Ana Maria Gondim Valença

Ana Maria Gondim Valença
Federal University of Paraíba | UFPB · Programa de Pós-Graduação em Saúde Coletiva

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204
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Publications

Publications (204)
Article
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This paper investigates the occurrence of severe oral mucositis and associated factors in blood and solid cancer pediatric patients subjected to cancer treatment, using a survival analysis. A longitudinal, descriptive, observational and inductive study of 142 pediatric patients aged from 0 to 19 years was conducted from 2013 to 2017. Data were coll...
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Rev. Bras. Cancerol. 2025; 71(1): e-144832 1 Este é um artigo publicado em acesso aberto (Open Access) sob a licença Creative Commons Attribution, que permite uso, distribuição e reprodução em qualquer meio, sem restrições, desde que o trabalho original seja corretamente citado.
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Introdução: O câncer configura-se como um conjunto de doenças com características agressivas e passíveis de disseminação pelos órgãos do corpo. É considerado um dos principais problemas de saúde pública, sendo apontado como causa predominante de morte na maioria da população. Objetivo: Caracterizar o câncer infantojuvenil e verificar a completude d...
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Objective Development and evaluation of a mobile application for remote monitoring and guidance of pediatric patients diagnosed with cleft lip and/or palate (CL ± P) and their caregivers. Design This is a pilot cross-sectional, applied, and quantitative study. Setting The study was conducted in two tertiary care treatment centers in Brazil. Part...
Article
This study aimed to investigate the relationship between epigenetic mechanisms and oral mucositis (OM) in paediatric patients with acute lymphoblastic leukaemia. Oral cells were collected from 76 participants, including 15 healthy individuals, 10 patients with acute lymphoblastic leukaemia but without a history of OM and 51 acute lymphoblastic leuk...
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Objective To identify factors associated with hospitalization in the intensive care unit in children and adolescents with COVID-19. Methods This was a retrospective cohort study using secondary data of hospitalized children and adolescents (zero to 18 years old) with COVID-19 reported in Paraíba from April 2020 to July 2021, totaling 486 records....
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The aim of this study was to investigate the DNA methylation profile in genes encoding catalase ( CAT) and superoxide dismutase (SOD3) enzymes, which are involved in oxidative stress mechanisms, and in genes encoding pro-inflammatory cytokines interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-α) in the oral mucosa of oncopediatric patie...
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Objective To measure the costs of preventive and therapeutic protocols of Photobiomodulation (PBM) for oral mucositis (OM) and their budgetary impact on Brazil’s Ministry of Health (BMH). Material and Methods A partial economic analysis was performed to estimate the costs using a bottom-up approach from a social perspective. Monetary values were a...
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RESUMO Objetivo Identificar fatores associados ao internamento na unidade de terapia intensiva de crianças e adolescentes com COVID-19. Método Estudo de coorte retrospectiva, com dados secundários, de crianças e adolescentes hospitalizados (zero a 18 anos), notificados com COVID-19 na Paraíba, de abril de 2020 a julho de 2021, totalizando 486 regis...
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Objective To report nine cases of pediatric patients with Acute Lymphoid Leukemia (ALL) or Acute Myeloid Leukemia who developed severe oral mucositis (SOM) at the first week of chemotherapy. Material and Methods The cases were selected from a sample of 105 children followed for 10 consecutive weeks. Hematological and personal data were obtained fr...
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Objetivou-se analisar os fatores associados ao atraso no início do tratamento de crianças e adolescentes com tumores de SNC submetidos ao tratamento nos hospitais de referência da Paraíba, Brasil no período de 2010 a 2019, por meio dos dados disponíveis nos Registros Hospitalares de Câncer (RHC). Trata-se de um estudo de corte histórico, analítico...
Article
Objective: We aimed to investigate the accuracy of remote examination by photographs compared to in-person clinical examination for detecting potentially malignant oral lesions (PMOLs). Methods: The Reporting Guide and Guidelines for Writing Systematic Reviews (Preferred Reporting Items for Systematic Reviews and Meta-Analysis [PRISMA]) guided the...
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The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) and the DNA methylation profiles of the DNA methyltransferase (DNMT) gene family with oral mucositis in children and adolescents with hematologic malignancies treated with methotrexate (MTX®). The population was comprised of healthy and oncopediatric...
