Ana Paula Zaderenko

Universidad Pablo de Olavide | UPO · Department of Physical, Chemical and Natural Systems

Four biocidal treatments based on nanoparticles were designed and their penetration depths were characterized by laser-induced breakdown spectroscopy (LIBS) technique. This kind of biocidal nanoparticles are being studied to be employed in historic buildings and stone monuments due to their capability to inhibit the growth of biofoulings. The effec...

Stability of metal-organic frameworks is a key factor for many applications in some fields that require working at harsh conditions. It is known that a large number of MOFs are vulnerable to humid air. It means that when they are exposed to water, a structural collapse of the crystal happens. In this work, Molecular Dynamics simulations using a Rea...

Malignancies such as lung, breast and pancreatic carcinomas are associated with increased expression of the epidermal growth factor receptor, EGFR, and its role in the pathogenesis and progression of tumors has made this receptor a prime target in the development of antitumor therapies. In therapies targeting EGFR, the development of resistance owi...

Decohesion of building materials caused by weathering translates into the need for recurrent interventions with consolidating treatments that often turn out useless for desired long-term consolidation owing to their poor in-depth penetration. Due to this, it is important to develop new products that allow evaluating their penetration in situ. In th...

Separation of benzene and cyclohexane is one of the greatest challenges in industry. Their close boiling points and similar properties make them difficult compounds to separate. In this context, adsorption-based separation using zeolites or aluminosilicates is a promising technology. In the present work, we combine experimental measurements, densit...

Currently the application of consolidants based on nanoparticles is common practice among restorers. Consolidants should not modify the properties of original materials according to international recommendation, which requires previous studies to decide the optimal option. The selection must be based on empirical results, and not only in the expert...

Stone has been widely used as a construction material since ancient times, and its preservation is crucial in historical and contemporary buildings. Biodeterioration and other alterations cause damage in stone monuments which leads to the need for repeated actions. Nanotechnology is increasing the development of new products for construction and re...

This study conducted a comparison between biocide treatments based on nanoparticles of silver, copper, ZnO, TiO2 and silver/ TiO2 nanocomposites to analyse their capability to inhibit microalgal fouling on stone buildings. Biofouling is one of the main alterations on stone façades, causes degradation of their constituent materials and interferes wi...

One of the main problems in the conservation of historical buildings and archaeological sites is the one caused by biodeterioration. Biopatina, biocrust or biofouling generate aesthetical changes and induce degradation processes within the stone matrix. In this work, three treatments based on silver nanoparticles and silver/titanium dioxide nanocom...

Progress in the field of biocompatible SERS nanoparticles has promising prospects for biomedical applications. In this work, we have developed a biocompatible Raman probe by combining anisotropic silver nanoparticles with the dye rhodamine 6G followed by subsequent coating with bovine serum albumin. This nanosystem presents strong SERS capabilities...

Currently, the application of consolidation treatments based on nanolimes (Ca(OH)2 nanoparticles) has become a common practice during the restoration of historical buildings. However, recent studies have showed that their effectiveness on stone materials is lower than expected. This result is due to the accumulation of nanolimes near the surface, w...

In this work, laser-induced breakdown spectroscopy (LIBS) was used to evaluate the depth penetration of nanoparticles employed as biocidal treatment in stones. The penetration of a biocidal treatment, based on silver nanoparticles, was studied on limestones from Utrera (Seville, Spain). This stone was commonly employed in historical buildings in so...

Biodeterioration of stone monuments is estimated to be as high as 20–30% of the total degradation suffered by Cultural Heritage constructions. With regard to this problem, bactericidal treatments are mainly based on cleaning. These processes, while effective in the short term, require frequent reapplications increasing potential damages to the monu...

Novel results concerning surface-enhanced Raman scattering mediated by thiol-immobilized capped silver nanoparticles attached to a silicon Si(100) substrate are presented. The attachment of the nanoparticles is achieved by chemically modifying the surface of Si(100) in order to provide sulfhydryl groups covalently linked to the substrate and then c...

Silver nanoparticles offer a huge potential for biomedical applications owing to their exceptional properties and small size. Specifically, cysteamine-capped silver nanoparticles could form the basis for new anticancer therapies combining the cytotoxic effect of the silver core with the inherent antitumor activity of cysteamine, which inhibit cance...

