André Rolim Baby

University of São Paulo | USP · Department of Pharmacy

The heightened susceptibility to skin cancer correlates with exposure to ultraviolet (UV) radiation, which can induce various cutaneous injuries. Inorganic UV filters, like zinc oxide (ZnO), are extensively utilized in sunscreens owing to their capacity to scatter and reflect UV radiation. The efficacy of inorganic UV filters can be augmented acros...

ChatGPT has emerged as a promising tool for enhancing clinical practice. However, its implementation raises critical questions about its impact on this field. In this scoping review, we explored the utility of ChatGPT in pharmacy practice. A search was conducted in five databases up to 23 May 2024. Studies analyzing the use of ChatGPT with direct o...

Recently, microalgal biotechnology has attained great acceptance among various researchers and industries for the green and sustainable production of different bioactive compounds. They provide multiple metabolites and molecules, making them an ideal candidate for cosmetic formulators and cosmeceutical companies. Nevertheless, numerous microalgae s...

Rutin, a flavonoid found in various plants, has gained attention for its potential applications in the cosmetic industry due to its antioxidant, anti-inflammatory, and potential photoprotective properties. Our review explored the use of rutin (rutoside, 3-O-rutinoside-quercetin) in cosmetics/dermocosmetics, focusing on its physicochemical propertie...

Different reaction control methods for producing nano/microstructures of poly(butyl cyanoacrylate) (PBCA) have been studied, focusing on pH and monomer-to-initiator ratios. However, these methods often require multiple steps and reagents. In the synthesis of PBCA microparticles using three versions of micromixers designed with HH geometry and varyi...

Rutin, a flavonoid compound found in various plants, has gained attention for its potential applications in the cosmetic industry due to its antioxidant, anti-inflammatory, and potential photoprotective properties. Our review explored the use of rutin (rutoside, 3-O-rutinoside-quercetin) in cosmetics/dermocosmetics, focusing on its physicochemical...

Given the burgeoning global market for deodorant products, it is paramount to develop novel, safe, and efficacious molecules that align with the cosmetic industry’s trend toward active compounds sourced from natural, sustainable, and renewable sources. In this context, we in vitro and in vivo investigated the deodorant potential of xylityl sesquica...

The integumentary system, a vital organ, constitutes a multifaceted barrier against pathogens and environmental factors, crucial for maintaining homeostasis. Intrinsic and extrinsic factors can accelerate skin aging and compromise its homeostatic functions and solar rays, particularly ultraviolet (UV) radiation, pose a significant risk for skin can...

Sustainable ingredients in cosmetics have been discussed for the past decade, and the COVID-19 pandemic has increased awareness of this significant topic. Consumers are informed and vigilant about clean labels, driving the necessity for sustainability throughout the cosmetic production chain. Moreover, nanotechnology and green chemistry approaches...

Skin is the ultimate barrier between body and environment and prevents water loss and penetration of pathogens and toxins. Internal and external stressors, such as ultraviolet radiation (UVR), can damage skin integrity and lead to disorders. Therefore, skin health and skin ageing are important concerns and increased research from cosmetic and pharm...

The use of clays in beauty care comes from ancient times, with therapeutic use since prehistory, and it is considerably relevant in the current cosmetic industry worldwide. In our review, we described types of clay and clay minerals used in cosmetics and dermocosmetics, compositions, usages as active compounds and cosmetic ingredients/starting mate...

The use of clays in beauty care comes from ancient times, with therapeutic use since prehistory, and it is considerably relevant in the current cosmetic industry worldwide. In our review, we described types of clay and clay minerals used in cosmetics and dermocosmetics, compositions, usages as active compounds and excipients, and observations about...

Oral candidiasis is an opportunistic infection usually related to predisposing factors. Oral manifestations in patients affected by COVID-19 have been reported, as the oral mucosa is the gateway to this viral infection. Xerostomia, as well as other oral symptoms, are predisposing factors for the emergence of oral candidiasis after the COVID-19 pand...

The biomass of vinification results in up to 20% by-products (seeds, skins, pulp, and/or stems) that can be used in the production of diverse functional food, nutraceutical, pharmaceutical, and cosmetic ingredients, mainly due to their high polyphenol content. Conventional polyphenol extraction techniques are based on the use of solvents that are h...

