Anastasiia Syrkasheva

Research Center for Obstetrics, Gynecology and Perinatology · Assistive reproductive technologies in infertility treatment

Vulvovaginal candidiasis (VVC) is considered as the second most common cause of vaginitis after bacterial vaginosis. About three quarters of women of reproductive age have a history of at least one episode of VVC, and about a half of women have two or more episodes. Candida albicans is responsible for85% to 90% of vulvovaginal candidiasis. There ar...

Introduction . Vitamin D administration is recommended for women with vitamin D insufficiency, who are planning to undergo assisted reproductive treatment (ART). The action of the active form of vitamin D is mediated through its vitamin D receptor (VDR). The presence of VDR in the cells and tissues of the female reproductive system suggests that vi...

Introduction . Infertility, i.e. the inability to achieve a clinical pregnancy within 12 months of a regular sexual life without contraception, is a current medical problem and affects up to 15-25% of married couples in Western countries. Objective . To evaluate the efficacy of prophylactic prescription of antioxidants in preparation for cycles of...

Aim. To analyze the relationship between the levels of heavy metals (cadmium, mercury, lead) in the blood, polymorphism of genes of the biotransformation system of xenobiotics and the outcomes of assisted reproductive technologies (ART) in infertile women. Materials and methods. 300 married couples underwent infertility treatment using ART. The lev...

The association between levels of trace elements, endocrine diseases and reproductive impairments is actively investigated currently. In this connection, it seems relevant to study elemental status (elemental composition of blood and amounts of elements therein) of infertile patients enlisted in programs employing assisted reproductive technologies...

Objective. To analyze the relationship between blood bisphenol A levels in men, sperm quality and in vitro fertilization (IVF) out-comes. Material and methods. Infertility treatment of 154 married couples was performed using ART. The level of bisphenol A in the blood of patients was determined by gas chromatography-mass spectrometry. The effect of...

Overall success rates for cryopreserved embryo transfer have increased over the past few years. The paper gives data on the higher efficiency of cryo protocols versus fresh in vitro fertilization (IVF) protocols. It demonstrates the greater contribution of cryopreserved embryo transfer to the total number of live births over the past decades. Moreo...

The higher infertile marriage rate in economically developed countries has necessitated the emergence and development of assisted reproductive technologies (ART). It should be noted that to date, more than 23% of the ART programs have been implemented in women aged 40 years and older. At the same time, the effectiveness of ART techniques using auto...

The paper analyzes the data available in the current literature on the role of molecular hydrogen in the combination therapy of subfertility and infertility. It gives data on the possible mechanisms of antioxidant action of molecular hydrogen, as well as those on the methods for its use, which are available in clinical practice. There are also resu...

Objective. To investigate the effectiveness of assisted reproductive technology (ART) programs in late reproductiveaged (LRA) patients undergoing preimplantation genetic screening (PGS). Subjects and methods. The prospective cohort study enrolled 160 LRA patients (aged >35 years) with infertility of different genesis who were stratified according t...

Objective. To investigate the effectiveness of preimplantation genetic screening (PGS) in the outcomes of assisted reproductive technology programs in patients with recurrent miscarriage and infertility. Subjects and methods. The prospective cohort study enrolled 196 women with infertility of different genesis, who had experienced 2 or more pregnan...

Background. Hatching from the zona pellucida is one of the most important stages of human preimplantation embryo development and spontaneous hatching inability is one of the causes of implantation failure in assisted reproductive technology (ART) cycles. The use of mechanical integrity disorders or complete destruction of the zona pellucida (assist...

Objective. To carry out a systematic analysis of the data available in the current literature on the effects of some anthropogenic chemicals on human fertility, including on the effectiveness of assisted reproductive technology programs. Material and methods. The review includes the articles by foreign and Russian authors on this topic, which have...

The aim of the study was to study the effectiveness of assisted reproductive technologies (ART) programs in patients of different age groups, taking into account clinical and laboratory data. Materials and methods. A prospective cohort study included 188 patients with infertility of various genesis who were stratified according to age: group 1 (n=...

The aim of the study was to assess the effectiveness of auxiliary reproductive technologies (ART) programs in patients with a habitual miscarriage (HM) in an anamnesis. Materials and methods. A prospective cohort study included 200 patients with infertility, 100 of whom had a history of HM (2 or more pregnancy loss before 22 weeks of gestation) - g...

Over the past few decades the incidence of infertility and sub-fertility has increased significantly, particularly in developed countries. External environmental factors, such as air and soil pollution, contact with different chemicals, are consdiered as the cause of both female and male fertility decline. Various lifestyle factors, such as nutriti...

The aim was to identify cell and genetic predictors of human blastocyst hatching success in assisted reproduction programmes via a prospective case–control study. Blastocysts, donated by couples in assisted reproduction programmes were used. Hatching success assessment was performed after 144–146 h post-fertilization. The mRNA expression levels of...

Oxidative stress develops due to an imbalance between the prooxidant and antioxidant systems of the body. The role of oxidative stress in the pathogenesis of various diseases has been demonstrated, while the impact of oxidative stress on the processes of folliculogenesis and oogenesis has been inadequately studied today. Objective: To evaluate the...

The human oocyte is surrounded by the zona pellucida—an elastic, transparent extracellular matrix consisting of specific glycoproteins. The zona pellucida is preserved after fertilization and surrounds the developing human embryo for a few days. The embryo needs to get out of the zona pellucida before implantation to establish cell contacts between...

The quality of oocytes and their morphology have a great impact on the outcomes of assisted reproductive technology (ART) programs. The literature contains contradictory data on the impact of abnormal smooth endoplasmic reticulum (SER) aggregates on the parameters of embryogenesis, the occurrence of pregnancy and its course. Objective. To reveal ri...

The problem ofdecreased fertility in women of advanced reproductive age is important today. The number of women of advanced age with infertility is increasing constantly, however efficiency of infertility treatment (even with the use of artificial reproductive technologies) remains low. There are many biological and other causes ofageassociated inf...

Objective. To summarize available data on different superovulation stimulation protocols in assisted reproductive technology programs, on their currently available modifications, and on indications for their use. Material and methods. Respective sources were sought for in the systems Medline, Cochrane Library, and Elibrary; these included publicati...

There are controversial data about the effect of different controlled ovarian hyperstimulation (COS) protocols on embryological stage and in vitro fertilization (ivf) outcomes. The aim of our study was to evaluate embryological and clinical outcomes according to COS protocol.Material and methods. This prospective cohort study included 521 patients...

Purpose: To evaluate the aneuploidy rates of 13, 18, and 21 and the X and Y chromosomes in embryos from patients with morphologically normal oocytes and different oocyte dysmorphisms. Methods: This prospective cohort study included 84 patients treated with in vitro fertilization (IVF) at a single academic center. The patients were divided into the...

A large proportion of human oocytes received from exogenous gonadotropin-stimulated cycles have different morphological attributes, or dysmorphisms. The presence of dysmorphism can affect the fertilization rate, the embryo quality and subsequently the frequency of occurrence of implantation and pregnancy. Special attention is paid to oocytes with c...