Andras Szasz

Hungarian University of Agriculture and Life Sciences | szie · Department of Biotechnics

Background: Modulated electro-hyperthermia (mEHT) is unique due to its combination of thermal and non-thermal effects. Method: This report summarizes the literature on the effects of mEHT observed in vitro and in vivo. Results: The thermal and electrical heterogeneity of tissues allows the radiofrequency signal to selectively target malignant tissu...

Peto’s paradox and the epidemiologic observation of the average six degrees of tumor prevalence are studied and hypothetically solved. A simple consideration, Petho’s paradox challenges our intuitive understanding of cancer risk and prevalence. Our simple consideration is that the more a cell divides, the higher the chance of acquiring cancerous mu...

[This corrects the article DOI: 10.3389/fimmu.2020.556335.].

Despite the long history of human treatments with the electromagnetic field, the topic has numerous unclear processes. Especially only a few investigations are devoted to the immune effects of the bioelectromagnetic interactions. Our recent review collects proven pieces of evidence of the immune-supportive activity of modulated electromagnetic fiel...

The role of Heat Shock Proteins (HSPs) is a “double-edged sword” with regards to tumors. The location and interactions of HSPs determine their pro- or antitumor activity. The present review includes an overview of the relevant functions of HSPs, which could improve their antitumor activity. Promoting the antitumor processes could assist in the loca...

Simple Summary This review shows the advantages of heterogeneous heating of selected malignant cells in harmonic synergy with radiotherapy. The main clinical achievement of this complementary therapy is its extreme safety and minimal adverse effects. Combining the two methods opens a bright perspective, transforming the local radiotherapy to the an...

The COVID-19 pandemic has experienced unprecedented limitations and extraordinary scientific efforts to address this exceptional situation. Despite blanket closures that have resulted in significant financial constraints and losses around the world, research has an “unlimited” budget, with an exceptional concentration of medical and scientific care...

Introduction Right now, we are facing a global pandemic caused by the coronavirus SARS-CoV-2 that causes the highly contagious human disease COVID-19. The number of COVID-19 cases is increasing at an alarming rate, more and more people suffer from it, and the death toll is on the rise since December 2019, when COVID-19 has presumably appeared. We n...

Hyperthermia treatment for solid tumors is a long-used, but poorly accepted method in clinical use. Modulated electro-hyperthermia (mEHT, trade name: oncothermia®) changes the paradigm, introduces a novel, cellularly selective and immunogenic cell-ruination. The mEHT method produces tumor-vaccination, presenting the unharmed genetic information of...

Lifetime analyses frequently apply a parametric functional description from measured data of the Kaplan-Meier non-parametric estimate (KM) of the survival probability. The cumulative Weibull distribution function (WF) is the primary choice to parametrize the KM. but some others (e.g. Gompertz, logistic functions) are also widely applied. We show th...

Heating as a medical intervention in cancer treatment is an ancient approach, but effective deep heating techniques are lacking in modern practice. The use of electromagnetic interactions has enabled the development of more reliable local-regional hyperthermia (LRHT) techniques whole-body hyperthermia (WBH) techniques. Contrary to the relatively si...

We studied the homeostatic equilibrium of the healthy organism. The homeostasis is controlled by oppositely effective physiologic feedback signal-pairs in various time-scales. We show that the entropy of every signal in this state is identical and constant: SE=1.8. The controlling physiological signals fluctuate around their average values. The flu...

The next generation of oncological hyperthermia involves the medical innovation of selectively heating up the malignant cells of the body in a controlled way. The easily-distinguishable biophysical and physiological characteristics of cancer cells and their immediate environment are the focus of the targeted energy delivery of this treatment. This...

We formulate a direct generalization of the Prigogine’s principle of minimum entropy production, according to a new isoperimetric variation principle by classical non-equilibrium thermodynamics. We focus our attention on the possible mathematical forms of constitutive equations. Our results show that the Onsager’s reciprocity relations are conseque...

One of the most frequently applied bioelectromagnetic effects is the deep heating of living species with electromotive force energy. Despite its long history, hyperthermia is a rarely applied oncotherapy because of controversial results and complicated control. The challenge in clinical studies of oncological hyperthermia is the disharmony of the l...

Angiogenesis is one of the main supporting factors of tumor-progression. It is a complex set of interactions together with hypoxia and inflammation, regulating tumor growth. The objective of this study is to examine the effect of angiogenesis with an allometric approach applied to angiogenesis and the regulating factors. The results show that allom...

