André Vicente

• MD, PhD
• Lund - Sweden at Skåne University Hospital

Purpose: The purpose of this study is to study the frequency, surgical transplantation technique and outcome in patients with aniridia-related keratopathy (ARK) with two-year follow-up period. Methods: A retrospective registry-study including all ARK cases performed in Sweden and Denmark between 2001 and 2016 and registered in the Swedish Cornea...

We aimed to study aniridia-related keratopathy (ARK) relevant cell signaling pathways [Notch1, Wnt/β-catenin, Sonic hedgehog (SHH) and mTOR] in normal human fetal corneas compared with normal human adult corneas and ARK corneas. We found that fetal corneas at 20 weeks of gestation (wg) and normal adult corneas showed similar staining patterns for N...

Purpose: To evaluate clinical practice in the diagnosis and treatment of progressive keratoconus with corneal crosslinking (CXL) in four Nordic countries. Methods: A questionnaire was sent to all centres at which keratoconus patients are evaluated and CXL is performed in Sweden, Denmark, Norway and Iceland. Nineteen of 20 centres participated....

The progression of keratoconus is commonly determined by comparing the results of corneal tomographic measurements on different occasions. However, investigations on the repeatability of measurements are commonly performed within the same day, thus not taking the inter-day variation into account. The effect of keratoconus disease severity on the me...

Background: To study aniridia-related keratopathy (ARK) relevant cell signaling pathways (Notch1, Wnt/β-catenin, Sonic hedgehog (SHH) and mTOR) in normal human fetal corneas in comparison with normal human adult corneas. Results: 20 wg fetal and normal adult corneas showed similar staining patterns for Notch1, however 10-11 wg fetal corneas showed...

PURPOSE: To establish an in vitro model of aniridia-related keratopathy (ARK) using CRISPR/Cas9 engineered human keratocytes with mutations in the PAX6 gene, and to study the Notch Homolog 1, Translocation-Associated (Notch1), sonic hedgehog (SHH), mammalian target of rapamycin (mTOR), and Wnt/β-catenin signaling pathways in the PAX6 mutant keratoc...

This paper aims to identify key biological processes triggered by resection surgery in the extraocular muscles (EOMs) of a rabbit model of strabismus surgery by studying changes in gene expression. Resection surgery was performed in the superior rectus of 16 rabbits and a group of non-operated rabbits served as control. Muscle samples were collecte...

Purpose: To study the Notch1, Wnt/beta-catenin, sonic hedgehog (SHH), and mammalian target of rapamycin (mTOR) cell signaling pathways in naïve and surgically treated corneas of aniridia cases with advanced aniridia-related keratopathy (ARK). Methods: Two naïve corneal buttons from patients with advanced ARK submitted to penetrating keratoplasty...

Background To study structural changes in naïve and surgically treated corneas of aniridia patients with advanced aniridia-related keratopathy (ARK). Methods and findings Two naïve corneal buttons from patients with advanced ARK submitted to penetrating keratoplasty for the first time, one corneal button from an ARK patient that had undergone a ke...

Purpose: We examined the pattern and extent of connective tissue distribution in the extraocular muscles (EOMs) and determined the ability of the interconnected connective tissues to disseminate force laterally. Methods: Human EOMs were examined for collagens I, III, IV, and VI; fibronectin; laminin; and elastin using immunohistochemistry. Conne...

Purpose: To report a case of Exophiala phaeomuriformis mycotic keratitis in a patient from a subarctic climate region. Dematiaceous fungi (black yeasts) have been gaining importance as corneal keratitis and ulcer causative agents in certain regions, but no cases have been described in Scandinavia. Methods: Case report of a patient with a persist...

Purpose: To report a case of Exophiala phaeomuriformis fungal keratitis in a patient from a subarctic climate region. Dematiaceous fungi (black yeasts) have been gaining importance as corneal keratitis and ulcer causative agents in certain regions but no cases have been described in Scandinavia. Setting/Venue: Ögonkliniken, Norrlands University Hos...

Introduction: Att utvärdera hornhinnans förändringar hos patienter med aniridierelaterad keratopati (ARK) före och efter hornhinnetransplantation med tonvikt på cellsignalvägar. ARK innebär vanligtvis limbal stamcellsbrist i samband med nedsatt epitelial celladhesion, korneal konjunktivalisering och grumling. ARK är av stor betydelse vid synskada h...