Objective: Nowadays, it is recognized the need for improved safety and efficacy protocols to evaluate the human stratum corneum (SC) and its interaction with topical and cosmetic formulations by minimally or non-invasive methodologies. The aim of our research work was to streamline the HPLC-TBARS-EVSC (high performance liquid chromatography - thio...

Natural moisturizing factor (NMF) includes several compounds in the stratum corneum (SC), among them, urocanic acid (UCA). Ultraviolet (UV) exposure turns the trans-UCA of the SC into its cis isomer. We investigated the impact of a topical emollient emulsion treatment on the UCA isomers of the SC exposed to artificial UV stress. Aliquots of emollie...

Titanium dioxide (TiO2) is a safe inorganic ultraviolet (UV) filter with activity against UV damage. However, the recombination of the carrier’s charge and the tendency for TiO2 aggregation are the main disadvantages. Substrate supports, such as mesoporous silica, are biocompatible strategies to incorporate TiO2, altering its interaction with the s...

Innovative prototype sunscreens with reduced ultraviolet (UV) filters are required to achieve safer, more effective, and more environmentally friendly formulations. Rosmarinic acid (RA) is a phenolic antioxidant and potential candidate for multifunctional sunscreens. We used RA (0.1% w/w) in combination with avobenzone (2.5% and 5.0% w/w), a UVA fi...

Sunscreens are currently considered cosmetic assets and their use has considerably increased since consumers have become greatly aware of the damages induced by ultraviolet (UV) radiation on the skin, such as premature aging and cancer. However, concerns have arisen over the percutaneous absorption of UV filters. In order to ensure both efficacy an...

As diseases caused by solar radiation have gained great prominence, several methods to prevent them have been developed. Among the most common, the use of sunscreens is customary and accessible. The application of theoretical methods has helped to design new compounds with therapeutic and protective functions. Natural compounds with described photo...

We investigated plausible reuse for the dermocosmetic industry of byproducts from the winemaking process of red grapes (Vitis vinifera L. cv. C. Sauvignon) through the evaluation of one extract (grape pomace extract, GPE) and two fractions (one chloroform, GPE-CHF; one ethyl acetate, GPE-EAF). The samples were characterized analytically by liquid c...

For dental caries and periodontal diseases initiated by dental plaque (as bacterial communities) and to inhibit the growth of oral pathogenic bacteria, oral care products containing antiseptic active ingredients are highly recommended, nonetheless, side effects of such actives are a concern (teeth discoloration/staining and taste perception, for ex...

The skin acts as a protective barrier, guarding the body against microorganisms, chemicals, and several environmental factors. Accordingly, this all-important organ must be kept healthy to maintain its optimal functionality. One approach to maintain skin health is the application of multifunction bioactive sunscreens containing antioxidant molecule...

This paper provides a review of the literature on the use of Pluronic® triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic® tribl...

Background: Glyoxylic acid has emerged as a safe alternative to formol (formaldehyde) use as a hair straightener/relaxer. However, the possible damage to the hair fiber after its application is low known and/or published in the literature. Aims: This work aims to characterize hair locks treated with glyoxylic acid compared to traditional alkalin...

The skin acts as a protective barrier, guarding the body against microorganisms, chemicals, and several environmental factors. Accordingly, this all-important organ must be kept healthy to maintain its optimal functionality. One approach to maintain skin health is the application of multifunction bioactive sunscreens containing antioxidant molecule...

Azadirachta indica (Neem) is a large tree that is native to India and is traditionally used due to its several properties, mainly to treat skin diseases, as well as its “herbicidal” activity. Its bark, leaves, seeds, fruits and flowers are widely used in medicinal treatment due to the presence of active secondary metabolites with biological effects...

There is an increasingly growing demand for the use of natural and sustainable bioactives in the field of the pharmaceutical and cosmetic industries. The biomass from black soldier fly larvae (Hermetia illucens) can be viewed as an innovative source of compounds with high aggregate value and marketing potential due to the sustainable organic matter...

Objective: Propolis has been used since antiquity, but recent reports of its biological properties hint that it could be employed as a topical pharmaceutical and cosmetic ingredient. This work aims to probe the action of Portuguese propolis extracts on skin cells, providing mechanistic insights into its mode of action and preliminarily assessing i...

Skin health is not only significantly affected by ageing, but also by other lifestyle-related factors, such as sun exposure, exercise and eating habits, smoking or alcohol intake. It is known that the cutaneous tissue can exhibit visible signs of senescence, in the form of, for example, dull complexion, loss of firmness, or changes in pigmentation....