Dominant technical solution for oncological hyperthermia devices is capacitive-coupling. However, it has the challenge of overheating the surface of adipose layers and burning cutaneous structures. The main technical solution of this is the intensive cooling of the surface. Our objective is studying the physiology and effect of the active cooling o...

Aim of study: The aim of the study is to show the possible differences on the same temperature and treatment time as control parameter of the variety of local hyperthermia techniques, pointing the possible differences in the local and systemic actions. Materials and methods: Debate about the apparent locality of malignancy and the problems of th...

Objective: To investigate the anti-tumor activity and molecular mechanism of Tonglian Decoction (, TLD) on esophageal carcinoma Eca109 cells. Methods: Eca109 cells were treated with TLD and its separated formulae, including the clearing-heat and detoxification formula (Q), activating-blood and promoting-qi formula (H) and nourishing-yin and bloo...

We describe the Norwich-Wong generalization of the Weber-Fechner law in the framework of a complex, self-controlling, self-similar feedback mechanism to ensure the condition of “dendritic democracy”.

We describe the basic quantum-mechanical categories and properties of the thermodynamical basis of Onsager’s theorem. 3 basic principles are used: 1. energy dissipation; 2. Hamiltonian formalism; 3. Onsager’s linearity. We obtain the 2 characteristic values of the observables, their main-value and the deviation, the first and second momentums o...

Hyperthermia in oncology needs a definite dose which fixes well the clinical protocols. The temperature is far not a dose, it is mass independent. The half of the mass has the same temperature in equilibrium, so the basic criteria of the dose mass-dependence are lost. The energy could be a great option for dosing, (like it is in radiation therapies...

The effect of a modulated electromagnetic field on the cytoskeleton is possible through the action of voltage-sensitive phosphatase (VSP). Field-controlled phosphorous hydrolysis could have important roles in cytoskeleton restructuring, as well as in resonant-type behavior.

Our objective is to generalize the Weaver-Astumian (WA) and Kaune (KA) models of thermal noise limit to the case of cellular membrane resistivity asymmetry. The asymmetry of resistivity causes different effects in the two models. In the KA model, asymmetry decreases the characteristic field strength of the thermal limit over and increases it below...

Dissipation is essential for the evolution of a quantum-damped oscillator. It is responsible for the decay of quantum states, the broadening of the spectral line, and the shifting the resonance frequency. This has been a persistent challenge for a long time since dissipation causes difficulties in the quantization of the damped oscillator [1, 2, 3]...

A theoretical study of the polymerization process of a cytoskeleton by an outside electric field is presented. We describe the reaction kinetics of polymerization of the cytoskeleton by Einstein's approximation. The thermodynamic study of the equilibrium constant of the reaction kinetics shows the possibility of the reorganization of the cytoskelet...

Background The treatment of intratumoral dentritic cells (DCs) commonly fails because it cannot evoke immunity in a poor tumor microenvironment (TME). Modulated electro-hyperthermia (mEHT, trade-name: oncothermia) represents a significant technological advancement in the hyperthermia field, allowing the autofocusing of electromagnetic power on a ce...

Our objective is to show the weakness of the recent thermodynamics of chemical reactions. We show that such a thermodynamic theory of chemical reactions, which could be similar to the generalized Onsager's theory in thermodynamics, is not reality at the moment.

Hyperthermia has been a modality to treat cancer for thousands of years. During this time, intensive efforts are concentrated on determining the dose of the proper treatment, but the dominantly in vitro induced cellular death does not provide enough confidence for the clinical dosing. The cell-death by heat-monotherapy applications in laboratory ex...

There are intensive debates about the effects and mechanisms of radiofrequency (RF) hyperthermia in oncology. We theoretically modelled the mechanism of the nanoheating effect of the RF current at the cellular and subcellular level. Then, we experimentally investigated the mechanism of heating in comparison with selective modulated electrohyperther...

Our aim is to describe the physical and physiological effects of local modulated electro-hyperthermia (mEHT). Themethod concentrates on the energy absorption of cluster rafts of the plasma membrane. The targeted cluster containstransmembrane proteins, which can form coherent working voltage-gated ion channels and/or TRP receptors in onedomain. This...

