Andrea Angelini

Andrea Angelini
University of Padova | UNIPD · Orthopedics and Orthopedic Oncology

Associate Professor at University of Padova, MD, PhD

About

155
Publications
34,406
Reads
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2,921
Citations
Citations since 2017
86 Research Items
2377 Citations
20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
Additional affiliations
December 2017 - present
University of Padova
Position
  • Professor (Associate)
December 2016 - present
University of Padova
Position
  • Orthopedic Surgeon
January 2012 - May 2016
University of Bologna
Position
  • PhD
Description
  • Istituto Ortopedico Rizzoli

Publications

Publications (155)
Article
Aims: We performed a systematic literature review to define features of patients, treatment, and biological behaviour of multicentric giant cell tumour (GCT) of bone. Methods: The search terms used in combination were "multicentric", "giant cell tumour", and "bone". Exclusion criteria were: reports lacking data, with only an abstract; papers not...
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Background: The aim of this study is to compare sublingual sufentanil and the administration device for its delivery (SSST-Zalviso®) with the traditional strategies used for the control of postoperative pain to establish if there is an actual benefit for the patient and healthcare personnel. Materials and methods: A retrospective study was condu...
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Recent studies have shown that fascial fibroblasts are sensitive to different stimuli (bio-chemical or biophysical), promoting extracellular matrix remodeling, as well as synthetic activity. Moreover, the extensive literature on the renin-angiotensin system (RAS) reported its involvement in tissue remodeling. This study aimed to investigate the pre...
Article
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Osteochondromas are common benign bone tumors, frequently found in adolescents or young adults. Most often asymptomatic and discovered by accidental findings, they may be diagnosed because of compression or dislocation. Vascular complications are an atypical presentation of osteochondromas, and include vessel perforation and thrombosis, arterial th...
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Patients with Gorham–Stout disease (GSD) present progressive destruction and resorption of bone. Typical bone-related symptoms include swelling, pain and functional impairment in the region involved. The three aspects of GSD etiopathology are osteoclasts, angiogenesis/lymphangiogenesis and osteoblast function. Multi-targeted pharmacological approac...
Chapter
Current treatments for bone sarcomas include limb-salvage surgery with wide-margin resection or amputation, with or without adjuvant treatments including chemotherapy and radiation therapy according to the tumor's histology. Patients with locally or distally advance sarcomas may benefit from palliative treatments. Surgery is the primary therapeutic...
Chapter
Large acetabular pelvic bone defects are frequently observed in the revision surgery of hip arthroplasty and in musculoskeletal oncology, representing a challenge in the reconstructive surgery. Three-dimensional (3D) printing is an emerging technology that have been attempted to improve the management of these patients. This chapter will focus on t...
Chapter
The proximal humerus is the third most common site for bone tumors, both primary and metastatic cancer. Regaining shoulder function is challenging due to the removal of muscles and bone to obtain safe surgical margins. When the axillary nerve and deltoid muscle can be spared, modular reverse total shoulder arthroplasty (mRTSA) can be used. Advantag...
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Arthrodesis has always been considered the main treatment of degenerative lumbar disease. Adjacent segment degeneration is one of the major topics related to fusion surgery. Non-fusion surgery may prevent this because of the protective effect of persisting segmental motion. The aims of the study were (1) to describe the radiological outcomes in the...
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Background Double ipsilateral femoral fractures account for 1–9% of femoral fractures. There is no clear advantage between single or double implant osteosynthesis. We present a series of patients with double ipsilateral femoral fractures, to address the challenges in treatment, namely the implants for osteosynthesis and complications of treatment.M...
Chapter
Tumor resection and solid arthrodesis of the lumbosacral region of the spine are challenging. Tumors in this region as well as their surgical resection can significantly influence the biomechanics of the sacropelvis resulting in failure of axial load transmission. Therefore, to perform an oncologically and functionally optimal surgery, both the ana...
Chapter
Pelvic tumors are rare entities. Metastases are the most common malignant tumors and can derive mainly from breast, lung, prostate, kidney, and thyroid cancers. Primary benign and malignant tumors may arise from bone or bone marrow in cases of hematological malignancies. There is a broad spectrum of pathology involving the pelvis and differential d...
