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Introduction
My current research interests are teaching assesment and ethics about the net.
I am finishing a book about first women in Medicine in America Continent
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August 1988 - April 2006
Publications
Publications (36)
BIOCYBERETHICS AND ARTIFICIAL INTELLIGENCE IN MEDICINE
The aim of this work is to expose the main ideas behind the Genetic, Nanotechnology and Robotic Revolution and make a bioethical approach to some of the possible issues related to it. The rol of Higher Education in this issue is also explore from an ethical point of view.
Mammographic screening has helped to identify breast cancer in its earliest stages, when treatment is most effective. The use of Artificial Intelligence in the analysis of mammograms has proved to be able to excel the human eye in detecting lesions in the breast that may be suspicious for cancer. The objective of this study is to make a reflective...
Immersed already in the 4th industrial revolution, clearly the digital age has invaded our lives. People tend to celebrate every technological and scientific advance without thinking properly about the possible undesired side effects or unexpected consequences. One of the most outstanding achievements of the last years has been the CRISPR/Cas9 tech...
Maud Leonora Menten nació en Canadá, tuvo cuatro títulos universitarios: Bachiller en Artes, Master en Fisiología, médica y Doctora en Bioquímica. Trabajó en Estados Unidos, Alemania y Canadá. Trabajó en diferentes áreas: en la distribución de los iones cloruro en el sistema nervioso central, en tumores experimentales y su tratamiento con bromuro d...
El desarrollo de la investigación científica pone de manifiesto la relevancia que tiene la ética a la hora de diseñar y aprobar protocolos de investigación. A los desafíos tradicionales, se suma el impacto de la globalización en lo que se refiere a aspectos culturales que deben ser tomados en cuenta (por ejemplo, en el consentimiento informado y el...
El presente trabajo tiene por objetivo relatar las vicisitudes de la vida de las familias de Karen Ann Quinlan, Nancy Cruzan y Terri Schiavo que, en diferentes épocas, fueron ejemplos de lucha por el reconocimiento del derecho a morir dignamente. Sus historias aportaron elementos necesarios para darle forma a una herramienta ética y, en algunos paí...
Resumen Los avances científico-tecnológicos revolucionaron la historia de la medicina. En este artículo, procuramos realizar un breve análisis de los principales dilemas éticos que han surgido como consecuencia del desarrollo tecnológico a partir de la mitad del siglo XX, y procuramos focalizar en el estudio acerca de cómo han abor-dado estas cuest...
In this paper we attempt a historical approach on some aspects related to the emergence, evolution and consolidation of Bioethics as a discipline. We focus on analyzing the number of publications containing the word Bioethics from 1971 to 2011. We analyze briefly the dominant theme in every year in that period and also the registering indexed journ...
Planning a schedule for medical appointments in health services must be efficient andflexible, butalso ithas to meettheneedsofpatients, healthprofessionalsandnon-medical staff. There are large differences in the opinión about the optimal duration to meetthese objectives, across countries. In this paperwe propose toperform a reviewof the literature...
Stress can alter a person's immune capacity, either through neurotransmitters or through hormones. Hormonal change that occurs as a result of stress affects the development of any disease. This implies that the physician should consider the patient not only as a carrier of a disease but also as a suffering being, both physically and emotionally, be...
Palmoplantar keratodermas are a heterogenic group of diseases characterized by abnormal skin thickening of the palms and soles. The main alteration is the excessive formation of keratin. There are acquired forms related to other diseases, such as chronic regional endemic hydroarsenicism. There are also multiple congenital variants, with recently di...
Current statistics show that overweight and obesity are seriously increasing, mainly in occidental countries with high industrialization rate. Simultaneously sedentarism has increased as a consequence of technological comforts that the dominant market economy offers. Obesity, sedentarism, excessive adiposity, especially if centrally distributed, in...
Current statistics show that overweight and obesity are seriously increasing, mainly in occidental countries with high industrialization rate. Simultaneously sedentarism has increased as a consequence of technological comforts that the dominant market economy offers. Obesity, sedentarism, excessive adiposity, especially if centrally distributed, in...
RESUMEN La enfermedad de hígado graso no alcohólica, en inglés non alcoholic fatty liver disease (NAFLD), es definida como una acumulación excesiva de grasa en los hepatocitos. Presenta una prevalencia mundial de alrededor del 15 al 25%. Los factores de riesgo asociados frecuentemente a NAFLD son obesidad, diabetes tipo 2 y dislipemia. Por un lado...
Non-alcoholic fatty liver disease (NAFLD), defined as excessive fat accumulation into the hepatocytes, has a prevalence of approximately 15 to 25%. Frequently associated risk factors for NAFLD are obesity, type 2 diabetes and dyslipidemia. It has been proponed that a mitochondrial dysfunction would play a crucial role in the disease development.On...
Antecedentes: Dentro de los factores de riesgo (FR) para el desarrollo del cáncer de mama (CM), algunos son invariables, como la edad, antecedentes familiares de CM, historia reproductiva, etc., y los denominaremos FR convencionales (FRC). Los relacionados con hábitos socioculturales y del cuidado de la salud, pueden ser modificados para disminuir...