Introduction Att rapportera ett fall av Exophiala phaeomuriformis, svampkeratit, hos en patient från subarktiska klimatregionen. Dematiaceous svampar (svarta jästsvampar) har visat sig vara agens vid hornhinnekeratiter och sår i vissa regioner i världen men inga fall har tidigare beskrivits i Skandinavien. Method Fallrapport rörande en patient med...

Purpose: To study the histopathological and cell signalling changes of transplanted healthy donor corneas in patients with aniridia-related keratopathy Methods: Three patients with advanced keratopathy that were retransplanted with a centered or decentered technique were included in this study. A control group with corneas from healthy controls was...

Purpose: To evaluate corneal changes in patients with aniridia-related keratopathy (ARK) before and after corneal transplantation. Aniridia-related keratopathy (ARK) usually involves limbal stem cell-deficiency associated with epithelial impaired cell adhesion, corneal conjunctivalization and opacification. Methods: Two corneal buttons from patient...

Purpose: To compare choroidal thickness (CT) between diabetic patients without diabetic retinopathy and a nondiabetic group. To explore how CT relates to disease duration, mean arterial pressure, glycemia, glycosylated hemoglobin, intraocular pressure, and ocular pulse amplitude. Methods: Choroidal thickness was assessed using a spectral-domain...

Objectives: To analyse drug development for open-angle glaucoma during the last 20 years. Methods: Research was performed by referring to clinical trials registered at the International Clinical Trials Registry Platform (ICTRP). A search for the condition "open-angle glaucoma" with the intervention "drug" was performed. We included trials regist...

Introduction: Corneal transparency is dependent on regular organization of collagen fibers. (Jester et al., 2008). α11β1 integrin has been identified as a mediator in cell adhesion to collagen I and IV and it has a stronger interaction with collagen I. This molecule has been associated with the organization of the corneal collagen matrix as cell-co...

Purpose Compare choroidal thickness (CT) between diabetic patients without diabetic retinopathy (DR) and a non-diabetic group. Explore how CT relates to disease duration, mean arterial pressure (MAP), glycaemia, glycosylated haemoglobin (HbA1c), intraocular pressure and ocular pulse amplitude (OPA). Methods In this cross-sectional study, CT was as...

Purpose This study was design to examine the correlation between retinal and choroidal thickness in diabetic patients without diabetic retinopathy. Methods 125 type 2 diabetic patients without diabetic retinopathy underwent a complete ophthalmological examination. Retinal total thickness and retinal layer automatic segmentation were assessed by us...

Diabetic retinopathy is an increasingly prevalent disease, and a leading contributor to the burden of all-cause blindness worldwide. In addition to retinal changes, choroidal abnormalities are common in patients with diabetes. The first studies concerning this vascular structure were based on histologic, indocyanine angiography and laser Doppler fl...

Purpose: To present a retrospective study of the postoperative astigmatism in patients with DSAEK with a determination of anterior and posterior corneal astigmatism. Methods: A retrospective study of corneal astigmatism of 80 eyes of 73 patients with Fuchs Dystrophy submitted to DSAEK was performed. Postoperative total astigmatism, posterior and a...

The purpose of this study is to evaluate the macular ganglion cell layer (GCL) and peripapillary retinal nerve fibre layer (RNFL) thickness in patients with unilateral posterior cerebral artery (PCA) ischaemic lesions using spectral-domain optical coherence tomography (SD-OCT). A prospective, case-control study of patients with unilateral PCA lesio...

Purpose The authors intend to present an analysis and comparison of the choroidal thickness in more distant superior regions. Choroidal thickness is increased in a heterogeneous pattern superiorly to the fovea in diabetic patients without diabetic retinopathy. Methods Observational case‐control study of 60 eyes of 60 patients with diabetes mellitu...

Purpose To evaluate the thickness of macular retina and determine which retinal layers are most affected by retrochiasmal visual pathways lesions. Methods Mean retinal thickness utilizing automated intraretinal layer segmentation of spectral domain optical coherence tomography scans was performed in 40 eyes of 40 patients with retrochiasmal visual...

Purpose To present a comparison of the thickness variation of the different retinal layers in diabetic patients without diabetic retinopathy. Methods A prospective observational study was performed. 175 eyes of 175 patients: 125 diabetic patients without diabetic retinopathy and 50 subjects without diabetes (age and gender matched) from the ophtha...

