Andrea Binelli

Andrea Binelli
University of Milan | UNIMI · Department of Life Sciences

Professor of Ecotoxicology

About

128
Publications
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Publications

Publications (128)
Article
Despite the pollution induced by plastics become a well-known and documented problem, bringing many countries to adopt restrictions about their production, commercialization and use, the impact of another emerging category of synthetic polymers, represented by the Water-Soluble Polymers (WSPs), also known as “liquid plastics”, is overlooked by scie...
Article
The more or less extensive lockdowns, quarantines, smart working and the closure of numerous recreational or personal care activities due to the COVID-19 pandemic have not only heavily changed the habits and behaviors of all of us, but have also had consequences on the release of some types of pollutants. The aim of this study was to evaluate the p...
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The study of the contamination of plastic mixtures sampled in natural environments is currently focused on their qualitative and quantitative assessment, while the evaluation of their effects on organisms is normally performed by experiments carried out at exposure conditions (size, shape, polymers) often far from the environmental ones. To improve...
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The adsorption of biomacromolecules is a fundamental process that can alter the behaviour and adverse effects of nanoparticles (NPs) in natural systems. While the interaction of NPs with natural molecules present in the environment has been described, their biological impacts are largely unknown. Therefore, this study aims to provide a first eviden...
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This study had the dual objective of both the qualitative and quantitative assessment of plastic mixtures sampled in 5 different sites located along the Lambro River (northern Italy), and the contemporarily determination of the ecotoxicological effects of the same mixtures sampled, through 21-day laboratory exposures of the freshwater bivalve Dreis...
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Physical and chemical properties of nanoplastics make them potential carriers for some environmental contaminants, modifying their biological effects. Nevertheless, the change in toxicity caused by pollutant adsorption on nanoplastics is...
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Information on the occurrence and effects of nanoplastics in ecosystems worldwide currently represent one of the main challenges from the ecotoxicological point of view. This is particularly true for terrestrial environments, in which nanoplastics are released directly by human activities or derive from the fragmentation of larger plastic items inc...
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The improper release of plastic items and wastes is nowadays one of the main environmental and social problems, whose solution or mitigation represents a great challenge worldwide. In this context, the growing use of the so-called biodegradable plastics could represent a possible solution in the short to medium term. The few information known about...
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The ongoing development of nanotechnology has raised concerns regarding the potential risk of nanoparticles (NPs) to the environment, particularly aquatic ecosystems. A relevant aspect that drives NP toxicity is represented by the abiotic and biotic processes occurring in natural matrices that modify NP properties, ultimately affecting their intera...
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Studies related to the evaluation of plastics in freshwaters have been increasing in recent years because approximately 80% of plastic items found in the sea are from inland waters. Despite the ecological relevance of these surveys, no information has been available until now about the hazard related to plastic mixtures in freshwaters. To fill this...
Article
Manganese (Mn) might stimulate the valve closure reflex in the freshwater bivalve Anodontites trapesialis, leading to metabolic suppression, while zinc (Zn) was not able to modify this behavior. To investigate this particular response, we exposed A. trapesialis specimens to Mn (0.5 mg L‐1) and Zn (1.0 mg L‐1) alone, and to their mixture, to measure...
Article
One of the current main challenges faced by the scientific community is concerning the fate and toxicity of plastics, due to both the well-known threats made by larger plastic items spreading in ecosystems and their fragmentation into micro- and nanoparticles. Since the chemical and physical characteristics of these smaller plastic fragments are ma...
Article
Microplastics (MPs)are now one of the major environmental problems due to the large amount released in aquatic and terrestrial ecosystems, as well as their diffuse sources and potential impacts on organisms and human health. Still the molecular and cellular targets of microplastics’ toxicity have not yet been identified and their mechanism of actio...
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Full-text available
DDx, PCBs, PBDEs, Hg, and As contamination in sediments and aquatic organisms of different trophic levels (zooplankton, mussel, fish) were analyzed in Lake Maggiore and Lake Lugano, two large deep perialpine lakes. In the period 2001–2015, we analyzed the spatial and temporal trends of the considered pollutants to detect potential contamination sou...
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The emerged threat of microplastics (MPs) in aquatic ecosystems is posing a new challenges in environmental management, in particular the civil Wastewater Treatment Plants (WWTPs) which can act both as collectors of MPs from anthropic use and as a source to natural environments. In this study, MP fate was investigated in one of the biggest WWTPs of...