Background: Among risk factors (RF) for breast cancer (BC) development, some of them are considered invariable, such as age, breast cancer family history, reproductive history, etc., and we named them conventional risk factors (CRF). There are other RF, related with cultural habits and health care, that can be modify to diminish their impact on BC...
The use of different combinations of drugs, among them adenosine-3′, 5′-monofosfate cyclic analogues, has expanded the search for therapeutical alternatives to treat breast cancer. From a current existing wide variety, the 8-chloro-adenosine-3′,5′-monophosphate (8-Cl-cAMP) is the most employed and at present, it is in phase II of clinical studies....
Because the etiology and progression of breast carcinoma remain unclear, novel mechanisms of disease pathogenesis need to be considered. Recent interest has focused on Epstein-Barr virus (EBV), an oncogenic ubiquitous herpesvirus. Investigations of this association could not only broaden understanding of breast cancer etiology but also have implica...
Context.—Because the etiology and progression of breast carcinoma remain unclear, novel mechanisms of disease pathogenesis need to be considered. Recent interest has focused on Epstein-Barr virus (EBV), an oncogenic ubiquitous herpesvirus. Investigations of this association could not only broaden understanding of breast cancer etiology but also hav...
The aim of this work was to analyze the effect of estradiol (E(2)), medroxyprogesterone and the two selective estrogen receptor modulators (SERMs) (tamoxifen (Tam) and raloxifene (Ral)) on the estrogen receptor (ER) conformers profile performed by size exclusion HPLC in relation to hormone dependence of mammary tumors.
Two types of mammary tumors w...
Histopathological effects of cAMP analog (8-Chloro-cAMP), tamoxifen, and medroxyprogesterone, alone or combined, upon BALB/c mice uteri are reported. 8-Chloro-cAMP diminished uterine weight, but did not modify its histopathology or estral cycle significantly. Tamoxifen diminished uterine weight showing cystic hyperplasia and an estral cycle arreste...
Three antitumoral drugs, tamoxifen (Tam), medroxyprogesterone acetate (MPA), and 8-Cl-cyclicAMP (8Cl), were administered separately and in combination to normal adult mice in order to record their effects on uterus weight, on estrous cycle, and on two estrogen receptor (ER) and progesterone receptor (PgR) parameters, namely content and nucleo-cytop...
A displacement assay with tamoxifen, based on the relative binding affinity of tamoxifen and estradiol for the estrogen receptor (ER), was proposed in 1990 as prognostic indicator for breast-cancer patients. Validation of its predictive results in relation to the outcome of 73 patients with ER+ tumors is analyzed. ER, progesterone receptor (PgR) de...
A displacement assay with tamoxifen, based on the relative binding affinity of tamoxifen and estradiol for the estrogen receptor (ER), was proposed in 1990 as prognostic indicator for breast‐cancer patients. Validation of its predictive results in relation to the outcome of 73 patients with ER⁺ tumors is analyzed. ER, progesterone receptor (PgR) de...
The type of hormone dependence in mammary neoplasias is usually defined by the presence or absence of estrogen and progesterone receptors. At present, new advances in the knowledge related to the functionality of these receptors are changing our previous concepts. Estrogen receptors classified as negative by biochemical or immunocytochemical method...
Interactions among transcription factors are one of the mechanisms that regulate gene expression. Through protein-protein associations different signaling pathways become connected and the message triggered by each of the molecules involved can modify other related routes. In a murine mammary tumor induced by medroxyprogesterone acetate (MPA), furt...
Excerpt
It is accepted that quantitative determination of steroid receptors, useful as it is as a first indication of hormone dependence in mammary neoplasias, is insufficient to accurately characterize the tumor biology, especially for deciding clinical conduct. Functional assays provide one step towards insight on the integrity of receptor behavi...
The close interaction between receptors and other transcription factors suggests that their corresponding transducing signals can trigger functional and structural changes in other related molecules. The effect of a progestinic agent, medroxyprogesterone acetate (MPA), on some of the estrogen-receptor (ER) parameters was studied in 2 murine mammary...
Cancer is a multistage process with sequential steps: initiation, promotion, progression. However, the distinction between the agents that can trigger any of these processes is less clear, depending on doses, biological stage of the tissue, molecular interactions, genomic and somatic mutation, etc. Thus, steroid receptors, classically considered as...
In vivo binding of [3H]estradiol ([3H]E2) in the rat uterus was performed by an intraluminal perfusion of the ligand for different time periods. In this way the binding takes place in the intact organ before processing the tissue. In 10 min, with 10 nM [3H]E2 apparent saturation or steady state incorporation of the [3H]E2 was achieved with a simila...
L as hormonas esteroideas regulan múltiples ac-tividades biológicas en las células animales, principalmente por mecanismos genómicos 1 . El efecto de las hormonas esteroides, por interacción con su receptor intracelular específico, resulta en la activa-ción de una batería de genes relacionados con la proli-feración celular. De ahí que la orientació...
