Andrea Dell'Isola

Andrea Dell'Isola
Lund University | LU · Department of Orthopaedics

PT, PhD

About

78
Publications
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449
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Publications

Publications (78)
Article
Full-text available
Background Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes representing different mechanisms of the disease. Methods The aim of this study is to identify the current evidence for the existenc...
Poster
Background: Osteoarthritis (OA) patients are more likely to have other comorbidities (Swain, Sarmanova et al. 2020). Improving the understanding of comorbidity profiles of OA patients may lead to improvement in their clinical care. Objectives: To identify sub-groups in patients diagnosed with hip OA using patterns of comorbidity. Methods: Routinely...
Presentation
Background: People with osteoarthritis (OA) are at higher risk of developing a wide array of comorbidities. Whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) contributes to the increased risk of some incident comorbidities remains unknown. Objectives: To examine the contribution of NSAIDs in the development of a wide range of comorb...
Preprint
Objective To examine whether persons infected with the SARS-CoV-2 omicron variant have an altered risk of post-covid complaints and healthcare use when compared to 1) persons testing negative, and 2) persons with delta. Design Prospective cohort study with 126 days follow-up and a time-to-event approach. Setting A registry-based study including N...
Article
Full-text available
Aim To study the risk of receiving a new (incident) osteoarthritis (OA) diagnosis in different joint sites based on conditions diagnosed in the 20 years prior the OA diagnosis. Methods We used register data for the entire population of the Skåne region (Sweden) to perform a nested case-control study. The outcome was newly diagnosed (incident) OA i...
Article
Full-text available
Introduction Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the comorbidities, role of analgesics and the causality and variation between populations are yet to be in...
Conference Paper
Purpose: Emerging evidence suggests that osteoarthritis (OA) may be associated with an increased risk of dementia. However, little is known about the implication of incipient dementia on healthcare use among people with OA. In this study we investigated the associations between incipient dementia and healthcare consultations, hospital admissions an...
Article
Full-text available
Introduction: Despite the publication of clinical practice guidelines, the quality of the care process as experienced by patients with osteoarthritis (OA) appears suboptimal. Hence, this study investigates how patients with OA experience their disease and care process, highlighting potential elements that can enhance or spoil it, to optimise their...
Article
Full-text available
Objective To investigate whether the first wave of the COVID-19 pandemic impacted healthcare consultations (HCC) and hospitalization among people with and without osteoarthritis (OA). Methods Using register data, we included individuals aged ≥35 years residing in Skåne region, Sweden, during 2009–2019 with (n = 123,523) and without (n = 552,412) a...
Article
Full-text available
Objectives To investigate the role of osteoarthritis (OA) in the incidence of musculoskeletal, metabolic, cardiovascular, digestive, neuro-psychological, kidney and other comorbidities/adverse events after (i) incident non-steroidal anti-inflammatory drug (NSAID) initiation and (ii) NSAID discontinuation. Methods We used register data for the popu...
Article
Objectives To describe and compare trends in the frequency of opioid prescribing/dispensing in English and Swedish patients with osteoarthritis prior to total knee replacement (TKR). Methods 49,043 patients from an English national database (Clinical Practice Research Datalink) and 5,955 patients from the Swedish Skåne Healthcare register undergoi...
Article
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Purpose To investigate the impact of COVID-19 in Sweden on rates of knee and hip surgeries. Methods We used healthcare data for the population of the southernmost region in Sweden (1.4 million inhabitants). We did an interrupted time-series analysis to estimate changes in rates and trends of joint replacements (JR), arthroscopies, and fracture sur...
Article
Full-text available
Currently, the coronavirus disease 2019 (COVID-19) severely influences physiotherapy education which is based mostly on face-to-face teaching. Thus, educators have been compelled to adapt their pedagogical approaches moving to digital education. In this commentary, we debate on digital education highlighting its effectiveness, the users’ perspectiv...
Article
Full-text available
Objective To examine the experience of the COVID-19 pandemic as lived by people with hip and knee osteoarthritis (OA), in Italy. Design A qualitative study based on semi-structured interviews. Setting Urban and suburban areas in northern Italy. Participants A total of 11 people with OA were enrolled through a purposeful sampling and completed th...
Article
Full-text available
Objectives To describe the prevalence of comorbidities in a population referred to standardised first-line intervention (patient education and exercise) for hip and knee osteoarthritis (OA), in comparison with the general population. Furthermore, we aimed to evaluate if eventual differences were associated with socioeconomic inequalities. Design R...
