Anand Kumara Deva

Anand Kumara Deva
Macquarie University · Australian School of Advanced Medicine

About

134
Publications
40,369
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5,147
Citations
Citations since 2016
70 Research Items
3736 Citations
20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
Introduction
Skills and Expertise

Publications

Publications (134)
Conference Paper
Background Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a newly recognised T cell lymphoma that occurs in women with textured implants and is mostly limited to the periprosthetic seroma space. However, it is not clear how this ALCL forms and whether the tumour microenvironment (TME) plays a key role in ALCL survival and pr...
Article
Background: Breast augmentation remains the commonest cosmetic surgical procedure worldwide, in spite of recent regulatory action. Objectives: We established a breast implant assessment clinic to evaluate women with breast implants and sought to capture clinical and implant data in women presenting to the service. Methods: Patients were enroll...
Article
Full-text available
The Gram-positive bacterium Staphylococcus aureus is responsible for serious acute and chronic infections worldwide and is well-known for its biofilm formation ability. Recent findings of biofilms on dry hospital surfaces emphasise the failures in current cleaning practices and disinfection and the difficulty in removing these dry surface biofilms...
Article
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Current protocols using liquid disinfectants to disinfect heat-sensitive hospital items frequently fail, as evidenced by the continued isolation of bacteria following decontamination. The contamination is, in part, due to biofilm formation. We hypothesize that mild positive pressure (PP) will disrupt this biofilm structure and improve liquid disinf...
Article
Introduction: Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) was recently recognized by the WHO as a lymphoma presenting a median of 8 years after insertion of breast implants for reconstructive surgery following breast cancer, for prophylactic mastectomy due to high genetic risk of breast cancer, e.g. BRACA1/2 mutations, or fo...
Article
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Topical antiseptics are often used to treat chronic wounds with biofilm infections and during salvage of biofilm contaminated implants, but their antibacterial efficacy is frequently only tested against non-aggregated planktonic or free-swimming organisms. This study evaluated the antibacterial and antibiofilm efficacy of four commercial surgical w...
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Frequent recurrent lung infections result in irreversible lung damage in children with cystic fibrosis (CF). This study aimed to determine if toothbrushes contain biofilms of pathogens, and act as potential reservoirs for lung re-infection following antibiotic treatment of acute exacerbations. Toothbrushes were collected from children with CF of lu...
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Breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) is a CD30-positive, anaplastic lymphoma kinase–negative T-cell lymphoma. Where implant history is known, all confirmed cases to date have occurred in patients with exposure to textured implants. The etiopathogenesis of BIA-ALCL is likely to be multifactorial, with current evidence-...
Article
Full-text available
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a distinct malignancy associated with textured breast implants. We investigated whether bacteria could trigger the activation and multiplication of BIA-ALCL cells in vitro. BIA-ALCL patient-derived BIA-ALCL tumor cells, BIA-ALCL cell lines, cutaneous ALCL cell lines, an immortal...
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Breast implant-associated lymphoma (BIA-ALCL) is a rare subtype of anaplastic large-cell lymphoma associated with breast prostheses. Most patients present with a localised periprosthetic effusion and are managed with removal of the implant and surrounding capsule. Less commonly, the lymphoma can form a mass associated with the capsule and rarely ca...
Article
Background: Silicone breast implants have been used for post-mastectomy breast reconstruction and cosmetic augmentation since the 1960s. Recent regulatory action has resulted in a few devices being suspended or cancelled from the Australian market. Objective: The aim of this article is to summarise important clinical information on how best to a...
Article
Full-text available
Breast implant‒associated anaplastic large cell lymphoma (BIA-ALCL) is a CD30-positive, anaplastic lymphoma kinase‒negative T-cell lymphoma. Where implant history is known, all confirmed cases to date have occurred in patients with exposure to textured implants. There is a spectrum of disease presentation, with the most common occurring as a seroma...
Article
Background Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an emerging cancer that has been linked to the use of textured devices. Recent increase in number and frequency of cases has led to worldwide regulatory action. Objective We aimed to longitudinally study the disease in Australia since the index case was first reporte...
Article
Background Specific antimicrobial breast pocket irrigations have been proven to reduce capsular contracture by 10x over the past 20 years, and with the emergence of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) and its link to bacteria/technique there has been a renewed interest in different ant-microbial breast pocket prepara...
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With the recent voluntary recall by Allergan of their Biocell textured implants, many plastic surgeons are left with questions of how to best manage asymptomatic patients who have concerns about having these devices. We realized that there is no clear, published recommendations or scientific data to guide surgeons on how to discuss options with the...
