Anastasios Koulaouzidis

Anastasios Koulaouzidis
University of Southern Denmark | SDU

Doctor of Medicine
MD DM PhD

About

449
Publications
114,763
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
5,770
Citations
Introduction
My research revolves around capsule endoscopy (CE), clinical & developmental, and other related platforms for minimally invasive GI diagnosis, and eventually, therapy. In addition, I am passionate about qualitative research on patient comfort, precision imaging, early GI diagnosis and, of course, eventual translation to broader adoption of CE in healthcare and preventative pathways. Expertscape data: https://www.expertscape.com/au/capsule+endoscopy/Koulaouzidis%2C+Anastasios https://www.experts
Additional affiliations
September 2014 - August 2020
The University of Edinburgh
Position
  • Fellow
September 2014 - June 2020
Lund University
Position
  • PhD in Medical Sciences
August 2014 - August 2020
College of Medicine & Veterinary Medicine, The University of Edinburgh
Position
  • Fellow

Publications

Publications (449)
Article
Full-text available
Iron deficiency is a common disorder; it can also be the first indicator of significant gastrointestinal pathology. Total iron stores are evaluated by ferritin measurement, but this is often difficult, as coexistent disease can obscure ferritin results. Bone marrow (BM) examination was previously felt to be superior to all known serological markers...
Article
Full-text available
The introduction of capsule endoscopy (CE) in clinical practice increased the interest for the study of the small-bowel. Consequently, in about 10 years, an impressive quantity of literature on indications, diagnostic yield (DY), safety profile and technical evolution of CE has been published as well as several reviews. At present time, there are 5...
Article
Background The advent of wireless capsule endoscopy (WCE) has revolutionized the diagnostic approach to small-bowel disease. However, the task of reviewing WCE video sequences is laborious and time-consuming; software tools offering automated video analysis would enable a timelier and potentially a more accurate diagnosis. Objective To assess the...
Article
Background and aims: Fecal calprotectin is a well-established marker of mucosal inflammation. Although the correlation of elevated calprotectin levels with colonic inflammation has been confirmed repeatedly, it is less established for the small bowel. The aim of the current study was to assess the diagnostic accuracy of calprotectin for the predict...
Article
Full-text available
Flexible colonoscopy remains the prime mean of screening for colorectal cancer (CRC) and the gold standard of all population-based screening pathways around the world. Almost 60% of CRC deaths could be prevented with screening. However, colonoscopy attendance rates are affected by discomfort, fear of pain and embarrassment or loss of control during...
Article
Full-text available
Capsule endoscopy (CE) is a valid alternative to conventional gastrointestinal (GI) endoscopy tools. In CE, annotation tools are crucial in developing large and annotated medical image databases for training deep neural networks (DNN). We provide an overview of the described and in-use various annotation systems available, focusing on the annotatio...
Article
Full-text available
There has been a steady increase (annual percentage growth rate of 19.2%, average of 18.3 citations per document) in capsule endoscopy (CE) publications from a global, interdisciplinary research community on a growing range of CE applications over the last 20+ years. We here present the status of CE as a field of research, tracing its evolution ove...
Article
Aims The primary aim of this study was to assess the reliability, intra- and inter-observer variation of the SPICE, Mucosal protrusion angle (MPA) and SHYUNG scores in differentiating a subepithelial mass (SEM) from a bulge. Methods This retrospective multicentre study analysed the 3 scores, radiological studies, enteroscopy and/or surgical findin...
Article
Full-text available
Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized; Methods: The Delphi technique was employed to reach agreement among a panel of SBCE experts. The nomenclature and definitions of SBCE lesions suggesting the pre...
Article
Full-text available
Background: Reading capsule endoscopy (CE) is time-consuming. The Express View (EV) (IntroMedic, Seoul, Korea) software was designed to shorten CE video reading. Our primary aim was to evaluate the diagnostic accuracy of EV in detecting significant small-bowel (SB) lesions. We also compared the reading times with EV mode and standard reading (SR)....
Article
Importance: Reading small bowel capsule endoscopy (SBCE) videos is a tedious task for clinicians, and a new method should be applied to solve the situation. Objectives: To develop and evaluate the performance of a convolutional neural network algorithm for SBCE video review in real-life clinical care. Design, setting, and participants: In this...
Article
Full-text available
Artificial intelligence (AI) is an integral part of clinical decision support systems (CDSS), offering methods to approximate human reasoning and computationally infer decisions. Such methods are generally based on medical knowledge, either directly encoded with rules or automatically extracted from medical data using machine learning (ML). ML tech...
