Ana Luisa Sosa-Ortiz

Ana Luisa Sosa-Ortiz
Instituto Nacional de Neurología y Neurocirugía | INNN · Laboratorio de Demencias

PhD Psychiatric Epidemiology

About

225
Publications
28,391
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5,188
Citations
Introduction
I have been working on Epidemiological studies on aging and dementia for several years. I am interested in Public health, and clinical aspects of dementia.
Additional affiliations
January 2000 - present
Instituto Nacional de Neurología y Neurocirugía
Position
  • Principal Investigator
Description
  • Our dementia research group has been working mainly in epidemiological topics, but we are working and colaborating with other groups on clinical and biomarkers research.
January 2000 - present
Instituto Nacional de Neurología y Neurocirugía
Position
  • Researcher in Medical Science "E"
January 2000 - present
Instituto Nacional de Neurología y Neurocirugía
Position
  • Head of Department
Education
January 1972 - December 1977

Publications

Publications (225)
Article
Full-text available
Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by...
Article
Full-text available
Background In fewer than 1% of patients, AD is caused by autosomal dominant mutations in either the presenilin 1 ( PSEN1 ), presenilin 2 ( PSEN2 ), or amyloid precursor protein ( APP ) genes. The full extent of familial AD and frequency of these variants remains understudied in Latin American (LatAm) countries. Due to the rare nature of these varia...
Article
Background: Age and gender specific prevalence rates for parkinsonism and Parkinson's disease (PD) are important to guide research, clinical practice, and public health planning; however, prevalence estimates in Latin America (LatAm) are limited. We aimed to estimate the prevalence of parkinsonism and PD and examine related risk factors in a cohor...
Book
El cambio demográfico que viven las sociedades actuales, permite vislumbrar en los años del nuevo siglo, la dinámica poblacional propiciará que México quede inmerso en una sociedad envejecida con los requerimientos y demandas propios de la misma. En el rubro de la atención a la salud, las personas adultas mayores dadas sus características biopsicos...
Article
Full-text available
Although the presence of anosognosia in amnestic mild cognitive impairment (aMCI) may be predictive of conversion to Alzheimer’s disease (AD), little is known about its neural correlates in AD and aMCI. Four different groups were compared using volumetric and diffusion magnetic resonance imaging metrics in regions of interest (hippocampus and cingu...
Presentation
Full-text available
Es fundamental que en el área del envejecimiento se dispongan de pruebas cognitivas específicas, sensibles, válidas transculturalmente y útiles, tanto en investigación como en el ámbito clínico (Patterson, 2018). Varios trabajos han sugerido que la prueba de memoria asociativa cara-nombre (FNAME) podría ser una herramienta válida, fiable y sensibl...
Article
Full-text available
Background The World Health Organization (WHO) has reframed health and healthcare for older people around achieving the goal of healthy ageing. The recent WHO Integrated Care for Older People (ICOPE) guidelines focus on maintaining intrinsic capacity, i.e., addressing declines in neuromusculoskeletal, vitality, sensory, cognitive, psychological, an...
Chapter
Dementia has been recognized by the World Health Organization as a public health problem since 2012 (WHO, 2012). According to estimates from the World Alzheimer Report from Alzheimer’s Disease International (ADI), in 2015, 46.8 million people worldwide had dementia, a number that is expected to increase to 74.7 million by 2030 and 131.5 million by...
Chapter
The world’s population is currently aging at an astonishing rate. It is estimated that the global proportion of older adults (age 60+ years) will almost double between 2015 and 2050, from 12% to 22%. This constitutes an increase from approximately 900 million older adults to 2 billion. It is worth noting that the current population of people age 80...
Article
Full-text available
The prevalence of dementia in Latin America and the Caribbean is growing rapidly, increasing the burden placed on caregivers. Exacerbated by fragile health-care systems, unstable economies, and extensive inequalities, caregiver burden in this region is among the highest in the world. We reviewed the major challenges to caregiving in Latin America a...
Article
Full-text available
Objectives: This study was designed to explore prevalence and correlates of self-reported loneliness and to investigate whether loneliness predicts mortality among older adults (aged 65 or above) in Latin America, China and India. Methods: The study investigated population-based cross-sectional (2003–2007) and longitudinal surveys (follow-up 2007–2...