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Breast device registries monitor devices encompassing breast implants, tissue expanders and dermal matrices, and the quality of care and patient outcomes for breast device surgery. Defining a standard set of quality indicators and risk adjustment factors will enable consistency and adjustment for case-mix in benchmarking quality of care across brea...
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Background:. Geographical differences in breast implant selection approaches exist, and clinical data to guide the process are limited. Developing knowledge of implant-related risk factors further complicates the process. This analysis aimed to establish expert consensus on considerations for breast implant selection in Australia and New Zealand ba...
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The risk for minor local complications for abdominoplasty remains high despite advances in strategies in recent years. The most common complication is the formation of seroma with reported rates ranging from 15% to 40%. The use of incisional negative-pressure wound therapy (iNPWT) on closed surgical sites has been shown to decrease the infection, d...
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The International Collaboration of Breast Registry Activities (ICOBRA) welcomes the opportunity to provide a submission to the FDA public hearing on the safety of breast implants and their use in cosmetic and reconstructive plastic surgery. ICOBRA is an active international collaboration of breast implant registries1. The subject of breast implan...
Article
The link between breast implants and systemic disease has been reported since the 1960s. Although many studies have looked at either supporting or refuting its existence, the issue still persists and has now been labeled "breast implant illness." The rise of patient advocacy and communication through social media has led to an increasing number of...
Article
BACKGROUND: With breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) now accepted as a unique (iatrogenic) subtype of ALCL directly associated with textured breast implants, we are now at a point where a sound epidemiologic profile and risk estimate are required. The aim of this article is to provide a comprehensive and up-to-date g...
Article
BACKGROUND: Standard of care treatment of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) involves surgical resection with implant removal and complete capsulectomy. We report a case series of BIA-ALCL reconstruction with proposals for timing and technique selection. METHODS: We retrospectively reviewed and prospectively enrolle...
Article
Background: The epidemiology and implant specific risk for BIA-ALCL has been previously reported for Australia and New Zealand. We now present updated data and risk assessment since our last report. Methods: New cases in Australia and New Zealand were identified and analyzed. Updated sales data from three leading breast implant manufacturers (i....
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Since their introduction into the market, breast implants have been the subject of many controversies. It is timely to examine the forces that have shaped the breast implant industry to make it what it is today. This review will concentrate more on the use of implants in aesthetic surgery rather than their use in breast reconstruction, but some of...
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Purpose of Review Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a recently recognised malignancy of T lymphocytes exclusively associated with textured breast implants. This review aims to evaluate existing theories regarding the epidemiology, pathogenesis, clinical evaluation and management of the disease. Recent Findings...
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Breast implantation either for cosmetic or reconstructive e purposes is one of the most common procedures performed in plastic surgery. Biofilm infection is hypothesised to be involved in the development of both capsular contracture and anaplastic large cell lymphoma (ALCL). Capsular contracture is one of the principal reasons for breast revision s...
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Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare form of T-cell lymphoma that occurs after implantation of breast prostheses. We performed comprehensive next generation sequencing based genomic characterization of 11 cases of BIA-ALCL including sequence variant detection on 180 genes frequently mutated in haematological...
Article
Background Pathogens can survive for extended periods when incorporated into biofilm on dry hospital surfaces (ie, dry-surface biofilm, DSB). Bacteria within biofilm are protected from desiccation and have increased tolerance to cleaning agents and disinfectants. Objective We hypothesized that gloved hands of healthcare personnel (HCP) become cont...
Article
Background: The introduction of texture to the outer shell of breast implants was aimed at increasing tissue incorporation and reducing capsular contracture. It has also been shown that textured surfaces promote a higher growth of bacteria and are linked to the development of breast implant-associated anaplastic large cell lymphoma. Methods: The...
Article
Background Outbreaks of endoscopy-related Carbapenem-resistant Enterobacteriaceae has highlighted failures in endoscope decontamination resulting in biofilm formation. Biofilms are tolerant to detergents and disinfectants. We evaluated decontaminated endoscope channels for residual bacterial contamination and biofilm presence. Methods 63 channels...
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Background: To investigate the effect of negative pressure wound therapy (NPWT) with and without instillation (NPWTi) on in vitro mature biofilm. Methods: Mature biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown under shear (130 rpm) on polycarbonate coupons in a CDC biofilm reactor for 3 days. Coupons containing biofilms were...
Article
Background: Organisms causing healthcare associated infections can be sourced from the inanimate environment around patients. Residing in a biofilm increases the chances of these organisms persisting in the environment. We aimed to characterise bacterial environmental contamination, genetically and physiologically, and relate this to general inten...