Purpose To evaluate choroidal thickness ( CT ) in diabetic patients without diabetic retinopathy ( DR ) using enhanced depth imaging spectral‐domain optical coherence tomography ( EDI SD ‐ OCT ). To correlate CT with disease duration, systemic blood pressure ( BP ), glycemia, intraocular pressure ( IOP ) and ocular pulse amplitude ( OPA ). Methods...

Purpose To evaluate retinal layers thickness in diabetic patients without diabetic retinopathy ( DR ) using spectral‐domain optical coherence tomography ( SD ‐ OCT ). To correlate retinal layers thickness in diabetic patients with disease duration, systemic blood pressure ( BP ), glycemia, glycosylate haemoglobin (HbA1c), intraocular pressure ( IOP...

Purpose The choroidal circulation receives nearly 95% of ocular blood flow and it is essential for a normal retinal structure and function. Recently, several clinical studies showed a variation in choroidal thickness ( CT ) even before the presence of diabetic retinopathy ( DR ), which the meaning remains uncertain and questionable. Our objective w...

Purpose The choroidal circulation receives nearly 95% of ocular blood flow and it is essential for a normal retinal structure and function. Recently, several clinical studies showed a variation in choroidal thickness ( CT ) even before the presence of diabetic retinopathy ( DR ), which the meaning remains uncertain and questionable. Our objective w...

Purpose Diabetes Mellitus is associated with changes in refractive parameters. Some aspects already studied were the corneal biomechanics and lens thickness. Although, the discussion about anterior chamber angle and depth is still open. The author objective was to analyze and correlate the anterior chamber depth, lens vault and lens thickness with...

Purpose Diabetes Mellitus is associated with changes in refractive parameters. Some aspects already studied were the corneal biomechanics and lens thickness. Although, the discussion about anterior chamber angle and depth is still open. The author objective was to analyze and correlate the anterior chamber depth, lens vault and lens thickness with...

Purpose Historically, is made the distinction between optic neuropathies and macular diseases. Although, in our practical experience we believe that optic nerve ( ON ) damage, such as nerve edema or atrophy, at certain point will affect the macula. We have analyzed the scientific/structural impact of this clinical impression. The authors studied th...

Purpose: To present a comparison of the thickness variation of the different retinal layers in diabetic patients without diabetic retinopathy. Methods: A prospective observational study was performed. 175 eyes of 175 patients: 125 diabetic patients without diabetic retinopathy and 50 subjects without diabetes (age and gender matched) from the ophth...

Purpose: To present a retrospective study of the postoperative astigmatism in patients with DSAEK with a determination of anterior and posterior corneal astigmatism. Setting: Centro Hospitalar Lisboa Central, Lisbon, Portugal Methods: A retrospective study of corneal astigmatism in 30 patients with Fuchs Dystrophy submitted to DSAEK was performed...

Purpose: The authors intend to present an analysis and comparison of the choroidal thickness in more distant superior regions. Choroidal thickness is increased in a heterogeneous pattern superiorly to the fovea in diabetic patients without diabetic retinopathy. Methods: Observational case-control study of 60 eyes of 60 patients with diabetes mellit...

Purpose: The authors present a case-report of a patient with a high voltage electrical burn with cataract formation. Setting: Centro Hospitalar Lisboa Central, Lisbon, Portugal Methods: A 59 years old male patient was referred to the Ophthalmology outpatient clinic with presbyopia complaints. He had suffered a high-voltage electrical burn 15 years...

Purpose: The authors aim to present a clinical case of a patient with macular telangiectasia type 2. Method: The patient was treated bilaterally with intravitreal bevacizumab after progression to proliferation. The patient was initially screened at the retina department for diminished visual acuity and suspicion of central serous coroidopathy. At...

Purpose: To evaluate the thickness of macular retina and determine which retinal layers are most affected by retrochiasmal visual pathways lesions. Methods: Mean retinal thickness utilizing automated intraretinal layer segmentation of spectral domain optical coherence tomography scans was performed in 40 eyes of 40 patients with retrochiasmal visua...

Purpose: The authors present a comparative study of corneal sensitivity in patients with diabetes mellitus type 2. Methods: Transverse observational study of 40 eyes of 40 diabetic patients. Corneal sensitivity was measured by esthesiometry using a handheld esthesiometer (Cochet-Bonnet). The measurements were performed in 4 quadrants: superior, tem...

To analyze the retinal ganglion cell layer (RGL) by optical coherence tomography (OCT) in toxic and nutritional optic neuropathy and to correlate its thickness and volume with functional damage. We conducted an observational cross-sectional study in healthy subjects and in patients with toxic optic neuropathy observed in the Neuro-Ophthalmology Dep...