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Objective: Evaluate the effect of a multidrug solution, adopted by a referral hospital for cancer to control and treat chemotherapy-induced oral mucositis in rats. Methods: Oral mucositis (OM) was induced by 5-Fluorouracil (5-FU), and the animals were treated with saline (n = 8, G1), 0.12% chlorhexidine (n = 8, G2); and multidrug solution (n = 8...
Article
Objective: To assess the impact of an oral health education and preventive program (OHEPP) for pediatric cancer patients. Methods: This was a single-arm study with 27 children and adolescents undergoing antineoplastic treatments. Patients were followed up for 10 weeks, and their oral health conditions were evaluated using the Modified Gingival Inde...
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Objetivo: Descrever a linha de cuidados e identificar dificuldades existentes na articulação dos três níveis assistência à saúde prestadas ao portador de câncer bucal no Sistema Único de Saúde (SUS) no Estado da Paraíba (Brasil). Métodos: Foi realizada uma abordagem qualitativa em amostra de profissionais de saúde (gestores e cirurgiões dentistas)...
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Objectives To test 8 models of linear surface roughness assessment in characterizing surface profile description and to correlate these models with equivalent areal parameters over sound human enamel in vitro.Materials and methodsThirty enamel blocks were randomly selected. The roughness data (2D—Rp; Rv; Rz; Rc; Rt; Ra; Rq; Rsk; Rku/3D—Sp; Sv; Sz;...
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Objetivo: caracterizar o câncer infantojuvenil no Brasil, a partir da investigação nacional e regional dos registros hospitalares de câncer (RHC), no período de 2000 a 2016. Métodos: estudo observacional, retrospectivo e de base secundária, com amostra de 71.925 registros contendo informações de crianças e adolescentes (0 a 19 anos). Resultados: o...
Article
Objective To investigate the relationship between the polymorphisms rs1544410 (BsmI), rs2228570 (FokI) and rs731236 (TaqI) and DNA methylation status in the VDR gene (vitamin D receptor) with oral mucositis (OM) in oncopaediatric patients treated with methotrexate (MTX®). Methods The population comprised healthy patients and with haematological ma...
Article
Aim In this study, we evaluated the impact of an integrated oral care protocol for pediatric patients undergoing antineoplastic treatment from the perspective of the multidisciplinary team, oral healthcare team, and caregivers.Subject and Methods This was a qualitative study carried out in the pediatric sector of a reference cancer hospital in Braz...
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This study aimed to analyze the distribution of childhood cancer and identify factors associated with delay in starting cancer treatment, in the state of Paraíba, from the Hospital-Based Cancer Registries (HBCR), from 2010 to 2018. Observational, descriptive and analytical study, with 896 records of children and adolescents (0-19 years), identifyin...
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Oral health education is an effective measure to prevent oral mucositis (OM) by improving self-management and effectively engaging patients in their health care. This systematic review aimed to determine the impact of oral health education interventions on the incidence and severity of OM. Bibliographical searches were carried out by two independen...
Preprint
Oral mucositis (OM) is the most common local adverse event of chemotherapy treatment and leads to a debilitating condition from the patient’s perspective. The aim of this study is to report nine cases of severe OM over 10 weeks after initiating chemotherapy in pediatric patients with leukemia. All patients showed changes in normality of hematologic...
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Objetivo: Descrever características demográficas, clínicas e de tratamento de crianças e adolescentes diagnosticados com tumores de Sistema Nervoso Central (SNC) na região nordeste do Brasil, no período de 2010 a 2016. Método: Estudo transversal, retrospectivo, de base secundária, em pacientes oncológicos pediátricos (0 a 19 anos) com tumores do SN...
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Objective: Oral mucositis (OM) is a painful inflammatory oral condition that affects children who undergo chemotherapy. Oxidative stress is a known OM mediator and pro-inflammatory cytokines contribute to the amplification of the immune response. To investigate the possible associations of rs4880 (superoxide dismutase 2, SOD2 47 C/T), rs7943316 (c...
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Background: The oral healthcare offered to pediatric cancer patients at the hospital level must include educational and preventive strategies based on dialogical and welcoming professional attitudes. Therefore, the current study aimed to evaluate the perception of pediatric cancer patients and their parents/guardians about an educational and preve...
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How to cite: Damascena LCL, Bezerra PMM, Santos FG, Lucena NNN, Vieira TI, Viana Filho JMC, et al. Impact of COVID-19 on oral healthcare for oncopediatric patients: the setting in a reference hospital in Northeast Brazil. Pesqui Bras ABSTRACT Objective: To describe the impact of the COVID-19 pandemic on dental care provided to pediatric cancer pati...