Article
Full-text available
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean...
Article
Full-text available
Introduction Neuroinflammation is involved in the pathophysiology of various neurological disorders, in particular Alzheimer disease (AD) and Parkinson’s disease (PD). Alterations in the blood-brain barrier may allow peripheral blood lymphocytes to enter the central nervous system; these may participate in disease pathogenesis. Objective To evalua...
Article
Full-text available
Introduction The increasing evidence of SARS‐CoV‐2 impact on the central nervous system (CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer's disease (AD), and other dementia. Methods The Alzheimer's Association and representatives from more than 30 countries—with technical guidance from the World Health...
Article
Full-text available
Introduction: The increasing evidence of SARS-CoV-2 impact on the central nervous system (CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer's disease (AD), and other dementia. Methods: The Alzheimer's Association and representatives from more than 30 countries-with technical guidance from the World Healt...
Article
Dementia prevalence in Mexico is 9% over 65 years old, 28% of those patients live in rural areas, dementia care in rural communities face special challenges due to often geographical, economical, sociocultural, functional and inaccessibility1. Although in the country dementia care is mostly family dependent and locally integrated there is a scarcit...
Article
Due to the high impact of dementia it is a priority to focus on the well‐being of those with this condition, enabling participation, inclusion and better functioning of people with this disease. In the research context it’s increasing the interest on documenting the needs reported by those living with dementia. The aim of this study was to describe...
Article
CAIDE (Cardiovascular Risk Factors, Aging, and dementia) Dementia Risk Score was developed to identify subjects with risk for developing dementia; using cardiovascular risk factors for dementia. CAIDE has showed to have a good predictive value. Mexican elders have different risk factors for dementia; the use of this type of score could be a good al...
Article
Social isolation (SI) (defined as infrequent social contact or people with limited social networks) has been association with cognitive impairment, however, some authors has argued there is not a relationship between both. In line with the World Health Organization (WHO). Dementia is a syndrome affecting memory, thinking, orientation, comprehension...
Article
More than 300 pathogenic variants in APP, PSEN1 and PSEN2 genes have been reported causing Dominant Inhered Alzheimer Disease (DIAD); most of these reports come from Northern hemisphere countries. In recent years, a growing number of familial AD cases have become known in Central and South American countries; however, little is known about epidemio...
Article
Subjective cognitive decline (SCD) represents a state in which a participant perceives a decline in cognitive functions, yet standardized psychological tests remain within expected performance compared to age‐ and education‐matched controls. SCD is growingly recognized as a risk state for mild cognitive decline (MCI), and eventually, dementia. In t...
Article
Posterior cortical atrophy (PCA) is a cognitive behavioral syndrome characterized by visual and cognitive alterations that is associated with neurodegeneration of the posterior cerebral cortex (occipital, parietal and posterior temporal). 95% of these cases also present neuropsychiatric symptoms (NPS), as anxiety, depression and irritability being...
Article
The cognitive‐motor syndrome (CMS) describes the association of cognitive and gait alterations, being potentially useful for predicting dementia. The criteria proposed for the CMS are: cognitive complaint, decrease in gait speed, preservation of daily life activities, and absence of dementia. This work is a population‐based cohort secondary analysi...
Article
Given the deleterious consequences for patients and families with autosomal dominant AD, it is necessary to identify individuals at risk in preclinical phases, with the objective of include them in clinical intervention trials We included 11 DNA samples from patients diagnosed with FAD and 9 DNA samples with of patients with EAD, which were analyze...
Article
Type 2 diabetes mellitus (T2D) and depression have both become pandemics over the last years. Both of these conditions have also been associated with signs of systemic inflammation, decreased insulin sensitivity, and autonomic dysfunction, all identified as risk factors for cognitive impairment and dementia. Our aim in this study was to explore the...
Article
