
Andrea Capucciati- PhD
- PostDoc Position at University of Pavia
Andrea Capucciati
- PhD
- PostDoc Position at University of Pavia
About
24
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Introduction
Andrea Capucciati currently works at the Department of Chemistry, University of Pavia. Andrea does research in Medicinal Chemistry, Chemical Biology and Biochemistry.
Current institution
Publications
Publications (24)
Neurodegenerative disorders are one of the main public health problems worldwide and, for this reason, they have attracted the attention of several researchers who aim to better understand the molecular processes linked to the etiology of these disorders, including Alzheimer’s and Parkinson’s diseases. In this review, we describe both the beneficia...
The oxidation of alcohols to the corresponding carbonyl derivatives has been realized under photoelectrochemical conditions in the presence of tetrabutylammonium decatungstate (TBADT) as the homogeneous photocatalyst. The protocol can be applied to both primary and secondary, benzylic and aliphatic alcohols. The desired products are obtained select...
Four melanin polymers prepared from different precursors (5,6‐dihydroxyindole, 5,6‐dihydroxyindole 2‐carboxylic acid, 1,8‐dihydroxynaphthalene and dopamine) have been adopted as photocatalysts in the reductive dehalogenation of a series of model α‐halogen carbonyl derivatives. The best performing melanin was that obtained from 5,6‐dihydroxyindole 2...
Nitrocellulose (NC) is the main component of propellants for small firearm ammunitions. Even though NC particles are ejected from gun barrels together with bullets and they are often recovered on close-to-muzzle targets, quantitative analysis of nitrocellulose for forensic purposes has been neglected so far. Moreover, although the presence of the n...
Recently, as the interest in cannabidiol (CBD) has grown due to its therapeutic potential, e-cigarette liquids containing CBD have proliferated on the market. Typically, e-liquids contain variable concentrations of CBD (from 2 mg∙mL−1 to 20 mg∙mL−1) in propylene glycol or 70:30 propylene glycol:glycerol mixture and are eventually flavored with food...
In the present work, we describe the electrochemical behaviour of two opioids structurally related to aroyl amides of forensic interest, namely U-47700 and AH-7921. The data obtained allowed for the mise-au-point of a voltammetric determination protocol, that relies on differential pulse voltammetry (DPV) at a glassy carbon electrode in ethanol/0.1...
Water‐soluble melanin‐protein‐Fe/Cu conjugates derived from norepinephrine and fibrillar β‐lactoglobulin are reliable models for neuromelanin (NM) of human brain locus coeruleus. Both iron and copper promote catecholamine oxidation and exhibit strong tendency to remain coupled in oligonuclear aggregates. The Fe‐Cu clusters are EPR silent and affect...
Water soluble melanin‐protein‐Fe/Cu conjugates derived from norepinephrine and fibrillar β‐lactoglobulin are reliable models for neuromelanin (NM) of human brain locus coeruleus . Both iron and copper promote catecholamine oxidation and exhibit strong tendency to remain coupled in oligonuclear aggregates. The Fe‐Cu clusters are EPR silent and affec...
Neuromelanins are compounds accumulating in neurons of human and animal brain during aging, with neurons of substantia nigra and locus coeruleus having the highest levels of neuromelanins. These compounds have melanic, lipid, peptide, and inorganic components and are contained inside special autolysosomes. Neuromelanins can participate in neuroprot...
The electrochemical behaviour of two alkaloids of forensic interest, namely glaucine and tetrahydropalmatine, has been investigated by Cyclic Voltammetry (CV) and Controlled Potential Electrolysis (CPE) and the results compared with those obtained with model compounds such as tetrahydroisoquinolines and methoxybenzenes. On the basis of these result...
The mono electronic oxidation of aryl mesylates and aryl diethylphosphates in organic/aqueous mixture in the presence of ammonium persulfate was investigated by means of time-resolved spectroscopy. The photoinduced electron transfer...
Identifying the composition and the physical characteristics of the bullet that generated a specific hole in the victim's clothes or skin may be crucial in shooting incident reconstructions. In forensics, chemographic tests are routinely conducted to visualize lead, copper, or nitrite deposits around entrance holes with the aim of confirming a proj...
Neuromelanin (NM) accumulates in catecholamine long-lived brain neurons that are lost in neurodegenerative diseases. NM is a complex substance made of melanic, peptide and lipid components. NM formation is a natural protective process since toxic endogenous metabolites are removed during its formation and as it binds excess metals and xenobiotics....
The neurotoxic activity of the tryptophan metabolite 3-hydroxykynurenine (3OHKyn) in neurodegenerative disorders as Parkinson’s and Alzheimer’s diseases, is related to oxidative stress and 3OHKyn interaction with cellular proteins. The pattern of protein modification induced by 3OHKyn involves the nucleophilic side chains of Cys, His, and Lys resid...
Dopamine (DA) is the most important catecholamine in the brain, as it is the most abundant and the precursor of other neurotransmitters. Degeneration of nigrostriatal neurons of substantia nigra pars compacta in Parkinson's disease represents the best‐studied link between DA neurotransmission and neuropathology. Catecholamines are reactive molecule...
Dopamine (DA) is the most important catecholamine in the brain, as it is the most abundant and the precursor of other neurotransmitters. Degeneration of nigrostriatal neurons of substantia nigra pars compacta in Parkinson’s disease represents the best‐studied link between DA neurotransmission and neuropathology. Catecholamines are reactive molecule...
In the substantia nigra of human brain, neuromelanin (NM) released by degenerating neurons can activate microglia with consequent neurodegeneration, typical of Parkinson’s disease (PD). Synthetic analogues of NM were prepared to develop a PD model reproducing the neuropathological conditions of the disease. Soluble melanin-protein conjugates were o...