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Objetivo: Verificar as evidências científicas reveladas por pesquisas de identificação do perfil da violência doméstica contra a mulher (VDCM) no Brasil. Metodologia: Trata-se de um estudo descritivo do tipo revisão integrativa da literatura. Foi estabelecida a utilização dos descritores: “violência contra a mulher” AND “violência doméstica”, aplic...
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Purpose To investigate the effectiveness of an Oral Health Education and Prevention Program (OHEPP) on the incidence and severity of oral mucositis (OM) in pediatric cancer patients. The OHEEP was a ludic strategy for promoting oral health and monitoring the oral health condition. Methods We compared the incidence and severity of OM in patients wh...
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Objetivou-se descrever as características do planejamento, programação e avaliação em Odontologia no Programa Saúde da Família (PSF) no Estado da Paraíba. Adotou-se uma abordagem indutiva com procedimento qualitativo e descritivo, técnica de observação direta intensiva por meio de entrevista. Uma amostra estratificada segundo região e densidade pop...
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The study investigated the relationship between genetic polymorphisms and the development of oral mucositis in pediatric patients undergoing chemotherapy involving methotrexate. A longitudinal study was conducted with 64 patients, and oral mucositis was evaluated by the modified Oral Assessment Guide, which aims to diagnose and classify oral mucosi...
Article
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The study investigated the relationship between genetic polymorphisms and the development of oral mucositis in pediatric patients undergoing chemotherapy involving methotrexate. A longitudinal study was conducted with 64 patients, and oral mucositis was evaluated by the modified Oral Assessment Guide, which aims to diagnose and classify oral mucosi...
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O objetivo deste estudo foi apresentar os desafios relacionados ao cumprimento dos novos protocolos de biossegurança, na perspectiva do retorno das atividades presenciais nas instituições de ensino superior em Odontologia, no cenário da pandemia da COVID-19. Tratou-se de um estudo qualitativo, de caráter exploratório, ancorado na técnica de pesquis...
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The purpose of this study was to implement a model of permanent oral health care for oncopediatric patients and to observe its effects on severe oral mucositis and subsequent treatment interruptions. We performed a quasi-experimental study in the Pediatric Department of Napoleão Laureano Hospital, in the city of João Pessoa, Brazil. A integrated or...
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Objective: To characterize the access to primary dental care and the work process of Oral Health Teams (OHTs), nationwide and by geographic region, based on data from the 3rd phase of the PMAQ-AB (the Program for Improving Access and Quality of Primary Care). Material and Methods: This was a cross-sectional study using data from the external assess...
Article
Aims To evaluate the unstimulated salivary flow (USF) and salivary colonization of total Streptococcus spp. (TS) and mutans-group (MS) in pediatric patients with hematological tumors. Correlations of salivary and microbiological changes with chemotherapy and patient-related factors were also verified. Methods and Results Eligible children (n = 31)...
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Objetivo: Analisar o perfil da atenção em saúde bucal ofertada a crianças e adolescentes na Atenção Básica e os fatores que influenciam a integralidade do cuidado para estes usuários. Metodologia: Foram entrevistados 68 cirurgiões-dentistas de João Pessoa/PB e levantadas informações do Programa Nacional de Melhoria do Acesso e da Qualidade da Atenç...
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ABSTRACT Objective: To analyze the distribution of childhood cancer in Brazil and the time between the diagnosis and the start of treatment, according to hospital-based cancer registries (2010-2016). Material and Methods: This was an observational descriptive study using secondary data (36,187 records) from hospital databases of the National Cancer...
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Aim This study aimed to evaluate the time to diagnosis of pediatric cancer and associated comorbidities during cancer therapy. Subject and Methods This was a prospective observational study with a 20-month follow-up of 146 pediatric patients diagnosed with cancer and treated in northeastern Brazil. Results The mean age of the participants was 8.2...
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Background: Childhood cancer is one of the main causes of child mortality and its treatment has debilitating effects on the oral cavity. Several oral mucositis (SOM) is one of the most common and may cause undesirable symptoms such as pain and risk of systemic infection. Material and methods: This was a longitudinal, retrospective, and observati...
