Anastassios Philippou

Anastassios Philippou
National and Kapodistrian University of Athens | uoa · Department of Medicine

Ph.D. FACSM

About

165
Publications
33,083
Reads
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2,432
Citations
Additional affiliations
January 2015 - present
National and Kapodistrian University of Athens
Position
  • Research Assistant
January 2010 - August 2011
University of Pennsylvania
Position
  • PostDoc Position

Publications

Publications (165)
Article
Full-text available
The aim of this study is the development of a prediction model indicating successful application of Oocyte Retrieval performed during the Luteal Phase (LuPOR) in poor responders, as defined by the retrieval of at least one MII oocyte. Recruitment included 1688 poor responders diagnosed as per Bologna Criteria, undergoing natural cycle ICSI between...
Article
Full-text available
Background Active cycle breathing technique (ACBT), which includes cycle of breathing control, thoracic expansion exercises and forced expiratory technique (FET), appears to have beneficial effects in patients with a variety of respiratory diseases. This systematic review provides an update on the new related studies, expanding the evidence base th...
Article
Full-text available
A growing body of in vitro and in vivo studies suggests that physical activity offers important benefits against cancer, in terms of both prevention and treatment. However, the exact mechanisms implicated in the anticancer effects of exercise remain to be further elucidated. Muscle-secreted factors in response to contraction have been proposed to m...
Article
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Background: The benefits derived from supervised aerobic exercise in people living with human immunofeficiency virus– HIV (PLWH) have not yet been clearly identified. Objective: To evaluate the impact of supervised aerobic exercise on immunological, cardiorespiratory, pulmonary, hemodynamic and mental parameters of PLWH. Methods: A systematic rev...
Article
Full-text available
Cardiomyocytes possess the ability to respond to mechanical stimuli by adapting their biological functions. This study investigated cellular and molecular events in cardiomyocyte-like H9C2 cells during differentiation as well as the signalling and gene expression responses of the differentiated cells under various mechanical stretching protocols in...
Article
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Background: Recent research indicates that both endocannabinoids (eCB) and heart rate variability (HRV) are associated with stress-induced experiences. However, these underlying mechanisms are not elucidated. The present study aims to investigate whether exposure to acute and chronic stress conditions can give rise to measurable changes, both to t...
Article
Inflammatory bowel diseases (IBD) include a spectrum of chronic inflammatory disorders of the gastrointestinal tract whose pathogenesis is yet to be elucidated. The intestinal microbiome has been studied as a causal component, with certain microbiotic alterations having been observed in subtypes of IBD. Physical exercise is a modulator of the intes...
Article
Study question Could embryo accumulation employing mild stimulation cycles prove beneficial for managing patients presenting with poor ovarian response (POR)? Summary answer Embryo accumulation may be an efficient POR management strategy, enabling a higher number and quality cohort of embryos, ultimately improving success results. What is known a...
Article
Study question Can successful implementation of luteal phase oocyte retrieval (LuPOR) following conventional follicular phase oocyte retrieval (FoPOR) be predicted for poor ovarian response (POR) patients? Summary answer Antral follicle count (AFC), number of small follicles recorded in FoPOR, and estradiol (E2) levels on FoPOR and LuPOR trigger d...
Conference Paper
Full-text available
Internal workload for athletic tasks have been linked to injury risk in athletes using Banister's heart-rate-derived training impulse (TRIMP) and session rating of perceived exertion (sRPE). Firefighters (FF), like sport athletes, perform tasks with high internal workloads which may contribute to the relative risk for cardiovascular and/or musculos...
Conference Paper
Special Operation Forces regularly engage in prolonged training field operations incorporating very strenuous exercise. Under these circumstances, hydration status can be seriously compromised and lead to detrimental effects on physical performance and cognitive function. Only a few studies have investigated hydration status in elite soldiers of Sp...
Article
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Peripheral myopathy consists of a hallmark of heart failure (HF). Exercise enhanced skeletal muscle angiogenesis, and thus, it can be further beneficial towards the HF-induced myopathy. However, there is limited evidence regarding the exercise type that elicits optimum angiogenic responses of skeletal muscle in HF patients. This study aimed to (a)...
Article
