
Andre SchmidtUniversitätsklinikum Jena · Department of Obstetrics
Andre Schmidt
Dr. rer. nat.
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51
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Publications (51)
https://proceedings.altex.org/data/2022-02/Altex_2022_%20Linz.pdf,
poster 204
Recent trends in 3D cell culturing has placed organotypic tissue models at another level. Now, not only is the microenvironment at the cynosure of this research, but rather, microscopic geometrical parameters are also decisive for mimicking a tissue model. Over the years, technologies such as micromachining, 3D printing, and hydrogels are making th...
Species differences are among the main reasons for the high failure rate of preclinical studies. A better awareness and understanding of these differences might help to improve the outcome of preclinical research. In reproduction, the placenta is the central organ regulating fetal exposure to a substance circulating in the maternal organism. Exact...
Throughout history, pandemics of infectious diseases caused by emerging viruses have spread worldwide. Evidence from previous outbreaks demonstrated that pregnant women are at high risk of contracting the diseases and suffering from adverse outcomes. However, while some viruses can cause major health complications for the mother and her fetus, othe...
Background:
Breast cancer is one of the most frequently diagnosed malignancies during pregnancy. Tumours often present characteristics of high malignancy and are hormone receptor negative/HER2 positive or triple negative. In general, pregnancy, including the postpartum period, is associated with a transiently increased risk of developing breast ca...
The current Zika virus (ZIKV) outbreak is associated with neurological malformations and disorders in neonates. Areas of increased incidence of malformations may overlap with dengue-hyperendemic areas. ZIKV infection is enhanced by antibodies against dengue virus (DENV) in cell culture and inbred mice. Sufficiently powered clinical studies or prima...
The proteomic analysis of complex body fluids by liquid chromatography tandem mass spectrometry (LC‐MS/MS) analysis requires the selection of suitable sample preparation techniques and optimal parameter settings in data analysis software packages to obtain reliable results. Proteomic analysis of follicular fluid, as a representative of a complex bo...
Background:
The use of fetal bovine serum (FBS) as growth supplement for human cell and tissue culture is widely spread in basic research as well as in clinical approaches, although several limitations must be considered, such as unstable composition and availability, biosafety and ethical aspects. Regarding interspecies differences, xenogeneic gr...
Breast cancer during pregnancy (BCP), although rare, is increasing, and treatment should be as similar as possible to that for non-pregnant young breast cancer patients. A group of specialists convened to review current guidelines and provide guidance on how recent advances in breast cancer diagnosis and treatment can be adapted for pregnant patien...
Analysis of Extracellular Vesicle Release and Composition after Treatment of Trophoblastic Cell Lines with Heavy Metals
Plazenta-Explantate als Modell für toxikologische Analysen
Multicellular tumor spheroids are widely used models in tumor research. Because of their three dimensional organization they can simulate avascular tumor areas comprising proliferative and necrotic cells. Nonetheless, protocols for spheroid generation are still inconsistent. Therefore, in this study the breast cancer cell lines MCF-7, MDA-MB-231 an...
Toxikologische Analysen an plazentarem Gewebe: Der Einfluss von Chemotherapeutika auf Trophoblastzellen
Effects of therapeutic drugs on human placenta explant cultures
Characterisation of six commonly used trophoblastic and trophoblast derived cell lines
The influence of placenta-conditioned medium on breast cancer cells
Cytotoxicity and inhibitory effects of chemotherapy on cervical cancer and trophoblast cells cultured in 2D or 3D
Human serum – an alternative growth supplement for cell culture?
Human serum – An alternative growth supplement for cell culture?
Toxicological testing on placenta-derived cells cultured as monolayer, multicellular spheroids or ex vivo explants
The influence of placenta-conditioned medium on breast cancer cells
Toxicological testing on placenta-derived cells cultured as monolayer, multicellular spheroids or ex vivo explants
Cytotoxicity and inhibitory effects of chemotherapy on cervical cancer and trophoblast cells cultured in 2D or 3D
Auswirkungen von Chemotherapeutika auf die Plazenta
Evaluation of cytotoxicity and inhibitory effects of cervical cancer treatment in 2D and 3D cell culture models
The placenta in toxicology: Observed effects of breast cancer treatment
Influence of human and fetal calf serum on spheroid formation with SiHa and SW756 cervix carcinoma cells
Breast cancer during pregnancy (BCP), although rare, is becoming more common and treatment should be as similar as possible to that for nonpregnant young patients with breast cancer. A group of specialists convened to review current guidelines and provide guidance on how recent advances in breast cancer diagnosis and treatment can be adapted for pr...
