lung health, but the underlying mechanisms are unclear. We assessed the effects of 3-hydroxy...

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Projects

Projects (4)
Archived project
Project
The development of animal models and vaccines. Understanding pathogenesis and transmission.
Archived project