Ana Tadijan

Ana Tadijan
Ruđer Bošković Institute | RBI · Division of Molecular Medicine

Ph.D., Postdoc

About

27
Publications
2,264
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
151
Citations
Citations since 2017
23 Research Items
142 Citations
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
Introduction
Works as a postdoc in the field of Molecular biology of Cancer at Ruđer Bošković Institute, Croatia.
Additional affiliations
May 2019 - present
Ruđer Bošković Institute
Position
  • PostDoc Position
Description
  • Laboratory for protein dynamics
November 2015 - February 2019
Ruđer Bošković Institute
Position
  • PhD Student
Description
  • Mentor: Andreja Ambriović Ristov, PhD, Senior Scientist. Project INSILCELL: Molecular mechanisms of chemosensitisation of human breast carcinoma and melanoma cell lines by silencing of integrins.
May 2013 - May 2015
Scuola Internazionale Superiore di Studi Avanzati di Trieste
Position
  • Researcher
Description
  • Mentors: Andrea Nistri, PhD, Full Prof. and Miranda Mladinić-Pejatović, PhD, Assoc.Prof.
Education
January 2016 - March 2019
University of Osijek
Field of study
  • Interdisciplinary studies- Molecular Biosciences
October 2010 - July 2012
University of Zagreb, Faculty of Science
Field of study
  • Molecular Biology
October 2007 - July 2010
University of Zagreb, Faculty of Science
Field of study
  • Molecular Bology

