Anais Vandevelde

Centre Hospitalier Universitaire de Tours · psychiatry

Objectif L’objectif de cette revue est d’identifier les corrélats anatomo-fonctionnels cérébraux lors d’un traitement par clozapine (CLZ) ainsi que les marqueurs anatomo-fonctionnels prédictifs de la réponse à la CLZ. Méthodes Nous avons réalisé une revue systématique de la littérature avec les bases de données MEDLINE et Web of Science afin d’ide...

Differential impact of Clozapine, atypical and typical antipsychotics on the fronto-striato-thalamic tracts in schizophrenia: a DTI-based tractography study A. Vandevelde 1,2,3, E. Leroux3, M. Tréhout1,2,3, S. Dollfus1,2,3 1 CHU de Caen, Service de Psychiatrie, Caen, France 2 Normandie Univ, UNICAEN, UFR de médecine (Medical School), Caen, France...

Objectives: Negative symptoms can be present at any stage of schizophrenia but their evaluation remains challenging. Self-evaluations may be particularly useful in screening negative symptoms quickly and effectively. The purpose of this study was to determine the sensitivity, the specificity, and the threshold beyond which the negative symptoms are...

Efforts to exclude past experiences from conscious awareness can lead to forgetting. Memory suppression is central to affective disorders, but we still do not really know whether emotions, including their physiological causes, are also impacted by this process in normal functioning individuals. In two studies, we measured the after-effects of suppr...

Many studies focus on the impact of equine assisted services (EAS) on social skills in autism spectrum disorder (ASD) but existing data are not consensual and the only available meta-analysis included only three studies and did not consider the social responsiveness scale (SRS). This meta-analysis aims to measure the impact of EAS on social skills...

Background During the last decades, a renewed interest for negative symptoms (NS) was brought about by the increased awareness that they interfere severely with real-life functioning, particularly when they are primary and persistent. Methods In this guidance paper, we provide a systematic review of the evidence and elaborate several recommendatio...

"Early detection Of schizophrenia, why and who to contact? Schizophrenia usually occurs in late adolescence or early adulthood but is generally preceded by a prodromal phase or by a "high risk mental state" which corresponds to the onset of the disease. Early detection of symptoms and rapid specialized intervention begin at this stage. Medical inte...

L'intoxication au lithium peut entraîner des complications neurologiques graves comme une altération de la conscience et un tableau d'encéphalopathie, avec un risque de décès ou de séquelles au long cours. Avec une présentation parfois atypique, voire même sans hyperlithiémie plasmatique initiale, le retard au repérage de ces complications peut êtr...

Background Schizophrenia is a common and severe mental disorder. The actual treatment is neuroleptic. Clozapine (CLZ), the atypical antipsychotic leader, is the best treatment of the resistant schizophrenia. Neuroimaging studies are important to understand better the neurological effects of CLZ. The main goal of this study is to analyze actual data...

The use and the choice of standardized assessment tools are necessary for improving identification of negative symptoms and for testing new efficient therapies. Most of the scales on negative symptoms are based on observer rating. Compared to these scales, self-assessments have been overlooked. Nevertheless, they are quite relevant since they are g...

Negative symptoms are considered to be the fundamental symptoms of schizophrenia. This book provides up-to-date, practical information on the management of negative symptoms in schizophrenia by describing the concepts, definitions, long-term course, evaluation (including rating scales), and treatment of such symptoms. Along with symptoms based on c...

The subjective construction surrounding the perception of negative experience is partly build upon bodily afferent information, comprising heart, gut or respiratory signals. While this bottom-up influence has been extensively described, the opposite pathway, the putative influence of cognitive processes over autonomic response, is still debatable....

Background The fronto-striato-thalamic circuitry is a key network associated with several symptoms observed in patients with schizophrenia (SZPs). In this study, we use diffusion tensor imaging (DTI) to investigate the integrity of white matter (WM) pathways involved in this network in SZPs relative to healthy controls (HCs). We also evaluate the d...

Background: The fronto-striato-thalamic circuitry constitutes a key network involved in several symptoms, like language disorders, observed in patients with schizophrenia (SZ) [1]. Several studies in diffusion tensor imaging (DTI) reported disturbed white matter (WM) integrity in this network in SZ [2] but no study has analyzed the differential imp...

Objectives: Impairments in language production are common of schizophrenia (SZ) and bipolar disorder (BD). Identifying distinct functional connectivity (FC) patterns in SZ and BD may provide biomarkers for their diagnoses. Methods: 49 participants (15 SZ, 14 BD, and 20 HC) underwent a verbal fluency task consisting of mentally generating verbs in F...

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Introduction The question of a continuum or a dichotomy between schizophrenia and bipolar disorders is not clearly elucidated. Objectives The objective of the present study was to identify specific functional connectivity (FC) patterns in schizophrenia and bipolar disorders. Aims Therefore, the aim was to explore FC within the language production...