Purpose: The authors describe a study of the corneal endothelium in patients with spontaneous IOL and capsular bag subluxation submitted to anterior chamber IOL implantation. Setting: Centro Hospitalar Lisboa Central, Lisbon, Portugal Methods: A retrospective study of 12 eyes of 10 patients. All the patients were operated by the same surgical tea...

Purpose: The authors present a case of a patient with anterior lens subluxation submitted to iris fixated AC IOL implantation after trauma with eyeglasses. Setting: Centro Hospitalar Lisboa Central, Lisbon, Portugal Methods: A 40 years old patient who suffered a penetrating corneoscleral eye injury that was initially sutured developed a traumatic...

Purpose: The authors present a case report of toric IOL and capsular bag tension ring implantation in a patient with zonular dehiscence. Setting: Centro Hospitalar Lisboa Central, Lisbon, Portugal Methods: A 72 years old patient with zonular dehiscence was submitted to phacoemulsification and a capsular bag tension ring (InjectoRing®, AMO) was im...

Introduction: To present an analysis of the automated macular ganglion cell complex measurements in patients with glaucoma and a comparison with structural optic disc evaluations performed by OCT and confocal microscopy (HRT). A comparison of the functional damage with structural evaluation was performed. Methods or Study Design: Retrospective stud...

Multifocal intraocular lenses (MF IOLs) have concentric optical zones with different dioptric power, enabling patients to have good visual acuity at multiple focal points. However, several optical limitations have been attributed to this particular design. The purpose of this study is to access the effect of MF IOLs design on the accuracy of retina...

Introduction: Optical disc drusen are congenital developmental anomalies of the optic nerve head, corresponding to calcified hyaline deposits, located anteriorly to the lamina cribrosa. Patients are usually asymptomatic and the diagnosis is mostly accidental. Methods: The authors present 5 cases of patients aged between 6 and 12 years referred to P...

Purpose: The compression of the optic chiasm by lesions such as pituitary adenoma can compromise visual function. The relationship between functional and structural measurements is extremely important in the management of diseases of the anterior visual pathways. The authors present an analysis of the retinal nerve fiber layer measurements and visu...

Purpose: The authors present a study of the indications, visual outcomes and complications of 57 eyes of 51 patients submitted to Descemet Stripping Automated Endothelial Keratoplasty. Introduction: The surgical treatment of endothelial disease is now mainly performed with Endotelial Keratoplasty. Fuchs endothelial dystrophy and pseudophakic bullou...

Purpose To evaluate the clinical presentation, microbiological results and treatment used in cases of infectious keratitis diagnosed in Centro Hospitalar Lisboa Central (CHLC) between July 2009 and July 2013 Methods Retrospective analysis of data from patients who underwent microbiological examination for suspected infectious keratitis between July...

Purpose To evaluate the differences between the thickness of the separate quadrants at the peripapillary RNFL, thickness and volume of the macula and choroidal thickness in Alzheimer disease ( AD) patients compared with a control group. Methods Transversal case control study in 50 eyes of AD patients and 150 eyes of heathy subjects, measuring the t...

Purpose The authors present an analysis of the automated macular ganglion cell complex measurements in patients with compressive chasmal lesions. Methods Observational study of 20 eyes of 20 patients with compressive chiasmal lesions followed at the neurophthalmology outpatient clinic. Optical Coherence Tomography (OCT SPECTRALIS® ‐ Heidelberg Engi...

Purpose To analyze the ganglion cell complex (GCC) by optical coherence tomography (OCT) in Parkinson´s disease and to correlate it with disease´s severity and duration. Methods We conducted a prospective, case‐control study, in healthy subjects and in patients with Parkinson´s disease (PD). Full ophthalmologic examination, OCT (Spectralis ®) and n...

Purpose: The authors present an analysis of subsequent surgical procedures performed and outcomes in patients with keratoconus following intracorneal ring segment insertion. Setting: Department of Ophthalmology - Centro Hospitalar Lisboa Central - Lisbon, Portugal Methods: A retrospective study of 422 eyes (326 patients) with keratoconus submitted...

Purpose: To compare the visual outcomes, disease progression, comorbidities and treatment efficacy in Toxoplasma uveitis between HIV-positive and non-infected patients. Setting: Department of Ophthalmology, Centro Hospitalar Lisboa Central, Lisbon, Portugal. Methods: The authors present a retrospective study of 14 eyes of 11 patients with Toxoplasm...

