Anastasia Lyon

Anastasia Lyon
University of Kentucky | UKY · Pharmacology

Bachelor of Science in Biochemistry and Molecular Biology

About

13
Publications
673
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74
Citations
Introduction
Anastasia Lyon currently works as a Graduate Research Assistant at the University of Kentucky.
Additional affiliations
June 2018 - June 2022
University of Kentucky
Position
  • Research Assistant

Publications

Publications (13)
Article
Full-text available
Metastatic melanoma remains an incurable disease for many patients due to the limited success of targeted and immunotherapies. BRAF and MEK inhibitors reduce metastatic burden for patients with melanomas harboring BRAF mutations; however, most eventually relapse due to acquired resistance. Here, we demonstrate that ABL1/2 kinase activities and/or e...
Article
Full-text available
The sclera is the protective outer layer of the eye. In fishes, birds, and reptiles, the sclera may be reinforced with additional bony elements called scleral ossicles. Teleost fish vary in the number and size of scleral ossicles; however, the genetic mechanisms responsible for this variation remain poorly understood. In this study, we examine the...
Article
Full-text available
The sclera is the tough outer covering of the eye that provides structural support and helps maintain intraocular pressure. In some fishes, reptiles, and birds, the sclera is reinforced with an additional ring of hyaline cartilage or bone that forms from scleral ossicles. Currently, the evolutionary and genetic basis of scleral ossification is poor...
Article
Full-text available
Simple Summary NRAS-mutant melanoma is a highly aggressive subtype with few treatment options. Although both BRAF-mutant and NRAS-mutant melanomas have activation of the MEK/ERK pathway, MEK inhibitors (MEKi) are only effective for the BRAF-mutant subtype. The aim of this study was to understand why MEKi are ineffective in NRAS-mutant melanomas wit...
Data
Phenotypic and genotypic data used to detect QTL for scleral ossification in the CF(Pa) x SF(Mx) F2 from Gross et al. [15] including genetic distances. (CSV)
Data
Phenotypic and genotypic data used to detect QTL for scleral ossification in the combined CF(Pa) x SF(Mx) F2 from Gross et al. [15] and CF(Pa) x SF(Tx) F2 from O'Quin et al. [13] including genetic distances. (CSV)
Data
Composite CF(Pa) x SF linkage map. Comparison of homologous linkage groups from CF(Pa) x SF(Mx) F2 hybrid and CF(Pa) x SF(Tx) F2 hybrid linkage maps published in Gross et al. [15] and O’Quin et al. [13]. (DOCX)
Data
Chi-square (χ2) analysis of observed and expected ratios of the CF(Pa) x SF(Mx) F2 progeny from Gross et al. [15]. Expected ratios for 0, 1, and 2 scleral ossicles estimated interactions of two genes caused by epistasis of one (single) or two (duplicate) loci. (DOCX)
Data
Analysis of scleral ossification among CF(Pa) x SF(Tx) F2 hybrids previously published in O'Quin et al. [13]. (PDF)
Data
Phenotypic and genotypic data used for QTL analysis of scleral ossification. (CSV)
Data
Phenotypic and genotypic data used for QTL analysis of eye diameter, eye area, and pupil area. (CSV)
Data
Quantitative trait loci (QTL) for Astyanax eye and lens size. Detailed view of the eye or pupil size QTL on Astyanax linkage groups (LG) 1, 2, 7, 11, 18, and 23. Red line indicates P = 0.05; any value above that threshold is considered statistically significant. Shaded fields indicate the 95% Bayesian confidence interval for the location of each QT...
Data
Summary statistics for all significant QTL found in this study. (DOCX)

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