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Objectives The aim of this study was to assess the in vitro caries preventive effect of nanocomplexed solutions of hydroxypropyl-β-cyclodextrin and γ-cyclodextrin associated with titanium tetrafluoride (TiF4) after different complexation times (12 or 72 h).Materials and methodsEnamel blocks were randomly distributed in 9 groups (n = 11): negative c...
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Evaluated the effect of CPP-ACP/NaF and xylitol/NaF varnishes in reduce erosion and progression of erosion. Forty enamel blocks were divided into four groups (n=10): G1=CPP-ACP/NaF varnish (MI varnishTM); G2=xylitol/NaF varnish (Profluorid®); G3=NaF varnish (Duraphat®, positive control) and G4=deionized water (MilliQ®, negative control). Samples we...
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During the last weeks, we are facing a global pandemic which affects the general population and health care system. Observing COVID-19 care, hospitals and health care services are focusing their attention on COVID-19 combat. Considering this emergency, structural and logistic impacts over health services are perceived evidently and conventional rou...
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Objective: To identify the factors associated with user satisfaction with the provision of oral health care in João Pessoa/PB, based on data from the 2nd cycle of the external evaluation of the National Program for Improving Access and Quality in Primary Care (PMAQ-AB). Methodology: Information contained in Module III and Module VI of the PMAQ-AB e...
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The aim of this study was to assess the effect of a newly developed nanocomplex formed of hydroxypropyl-b-cyclodextrin and 1% titanium tetrafluoride (TiF4) after distinct complexation periods (12/72 h) on demineralization of bovine enamel in vitro. Enamel blocks (n=60) were allocated in different groups: Mili-Q water, hydroxypropyl-b-cyclodextrin,...
Article
Objective To compare the effectiveness and acceptability of a newly developed pediatric sialometer as an alternative to the conventional spitting method. Methods A clinical study was carried out with healthy children (G1; n = 30) and oncological children (G2; n = 30). A newly developed pediatric sialometer was compared to the traditional spitting...
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The aim of this study is to evaluate salivary and microbiological parameters of pediatric oncological patients and their correlation with severe oral mucositis (SOM).This study aims to evaluate the salivary parameters and cariogenic microbiota of pediatric oncological patients and their correlation with severe oral mucositis (SOM). A preliminary lo...
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The objective of this study was to identify the factors associated with the user’s satisfaction about the provision of oral health care in the State of Paraíba. The research based on data regarding the 2nd cycle of the external evaluation of the National Program for Improving Access and Quality in Primary Care (PMAQ-AB). The responses of users who...
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Objective: To determine the occurrence and severity of oral mucositis (OM) and the factors associated with the onset of severe oral mucositis (SOM) in pediatric cancer patients. Material and Methods: This was a longitudinal and prospective study with 85 children and adolescents (aged 0 to 19 years) admitted to the Pediatric Oncology Sector of Napo...
Article
The oral cytotoxicity, antimicrobial and anti-demineralizing effects of a tincture from Bauhinia forficata Link tincture (BFLT) were evaluated in vitro and ex vivo. Susceptibility tests (minimum inhibitory and microbicidal concentrations-MIC and time-kill assay-MMC) were performed against planktonic oral microorganisms. The contents of phenolic com...
Chapter
Bauhinia forficata Link has been described as having bioactive properties including antimicrobial activity. However, this natural product has not yet been tested against dental biofilm. This book chapter evaluated by means of a laboratory study the effects of a tincture made from Bauhinia forficata Link leaves (TBF) on Streptococcus mutans biofilm...
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This study aimed to evaluate the factors associated with the occurrence of severe oral mucositis (SOM) in pediatric oncology patients during the chemotherapeutic treatment. This is a nested case-control to a prospective cohort that monitored 105 patients for 10 consecutive weeks after the beginning of the chemotherapy treatment. Logistic regression...
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The present study aimed to report the trajectory of research conducted with pediatric oncological patients developed over the past nine years at the Napoleão Laureano Hospital (HNL), by students and professors of the Graduate Program in Decision and Health Models (PPGMDS/UFPB). We describe the insertion of these researchers in the Pediatric Oncolog...
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Objective: This study sought to identify the differences between the oral changes presented by patients with solid and hematologic tumors during chemotherapeutic treatment. Methodology: This is an observational, prospective and quantitative study using direct documentation by follow-up of 105 patients from 0 to 18 years using the modified Oral A...
