Andrea Cherubini

Cosmo Pharmaceuticals · Artificial Intelligence

Accurate in-vivo optical characterization of colorectal polyps is key to select the optimal treatment regimen during colonoscopy. However, reported accuracies vary widely among endoscopists. We developed a novel intelligent medical device able to seamlessly operate in real-time using conventional white light (WL) endoscopy video stream without virt...

To address overfitting and enhance model generalization in gastroenterological polyp size assessment, our study introduces Feature-Selection Gates (FSG) or Hard-Attention Gates (HAG) alongside Gradient Routing (GR) for dynamic feature selection. This technique aims to boost Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs) by prom...

Detection and diagnosis of colon polyps are key to preventing colorectal cancer. Recent evidence suggests that AI-based computer-aided detection (CADe) and computer-aided diagnosis (CADx) systems can enhance endoscopists' performance and boost colonoscopy effectiveness. However, most available public datasets primarily consist of still images or vi...

Artificial intelligence (AI) has the potential to assist in endoscopy and improve decision making, particularly in situations where humans may make inconsistent judgments. The performance assessment of the medical devices operating in this context is a complex combination of bench tests, randomized controlled trials, and studies on the interaction...

Artificial Intelligence ( ai ) systems are precious support for decision-making, with many applications also in the medical domain. The interaction between md s and ai enjoys a renewed interest following the increased possibilities of deep learning devices. However, we still have limited evidence-based knowledge of the context, design, and psycholo...

Artificial Intelligence (AI) systems are precious support for decision-making, with many applications in the medical domain. However, there is little understanding of how human experts interact with AI. Health policy-makers fear flat reliance on AI advice. In this multicentric study, twenty-one endoscopists reviewed 504 videos of lesions from real...

Aims The causes of distinct patterns of reduced cortical thickness in the common human epilepsies, detectable on neuroimaging and with important clinical consequences, are unknown. We investigated the underlying mechanisms of cortical thinning using a systems-level analysis. Methods Imaging-based cortical structural maps from a large-scale epileps...

In the acne severity evaluation, the quantification of inflammatory lesions on the patients’ face is a fundamental step. The aim of this work is to develop a method that automatically performs acne lesions counting. We acquired high-resolution multi-polarization images of facial skin using the visible spectrum. 1089 patients with acne grading rangi...

The common human epilepsies are associated with distinct patterns of reduced cortical thickness, detectable on neuroimaging, with important clinical consequences. To explore underlying mechanisms, we layered MRI-based cortical structural maps from a large-scale epilepsy neuroimaging study onto highly spatially-resolved human brain gene expression d...

Background and purposeCorpus callosum (CC) is frequently involved in relapsing–remitting multiple sclerosis (RRMS). Magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) allow to study CC macrostructural and microstructural tissue integrity. Here, we applied a data-driven approach to MRI and DTI data of normal-appearing CC in RRMS sub...

Introduction: The evaluation of Acne using ordinal scales reflects the clinical perception of severity but has shown low reproducibility both intra- and inter-rater. In this study, we investigated if Artificial Intelligence trained on images of Acne patients could perform acne grading with high accuracy and reliabilities superior to those of exper...

Importance Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert to normal. Earlier progression to AD among patients who were β-amyloid positive vs those who were β-amyloid negative has been previously observed. Current research now accepts that a combination of biomarkers...

Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain...

In this work, we investigated motor network structure in patients affected by essential tremor (ET) with or without resting tremor, using probabilistic tractography of the cerebello–thalamo–basal ganglia–cortical loop. Twenty-five patients with ET, twenty-two patients with ET associated with resting tremor (rET), and twenty-five age- and sex-matche...

Pretest on concrete trait-inconsistent behaviors. (DOCX)

Analyses of trait-inconsistent behavior frequency in Study 3 with the cue-validity index. (DOCX)

Participants’ prior probability estimates of traits and derived probabilities of occurrence of behaviors. (DOCX)

Original version in Italian and the English translation of the 48 items used in Study 3. (DOCX)

Pretest on Trait-Domain Relatedness. (DOCX)

General variability as a measure of trait-behavior relations. (DOCX)

Preliminary study. (DOCX)

Trait valence pretest. (DOCX)

Motor phenotypes of Parkinson's disease (PD) are recognized to have different prognosis and therapeutic response, but the neural basis for this clinical heterogeneity remains largely unknown. The main aim of this study was to compare differences in structural connectivity metrics of the main motor network between tremor-dominant and nontremor PD ph...