Progressively growing diagnoses of skin cancer trigger public health concerns about excessive sun exposure, awareness of the deleterious effects of ultraviolet (UV) radiation on the skin, and the proper use of sunscreens. Studies show that bioactive molecules, such as rosmarinic acid (RA), may potentiate the photoprotective and antioxidant activity...

From tilapia (Oreochromis niloticus) farming, the by-products have been identified as a source of collagen that could be used for the development of dermocosmetics or pharmaceutical products. However, the characteristics of collagen related to a specific strain or culture must be well defined prior to its application. Collagen was extracted from th...

Objective The harmful effects induced by ultraviolet exposition and the significant increment in skin cancer diagnosis confirm the necessity to develop effective and safe sunscreens. Limited efficacy and cutaneous adverse reactions of traditional formulations drove the incorporation of natural extracts into multifunctional sunscreens. Vaccinium myr...

“Vegan” and “sustainable” characteristics are strong claim trends behind the development of innovative skincare, fragrances, and makeup products. This created a need in the market for compliant ingredients. To date, there have been no records evidencing the use of the microalgae Neochloris oleoabundans (NA) in dermocosmetics. Therefore, we studied...

Candelilla wax (CW) and 12-hydroxystearic acid (12HSA) are classic solid-fiber-matrix organogelators. Despite the high number of studies using those ingredients in oily systems, there is scarce literature using a mixture of oil and antioxidants. Vitamin E (VE) is an important candidate for its lipophilicity and several applications on pharmaceutica...

CBIOS is very glad to welcome you to the 1st edition of InnovDelivery. This international virtual meeting aims to explore the theme “Nature as inspiration for innovation in Health and Well-being”, bringing you the insights of leading researchers from the Lusophone world - Portugal and Brazil. The four scientific sessions will look into the future d...

Development and validation of a simple and fast method of high-performance liquid chromatography with diode array detection (HPLC-DAD) for the simultaneously analysis of rutin, avobenzone, and octyl p-methoxycinnamate is presented. These substances were separated using a Kromasil C18 (250×4.6 mm, 5 μm) column, methanol: water (88:12 v/v) as the mob...

Diet has a fundamental role in the homeostasis of bodily functions, including the skin, which, as an essential protective barrier, plays a crucial role in this balance. The skin and intestine appear to share a series of indirect metabolic pathways, in a dual relationship known as the “gut–skin axis”. Hence, the gut–skin axis might be receptive to m...

To promote broad-spectrum protection, the most sunscreen products combine two or more filters for UVA and UVB. The photoprotective efficacy may be affected by the instability of the chemical combination and it is possible to use natural photo-stabilizing substances with antioxidant activity, adding value to the formulation. This study aims to evalu...

In addition to dermatological complications, acne can affect the quality of life of individuals in numerous ways, such as employment, social habits and body dissatisfaction. According to our expertise, caprylic acid and propanediol would not have a direct action on Cutibacterium acnes. Despite this, we investigated the existence of a synergistic ef...

Innovative technologies have been designed to improve efficacy and safety of chemical UV filters. Encapsulation can enhance efficacy and reduce transdermal permeation and systemic exposure. The aims of this work were (i) to determine the cutaneous biodistribution of avobenzone (AVO), oxybenzone (OXY), and octyl methoxycinnamate (OMC) incorporated i...

The combination of butyl methoxydibenzoylmethane (BMBM) and octyl methoxycinnamate (EHMC) is widely used in pharmaceutical formulations but may exhibit alteration in spectral absorption following exposure to UV radiation. The addition of natural substances in sunscreen formulations has been explored regarding photoprotective efficacy. The main obje...

The topical application of enzymes for UV-induced damage repair, such as catalase, represents an interesting strategy for "active" photoprotection. However, catalase, a large and hydrophilic molecule, needs to penetrate the skin to present activity and, in this sense, nanocarriers can provide an aid for barrier crossing. Among the nanocarriers, pol...

Herbal extracts have been widely used in dermocosmetics as a source of biomolecules and also as a natural claim. Fruits from Caesalpinia spinosa show great potential for their polyphenolic content, preservative, and film-forming features, as previously reported in specialized literature; however, the toxicity requires investigation. We explored Ore...