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This study aimed to investigate the contribution of motor changes to oral mucositis in children and adolescents with cancer undergoing antineoplastic treatment in a referral hospital. This was an observational, cross-sectional study with 70 patients aged 2 to 19 years, diagnosed with any type of cancer and treated in a pediatric hospital cancer war...
Article
The estimation of the age of majority is crucial to determine the legal accountability of an individual. With this purpose, the analysis of the dental development process has proven to be an effective, elucidatory method. This study investigated the applicability of the Third Molar Maturation Index (I3M), proposed by Cameriere et al. (2008), to est...
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Introduction Antimicrobial sutures are a therapeutic alternative for the control of oral infections. Objective Incorporate Chlorhexidine (CHX) and Cinnamaldehyde (CN) in sutures and evaluate the anti-Candida effect, release of antimicrobials and mechanical properties. Material and method Silk (S) and Polyglactin 910 (P) sutures were aseptically s...
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Background: It is known that chemotherapeutic agents are not equally stomatotoxic and oral cavity lesions are the most frequent complications encountered in antineoplastic chemotherapy. Aims: The objective of this study was to evaluate the occurrence of severe oral mucositis during a chemotherapy treatment and to identify its relationship with t...
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One of the strategies used in recent years to increase the commitment and motivation of patients undergoing rehabilitation is the use of graphical systems, such as virtual environments and serious games. In addition to contributing to the motivation, these systems can simulate real life activities and provide means to measure and assess user perfor...
Preprint
Applications for learning and training have been developed and highlighted as important tools in health education. Despite the several approaches and initiatives, these tools have not been used in an integrated way. The specific skills approached by each application, the absence of a consensus about how to integrate them in the curricula, and the n...
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Objective The aim of this study was to evaluate microbiological changes, oral soft tissue toxicity, and caries-preventive effect of an experimental titanium tetrafluoride (TiF4) varnish compared with a commercially available fluoride varnish (NaF), using in situ and in vivo models. Materials and methods The treatment groups were the following: TiF...
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Objective: To describe oral health actions against oral cancer promoted by Primary Health Care Teams in northeastern Brazil. Methods: This is a descriptive and inferential study based on data related to detection, referral, registration, follow-up and documents related to these actions in the External Evaluation of the 1st and 2nd Program for Impro...
Article
Purpose The use of simulators based on virtual reality has become more common in different areas. In the field of health sciences, their use ranges from the training of future professionals to planning and performing surgical procedures in real cases. Different procedures can be trained through these programs, one of them being the surgical incisio...
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Objective: The aim of this study was to evaluate the prevalence of Candida colonizationon oral cavity of pediatric individuals with acute lymphocytic leukemia (ALL) and its susceptibility/resistance to nystatin and amphotericin B. Methods: This was a cross sectional study with observational, descriptive and analytic approach. Saliva was collected f...
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Objetivo: Descrever a condição de saúde bucal de pacientes pediátricos oncológicos assistidos em um hospital de referência em João Pessoa/PB, avaliando o acesso aos serviços odontológicos, bem como o cuidado odontológico e eles ofertado. Materiais e Métodos: Procedeu-se um estudo transversal, cuja coleta de dados se deu mediante exame clínico, uso...
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Objetivo: Avaliou-se qualidade de vida e as condições de higiene de próteses dentárias em idosos residentes em instituição de longa permanência, na cidade de João Pessoa-PB. Metodologia: Foi aplicado o Geriatric Oral Health Assessment Index (GOHAI) para avaliar a qualidade de vida, em alta e moderada-baixa, incluindo perguntas sobre higienização de...
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Resumo O crescimento da implantação do Núcleo Ampliado de Saúde da Família e Atenção Básica na Paraíba e sua influência na melhoria da qualidade da assistência das equipes de atenção primária torna relevante conhecer a organização do processo de trabalho destes núcleos. O estudo analisou ações de planejamento, oferta de formação inicial e de educaç...
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Objective: To verify differences between salivary flow in pediatric cancer patients before starting antineoplastic treatment and in healthy pediatric patients. Material and Methods: This is an observational, cross-sectional, paired study with sample of 120 children and adolescents (3-18 years). Thirty pediatric cancer patients were selected for co...
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Objective: To perform chemical analysis and to evaluate the anti-biofilm and hemolytic effect of the essential oil of Cymbopogon citratus. Material and Methods: Gaseous chromatography coupled to mass spectrometer was performed for chemical characterization of the essential oil. To verify the antimicrobial action, the Minimum Inhibitory Concentrati...
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