Conventional and morphometric magnetic resonance (MR) techniques provide an accurate representation of the brain’s anatomy at a macroscopic scale, but they do not provide information on the topography of white matter bundles. The study of the anisotropic diffusion of water molecules (diffusion tensor imaging; DTI) and tractography (fibre tracking)...

Alzheimer’s disease (AD) was traditionally defined as a form of dementia in which clinical diagnosis could become “definite” only after post-mortem confirmation. Moreover, clinical diagnosis could only be assigned at advanced disease stages, when significant functional disability had already occurred. In order to overcome past limitations, novel cr...

Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain...

This study presents a voxel-based multiple regression analysis of different magnetic resonance image modalities, including anatomical T1-weighted, T2* relaxometry, and diffusion tensor imaging. Quantitative parameters sensitive to complementary brain tissue alterations, including morphometric atrophy, mineralization, microstructural damage, and ani...

Objective: Corpus callosum (CC) abnormalities are frequently reported in patients with refractory mesial temporal lobe epilepsy (rMTLE). However, whether CC structural alterations are related to the epileptic syndrome itself or to refractoriness is still unknown. Thus, we aimed to compare patterns of CC change in patients with rMTLE and benign MTL...

Introduction Several neuroimaging studies have been carried out to gain insight on the pathological processes that cause PD, but literature findings are inconsistent. The aim of this study was to combine information carried by functional imaging with DA transporter ligands and structural MRI. Methods Forty-two untreated, de novo-PD patients and 30...

Background: Dopamine transporter (DaT) imaging (DaTSCAN) is useful for the differential diagnosis of parkinsonian syndromes. Visual evaluation of DaTSCAN images represents the generally accepted diagnostic method, but it is strongly dependent on the observer's experience and shows inter- and intra-observer variability. A reliable and automatic met...

This study presents a voxel-based multiple regression analysis of different magnetic resonance image modalities, including anatomical T1-weighted, T2* relaxometry, and diffusion tensor imaging. Quantitative parameters sensitive to complementary brain tissue alterations, including morphometric atrophy, mineralization, microstructural damage, and ani...

Temporal and extratemporal white matter abnormalities have been identified frequently in patients with refractory mesial temporal lobe epilepsy (rMTLE). However, the identification of potential water diffusion abnormalities in patients with drug-responsive, benign MTLE (bMTLE) is still missing. The aim of this study was to identify markers of refra...

White matter hyperintensities (WMH) are commonly seen in the brain of healthy elderly subjects and patients with several neurological and vascular disorders. A truly reliable and fully automated method for quantitative assessment of WMH on magnetic resonance imaging (MRI) has not yet been identified. In this paper, we review and compare the large n...

To evaluate if an automatic magnetic resonance imaging (MRI) processing system may improve detection of hippocampal sclerosis (Hs) in patients with mesial temporal lobe epilepsy (MTLE). Eighty consecutive patients with a diagnosis of MTLE and 20 age- and sex-matched controls were prospectively recruited and included in our study. The entire group h...

Significant corpus callosum (CC) involvement has been found in relapsing–remitting multiple sclerosis (RRMS), even if conventional magnetic resonance imaging measures have shown poor correlation with clinical disability measures. In this work, we tested the potential of multimodal imaging of the entire CC to explain physical and cognitive disabilit...

Background The aim of the current study was to distinguish patients who had tremor-dominant Parkinson's disease (tPD) from those who had essential tremor with rest tremor (rET).Methods We combined voxel-based morphometry-derived gray matter and white matter volumes and diffusion tensor imaging-derived mean diffusivity and fractional anisotropy in a...

Background: The North American Alzheimer's Disease Neuroimaging Initiative (NA-ADNI) was the first program to develop standardized procedures for Alzheimer's disease (AD) imaging biomarker collection. Objective: We describe the validation of acquisition and processing of structural magnetic resonance imaging (MRI) in different Italian academic A...

The aim of the current study was to distinguish patients with Parkinson disease (PD) from those with progressive supranuclear palsy (PSP) at the individual level using pattern recognition of magnetic resonance imaging data. We combined diffusion tensor imaging and voxel-based morphometry in a support vector machine algorithm to evaluate 21 patients...

Evidence evaluation is a crucial process in many human activities, spanning from medical diagnosis to impression formation. The present experiments investigated which, if any, normative model best conforms to people’s intuition about the value of the obtained evidence. Psychologists, epistemologists, and philosophers of science have proposed severa...