Chapter
The principal goal of the surgical treatment of primary pelvic tumor is to obtain a free margin resection, facing the reconstructive surgeon to large soft-tissue defects. A concomitant one-step autologous reconstruction has been proved to lead to better results than delayed strategies, especially when radiotherapy or infections compromise the donor...
Chapter
Three-dimensional (3D) printing is an emerging technology used in numerous fields of orthopedics and traumatology. There are at least three possible applications of this technology in musculoskeletal oncology: anatomical models, surgical tools and jigs, and implantable prostheses to reconstruct large bone defects. The combination of 3D-printed appl...
Chapter
Pelvic tumors are rare entities. The rates of cure for malignant tumors involving the pelvis are often lower than those involving the extremities, with significant morbidity and mortality. This may be due to the complexity of the anatomy of the pelvis and the usually large tumor volume, making resection with adequate margins very difficult. Managem...
Chapter
Adequate oncologic resection of pelvic tumors with safe margins is challenging. The late diagnosis and wide spread of these tumors at the time of initial detection, the highly demanding procedures for complete resection of pelvic tumors, and the high rate of complications following these procedures are some of the causative factors for the poor pro...
Chapter
External hemipelvectomy, also known as a hindquarter amputation, and its various subtypes, are mainly used for the treatment of aggressive pelvic tumors involving the pelvis, hip, and upper thigh. The indications for ablative (external) hemipelvectomy include circumstances where limb-salvage cannot be performed. These include anatomic involvement o...
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Objective: Wide-margin resection is mandatory for malignant bone and soft tissue tumors. However, this increases the complexity of resections, especially when vessels are involved. Patients in this high-risk clinical setting could be surgically treated using the multidisciplinary orthopedic-vascular approach. This study was carried out in this heal...
Book
Approaches to complex pelvic surgery have changed dramatically in recent years thanks to the development of the entire field of orthopedic surgery. This volume focuses on the mastery of diagnosis, management and operative techniques for tumors of the pelvis. It also provides a thorough understanding of how to select the best procedure, how to avoid...
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Background and Objectives. Wide surgical resection is a relevant factor for local control in sarcomas. Plastic surgery is mandatory in demanding reconstructions. We analyzed patients treated by a multidisciplinary team to evaluate indications and surgical approaches, complications and therapeutic/functional outcomes. Methods. We analyzed 161 patien...
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Background The management of limb deformity, shortening, and bone defects in treatment of Ollier’s disease is a major challenge. This study aims to summarize and compare the different surgical treatments, and to evaluate the outcome and possible prognostic factors of leg lengthening in these patients. Materials and methodsA systematic review of the...
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Background: According to the required reorganization of all hospital activities, the recent COVID-19 pandemic had dramatic consequences on the orthopedic world. We think that informing the orthopedic community about the strategy that we adopted both in our hospital and in our Department of Orthopedics could be useful, particularly for those who ar...
Article
Reconstruction of the dorsum of the hand and fingers is one of the main challenges in hand surgery. Regional flaps from the forearm, free flaps, or pocket procedures are options when multiple digits are injured with tendon damage and bone exposure. These procedures can be technically demanding and are often plagued by a texture mismatch. We conduct...
Article
Introduction Long bone metastases are a disease of high social importance. The goals of surgical treatment are to relieve pain, maintain or restore joint function, and prevent or treat pathological fractures. “Oligometastases” is a disease with a limited number (3–5) of metastatic lesions in the same body district, where an aggressive treatment can...
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As there are no clear and unique radiographic predictors of healing disturbances for acute midshaft clavicle fractures, their treatment is still controversial. The aim of the study was to evaluate in midshaft clavicle fractures treated nonoperatively if fracture type (FT), shortening, and displacement, assessed before and after figure-of-eight band...
Article
Approximately one-fourth of osteosarcoma patients have metastases at presentation. The best treatment options for these patients include chemotherapy, surgery, and radiotherapy; however, the optimal scheme has not yet been defined. Standard chemotherapy for osteosarcoma metastatic at presentation is based on high-dose methotrexate, doxorubicin, and...
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Multifocal, extraosseous, and surface aneurysmal bone cysts are rare variants of the primary lesions. The clinicopathological features are similar, and the optimal treatment is surgical. Although local recurrences may occur, the prognosis is excellent. This review article introduces the readers to a rare diagnosis which they may have been previousl...