Article
Background: Capsule endoscopy (CE) has become a widespread modality for non-invasive evaluation of the gastrointestinal (GI) tract, with several CE models having been developed throughout the years. The aim of this systematic review and meta-analysis is to evaluate performance measures such as completion, detection and retention rates of CE. Meth...
Article
Colon capsule endoscopy (CCE) was introduced nearly two decades ago. Initially, it was limited by poor image quality and short battery time, but due to technical improvements, it has become an equal diagnostic alternative to optical colonoscopy (OC). Hastened by the coronavirus disease 2019 pandemic, CCE has been introduced in clinical practice to...
Article
Background Little is known about small bowel capsule endoscopy (SBCE) outcomes in patients with surgically altered anatomy. Aims To assess the feasibility and diagnostic yield of orally ingested SBCE to investigate obscure gastrointestinal bleeding (OGIB) in patients with surgically altered gastric anatomy, compared to native gastric anatomy. Met...
Article
Full-text available
Background: The European Colonoscopy Quality Investigation (ECQI) Group aims to raise awareness for improvement in colonoscopy standards across Europe. We analysed data collected on a sample of procedures conducted across Europe to evaluate the achievement of the polyp detection rate (PDR) target. We also investigated factors associated with PDR,...
Article
Full-text available
[This corrects the article DOI: 10.1055/a-1728-9371.].
Article
Full-text available
The European Colonoscopy Quality Investigation (ECQI) Group aims to raise awareness for improvement in colonoscopy standards across Europe. We analyzed data collected on a sample of procedures conducted across Europe to evaluate the achievement of the European Society of Gastrointestinal Endoscopy (ESGE) mean withdrawal time (WT) target. We also in...
Article
Full-text available
The small intestine, an anatomical site previously considered inaccessible to clinicians due to its small diameter and length, is the part of the gastrointestinal tract between the stomach and the colon. Since its introduction into clinical practice two decades ago, capsule endoscopy has become established as the primary modality for examining the...
Article
Full-text available
The introduction of capsule endoscopy two decades ago marked the beginning of the “small bowel revolution”. Since then, the rapid evolution of microtechnology has allowed the development of drug delivery systems (DDS) designed to address some of the needs that are not met by standard drug delivery. To overcome the complex anatomy and physiology of...
Article
Full-text available
Artificial intelligence (AI) has shown promising results in digestive endoscopy, especially in capsule endoscopy (CE). However, some physicians still have some difficulties and fear the advent of this technology. We aimed to evaluate the perceptions and current sentiments toward the use of AI in CE. An online survey questionnaire was sent to an aud...
Article
Lower gastrointestinal diagnostics have been facing significant capacity constraints, which the COVID-19 pandemic has exacerbated due to significant reductions in endoscopy procedures. Colon Capsule Endoscopy (CCE) provides a safe, viable solution to offset ongoing demand and could be a valuable tool for the recovery of endoscopy services post-COVI...
Article
We read with interest a consensus statement of the ScotCap clinical leads collaboration reported by Macleod et al. on the use of Computer Tomography Colonography (CTC) and Colon Capsule Endoscopy (CCE) as promoted diagnostic modalities in the Covid-19 era and how to deal with diminutive and small polyps with a 'realistic medicine' approach (1). The...
Article
Full-text available
Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, which is estimated to affect 20-30% of the adult population in Europe. Several studies have shown an association of NAFLD with multiple cardiovascular risk factors such as abdominal obesity, atherogenic dyslipidaemia, hypertension, insulin resistance,...
Preprint
Background: Little is known about small bowel capsule endoscopy outcomes in 23 patients with surgically altered anatomy. Aims: To assess the feasibility and diagnostic 24 yield of orally ingested small bowel capsule endoscopy to investigate obscure 25 gastrointestinal bleeding in patients with surgically altered gastric anatomy, compared to 26 nati...
Article
Background The use of magnetically controlled capsules for gastroscopy is in the early stages of clinical adoption. We aimed to evaluate the safety and efficacy of a fully automated magnetically controlled capsule endoscopy (FAMCE) system in clinical practice for gastroscopy and small bowel examination. Methods We did a prospective, comparative st...
Article
Full-text available
Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy including preference of investigation modality, tolerabili...
Preprint
Colon capsule endoscopy as an alternative to colonoscopy for diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonos-copy including preference of investigation modality, tolerability...
Preprint
Full-text available