In this study, we used an automated segmentation of regions of interest and co-registration to diffusion tensor imaging (DTI) images to investigate whether microstructural abnormalities occur in gray structures of the frontal-subcortical circuits in patients with amyotrophic lateral sclerosis (ALS). Twenty-four patients with probable or definite sp...

Nella vita quotidiana è frequente l’utilizzo di regole per organizzare pensieri ed azioni al fine di raggiungere obiettivi prefissati. Per le situazioni più semplici, singole regole condizionali (“se… allora…”) sono sufficienti. Situazioni più complesse, tuttavia, richiedono la considerazione contemporanea di molteplici regole, organizzate sia in t...

Neurodegeneration of the striatum in Huntington disease (HD) is characterized by loss of medium-spiny neurons, huntingtin nuclear inclusions, reactive gliosis, and iron accumulation. Neuroimaging allows in vivo detection of the macro- and micro-structural changes that occur from presymptomatic stages of the disease (preHD). The aim of our study was...

In two studies, we investigated how people use base rates and the presence versus the absence of new information to judge which of two hypotheses is more likely. Participants were given problems based on two decks of cards printed with 0-4 letters. A table showed the relative frequencies of the letters on the cards within each deck. Participants we...

A reasoning strategy is iterative when the initial conclusion suggested by a set of premises is integrated into that set of premises in order to yield additional conclusions. Previous experimental studies on game theory-based strategic games (such as the beauty contest game) observed difficulty in reasoning iteratively, which has been partly attrib...

When examining social targets, people may ask asymmetric questions, that is, questions for which “yes” and “no” answers are neither equally diagnostic nor equally frequent. The consequences of this information-gathering strategy on impression formation deserve empirical investigation. The present work explored the role played by the trade-off betwe...

Although in literature almost 150 patients with Lance-Adams Syndrome (LAS) have been reported, neuroradiological evaluations were often performed in late stages and there is no serial study evaluating LAS from early stages. We herein report a serial neuroimaging study demonstrating early and transient involvement of cerebellum and thalami in a LAS...

We have already shown that brain MR imaging of healthy individuals frequently reveals either unilateral or bilateral Hh, which is considered a hallmark of hippocampal sclerosis. We performed a follow-up (5-year interval) clinical and advanced imaging study of these individuals to address whether Hh may have masked occult brain atrophy or contribute...

Studies have demonstrated brain iron deposition in neurodegenerative disease and in normal aging. Data on this topic are lacking in essential tremor (ET). The aim of our study was to investigate brain iron content in patients with ET, using quantitative magnetic resonance imaging (MRI) T2*-relaxometry. We enrolled 24 patients with ET and 25 age-mat...

Purpose: To investigate white matter heterogeneity using a multichannel segmentation of a large sample of structural and diffusion magnetic resonance imaging (MRI) data. Materials and methods: A sample of 50 subjects was segmented using channels comprising exclusively structural (longitudinal and transverse relaxation times T1 and T2 and transve...

Three studies using abstract materials tested possible moderators of the feature-positive effect in hypothesis evaluation whereby people use the presence of features more than their absence to judge which of 2 competing hypotheses is more likely. Drawing on a distinction made in visual perception research, we tested whether the feature-positive eff...

This article examines individuals' expectations in a social hypothesis testing task. Participants selected questions from a list to investigate the presence of personality traits in a target individual. They also identified the responses that they expected to receive and the likelihood of the expected responses. The results of two studies indicated...

In three studies, we investigated whether and to what extent the evaluation of two mutually exclusive hypotheses is affected by a feature-positive effect, wherein present clues are weighted more than absent clues. Participants (N = 126) were presented with abstract problems concerning the most likely provenance of a card that was drawn from one of...

Research has shown that warmth and competence are core dimensions on which perceivers judge others and that warmth has a primary role at various phases of impression formation. Three studies explored whether the two components of warmth (i.e., sociability and morality) have distinct roles in predicting the global impression of social groups. In Stu...

Section 1: Videofluoroscopy in 2007 showing basic anatomical structures visualized on videofluoroscopy followed by demonstrable abnormalities in the oropharyngeal stage of swallowing and 1 episode of aspiration. Section 2: Clinical examination in 2008 showing asym-metric bradykinesia and tremor, facial hypomimia, and a prominent tongue tremor. Sect...

We investigated whether two basic forms of deductive inference, Modus Ponens and Disjunctive Syllogism, occur automatically and without awareness. In Experiment 1, we used a priming paradigm with a set of conditional and disjunctive problems. For each trial, two premises were shown. The second premise was presented at a rate designed to be undetect...