Article
Triclosan (TCS, 5‑chloro‑2‑(2,4‑dichlorophenoxy) phenol) is becoming a major surface waters pollutant worldwide at concentrations ranging from ng L-1 to μg L-1. Up to now, the adverse effects on aquatic organisms have been investigated at concentrations higher than the environmental ones, and the pathways underlying the observed toxicity are still...
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This study aimed to assess the toxicological consequences related to the interaction of fullerene nanoparticles (C60) and Benzo(α)pyrene (B(α)P) on zebrafish embryos, which were exposed to C60 and B(α)P alone and to C60 doped with B(α)P. The uptake of pollutants into their tissues and intra-cellular localization were investigated by immunofluoresce...
Article
One of the crucial and unsolved problems of the airborne carbon nanoparticles is the role played by the adsorbed environmental pollutants on their toxicological effect. Indeed, in the urban areas, the carbon nanoparticles usually adsorb some atmospheric contaminants, whose one of the leading representatives is the benzo(α)pyrene. Herein, we used th...
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Microplastics (MPs), plastic debris smaller than 5mm, are widely found in both marine and freshwater ecosystems. However, few studies regarding their hazardous effects on inland water organisms, have been conducted. For this reason, the aim of our research was the evaluation of uptake and chronic toxicity of two mixtures (MIXs) of virgin polystyren...
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Illicit drugs have been identified as emerging aquatic pollutants because of their widespread presence in freshwaters and potential toxicity towards aquatic organisms. Among illicit drug residues, cocaine (COC) and its main metabolites, namely benzoylecgonine (BE) and ecgonine methyl ester (EME), are commonly detected in freshwaters worldwide at co...
Article
Illicit drugs have been recently identified as a serious environmental problem because of the growing evidence regarding their occurrence in aquatic environment and potential toxicity towards non-target organisms. Among them, cocaine (COC) and its main metabolites, namely benzoylecgonine (BE) and ecgonine methyl ester (EME), are commonly measured i...
Article
Carbon-based nanoparticles are largely distributed worldwide due to fossil fuel combustion and their presence in many consumer products. In addition to their proven toxicological effects in several biological models, attention in recent years has focused on the role played by carbon-based nanoparticles as Trojan-horse carriers for adsorbed environm...
Article
The increasing use of nanomaterials opens several concerns regarding their potential risk for the environment and human health. In particular, the aquatic ecosystems appear highly susceptible. Our research wanted to breakthrough this aspect investigating the interplay between carbon nanopower (CNPW) and a common pollutant such as Benzo(α)pyrene (B(...
Article
Antidepressants are one of the main pharmaceutical classes detected in the aquatic environment. Nevertheless, there is a dearth of information regarding their potential adverse effects on non-target organisms. Thus, the aim of this study was the evaluation of sub-lethal effects on the freshwater mussel Dreissena polymorpha of two antidepressants co...
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Despite the growing interest on the presence of illicit drugs in freshwater ecosystems, just recently the attention has been focused on their potential toxicity towards non-target aquatic species. However, these studies largely neglected the effects induced by exposure to complex mixtures of illicit drugs, which could be different compared to those...
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Full-text available
Canadian goldenrod (Solidago canadensis L.) is a plant that grows in a variety of environmental conditions. It shows high capability to spread in various habitats, including fallow lands and brownfield land. The research aimed at analyzing the content of Pb and Zn in the underground (roots, rhizomes) and aboveground parts (stems, leaves, inflorence...
Article
Cannabis is the most used illicit drug worldwide and in some Countries a new regulatory policy makes it legal under some restrictions. This situation could lead to a substantial increase of the environmental levels of the cannabis active principle (Δ-9-tetrahydrocannabinol; Δ-9-THC) and its main metabolite, the 11-nor-9-carboxy-Δ9-tetrahydrocannabi...
Article
Dreissena polymorpha is awidespread ?lter-feeder species, resistant to a broad range of environmental conditions and different types of pollutants,which has recently colonized Italian freshwaters. Althoughwidely used tomonitor pollution in freshwater environments, this species is also an important food source for some ?sh and water birds. It can al...