Purpose: The authors present an analysis of the indications, outcomes and complications of amniotic membrane transplantation in patients with ocular surface disease. Setting/Venue: Department of Ophthalmology - Centro Hospitalar Lisboa Central - Lisbon, Portugal. Methods: A retrospective study of 44 eyes of 42 patients with ocular surface disease s...

Purpose: The authors present a comparison between intraocular pressure (IOP) measurements with dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) after corneal ring segment implantation in patients with keratoconus. Setting/Venue: Department of Ophthalmology - Centro Hospitalar Lisboa Central - Lisbon, Portugal. Methods: A tra...

Purpose: To compare structural optic disc evaluations performed by optic coherence tomography (OCT) and confocal microscopy (HRT). Structural evaluations were also compared to functional damage using static perimetry (SP). Methods: The authors present a retrospective study of 90 patients with glaucoma. Structural evaluation was performed with OCT...

Nonarteritic anterior ischemic optic neuropathy (NA-AION) is the most common nonglaucomatous optic neuropathy in adults over 50 years of age. It is usually related to cardiovascular risk factors. The primary objective of this study was to evaluate choroidal thickness in patients with chronic NA-AION, and the secondary objective was to evaluate macu...

Purpose: To evaluate the clinical outcomes of patients with suprachoroidal drainage devices. Methods: The authors describe 4 cases of patients presenting with preoperative intraocular pressures (IOP) between 30-40 mmHg, under triple glaucoma medication and history of multiple intraocular surgeries, who underwent suprachoroidal drainage device (Star...

Objective/Purpose: The authors present a retrospective study of 30 eyes of 26 patients with Fuchs dystrophy treated with Descemet Stripping Automated Endothelial Keratoplasty and compare its association with cataract surgery. Fuchs dystrophy is a hereditary endothelial disease characterized by a progressive loss of endothelial cells that leads to p...

Objective/Purpose: To report two different cases of Terrien’s marginal corneal degeneration. This is a rare corneal degeneration characterized by peripheral corneal ectasia. The chronic progressive thinning of the periphery occurs with vascularization and lipid deposition. It can be unilateral or bilateral and has no gender preference. As it progre...

Purpose: To present two patients with a sudden unexplained decrease in central corneal thickness. Materials/Patients: The patients were 30 and 33 years old and were referred to the outpatient clinic for Laser-Assisted in Situ Keratomileusis (LASIK). Methods: Visual acuity (VA) and pachymetry (central corneal thickness - CCT) were recorded throughou...

Purpose: To compare intraocular pressure (IOP) measurements with dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) after Descemet’s stripping automated keratoplasty (DSAEK). Setting: Department of Ophthalmology - Centro Hospitalar Lisboa Central - Lisbon, Portugal Methods: Transverse observational study of 22 eyes of 19 pat...

Purpose: To present the surgical management with anterior chamber IOLs of 10 patients with spontaneous IOL and capsular bag subluxation. Introduction: Spontaneous subluxation of the IOL and capsular bag complex after cataract surgery is a recurrent serious but rare complication. Pseudoexfoliation has been associated with this complication. Neverthe...

Purpose: To present a retrospective study of 51 eyes of 47 patients submitted to Descemet Stripping Automated Endothelial Keratoplasty. Introduction: Endotelial keratoplasty is the preferred surgical approach when treating endothelial disease. There are various indications for DSAEK. The most common indication for DSAEK is pseudophakic bullous kera...

Purpose: To present a clinical case of a patient with a corneal ulcer and descemetocele treated with amniotic membrane transplantation. The procedure has been described has an adjunctive or alternative therapy in ocular surface disorders. This is especially relevant in non-healing corneal lesions as there is an increased risk of perforation. Settin...

Purpose: We report a case of scleromalacia after keratoplasty. Scleromalacia is a rare and severe condition. It can occur after surgical procedures, trauma, chronic eye inflammation and several systemic diseases such as Rheumatoid Arthritis and Wegener Granulomatosis. The treatment is mainly surgical with tissue reinforcement. Different surgical pro...

Purpose: To present a clinical case of a patient submitted to limbal stem cell transplant in the surgical treatment of pterygium. Setting/Venue: Pterygium is a degenerative growing of conjunctival tissue from the limbal region towards the cornea. Its incidence is influenced by geography and is higher in tropical climates. The pathogenesis can be ex...