Biodegradation of stones is a common and undesirable alteration in historical buildings. Restorers have been using different treatments, especially chemical methods, to prevent biodeterioration. These treatments often have disadvantages such as low long-term effectiveness, high toxicity on human health and the environment and/or physicochemical inc...

La biodegradación en piedra es una alteración común e indeseable en los edificios históricos. Los restauradores han estado utilizando diferentes tratamientos para la prevención del biodeterioro, especialmente métodos químicos. Estos tratamientos suelen tener ciertas desventajas, tales como baja durabilidad a largo plazo, alta toxicidad para el homb...

Cell cytoskeleton makes profound changes during apoptosis including the organization of an Apoptotic Microtubule Network (AMN). AMN forms a cortical structure which plays an important role in preserving plasma membrane integrity during apoptosis. Here, we examined the cytoskeleton rearrangements during apoptosis induced by camptothecin (CPT), a top...

Systemic treatments for hepatocellular carcinoma (HCC) have been largely unsuccessful. This study investigated the antitumoral activity of Amitriptyline, a tricyclic antidepressant, in hepatoma cells. Amitriptyline-induced toxicity involved early mitophagy activation that subsequently switched to apoptosis. Amitriptyline induced mitochondria dysfun...

Tannic acid (TA) has multiple effects against cancer, being especially promising in those types that overexpress the epidermal growth factor receptor (EGFR), as TA modulates its activation and downstream signaling pathways, triggering apoptosis. Nonetheless, despite the important role of this receptor in the pathogenesis and progression of a wide v...

Gaucher disease (GD) is caused by mutations in the GBA1 gene, which encodes lysosomal -glucocerebrosidase. Homozygosity for the L444P mutation in GBA1 is associated with high risk of neurological manifestations which are not improved by enzyme replacement therapy. Alternatively, pharmacological chaperones (PCs) capable of restoring the correct fol...

Camptothecin (CPT; (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2- b]quinoline-3,14-(4H,12H)-dione) is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor water-solubility and chemical instability and, as a consequence, no effective administration means have been designed. In this w...

Apoptosis is characterized by degradation of cell components but plasma membrane remains intact. Apoptotic microtubule network (AMN) is organized during apoptosis forming a cortical structure beneath plasma membrane that maintains plasma membrane integrity. Apoptotic cells are also characterized by high reactive oxygen species (ROS) production that...

Apoptotic microtubule network (AMN) is organized during apoptosis, forming a cortical structure beneath the plasma membrane which plays a critical role in preserving cell morphology and plasma membrane integrity. The aim of this study was to examine the effect of cold/warming exposure on apoptotic microtubules and plasma membrane integrity during t...

Apoptotic microtubule network (AMN) is organized during apoptosis, forming a cortical structure beneath plasma membrane, which has an important role in preserving cell morphology and plasma membrane permeability. The aim of this study was to examine the role of AMN in maintaining plasma membrane integrity during the execution phase of apoptosis. We...

Theoretical studies on the interactions of rhodamine 6G (R6G) with silver nanoparticles have been carried out. R6G exhibits Surface Enhanced Raman Scattering (SERS) effect on most sensors and has been extensively studied experimentally, so it is a suitable benchmark. By means of density functional quantum chemical calculations by the B3LYP method a...

Infrared spectra (IR) of a great variety of zeolite frameworks in the limit of pure silica composition are calculated by molecular dynamics and also recorded experimentally. This enables us to study and assess the effect of three flexible force fields from the literature developed for zeolites in reproducing the IR spectra: the force fields by Demo...

Silver nanoparticles are emerging as a powerful tool in bioimaging applications owing to their unique plasmonic properties i.e., extremely high molar extinction coefficients, resonant Rayleigh scattering and enhanced local electromagnetic fields. Through the optimization of these properties, by controlling composition, size, shape, and interparticl...

There is a growing interest in nanoparticles as carriers of chemotherapeutic agents in order to improve their administration and minimize their side effects. Despite the fact that silver nanoparticles can be conjugated to therapeutic agents, offering additionally advantages due their unique and tunable optical properties, few examples have been des...