Recent magnetic resonance imaging (MRI) studies suggest that abnormalities in Huntington's disease (HD) extend to white matter (WM) tracts in early HD and even in presymptomatic stages. Thus, changes of the corpus callosum (CC) may reflect various aspects of HD pathogenesis. We recruited 17 HD patients, 17 pre-HD subjects, and 34 healthy age-matche...

We present a new application based on genetic algorithms (GAs) that evolves a Cellular Neural Network (CNN) capable of automatically determining the lesion load in multiple sclerosis (MS) patients from magnetic resonance imaging (MRI). In particular, it seeks to identify brain areas affected by lesions, whose presence is revealed by areas of higher...

Microstructural analyses by MRI brain scans and by DTI analysis of MR images were used to investigate the possible relationship between deep gray matter structures (amygdala and hippocampus) and dreaming in healthy subjects. Thirty-four subjects ranging in age 20s to 70s underwent to a MRI protocol for the assessment of volume and mean diffusivity...

Three experiments examined how people gather information on in-group and out-group members. Previous studies have revealed that category-based expectancies bias the hypothesis-testing process towards confirmation through the use of asymmetric-confirming questions (which are queries where the replies supporting the prior expectancies are more inform...

Previous studies found mixed results concerning the role of working memory (WM) in the gambling task (GT). Here, we aimed at reconciling inconsistencies by showing that the standard version of the task can be solved using intuitive strategies operating automatically, while more complex versions require analytic strategies drawing on executive funct...

Research on the two fundamental dimensions of social judgment, namely warmth and competence, has shown that warmth has a primary and a dominant role in information gathering about others. In two studies we examined whether the sociability and morality components of warmth play distinct roles in such a process. Study 1 (N = 60) investigated which tr...

Research on decision making suggests that a wide range of spontaneous processes may influence medical judgment. We considered an easily accessible strategy, anchoring and insufficient adjustment, which might contribute to health care professionals' miscalibration of patients' pain. A sample (n=423) of physicians, nurses, medical students, and nursi...

Education has been extensively considered an influential factor in the modulation of interindividual differences in cognitive performance and cerebral structure. Consequently, education has been linked to the concept of reserve, which refers to an unspecified aspect of brain structure or function that enables people with more education to cope bett...

One objective of modern neuroimaging is to identify markers that can aid in diagnosis, disease progression monitoring and long-term drug impact analysis. In this study, Parkinson-associated physiopathological modifications were characterized in six subcortical structures by simultaneously measuring quantitative magnetic resonance parameters sensiti...

Rest tremor associated with essential tremor (ET) is a condition that poses challenges in diagnosing Parkinson's disease (PD). We investigated tremor parameters in PD and ET patients with rest tremor. Fifteen patients with PD and 15 patients with ET underwent electrophysiological examination to evaluate characteristics of muscle bursting in rest po...

Previous studies have demonstrated the presence of an outcome bias in medical decision making, which can be represented by a tendency to overweight outcome information when evaluating the quality of a decision. This study investigates whether the outcome of a previous decision on a medical case affects a later decision on a similar case. Thirty-six...

Background Neuroimaging studies showed impairment of the basal ganglia and thalamus in preclinical stages of Huntington's disease (HD) characterised by progressive volume loss, microstructural impairment and microglial activation. Therefore, biomarkers sensitive to all of these changes are needed. Aims We assessed the multimodal MRI as biomarker of...

Deduction allows us to draw consequences from previous knowledge. Deductive reasoning can be applied to several types of problem, for example, conditional, syllogistic, and relational. It has been assumed that the same cognitive operations underlie solutions to them all; however, this hypothesis remains to be tested empirically. We used event-relat...

The corpus callosum (CC) has been shown to be susceptible to atrophy in Alzheimer disease (AD) as a correlate of wallerian degeneration or retrogenesis. However, when and where these 2 mechanisms intervene is still unclear. In 3 memory clinics, we recruited 38 patients with amnestic mild cognitive impairment (MCI), 38 patients with mild AD, and 40...

Diffuse axonal injury (DAI), associated with deafferentation and functional rearrangement, probably plays a role in the chronic phase of traumatic brain injury (TBI). DAI with a haemorrhagic component can be quantified using magnetic resonance imaging (MRI) thanks to the iron-based susceptibility effect of haemosiderin, which increases with magneti...