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Background: The importance of biofilms to clinical practice is being increasingly realised. Biofilm tolerance to antibiotics is well described but limited work has been conducted on the efficacy of heat disinfection and sterilization against biofilms. Aim: To test the susceptibility of planktonic, hydrated biofilm and dry-surface biofilm forms o...
Article
Background: To determine the effect of multiple use and processing cycles on instrument quality over the life of stainless steel, complex designed clinical surgical instruments. Methods: Steam sterilised surgical instruments due to be discarded from Australian hospitals, because of loss of functionality, were assessed for contaminating protein and...
Article
Background: Bacteria/biofilm on breast implant surfaces has been implicated in capsular contracture and breast implant-associated anaplastic large-cell lymphoma (ALCL). Macrotextured breast implants have been shown to harbor more bacteria than smooth or microtextured implants. Recent reports also suggest that macrotextured implants are associated...
Article
Background During functionality testing and packaging of reusable surgical instruments (RSI) for sterilisation, instruments are frequently touched. Considering the lack of standards relating to hand hygiene frequency and use of gloves in the sterilising service unit packing area, we aimed to determine the effect of hand hygiene and glove use on mai...
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Background: The association between breast implants and breast implant associated anaplastic large cell lymphoma (BIA-ALCL), has been confirmed. Implant related risk has been difficult to estimate due to incomplete or unknown implant histories and lack of clarity on the number of implants utilized. Methods: All cases in Australia and New Zealand...
Article
Background: The development of chronic nodules and granulomatous inflammation after filler injections has been attributed to bacterial biofilm infection. The authors aimed to investigate the relationship between filler and bacterial biofilm using a combined in vitro and in vivo study. Methods: In vitro assays to investigate the ability of filler...
Article
Background: An estimated 200 patients have been reported with breast implant associated anaplastic large cell lymphoma (BI-ALCL), a rare T-cell lymphoma developing around breast prostheses. The purpose of this study was to review federal database submissions relating to BI-ALCL in 37 countries representing the majority of breast implant markets wo...
Article
“Our surgical patients are exposed to infections from the medical wards, and especially to a disease, the hospital sore, which seizes all those who have even the smallest incisions practiced upon them: It infects all the ulcers, changes the slightest sores into gangrenes; and this disease, which is frequent in exact proportion to the size of an hos...
Data
Appendix 1, available as Supplementary Material at www.aestheticsurgeryjournal.com
Article
Full-text available
Systemic anaplastic large cell lymphoma (sALCL) is an aggressive T-cell non Hodgkin lymphoma which is divided into two categories based on the expression of the anaplastic lymphoma kinase (ALK) protein (i.e. ALK-positive ALCL and ALK-negative ALCL). ALK-negative sALCL typically presents with
Article
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Forty disposable medical shoe covers were briefly exposed to the surgical floor and were found contaminated by a large number of bacteria. This study also demonstrated live bacteria, including pathogens attached to contaminated shoe covers, can be subsequently transferred to surgical bedsheets. We suggest an infection control policy should be consi...
Article
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The International Collaboration of Breast Registry Activities (ICOBRA) involves the national plastic surgery societies of several countries, including Australia, Austria, Canada, France, Germany, Ireland, Italy, the Netherlands, New Zealand, South Africa, the United Kingdom, and the United States.1 Its inception was triggered by the Poly Implant Pr...
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Background: Dry hospital environments are contaminated with pathogenic bacteria in biofilms, which suggests that current cleaning practices and disinfectants are failing. Aim: To test the efficacy of sodium hypochlorite solution against Staphylococcus aureus dry-surface biofilms. Methods: The Centers for Disease Control and Prevention Biofilm...
Article
Full-text available
Almost 200 women worldwide have been diagnosed with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The unique location and specific lymphoma type strongly suggest an etio-pathologic link between breast implants and BIA-ALCL. It is postulated that chronic inflammation via bacterial infection may be an etiological factor. BIA-AL...
Article
Background: A recent association between breast implants and the development of anaplastic large-cell lymphoma (BIA-ALCL) has been observed. Both animal and human studies have shown bacterial biofilm infection causes capsular contracture and that a higher bacterial load produces chronic immune activation around breast implants. Aim: to identify...
Article
Full-text available
Background: Biofilm infection of breast implants significantly potentiates capsular contracture. This study investigated whether chronic biofilm infection could promote T-cell hyperplasia. Methods: In the pig study, 12 textured and 12 smooth implants were inserted into three adult pigs. Implants were left in situ for a mean period of 8.75 months...
Article
Full-text available
The environment has been shown to be a source of pathogens causing infections in hospitalised patients. Incorporation of pathogens into biofilms, contaminating dry hospital surfaces, prolongs their survival and renders them tolerant to normal hospital cleaning and disinfection procedures. Currently there is no standard method for testing efficacy o...