Background and study aims Colon capsule endoscopy (CCE) is an alternative to conventional colonoscopy (CC) in specific clinical settings. High completion rates (CRs) and adequate cleanliness rates (ACRs) are fundamental quality parameters if CCE is to be widely implemented as a CC equivalent diagnostic modality. We conducted a systematic review and...
Article
Full-text available
Background and study aims The European Colonoscopy Quality Investigation (ECQI) Group comprises expert colo- noscopists and investigators with the aim of raising colo- noscopy standards. We assessed the levels of monitoring and achievement of European Society of Gastrointestinal Endoscopy (ESGE) performance measures (PMs) across Eur- ope using resp...
Article
Full-text available
Prompted by the core idea of wireless capsule endoscopy as a painless gastrointestinal examination, and the easy adoption of small bowel capsule endoscopy, the armamentarium of the capsule-based imaging platforms has grown to include colon capsule devices as well [...]
Preprint
The introduction of capsule endoscopy two decades ago marked the beginning of the "small bowel revolution". The rapid evolution of microtechnology since then has allowed the development of drug delivery systems (DDS) designed to address some of the unmet needs from standard drug delivery. In order to overcome the complex anatomy and physiology of t...
Article
This study aimed to evaluate the global distribution, associated factors, and epidemiologic trends of gallbladder cancer (GBC) by country, sex, and age groups. The Global Cancer Observatory was interrogated for the disease burden of GBC using age-standardized rates (ASR). The prevalence of different potential risk factors for each country was extra...
Preprint
Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, which is estimated to affect 20–30% of the adult population in Europe. Several studies have shown an association of NAFLD with multiple cardiovascular risk factors such as abdominal obesity, atherogenic dyslipidaemia, hypertension, insulin resistance,...
Article
Colon capsule endoscopy (CCE) was introduced in 2006 as a novel way to visualise the colonic mucosa. Initially, CCE validity was limited by low completion rates (CR) and poor image quality. Through technical progress and improved bowel preparations, CCE now offers an adjunct to diagnostic colonoscopy. As referred in this review, several studies hav...
Article
Background We aimed to document international practices in small-bowel capsule endoscopy (SBCE), measuring adherence to European Society of Gastrointestinal Endoscopy (ESGE) technical and clinical recommendations. Methods Participants reached through the ESGE contact list completed a 52-item web-based survey. Results 217 responded from 47 countries...
Article
Objective: Reading small bowel capsule endoscopy (SBCE) is a tedious task. We aim to evaluate the performance of a Convolutional Neural Network (CNN) algorithm (SmartScan)-assisted reading in the setting of real-life clinical care. Design: A total of 5,825 SBCE examinations (comprising 295,314,067 images) performed in 51 Chinese medical centres we...
Article
Full-text available
Gastrointestinal (GI) cancers remain high on the list of the leading causes of death worldwide; however, the recent emergence of new and ongoing global healthcare threats, such as the COVID-19 pandemic, has led to a temporary reduction in elective endoscopic procedures [...]
Article
Full-text available
Capsule endoscopy (CE) emerged out of the pressing clinical need to image the small bowel (SB) in cases of midgut bleeding and provide an overall comfortable and reliable gastrointestinal (GI) diagnosis 1. Since its wider adoption in clinical practice, significant progress has been made in several areas including software development, hardware feat...
Article
Full-text available
Colorectal cancer is common and can be devastating, with long-term survival rates vastly improved by early diagnosis. Colon capsule endoscopy (CCE) is increasingly recognised as a reliable option for colonic surveillance, but widespread adoption has been slow for several reasons, including the time-consuming reading process of the CCE recording. Au...
Article
Full-text available
In the constantly developing era of minimal diagnostic invasiveness, the role of colon capsule endoscopy in colonic examination is being increasingly recognised, especially in the context of curtailed endoscopy services due to the COVID-19 pandemic. It is a safe diagnostic tool with low adverse event rates. As with other endoscopic modalities, vari...
Article
Full-text available
In recent years, panintestinal capsule endoscopy (PCE) with double-headed capsules has been used to perform complete, single-sitting exploration of both small bowel and colon in different clinical conditions. Double-headed capsules for colonic examination (CCE) have been exploited first in this setting, followed by newer generations of capsules (i....
Article
Background and aims Capsule endoscopy (CE) interpretation requires the review of many thousands of images, with lesions often limited to just a few frames. In this study we aim to determine whether lesion detection declines according to the number of capsule videos read. Methods 32 participants, 16 of which were novices (NR) and 16 experienced (ER...