Article
Full-text available
Background During COVID-19 pandemic, physiotherapy lecturers faced the challenge of rapidly shifting from face-to-face to online education. This retrospective case-control study aims to compare students’ satisfaction and performances shown in an online course to a control group of students who underwent the same course delivered face-to-face in the...
Poster
Co-existence of comorbidities is common among individuals with osteoartritis, but the association remains still largely unknown. In this observational register-based study we describe comorbidities in a specified osteoarthritis population; patients who had been referred to participate in a nationwide standardized first-line intervention for hip and...
Article
Background The care process is often a complex and intimate process experienced by patients. Osteoarthritis (OA) care is usually characterised by multimodal interventions that consider the broader array of symptoms and functional limitations and often require a high level of patients’ compliance. Despite efforts to improve the quality of care of pa...
Conference Paper
Full-text available
Background Many countries imposed lockdowns in March 2020, in anticipation of the “first wave” of COVID-19 and the massive healthcare resources required to meet its acute medical needs. Sweden adopted a different strategy to contain the epidemic, opting for non-binding recommendations. Nonetheless, elective and acute surgical procedures in health c...
Article
Full-text available
Objective To estimate the risk of developing comorbidities in patients after physician-diagnosed knee or hip osteoarthritis (OA). Design Cohort study using Swedish longitudinal healthcare register data; we studied residents in the Skåne region aged ≥35 years at January 1, 2010 free from diagnosed hip or knee OA (n= 548,681). We then identified sub...
Article
Full-text available
Introduction Implementation of clinical practice guidelines (CPGs) to manage musculoskeletal conditions among physiotherapists appears suboptimal. Osteoarthritis is one of the most disabling conditions worldwide and several studies showed a lack of knowledge of and adherence to osteoarthritis CPGs in physiotherapists’ clinical practice. However, th...
Article
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Objectives To investigate whether the association between pain intensity and willingness to undergo surgery is explained by walking difficulties, in patients with knee or hip osteoarthritis (OA). Methods This is an observational study using data from the Better management of patients with Osteoarthritis (BOA) register, which collects data from a p...
Article
Objectives: To examine whether physical activity (PA) was associated with fatigue, and quantify the extent of potential mediation through depressive symptoms or physical function (PF) on the relationship between PA and fatigue in symptomatic knee osteoarthritis (KOA). Method: This longitudinal study used data from the Multicenter Osteoarthritis St...
Article
Full-text available
Objective To systematically identify and evaluate factors related to fatigue in individuals with hip and/or knee osteoarthritis (OA). Methods A systematic literature search was conducted using AMED, CINAHL, MEDLINE, ProQuest and Web of Science Core Collections databases. Inclusion criteria comprised cross-sectional, case-control or longitudinal st...
Article
Full-text available
Objective to assess the proportion of participants reconsidering their willingness to undergo surgery after three and 12 months. Secondary aims are to analyse and compare the characteristics of people willing and unwilling to undergo joint surgery for osteoarthritis (OA) before a first‐line intervention; to study the association between pain intens...
Article
Full-text available
Objective: This study explored the association of patients' demographics, health status, symptom severity, previous osteoarthritis (OA) care, and psychological status with the change in pain severity following a first-line intervention including education and exercise for OA provided nationwide in Swedish primary care. Methods: This register-bas...
Article
Full-text available
Background Osteoarthritis (OA) is the most prevalent joint disease in the world, and one of the top causes of disability [1]. OARSI and EULAR guidelines recommend non-surgical interventions as first-line interventions for OA [2]. Despite this, only less than 40% of people suffering from OA receive the recommended intervention [3]. Objectives The a...
Conference Paper
Background Fatigue is an important, under-researched and poorly understood symptom among hip and/or knee osteoarthritis (OA) populations. To devise the best fatigue management strategy in these populations, it is necessary to evaluate the evidence on risk factors for fatigue. This study aimed to give an overview and evaluate the evidence on the fac...
Conference Paper
Background Fatigue is believed to include both physical and mental components, suggesting there may be fatigue dimensions. Evidence suggests that physical activity (PA) and mental activity (MA) play a role on fatigue in those with knee osteoarthritis (OA); however, it is unclear how the patterns of physical and mental activity relate to fatigue and...
Article
Full-text available