The laser desorption/ionization (LDI) assisted by gold nanospheres, nanorods and nanostars has been investigated. Laser fluence thresholds for the appearance of cationized adducts of a polydispersed polyether standard (polyethylenglycol PEG600) have been determined at the near ultraviolet–visible–near infrared wavelengths delivered by a Nd:YAG lase...

Silver nanoparticles possess many valuable optical properties that have opened the door to new approaches in sensing and imaging applications, offering a wide range of detection modes such as colorimetric, scattering, SERS, and MEF techniques, at extremely low detection limits. Moreover, nanoparticles have made possible the use of scattering imagin...

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Unlabelled: We characterized a method to conjugate functional silver nanoparticles with vasoactive intestinal peptide (VIP), which could be used as a working model for further tailor-made applications based on VIP surface functionality. Despite sustained interest in the therapeutic applications of VIP, and the fact that its drugability could be la...

Capped silver nanoparticles that can be coupled to a variety of molecules and biomolecules are of great interest owing to their potential applications in biomedicine. However, there are no data about their toxicity or functional effects on a key innate immune response, such as IL-6 secretion, after the engagement of the main group of pathogen-assoc...

We report a novel method for the fabrication of films of silver nanoparticle aggregates that are strongly attached to Si substrates (Thiol-immobilized silver nanoparticle aggregates or TISNA). The attachment is achieved by chemically modifying the surface of a Si(100) surface in order to provide SH groups covalently linked to the substrate and then...

The crystal structure of the diethyl 2-benzimidazol-1-ylsuccinate-picric acid (1/1) molecular complex has been determined by X-ray diffraction analysis. Diethyl 2-benzimidazol-1-ylsuccinate molecules form channels along the a axis, in which the picric acid molecules are located. The benzimidazole moiety and the phenol group are held together by hyd...

The regioselectivity of nucleophilic addition of azoles to unsymmetrical fumarates yielding the corresponding (+/-)-2-azol-1-ylsuccinates has been studied. The major regioisomer has been identified as the one obtained from the attack of the azole to the more congestive side of the double bond. These results have been interpreted in terms of HOMO-LU...

The crystal zwitterion structures of imidazol-1-ylacetic acid 1 and (±)-3-ethoxycarbonyl-2-imidazol-1-ylpropionic acid2 have been determined by X-ray diffraction analysis. Spectroscopic 13C NMR studies in the solid state, by the CP/MAS technique, and in solution have revealed the presence of the zwitterion structure in H2O and D2O solutions. Result...

The molecular dynamics of hydantoin,5,5-dimethylhydantoin,5,5-diphenylhydantoin, barbituric acid and 5-ethyl-5-phenylbarbituric acid in solution are determined to investigate the molecular basis for the activity of these neuroactive drugs. From dipolar 13C and 15N spin-lattice relaxation times the correlation times for the rotational dynamics of sp...

(±)-2-Imidazol-1-ylsuccinic esters were synthesized by thermal addition of imidazole to either fumaric or maleic esters. Acceleration of the reaction was achieved, in some cases, using microwave heating. These esters underwent an easy regioselective hydrolysis, under neutral conditions, to give the corresponding half-esters: (±)-3-(alkoxycarbonyl)-...

Some racemic 2-imidazol-1-yl and 2-pyrazol-1-ylsuccinic esters, prepared by nucleophilic addition of the corresponding azole to fumaric esters, have been resolved. The enantioselective inclusion methodology has been applied using compounds derived from tartaric acid as chiral hosts.

(+/-)-2-Imidazol-1-ylsuccinic esters were synthesized by thermal addition of imidazole to either fumaric or maleic esters. Acceleration of the reaction was achieved, in some cases, using microwave heating. These esters underwent an easy regioselective hydrolysis, under neutral conditions, to give the corresponding half-esters: (+/-)-3-(alkoxycarbon...

Referencia OEPM: P9700496.-- Fecha de solicitud: 06/03/1997.-- Titulares: Universidad Nacional de Educación a Distancia (UNED), Consejo Superior de Investigaciones Científicas (CSIC). Peer reviewed