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Purpose: Incisional biopsy is still used to obtain material for a straightforward histological diagnosis in musculoskeletal lesions. The aim of our study was to evaluate 1) the percentage of diagnostic procedures, 2) diagnostic accuracy, and 3) the incidence of complications after imaging-guided percutaneous biopsy (PCB). Case Series: This is a ret...
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Background From February 21, the day of hospitalisation in ICU of the first diagnosed case of Covid-19, the social situation and the hospitals’ organisation throughout Italy dramatically changed.Methods The CIO (Club Italiano dell’Osteosintesi) is an Italian society devoted to the study of traumatology that counts members spread in public and priva...
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Spinal infection poses a demanding diagnostic and treatment problem for which a multidisciplinary approach with spine surgeons, radiologists, and infectious disease specialists is required. Infections are usually caused by bacterial microorganisms, although fungal infections can also occur. The most common route for spinal infection is through hema...
Article
Background Three-dimensional (3D) printing is an emerging technology used in numerous medical fields. Reconstruction of large bone defects after tumor resections or complex revision surgeries is challenging especially in specific sites where modular prostheses are not available. The possibility to realize custom-made 3D-printed prostheses improves...
Article
Background/aim: Chondrosarcomas (CS) of the chest wall are rare, but present an aggressive biological behavior compared to CS of the extremities. The aims of the present study were to determine factors associated with oncological outcomes as well as complications. Patients and methods: We retrospectively analyzed 53 patients (42 primary, 11 recu...
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The spinal column represents the third most common site for metastases after the lungs and the liver, and the most common site for metastatic bone disease. With life-extending advances in the systemic treatment of cancer patients, the surgical procedures performed for spinal metastases will increase, and their related complications will increase un...
Article
Posterior dislocation of the sternoclavicular joint is a rare and emergent injury. Diagnosis is often missed or delayed. Treatment is challenging because of the joint's inherent instability. This article presents a 15-year-old adolescent who experienced a traumatic posterior dislocation of his right sternoclavicular joint that was treated successfu...
Article
Acromion fractures are uncommon clinical entities, and acromion stress fractures are even rarer, with few cases reported. Due to their rarity, acromion stress fracture often failed to be diagnosed. Here, we report a case of an elderly patient with an acromion stress fracture, which was overlooked, resulting in pseudoarthrosis followed by the displa...
Article
The aim of the study was to analyze our experience with a single system of modular proximal femoral replacement, evaluating oncologic results, complications, and functional results. We reviewed data on 38 patients (21 men and 17 women; mean age 59 y) treated with proximal femoral reconstructions by two orthopaedic surgeons. Reconstruction was perfo...
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Calcific myonecrosis is a rare disease that has been shown to be a late sequela of trauma. This article presents a 68-year-old man with calcific myonecrosis of the leg 40 years after a tibial fracture complicated with peroneal nerve palsy. The soft tissue mass increased in size after another injury to the leg that occurred two years before his pres...
Article
Background: After proximal humerus resection for bone tumors, restoring anatomy and shoulder function remains demanding because muscles and bone are removed to obtain tumor-free surgical margins. Current modes of reconstruction such as anatomic modular prostheses, osteoarticular allografts, or allograft-prosthetic composites and arthrodeses are as...
Article
Objective: Infection after orthopaedic oncology surgery is a relatively frequent complication. Infection rate ranges in the literature between 3.7% and 19.9%, increasing up to 47% after pelvic resection and reconstruction. It represents a challenging topic when occurring in oncologic patients because of the delay of systemic and local treatments,...
Article
Schwannoma is a soft tissue tumor that rarely presents in the foot. Patients are usually asympto-matic, but in some cases symptoms typically result from the mass effect and direct involvement of the nerve and surrounding tissue. We report on four consecutive cases. The first patient was a 57-years-old female that referred symptoms similar to the Mo...
Article
Giant cell reparative granulomas (GCRGs) are non-neoplastic inflammatory lesions, usually observed in the maxilla, mandible or small bones of the hands and feet. These lesions present a wide range of morphology and the misinterpretation with other giant cell lesions can often occur. We report the case of a 47-year-old woman with GCRG in the left sc...