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This study analyses the seasonal trend of polychlorinated biphenyls (PCB) concentrations in air and soil from a high-altitude mountain pasture in the Italian Alps. PCB concentrations in soil were generally comparable to background levels and were lower than those previously measured in the same area. Only CB-209 unexpectedly showed high concentrati...
Article
We carried out a project aimed to evaluate the possible role played by the freshwater zebra mussel (Dreissena polymorpha) in the possible decrease of some environmental pollutants recalcitrant to tradition wastewater treatments. By the help of a pilot-plant built in the largest wastewater treatment plant of Milan (Italy), we tested several waste mi...
Article
The metallic element pollution is a serious environmental problem but still unsolved since these contaminants are released mainly by human activity, reaching all the environmental compartments. Traditional wastewater treatment plants are very efficient in removing metallic elements only when their concentration is in the order of mg/L, but are not...
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Opioids are considered as emerging contaminants in aquatic ecosystems, mainly due to their large illicit consume worldwide. Morphine (MOR) is the main opiate and it was commonly found at measurable concentrations in freshwaters. Even though its occurrence is well documented, just limited information is available regarding its hazard to nontarget or...
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Full-text available
Recent monitoring studies showed measurable levels of the 3,4-methylenedioxymethamphetamine (MDMA) in aquatic environments. However, no information is currently available on its potential hazard to aquatic non-target organisms. The aim of this study was to investigate the potential sub-lethal effects induced by 14-day exposures to low MDMA concentr...
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Because of the reduction in the use of polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCD), novel brominated flame retardants (NBFRs), including 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), decabromodiphenyl ethane (DBDPE), hexabromobenzene (HBB), and pentabromoethylbenzene (PBEB), started to be marketed as alternatives to th...
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The Lake Maggiore (Northern Italy) has been recognized as an aquatic environment heavily contaminated by persistent organic pollutants, mainly organochlorine compounds, but to date limited information is available regarding another class of widespread and hazardous pollutants, such as the polycyclic aromatic hydrocarbons (PAHs). The aim of this stu...
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Drugs of abuse and their human metabolites have been recently recognized as emerging environmental contaminants. Notwithstanding the fact that these kinds of compounds share some features with pharmaceuticals, their ecotoxicology has not yet been extensively investigated, although some of their characteristics may potentially threaten aquatic ecosy...
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Tanzania is an equatorial country characterized by warm temperatures, which should increase the volatilization of persistent organic pollutants (POPs), but this scenario could be different in mountainous areas like Mount Meru, a volcano situated in the East African Rift (Tz). We collected soil samples along an altitudinal transect upto 4577 m a.s.l...
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This study investigates the contamination by 13 polybrominated diphenyl ether (PBDE) congeners in an altitudinal soil transect on Mt. Meru area, Northern Tanzania. A ∑13PBDEs mean concentration of 386±200pg/g d.w. (4900±3500pg ∑13PBDEs/g soil organic matter - SOM) was measured, pointing out that, in a prevalently agricultural area from the southern...
Article
Since the 1990s, the Lake Maggiore (Northern Italy) has been recognized as an aquatic environment contaminated by DDTs and other persistent organic pollutants, but to date just few studies were carried out to investigate the effects of pollution to aquatic organisms. The aim of this study was the application of a stepwise approach based on chemical...
Article
PCBs are a persistent environmental problem due to their high stability and lipophilicity. The non-ortho- and the mono-ortho-substituted PCBs (dioxin-like-PCBs) share a common and well-described toxicity mechanism in vertebrates, initially involving binding to cytosolic AhRs. Invertebrate AhRs, however, show a lack of dioxin binding, and little inf...
Article
Illicit drugs have been recognized as emerging environmental pollutants that could represent a potential risk for aquatic communities. Even if many studies have shown the occurrence of several drugs of abuse and their metabolites in freshwaters in the High ng/L to Low μg/L range worldwide, no information on their potentially harmful effects on non-...
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Full-text available
Pharmaceuticals and personal care products (PPCPs) have been detected in several aquatic ecosystems during the last two decades, but their potential for biological effects to nontarget organisms is only now being studied. The aim of this study was to compare and rank the cyto-genetic effects induced by 96-hour exposure to an environmental concentra...
Article
A multibiomarker approach was used to assess effects of different environmental conditions in the clam Ruditapes philippinarum. Bivalves were monthly collected from March 2009 to February 2010 in two sites of the Lagoon of Venice differently influenced by both anthropogenic impact and natural conditions: a seaward site (Punta Sabbioni, PS), close t...