Bioelectromagnetic and Subtle Energy Medicine focuses on a wide variety of evidence-based bioelectromagnetic and subtle energy therapies for disorders ranging from cancer, cardiomyopathy, and Parkinson's disease to depression, anxiety, and pain. Since publication of the first edition more than a decade ago, there have been so many advances in these...

Hyperthermia was the very first oncotherapy in human medicine. Despite its long history it has not achieved any breakthrough in clinical practices. The discovery of electromagnetism gave new hopes a century ago, however some controversies blocked its wide application. Oncothermia is a renewal, applying the synergy of the bioelectromagnetism with fr...

Despite the large economic and intellectual efforts, cancer is still not easily treatable disease by conventional therapies. This led ultimately to reconsider hyperthermia, like one of interesting treatment methods connected to immunity and tumor metabolism. Hyperthermia has also the ability to play an additional role when used together with the co...

Lung cancer is one of the most common malignant tumors, and it has the highest death rate. Oncothermia is a feasible and successful treatment for lung cancer. Results show a remarkable survival benefit for patients, with a good quality of life. The treatment has no, or in some cases mild, side-effects and could decrease the adverse effects of the c...

To face the challenges in hyperthermic oncology we have made research on nano-heating the malignant and healthy cells and this review paper shows our results which were presented at the largest OMICS Group Conference in the United States in 2013. We introduced nano-heating technology which means selecting and heating the membrane of the malignant c...

Phenomena of damped harmonic oscillator is important in the description of the elementary dissipative processes of linear responses in our physical world. Its classical description is clear and understood, however it is not so in the quantum physics, where it also has a basic role. Starting from the Rosen-Chambers restricted variation principle a H...

In "hypethermia", the procedure of raising the temperature of a part, or the whole body, up to 42 degrees C to kill cancer cells for a defined period of time is applied alone or as an adjunctive with various established cancer treatment modalities such as radiotherapy and chemotherapy. However, "hyperthermia" is not generally accepted as convention...

Hyperthermia method was “reborn” with the electromagnetic applications a century ago when deep heating became a realistic goal. The lack of its wide application is that the locally targeted volume has physiological consequences; the systemic control of the human body tries to compensate the active deviation from the homeostatic equilibrium. Clues f...

In order to provide a comprehensive insight into the indications under which patients are being treated with oncothermia we would like to present a few representative cases. Some of the cases are very new, some of them were treated over a 5-year period, used for follow-up cases and other possibilities. These old treatments are new results for the f...

Oncothermia has a long-time history with large number of documented case reports and clinical trials [1]. During more than 20 years 43 studies were performed involving more than 2000 patients all together from 14 clinics in 4 countries (see Table 1.) Details of the clinical effects is summarized in the publications as well as in the specialized mon...

Oncothermia is a highly personalized treatment modality. It is not a “gold standard” yet, but it is on the way to reach its position as a “fourth column” among the main oncotherapy modalities. It has wide-range applicability for every solid tumors in all possible localizations, irrespective its primary or metastatic form. It could be applied comple...

Non-small cell lung cancer (NSCLC) represents 85 % of all malignant lung cancers. In metastatic disease the principle goal of palliative therapy is to prolong survival with least toxicity and best patients' quality of life. Bevacizumab (BEV) has been approved as first line treatment in combination with platinum based chemotherapy and maintenance th...

Hyperthermia was the very first first oncotherapy in human medicine based directly on sacral and philosophical roots in ancient cultures. The discovery of electromagnetism gave new hopes a century ago, however until up to now it has been suffering from lack of wide applications. Oncological hyperthermia struggles with multiple technical and medical...

Radiotherapy has a relevant action on the tumor environment and its distant component. Abscopal effect is the bystander effect of radiotherapy observed at a site distant to the irradiated one within the same patient. Abscopal effect even though described, is not a common clinical event. We are reporting a documented observation of an abscopal effec...

Oncothermia (OTM) is an electro-hyperthermia modality, a long time (since 1989) applied method, [1], used successfully in human oncology [2]. OTM changes the paradigm of hyperthermia by targeted microscopic heat-liberation at the membrane of the malignant cells. This method creates inhomogeneous heating, and the microscopic temperature greatly diff...

Conventional hyperthermia is based on the local or systemic heating, which is measured by the realized temperature in the process. Oncothermia applies nano-heating, which means high energy absorption in nanoscopic range of the malignant cell-membrane selectively. This high temperature and its consequent stress create special effects: it evolves pos...