Chapter
Introduction. Patients with pelvic bone metastasis present a wide range of symptoms, and therapeutic strategies should be individualized in order to obtain the best possible quality of life despite the advanced stage of disease. A multidisciplinary approach among the oncologist, radiation therapist, and orthopedic surgeon is mandatory. The goals of...
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Angular stability plates are largely used for treating complex fractures, but the incidence of nonunion is high. The innovative dynamic internal fixator (DIF) system is comprised of a plate with angular stability that combines the principles of internal fixator with dynamic device. In this study, we evaluate the feasibility of surgical reconstructi...
Article
Background The use of custom-made 3D-printed prostheses for reconstruction of severe bone defects in selected cases is increasing. The aims of this study were to evaluate (1) the feasibility of surgical reconstruction with these prostheses in oncologic and non-oncologic settings and (2) the functional results, complications, and outcomes at short-t...
Article
A concept consolidated in recent years is that tumor growth depends to a great extent on the micro‐environment surrounding the tumor, which has a fundamental role in tumor progression and in determining the effectiveness of therapies. Our analysis focuses on chondrosarcoma, the second primary malignant bone tumor, resistant to both chemotherapeutic...
Article
Chondroblastoma (CB) of the foot is a rare lesion. The purpose of this report was to report a large series from a single institution to analyze clinical, radiographic, and histologic characteristics; treatment; and local recurrence. We present 40 patients (30 males, 10 females; mean age 25 years) diagnosed and treated for CB of the foot from 1975 t...
Article
Background Metastatic lesions to the proximal femur occur frequently and require special consideration due to the high risk of pathologic fractures. Type of surgery might influence patient survival considering the growing concept of oligometastases. In fact, the use of modular tumor megaprosthesis is increasing in the last decades compared to intra...
Article
Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) is the imaging method of choice in sarcoma patients. PET may help in diagnosis, grading, staging, biopsy guidance, monitoring response to therapy, restaging for recurrence, and prognosis. 18F-FDG-PET/MRI combines the higher tissue contrast of MRI in the study of so...
Article
Fractures of the forearm in the growing skeleton in a common event, accounting for 10% of the overall fracture and at the third place for long bone fractures. Most of these fractures present a simple line. There are several classification but the most widely use is the anatomo-radiological one. The majority of the fracture require closed reduction...
Article
Purpose: Aneurysmal bone cyst (ABC) is a rare skeletal tumor usually treated with surgery/embolization. We hypothesized that owing to similarities with giant cell tumor of bone (GCTB), denosumab was active also in ABC. Methods: In this observational study, a retrospective analysis of ABC patients treated with denosumab was performed. Patients un...
Article
Recently, alterations in fascial gliding‐like movement have been invoked as critical in the etiology of myofascial pain. Various methods have been attempted for the relief of this major and debilitating clinical problem. Paramount have been attempts to restore correct gliding between fascial layers and the movement over bone, joint, and muscular st...
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Sarcomas represent less than 1% of adult cancers and they account for approximately 21% of pediatric malignancies. The heterogeneity of these tumors results in variable responses to generalized therapeutic strategies. In the last four decades, significant advances in the treatment of patients with bone and soft tissue sarcomas have been made. Histo...
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Introduction The goal of this retrospective, observational, case series study was to evaluate the medium-long-term clinical and radiographic results of the three most common surgical osteosynthesis techniques used for the treatment of articular tibial pilon fractures: ORIF, MIPO, and EF. Materials and Methods A consecutive series of patients with...
Article
Background: Synovial cysts of the hip are relatively rare lesions comparing to other joints. Patients are usually asymptomatic, but in some cases symptoms such as pain and/or compression of vessels or nerve could be present. Purpose of the study was to define clinical features and optimal management of synovial cyst of the hip joint through an acc...
Article
Tumor megaprostheses are modular systems commonly used for joint reconstructions following bone resection. In the last two decades, indications on the use of modular prostheses have progressively increased even in non-cancer patients, mainly as a review of implants, in particularly favorable conditions for hip and knee and with severe bone loss. Ai...
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Aim: The aim of this study was to investigate the diagnostic accuracy of (18)F-FDG-PET/CT in osteosarcoma patients suspicious for disease recurrence after adequate surgical therapy. Methods: Inclusion criteria were: a) adequate surgical treatment for proven osteosarcoma and documented complete remission after therapy; b) (18)F-FDG-PET/CT perform...