Pregnancy associated microRNA clusters
The placenta is one of the organs with the highest evolutionary diversity among animal species. In consequence, an animal model that reflects human placentation exactly does not exist. However, the mouse is the most frequently used animal model for placenta and pregnancy research. It possesses a hemochorial placenta, which is similar, but also diff...
Only humans have human placentas
MicroRNAs (miRNAs) regulate the expression of a large number of genes in plants and animals. Placental miRNAs appeared late in evolution and can be found only in mammals. Nevertheless, these miRNAs are constantly under evolutionary pressure. As a consequence, miRNA sequences and their mRNA targets may differ between species, and some miRNAs can onl...
Every organism can be characterized by the amino acid composition of its proteome. So far it was assumed that these compositions are determined by the GC content of the DNA or, in some cases, by extreme lifestyles, like thermophily or halophily. Here, we focussed our analysis on eight amino acids, each of which is encoded by both, GC and AT rich co...
Metallothioneins and metallohistins are short peptides with a high cysteine and/or histidine content able to coordinate metals intracellularly, thereby increasing the tolerance against elevated concentrations of metals. Because of their features, they can be detected by in silico prediction from proteomes annotated from sequenced genomes. Here, we...
The responses of microorganisms to heavy metal stress involve both extracellular and intracellular mechanisms. In contaminated
soils, streptomycetes are an important group with a particularly versatile secondary metabolism. The roles of extracellular
and intracellular mechanisms for heavy metal retention in growth at contaminated sites were investi...
The psychrotolerant bacterium Shewanella sp. G5 was used to study differential protein expression on glucose and cellobiose as carbon sources in cold-adapted conditions. This strain was able to growth at 4 °C, but reached the maximal specific growth rate at 37 °C, exhibiting similar growing rates values with glucose (μ: 0.4 h−1) and cellobiose (μ:...
Contamination of large areas by industrial or mining activities is a serious environmental problem. Selection pressure in these polluted habitats led to adaptation in microorganisms now containing special resistance mechanisms as a result to the permanent exposure to exceedingly high concentrations of heavy metals. Banks of a creek in a former uran...
Contamination of large areas by industrial or mining activities is a serious environmental problem. Selection pressure in these polluted habitats led to adaptation in microorganisms now containing special resistance mechanisms as a result to the permanent exposure to exceedingly high concentrations of heavy metals. Banks of a creek in a former uran...
Superoxide dismutases are essential enzymes involved in detoxification of reactive oxygen by dismutation of the superoxide radical anion. A class of nickel containing superoxide dismutases has been described for streptomycetes and cyanobacteria. In silico analysis was used to study the distribution of genes coding for NiSOD in other taxa and to elu...
Unlike synthetic metal chelators, microbe-assisted phytoremediation provides plants with natural metal-solubilizing chelators which do not constitute a potential source of environmental pollution. Concurrently with microbial chelators, plant growth promotion can be enhanced through bacterially-produced phytohormones. In this work, the simultaneous...
Industrial or mining activities can cause serious environmental problems by the contamination of large areas. In these polluted habitats selection pressure have led to adaptation in microorganisms now containing special resistance mechanisms as a result of the permanent exposure to exceedingly high concentrations of heavy metals. Recently van Nostr...
Heavy metal tolerant and resistant strains of streptomycetes isolated from a former uranium mining site were screened for their superoxide dismutase expression. From the strains tolerating high concentrations of different heavy metals, one was selected for its tolerance of concentrations of heavy metals (Ni, Cu, Cd, Cr, Mn, Zn, Fe). This strain, St...
A site in the former uranium mining area of Eastern Thuringia near Ronneburg was investigated with regard to effects of acid mine drainage (AMD) on reactive transport and bioattenuation. Processes involved in this attenuation might include physico-chemical reactions in reactive transport as well as activities of microorganisms for bioattenuation. I...