Publications

Publications (27)
Article
Full-text available
Metastatic melanoma is one of the most aggressive tumors, with frequent mutations affecting components of the MAPK pathway, mainly protein kinase BRAF. Despite promising initial response to BRAF inhibitors, melanoma progresses due to development of resistance. In addition to frequent reactivation of MAPK or activation of PI3K/AKT signaling pathways...
Article
Full-text available
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic cannabinoids have received growing interest as treatment options in neurodegenerative conditions. In various experimental settings, they have displayed antioxidative, anti-inflammatory, antiapoptotic, immunomodulatory, and neuroprotective effects. However, due to nu...
Article
Full-text available
Regardless of the significant improvements in treatment of melanoma, the majority of patients develop resistance whose mechanisms are still not completely understood. Hence, we generated and characterized two melanoma-derived cell lines, primary WM793B and metastatic A375M, with acquired resistance to the RAF inhibitor vemurafenib. The morphology o...
Article
Full-text available
Integrins are heterodimeric cell surface glycoproteins used by cells to bind to the extracellular matrix (ECM) and regulate tumor cell proliferation, migration and survival. A causative relationship between integrin expression and resistance to anticancer drugs has been demonstrated in different tumors, including head and neck squamous cell carcino...
Article
Full-text available
Cutaneous melanoma is the most aggressive form of skin cancer. Despite the significant advances in the management of melanoma in recent decades, it still represents a challenge for clinicians. The TP53 gene, the guardian of the genome, which is altered in more than 50% of human cancers, is rarely mutated in melanoma. More recently, researchers star...
Article
Full-text available
The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all family members should be considered. Each family member possesses two promoters and alternative translati...
Article
Full-text available
High fat diet (HFD) is an important factor in the development of metabolic diseases, with liver as metabolic center being highly exposed to its influence. However, the effect of HFD-induced metabolic stress with respect to ovary hormone depletion and sirtuin 3 (Sirt3) is not clear. Here we investigated the effect of Sirt3 in liver of ovariectomized...
Article
The Kank (kidney or KN motif and ankyrin repeat domain-containing) family of proteins has been described as essential for crosstalk between actin and microtubules. Kank1, 2, 3 and 4 arose by gene duplication and diversification and share conserved structural domains. KANK proteins are localised mainly to the plasma membrane in focal adhesions, indi...
Article
Molybdenum trioxide (MoO3) nanoparticles (NPs) embedded in polymer films have been proposed as a cheap way of producing antibacterial coatings on external surfaces. Recently, we synthesized MoO3 nanowires in a unique shape and degree of anisotropy, which enables their fast water dissolution and quick antimicrobial reaction. Potential human health r...
Article
Full-text available
Integrins are heterodimeric cell surface receptors composed of α and β subunits that control adhesion, proliferation and gene expression. The integrin heterodimer binding to ligand reorganises the cytoskeletal networks and triggers multiple signalling pathways that can cause changes in cell cycle, proliferation, differentiation, survival and motili...
Article
Full-text available
Estrogen (E2) is a major risk factor for the initiation and progression of malignancy in estrogen receptor (ER) positive breast cancers, whereas sirtuin 3 (Sirt3), a major mitochondrial NAD+-dependent deacetylase, has the inhibitory effect on the tumorigenic properties of ER positive MCF-7 breast cancer cells. Since it is unclear if this effect is...
Article
Full-text available
Integrins are heterodimeric glycoproteins that bind cells to extracellular matrix. Upon integrin clustering, multimolecular integrin adhesion complexes (IACs) are formed, creating links to the cell cytoskeleton. We have previously observed decreased cell migration and increased sensitivity to microtubule (MT) poisons, paclitaxel and vincristine, in...
Article
Full-text available
Metabolic homeostasis is differently regulated in males and females. Little is known about the mitochondrial Sirtuin 3 (Sirt3) protein in the context of sex-related differences in the development of metabolic dysregulation. To test our hypothesis that the role of Sirt3 in response to a high-fat diet (HFD) is sex-related, we measured metabolic, anti...
Poster
Breast cancer is the most frequent cancer among women, and 70% of all breast cancer cases are estrogen receptor (ER) positive. Sirtuin 3 (Sirt3) has a promising role in cancer tumorigenesis and treatment, but there have been controversies about its role as oncogene or tumor suppressor in different types of cancer. We have recently shown that de nov...
Presentation
Sirtuin 3 (Sirt3), a major mitochondrial NAD+-dependent deacetylase, has bifunctional role in cancer tumorigenesis, acting as both oncogene and tumor suppressor, depending on the tissue and cancer-type specific metabolic programs. Changes in its expression are associated with the excessive production of reactive oxygen species (ROS), thus contribut...
Article
Low survival rates of patients with metastatic triple negative breast cancer (TNBC) and melanoma, in which current therapies are ineffective, emphasize the need for new therapeutic approaches. Integrin β1 appears to be a promising target when combined with chemotherapy, but recent data have shown that its inactivation increases metastatic potential...
Conference Paper
Full-text available
Introduction Integrins are heterodimeric glycoproteins that bind cells to extracellular matrix proteins. Upon integrin clustering, multimolecular integrin adhesion complexes (IACs) form that facilitate the linkage between integrins and the actin cytoskeleton and permit bidirectional signalling. The αV integrin is expressed in most tumour cells wher...
Conference Paper
Full-text available
Introduction Integrin signalling regulates proliferation, migration, metastasis and cell death and has been suggested as a possible target in antitumor therapy. The aim of this study was to investigate the potential of different integrin α subunits knockdown in increasing sensitivity of triple-negative breast cancer (TNBC) and melanoma cell lines t...
Article
Sirtuin 3 (Sirt3) has a promising role in cancer tumourigenesis and treatment, but there have been controversies about its role as oncogene or tumour suppressor in different types of cancer. Changes in its expression are associated with the excessive production of reactive oxygen species (ROS), thus contributing to mitochondrial dysfunction and age...
Article
Endocannabinoids acting on cannabinoid-1 receptors (CB1Rs) are proposed to protect brain and spinal neurons from excitotoxic damage. The ability to recover from spinal cord injury (SCI), in which excitotoxicity is a major player, is usually investigated at late times after modulation of CB1Rs whose role in the early phases of SCI remains unclear. U...
Article
Mostly-incurable central nervous system diseases and disorders, such as neurodegenerative diseases, stroke, brain and spinal cord injuries and psychiatric illnesses, represent one of the most difficult health problems today, in terms of mortality, disability, productivity loss and health-care costs. After disappointing results regarding the transla...
Article
Full-text available
The present study identified ATF3 as a novel dynamic marker for ependymal stem/progenitor cells (nestin, vimentin and SOX2 positive) around the central canal of the neonatal or adult rat spinal cord. While quiescent ependymal cells showed cytoplasmic ATF3 expression, during 6-24h in vitro these cells mobilized and acquired intense nuclear ATF3 stai...

Network

Cited By