Article
The introduction of a multidisciplinary approach with chemotherapy and radiotherapy, and the advances and improvements in surgical and diagnostic techniques now allow limb salvage surgery in most patients with bone sarcomas instead of amputation. Megaprostheses have been used more frequently in the last 3 decades and are now the most common method...
Article
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Tumors of the hand comprise a vast array of lesions involving skin, soft tissue and bone. The majority of tumors in the hand are benign. Malignant tumors, although rare, do occur and frequently have unique characteristics in this specific anatomic location. Careful staging, histological diagnosis and treatment are essential to optimize clinical out...
Article
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An intercalary reconstruction is defined as replacement of the diaphyseal portion of a long bone after segmental skeletal resection (diaphysectomy). Intercalary reconstructions typically result in superior function compared to other limb-sparing procedures as the patient's native joints above and below the reconstruction are left undisturbed. The m...
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Purpose: To analyze the clinical and radiographic characteristics, treatment, and outcome of patients with elbow osteoblastoma. Patients and methods: We present 13 patients (7 males and 6 females; mean age, 28 years) diagnosed and treated for an elbow osteoblastoma from 1975 to 2012. Mean follow-up was 29 months (range 12-60 months). Clinical pr...
Article
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Purpose: Chondroblastoma (CB) is a rare benign tumor that occurs most commonly in the second decade of life. No studies on CB in adulthood have been reported. Our purposes were to report a single-institution experience on CB in adults and to discuss the clinical and imaging findings, type of treatment, oncologic and functional outcomes. Patients...
Article
Background The survival of patients with tumors around the shoulder treated with extra-articular resection, the rates of reconstructions-related complications, and the function of the shoulder cannot be estimated because of limited available data from mainly small published related series and case reports. Methods We studied 54 patients with tumor...
Article
The introduction of multidisciplinary approach with chemo and radiotherapy, the advances in surgical and the improvements of diagnostic techniques allowed limb salvage surgery in most cases of bone sarcomas instead of amputation. Modular megaprostheses are the most common method of reconstruction after segmental resection of the long bones in the e...
Chapter
Arterial embolization for tumors was first described in 1975 [1, 2]. Since then, embolization for sacral tumors either primary or metastatic has been used extensively as a useful primary, palliative, or adjuvant therapy [3–6]. Preoperative embolization of hypervascular metastatic lesions reduces intraoperative blood loss and improves the surgeon’s...
Chapter
Nerve sheath tumors comprise only a small portion of the wide variety of lesions that occur in the sacrum [1–5]. Schwannomas (neurilemomas) are benign, slow-growing neurogenic tumors arising from Schwann cells of the peripheral nerve sheath. Sacral schwannomas are exceedingly rare, with merely around 50 cases reported in related literature [6]. Due...
Chapter
Osteoblastoma is a rare benign bone-forming tumor that accounts for approximately 1% of all bone neoplasm [1–4]. It may occur in any area of the skeleton, but it is more frequently observed in the spine (mainly in the mobile segments whereas sacrum is rarely affected) [1, 5]. Due to the rarity of the tumor and the usual delay in diagnosis, the opti...
Chapter
Primary malignant tumors of the sacrum are rare [1–3]. The most frequent are chordomas followed by hematologic neoplasms, osteosarcomas, Ewing’s sarcomas, and in very rare cases, chondrosarcomas [3]. Chondrosarcomas (CS) can be classified as a primary malignant bone tumor (>90%) when they arise de novo or as a secondary malignant transformation of...
Chapter
The most common malignancy to occur in the sacrum is metastatic bone disease [1–3]. The most common primary cancers are breast, lung, prostate, renal, and thyroid cancer [4–7]. Other less common primary lesions include lymphoma, myeloma/plasmacytoma, melanoma, and tumors of unknown origin [8]. Spread is mainly by hematogenous dissemination, althoug...
Chapter
Neoplasms of the sacrum are relatively uncommon, representing 1–2% of all musculoskeletal tumors [1]. They can be classified as primary or metastatic, the former being either benign or malignant. The most common malignancy of the sacrum is metastatic disease, whereas the most common primary sacral tumor is chordoma; more rare sacral malignancies in...