Social distancing is conducive to grow the impact of artificial light in the daily life of the worldwide population with reported consequences to the skin. Sunlight is also essential for human development, indeed, solar radiation is composed of different types of wavelengths, which generate different skin effects. It can be divided into ultraviolet...

Obtaining new cosmetic ingredients, mainly from sustainable sources, as novel excipients or even active compounds is noteworthy for the cosmetic industry to enhance new innovative dermocosmetics. Thus, it is essential to establish the safety of these new ingredients to avoid adverse events, mainly those associated with clastogenic effects from the...

Objective: A method is presented for integrating the mind mapping methodology into Pharmacy course classes. An evaluation was made of the students’ performance and their perception of achievement of significant learning. Method: Weekly reviews and group assignments using mind maps were carried out on a Small-Scale Drug Formulation class concerning...

Carotenoids and coenzyme Q10 are naturally occurring antioxidant compounds that are also found in human skin. These bioactive compounds have been the focus of considerable researches due to their antioxidant, anti-inflammatory and photoprotective properties. In this review, the current state of the art in the encapsulation of carotenoids and coenzy...

Vitamins are part of the antioxidant system of human skin, and are detectable in different layers, so the topical application can be an alternative to maintain the functionality of the system. The capacity of the antioxidant gradient of keratinocytes is associated with attenuation of the action of related free radicals in both esthetics and health....

Antioxidants of natural origin are used in medicines and cosmetics with several benefits, such as: photoprotective action, anti-aging, moisturizing and anti-pollutant. The human epidermis has an important barrier effect and limited anti-oxidative capacity, so studies with the epidermis is essential. Shed snakeskin (SS) is composed of the stratum co...

Considering the importance of the cutaneous tissue investigation and the need for the development of new protocols to non-invasively establish the safety and efficacy of dermocosmetics and topical products, we aimed at developing an HPLC-TBARS-EVSC (high performance liquid chromatography–thiobarbituric acid reactive species–ex vivo stratum corneum)...

Bigels have been studied as topical formulations for its benefits over sensory and drug delivery parameters. However, there is still few evidences about the properties of the combination of organogelators, oily phases and bioactive molecules into rheological and stability behavior. We investigated the use of classical organogelators (candelilla wax...

Background Unprotected chronic exposure to ultraviolet (UV) radiation generates many harmful effects to human skin and sunscreens are essential to health, however, traditional products do not provide enough protection against cutaneous oxidative stress, a process amplified by UV radiation. Therefore, the development of multifunctional photoprotecti...

This chapter highlights researches about the use of marine structures in the cosmetic area. In the last years, products containing algae compounds have been used to repair damages in both skin and hair. Algae species with wide distribution and valuable chemical composition have high potential as natural sources of biologically active ingredients. T...

Obtaining new cosmetic ingredients, mainly from sustainable sources, as novel excipients or even active compounds is noteworthy for the cosmetic industry to enhance new innovative dermocosmetics. Thus, it is essential to establish the safety of these new ingredients to avoid adverse events, mainly those associated with clastogenic effects from the...

Among photosynthetic microorganisms, Cyanobacteria and Microalgae species have been highly studied thank to their high value-added compounds for several industrial applications. Thus, their production is increasing in the last decade to produce raw material for cosmetics. In fact, the daily routine includes the use of cosmetics and sunscreens to pr...

In winemaking, a large amount of grape pomace is produced that is rich in polyphenolics and highly beneficial for human health, as phenols are useful for skin ultraviolet (UV) protection. In this investigation, we evaluated the safety and clinical efficacy of a sunscreen system containing a grape pomace extract from Vitis vinifera L. as a bioactive...

Urocanic acid is a chromophore found in the skin that has been identified as an important immunosuppressant and carcinogenesis mediator through its photoisomerization from trans to cis form induced by ultraviolet radiation. Research on analytical methods that explore urocanic acid isomerization is indispensable to fully understand the deleterious e...

Photosynthetic microorganisms convert carbon dioxide and solar radiation into interesting bioactive compounds not yet entirely explored. Several species of microalgae are known to be rich in colored high-valuable components that, although remarkable, are poorly explored as natural sources of pigments for cosmetics. Pigments associated to photosynth...

The cosmetic industry is continually searching for innovative ingredients, and there is a current trend in sourcing materials of natural origin. The Hermetia illucens (Linnaeus) larvae biomass is a potential source of compounds with applicability in cosmetics due to its high lipid, protein, and polysaccharide content. High concentrations of lauric...