Introduction Acute exercise and exercise training may confer epigenetic modifications in healthy subjects. Epigenetic effects after exercise have been showed in patients with cardiovascular disease. The aim of this systematic review was to summarize the evidence from available clinical trials that study epigenetic adaptations after exercise in pati...
Article
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The Effectiveness of Manual Therapy on Musculoskeletal and Respiratory Parameters in Patients with Chronic Low Back Pain: A Systematic Review pages 71-101 DOI: 10.1615/CritRevPhysRehabilMed.2021038977 Petros Tatsios School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Laboratory of Advanced Physiotherapy (LAdPhys), P...
Article
The induction of wound healing by insulin-like growth factor-I (IGF-I) has been demonstrated in several animal studies; however, there are disproportionately fewer studies assessing its value in humans. The aim of the present review is to provide a comprehensive summary of all the available evidence pertaining to the effects of IGF-I administration...
Article
Objectives The interaction between high physical performance under extreme conditions in military and the simultaneous control of the cognitive executive functioning has been a subject of research in literature for the past few decades. Stroop test and Heart-rate variability (HRV), have been verified valuable clinical tools for the assessment of ce...
Article
Full-text available
Eccentric exercise has been extensively used as a model to study the contraction-induced muscle damage and its consequent processes. This study aimed at examining molecular responses associated with tissue remodelling, inflammation and angiogenesis in skeletal muscle during the recovery period after eccentric exercise in humans. Ten healthy men per...
Article
This retrospective study compares four different strategies for managing poor ovarian response (POR), namely, conventional stimulation (300 IUs) IVF–fresh embryo transfer (CONVF), mild stimulation (150 IUs) IVF–fresh embryo transfer (MILDF), mild stimulation embryo banking (MILDB), and embryo banking in natural cycles (NATB). In total, 796 POR pati...
Article
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Stress resilience plays a key role in task performance during emergencies, especially in occupations like military special forces, with a routine consisting of unexpected events. Nevertheless, reliable and applicable measurements of resilience in predicting task performance in stressful conditions are still researched. This study aimed to explore t...
Article
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The process of myogenesis gradually deteriorates as the skeletal muscle ages, contributing to muscle mass loss. The aim of this study is to investigate the effect of senescence/aging on skeletal myogenesis, in vitro. A model of multiple cell divisions of C2C12 myoblasts was used to replicate cell senescence. Control and aged myoblasts were investig...
Article
The acute and delayed hormonal and blood cell responses to a high-intensity interval training (HIIT) session, were examined before and after a 3-week intervention (9 HIIT sessions of 4–6 × 30 s high-intensity cycling bouts) in eight recreationally active male volunteers (age: 24.3 ± 1.4 y, VO2max: 41.2 ± 3.2 ml/kg/min). Blood samples were collected...
Article
Objective To shed light on the effect of remote ischemic conditioning (RIC) on the properties of blood plasma of patients with acute myocardial infarc-tion (AMI), using differential scanning calorimetry (DSC), which has recently emerged as a novel tool in biomedicine. MethOd We used DSC to examine the protein denaturation heat capacity profiles of...
Article
The human blood plasma proteome profile has been an area of intensive investigation and differential scanning calorimetry (DSC) has come forward as a novel tool in analyzing plasma heat capacity changes to monitor various physiological responses in health and disease. This study used DSC to assess potential alterations in the plasma heat capacity p...
Article
Full-text available
Cardiomyocytes possess the ability to respond to mechanical stimuli by reprogramming their gene expression. This study investigated the effects of different loading protocols on signaling and expression responses of myogenic, anabolic, inflammatory, atrophy and pro-apoptotic genes in cardiomyocyte-like H9C2 cells. Differentiated H9C2 cells underwen...
Article
Ketamine, a phencyclidine derivative and N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used as an anesthetic, analgesic, and sedative agent in daily pediatric practice. Experimental studies have suggested that early prenatal or postnatal exposure to ketamine can induce neuroapoptosis, and establish neurobehavioral deficits that are evi...
Preprint
Full-text available
Background The interaction between high physical performance under extreme conditions and the simultaneous control of the cognitive executive functioning has been a subject of research in literature for the past few decades. Stroop test and Heart-rate variability (HRV), have been verified as a valuable clinical tool for the assessment of cerebral a...
