Anand Murugan

Anand Murugan
Princeton University | PU · Department of Physics

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12
Publications
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1,083
Citations

Publications

Publications (12)
Article
The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ recombination, followed by functional selection of cells according to the interaction of their surface receptors...
Article
Full-text available
Learning to read and write the transcriptional regulatory code is of central importance to progress in genetic analysis and engineering. Here we describe a massively parallel reporter assay (MPRA) that facilitates the systematic dissection of transcriptional regulatory elements. In MPRA, microarray-synthesized DNA regulatory elements and unique seq...
Article
Stochastic rearrangement of germline V-, D-, and J-genes to create variable coding sequence for certain cell surface receptors is at the origin of immune system diversity. This process, known as "VDJ recombination", is implemented via a series of stochastic molecular events involving gene choices and random nucleotide insertions between, and deleti...
Article
Full-text available
Learning to read and write the transcriptional regulatory code is of central importance to progress in genetic analysis and engineering. Here we describe a massively parallel reporter assay (MPRA) that facilitates the systematic dissection of transcriptional regulatory elements. In MPRA, microarray-synthesized DNA regulatory elements and unique seq...
Article
Cells use protein-DNA and protein-protein interactions to regulate transcription. A biophysical understanding of this process has, however, been limited by the lack of methods for quantitatively characterizing the interactions that occur at specific promoters and enhancers in living cells. Here we show how such biophysical information can be reveal...
Article
We demonstrate a new technique for probing the function of a regulatory sequence, using ultra-high-throughput sequencing to generate large data sets of the activity of mutant sequences. An information theoretic data analysis technique is then used to model the activity, avoiding assumptions about noise in the experiment. We apply this technique to...
Article
Full-text available
For a large enough Schwarzschild black hole, the horizon is a region of space where gravitational forces are weak; yet it is also a region leading to numerous puzzles connected to stringy physics. In this work, we analyze the process of gravitational collapse and black hole formation in the context of light-cone M theory. We find that, as a shell o...

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