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Full-text available
We evaluated the imbalance of the oxidative status in zebra mussel (Dreissena polymorpha) specimens exposed for 96 h to environmentally relevant concentrations (0.1, 0.5, and 1 μg/L) of the 2,2′,4,4′,5,6′-hexa BDE (BDE-154). The activities of three antioxidant enzymes, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and th...
Article
Triclosan (TCS, 5-chloro-2-(2,4-dichlorophenoxy)phenol) is commonly used in several personal care products, textiles, and children's toys. Because the removal of TCS by wastewater treatment plants is incomplete, its environmental fate is to be discharged into freshwater ecosystems, where its ecotoxicological impact is still largely unexplored. Prev...
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Full-text available
This study investigates contamination by 13 polybrominated diphenyl ether (PBDE) congeners in a high-mountain pasture located in the Italian Alps. The trend of PBDE contamination in three soil layers was investigated by a spring-summer sampling period to understand the importance of different environmental variables, such as seasonality, topographi...
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Full-text available
Non-steroidal anti-inflammatory drugs (NSAIDs) are the sixth top-selling drugs worldwide and are commonly found in freshwater ecosystems in the high ng/l to low μg/l range. Recent studies have investigated both the acute and the chronic toxicity of single NSAIDs on different biological models, but these studies have completely neglected the fact th...
Article
Polybrominated diphenyl ethers (PBDEs) are a group of highly hydrophobic and persistent chemicals that has been used as flame retardants in several industrial applications. They have been detected in various environmental matrices worldwide and an increasing number of studies have recently been carried out to investigate their potential toxicity on...
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Full-text available
The origin and distribution of 19 priority pollutant polycyclic aromatic hydrocarbons (PAHs) in core sediments (<63 μm) from the Sundarban mangrove wetland, northeastern part of Bay of Bengal, India, were investigated by gas-chromatography/mass spectrometry (GC/MS). Sedimentary organic carbon and textural properties were also analyzed in order to a...
Article
The increase in global consumption of illicit drugs has produced not only social and medical problems but also a potential new environmental danger. Indeed, it has been established that drugs consumed by humans end up in surface waters, after being carried through the sewage system. Although many studies to measure concentrations of several drugs o...
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It has recently been established that the use of proteomics can be a useful tool in the field of ecotoxicology. Despite the fact that the mussel Dreissena polymorpha is a valuable bioindicator for freshwater ecosystems, the application of a proteomic approach with this organism has not been deeply investigated. To this end, several zebra mussel spe...
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Full-text available
This study presents the first evaluation of the current pollution by polybrominated diphenyl ethers (PBDEs) of surface sediments from the Lagoon of Venice. We focused the research on tri-to hepta-BDEs, the main components of penta- and octa-mixtures, which are considered to be the most toxic for the biocoenosis. The results pointed out a quite homo...
Article
The sub-lethal effects induced by the non-steroidal anti-inflammatory drug ((NSAID) ibuprofen (IBU; ((±)-2-(p-isobutylphenyl) propionic acid))) were investigated using a battery of biomarkers on the freshwater bivalve Dreissena polymorpha. According to the results from a semi-static in vivo approach, mussels were exposed for 96 h to increasing leve...
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Full-text available
A battery of eight biomarkers was used on the freshwater bivalve Dreissena polymorpha in order to evaluate potential sub-lethal effects of the nonsteroidal anti-inflammatory drug diclofenac (DCF; 2-[(2,6-dichlorophenyl)amino]phenylacetic acid). By an in vivo approach, mussels were exposed for 96h to increasing concentrations (0.3, 1, and 2nM) of DC...
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Full-text available
Soils are an important sink for persistent organic pollutants (POPs), and high mountain soils are considered a stable reservoir for many compounds due to their high organic matter content. This study focuses on the small-scale variability on the environmental distribution of dichlorodiphenyltrichloroethane (DDT) in mountain soils. Several soil samp...
Article
Full-text available
The biocide triclosan (TCS, 5-chloro-2-(2,4-dichlorophenoxy)phenol) is commonly used in several personal care products, textiles, and children’s toys. Because the removal of TCS by wastewater treatment plants is incomplete, its environmental fate is to be discharged into freshwater ecosystems, where its ecological impact is largely unknown. The aim...