Article
Full-text available
This study examined the phenomenon of transient hypoglycemia and metabolic responses to pre-exercise carbohydrate (CHO) maltodextrin ingestion in cycling and running on the same individuals. Eleven active males cycled or ran for 30 min at 80% maximal heart rate (HRmax) after ingestion of either 1g/kg body mass maltodextrin (CHO-Cycle and CHO-Run re...
Article
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Exercise training has become one of the most fundamental components of cardiac rehabilitation. This systematic review with meta-analyses has the objective to determine the effectiveness of exercise on selected cardiac rehabilitation outcomes, i.e. peak oxygen consumption (VO 2 peak), hospitalization and quality of life (QOL) of patients with heart...
Article
Background/aim: Insulin-like growth factor-I (IGF-I) regulates various aspects of cancer biology. There is a growing body of evidence regarding the potential distinct role of IGF-I isoforms, particularly of IGF-IEc, in the pathophysiology of various human cancer types, however, there are no studies which examined the expression of the different IG...
Article
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Chronic hyperinsulinemia due to insulin resistance and elevated levels of insulin-like growth factor (IGF)-1 and IGF-2 are suggestive of a significantly higher risk of endometrial carcinoma. There is a wealth of evidence showing differential expression of IGF-1 isoforms in various types of cancer. In the present study, 99 archived endometrial carci...
Article
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Purpose of review: Heart failure (HF) is a structural or functional cardiac abnormality which leads to failure of the heart to deliver oxygen commensurately with the requirements of the tissues and it may progress to a generalized wasting of skeletal muscle, fat tissue, and bone tissue (cardiac cachexia). Clinically, dyspnea, fatigue, and exercise...
Article
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Background/aim: Mechanical loading of differentiated myoblasts in vitro may mimic loading patterns of skeletal muscle in vivo. However, it is still uncharacterized the loading conditions that can produce the most effective muscle cells' biological responses, in vitro. This study investigated the effects of different loading protocols on the expres...
Preprint
Full-text available
Background: Cardiomyocytes are sensitive to mechanical loading, possessing the ability to respond to mechanical stimuli by reprogramming their gene expression. In this study, signaling as well as expression responses of myogenic, anabolic, inflammatory, atrophy and pro-apoptotic genes to different mechanical stretching protocols were examined in di...
Article
Full-text available
A growing body of evidence suggests that physical activity (PA) can be a complementary intervention during breast cancer (BCa) treatment, contributing to the alleviation of the chemotherapy-related side-effects. The purpose of this study was to assess physical activity (PA) levels and quality of life (QoL) parameters of BCa patients undergoing chem...
Article
Background: Increased levels of circulating cortisol have been associated with pain severity in patients with chronic musculoskeletal disorders (CMD). Little is known about the potential association between pain management and salivary cortisol alterations in CPM patients treated with different regimens. Objectives: This prospective feasibility...
Article
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Aim: Aerobic, resistance, or isometric exercise has been shown to reduce blood pressure (BP) in normotensive and hypertensive individuals. The aim of this study was to examine the acute effect of combining resistance and isometric exercise and the training effect of combining all 3 types (aerobic, resistance and isometric exercise) in hypertensive...
Article
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AIM: Sedentary lifestyle is related to many non-communicable diseases and psychological disorders. Family caregivers often have physical and psychological health problems, similar to those characterizing a sedentary lifestyle. The aim of this study was to determine the levels of physical activity, depression, anxiety, burden, and quality of life in...
Article
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AIM: There is some evidence to suggest that exercise in the evening, compared with exercise in the morning, has a more beneficial impact on glycemia in patients with type 2 diabetes (T2D). The aim of this study was to examine a possible acute effect of aerobic exercise performed at different times of day on blood glucose levels during and after exe...
Article
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Background: How do stress related phenomena during labor differ between vaginal delivery (VD) and elective cesarean section (CS), remains of heightened interest. The purpose of this study is to investigate discrepancies regarding the stress response during VD and CS. Methods: Cortisol, interleukin 6 (IL-6), growth hormone (GH) and insulin-like g...