András SárközyUniversity of Pennsylvania | UP · Department of Microbiology (Medicine)
Doctor of Pharmacy
Postdoc at UPenn under Norbert Pardi supervision, focusing of the development and evaluation of mRNA-LNP vaccines.
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Citations since 2017
8 Research Items
Currently I'm a postdoc at UPenn under Norbert Pardi supervision, focusing of the development and evaluation of mRNA-LNP vaccines. Previously worked with separation techniques (TLC, Flash, HPLC,...) to separate pharmacologically active mushroom metabolites.
Combined vaccine formulations targeting not only hemagglutinin but also other influenza virus antigens could form the basis for a universal influenza virus vaccine that has the potential to elicit long-lasting, broadly cross-reactive immune responses. Lipid nanoparticle (LNP)-encapsulated messenger RNA (mRNA) vaccines can be utilized to efficiently...
Investigation of the methanol extract of the poroid fungus Fuscoporia torulosa resulted in the isolation of a novel triterpene, fuscoporic acid (1), together with inoscavin A and its previously undescribed Z isomer (2 and 3), 3,4-dihydroxy-benzaldehide (4), osmundacetone (5), senexdiolic acid (6), natalic acid (7), and ergosta-7,22-diene-3-one (8)....
Investigation of the methanol extract of the poroid fungus Fuscoporia torulosa resulted in the isolation of a novel triterpene, fuscoporic acid (1) together with inoscavin A and its previously undescribed Z isomer (2 and 3), 3,4-dihydroxy-benzaldehide (4), osmundacetone (5), senexdiolic acid (6), natalic acid (7), and ergosta-7,22-diene-3-one (8)....
The detailed chemical analysis of the methanol extract of Meripilus giganteus (Pers.) P. Karst. led to the isolation of two new cerebrosides, mericeramides A (1) and B (2) together with cerebroside B (3), ergosterol (4), 3β-hydroxyergosta-7,22-diene (5), cerevisterol (6), 3β-hydroxyergosta-6,8(14),22-triene (7), 3β-O-glucopyranosyl-5,8-epidioxyergo...
The chemical analysis of the methanol extract of Porodaedalea chrysoloma (Fr.) Fiasson & Niemelä afforded the isolation of five compounds (1-5). The first two are phenolic derivatives: methyl (E)-3-(4-methoxycarbonylphenoxy)-acrylate (1) is a new natural product, while methyl 3-(4-methoxycarbonylphenoxy)-propionate (2) was isolated from a natural s...
Cordyceps militaris and its close relative, Cordyceps sinesnis are well-known medicinal mushrooms in the oriental traditional medicine. Mostly due to its atypical, butterfly pulpa-parasitic lifestyle and rarity, it is considered as the key of longevity in China, Japan and Korea. C. sinensis is also native to Hungary. The aim of our work was the myc...
Twelve compounds (1–12) were isolated from the methanol extract of brick cap mushroom (Hypholoma lateritium (Schaeff.) P. Kumm.). The structures of the compounds were elucidated using extensive spectroscopic analyses, including NMR and MS measurements. Lanosta-7,9(11)-diene-12β,21α-epoxy-2α,3β,24β,25-tetraol (1) and 8-hydroxy-13-oxo-9E,11E-octa-dec...