Background: Fatigue may include both physical and mental dimensions. Evidence suggests that physical and mental activity may influence fatigue in knee osteoarthritis (OA). However, how physical and mental activities relate to fatigue dimensions in knee OA is unclear. Purpose: This study estimated intra-day contributions of physical and mental fatig...
Article
Full-text available
Background Osteoarthritis (OA) is highly prevalent in older adults and a growing cause of disability. Easily accessible first-line treatment of OA is increasingly important. Digital self-management programs have in recent years become available. Evidence of short-term effects of such programs are abundant, yet reports on long-term benefits and adhe...
Article
Aim: The aim of the study was to identify sociodemographic, disease-related, physical and mental health-related determinants of fatigue at 2-year follow-up in individuals with symptomatic knee osteoarthritis (OA). Methods: A longitudinal analysis of participants with symptomatic knee OA from the Multicenter Osteoarthritis Study (MOST) was conducted...
Article
Full-text available
Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type 2 diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycemia toxicity and physical inactivity have been suggested as potenti...
Article
Full-text available
We evaluated a structured education-and exercise-based self-management program for patients with knee or hip osteoarthritis (OA), using a registry-based study of data from 44,634 patients taken from the Swedish "Better Management of Patients with Osteoarthritis" registry. Outcome measures included a numeric rating scale (NRS), EuroQol five dimensio...
Article
Full-text available
Objectives: To compare the effectiveness of (1) education only (ED), 2) home exercise (HE) and 3) supervised exercise (SE) as provided in a nationally implemented rehabilitation programme (the BOA programme) for patients with hip and knee osteoarthritis (OA). In addition, we analysed whether the effect of the treatments differed based on the joint...
Article
Background: Lateral wedge insoles (LWIs) are non-surgical interventions used in medial knee osteoarthritis (KOA) aiming at restoring correct joint biomechanics. However, the mechanical efficacy of LWIs, based on modulation of the external knee adduction moment, is partially proved and high variability in response to these devices was observed. Rese...
Article
Full-text available
Background: To investigate (1) the association of specific biomechanical factors with knee osteoarthritis and knee osteoarthritis development, and (2) the impact of other relevant risk factors on this association. Methods: MEDLINE, EMBASE, CINAHL and SPORTDiscus were searched up until April 2017. Studies were included if they fulfilled the follo...
Conference Paper
Full-text available
Introduction Lateral wedged foot orthoses (LWFO) aim to re-establish correct biomechanics in patients with medial knee osteoarthritis (MKOA). However, evidence supporting the effectiveness of LWFO is contrasting and may depend on orthoses design [1]. Therefore, the purpose of this study was to estimate the effect of two different LWFO designs on t...
Article
Full-text available
Background and purpose — Knee extensor (KE) muscle weakness is a modifiable feature commonly observed in individuals with knee osteoarthritis (KOA) and constitutes a potential target for patient-specific interventions. Therefore, in this study, we explored whether KE weakness is associated with radiographic (medial and/or lateral) KOA progression a...
Poster
Full-text available
Fatigue is an important symptom which significantly impacts quality of life among individuals with knee osteoarthritis (KOA) 1,2. However, factors which influence fatigue have not been extensively studied in individuals with KOA. Aims (1) to establish the prevalence of fatigue in those with and without symptomatic KOA. (2) to evaluate associations...
Preprint
Full-text available
Background and purpose: Knee extensor (KE) muscle weakness is a modifiable feature commonly observed in individuals with knee osteoarthritis (KOA) and constitutes a potential target for patient-specific interventions. Therefore, in this study, we explored whether KE weakness is associated with radiographic (medial and/or lateral) KOA progression a...
Article
Full-text available
Objectives The existence of phenotypes has been hypothesized to explain the large heterogeneity characterizing the knee osteoarthritis. In a previous systematic review of the literature, six main phenotypes were identified: Minimal Joint Disease (MJD), Malaligned Biomechanical (MB), Chronic Pain (CP), Inflammatory (I), Metabolic Syndrome (MS) and B...
Data
Description of the variables used for the classification process. (DOCX)
Conference Paper
Full-text available
Medial compartment knee osteoarthritis (KOA) is a common musculoskeletal disease characterised by pain and functional limitations. Modifications in the foot progression angle and step width have been used as a strategy to reduce the external knee load. In this study, a subject-specific musculoskeletal model was implemented to analyse the mechanical...
Article
Full-text available
Purpose: Multiple phenotypes characterized by different disease mechanisms have been hypothesized to explain the large variability in the knee osteoarthritis (KOA) population. The purpose of this study was: to estimate and compare the medial and lateral knee compression forces (CF) during gait of three subgroups of KOA subjects characterized by di...
Poster
Full-text available
An exploration of a varus malaligned phenotype in knee osteoarthritis