The highest proportion of deaths occurs in people over 65 years. Factors related to mortality differ between clinical and community population. In Mexico there are few population‐based studies that explore sociodemographic factors, comorbidities, cognitive status and disability, associated with mortality in community elders. This is a secondary ana...
Article
The Face‐Name Associative Memory Exam (FNAME) has been shown to detect memory deficits early in the spectrum of Alzheimer’s disease. In this study, we used a newly developed and further extended version of the FNAME, to evaluate the discriminating ability of this test in amnestic cognitive decline (aMCI), amnestic subjective cognitive decline (aSMD...
Article
Full-text available
Background: Decreased levels of repressor element-1 silencing transcription (REST) factor in the brain, plasma, and neuronderived exosomes are associated with Alzheimer's disease (AD). Objective: The objective of the study was to test the viability of serum REST as a possible blood-based biomarker for AD, comparing serum REST levels in AD patien...
Article
Full-text available
Background: A growing number of studies have explored how features of the neighbourhood environment can be related to cognitive health in later life. Yet few have focused on low- and middle-income countries and compared the results across different settings. The aim of this study is to investigate the cross-sectional associations between neighbour...
Article
Objective Describe the protocol sample and instruments of the Cognitive Aging Ancillary Study in Mexico (Mex-Cog). The study performs an in-depth cognitive assessment in a subsample of older adults of the ongoing Mexican Health and Aging Study (MHAS). The Mex-Cog is part of the Harmonized Cognitive Assessment Protocol (HCAP) design to facilitate cr...
Article
Full-text available
Background To date, dementia prediction models have been exclusively developed and tested in high-income countries (HICs). However, most people with dementia live in low-income and middle-income countries (LMICs), where dementia risk prediction research is almost non-existent and the ability of current models to predict dementia is unknown. This st...
Preprint
Full-text available
Background Research carried out in high income countries suggests that loneliness may be a common experience among older adults living in these settings. Loneliness is correlated with poor socioeconomic status, living alone, being widowed and is associated with adverse health outcomes, including mortality. There is still a lack of evidence about th...
Article
Full-text available
One of the characteristics of the cerebral aging process is the presence of chronic inflammation through glial cells, which is particularly significant in neurodegeneration. On the other hand, it has been demonstrated that the aryl hydrocarbon receptor (AHR) participates in the inflammatory response. Currently, evidence in animal models shows that...
Article
Full-text available
Objectives: Depression and anxiety are common mental disorders in later life. Few population-based studies have investigated their potential impacts on mortality in low- and middle-income countries (LMICs). The aim of this study is to examine the associations between depression, anxiety, their comorbidity and mortality in later life using a popula...
Preprint
Full-text available
Background The World Health Organization has reframed health and healthcare for older people around achieving the goal of healthy ageing. Recent evidence-based guidelines on Integrated Care for Older People focus on maintaining intrinsic capacity, addressing declines in mobility, nutrition, vision and hearing, cognition, mood and continence aiming...
Article
Full-text available
World population is experiencing a demographic transition, which introduces changes in the workforce structure, such as increasing retirement. At the same time, retirement produces several life-style modifications that significantly influence well-being and can lead to depression. Thereby, this study aimed to estimate the association between retire...
Conference Paper
Full-text available
Background: Alzheimer disease presents a complex set of assessment problems, including early and accurate diagnosis, development of sensitive but efficient cognitive measures, in addition to the need of brief measures in individuals with cognitive impairment that can have difficulties for tolerating long assessment procedures. So, the aim of this s...
Article
Full-text available
The α-synucleinopathies are a group of neurodegenerative diseases characterized by abnormal accumulation of insoluble α-synuclein in neurons and glial cells, comprising Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Although varying in prevalence, symptom patterns, and severity among disorders, all α-sy...
Article
Full-text available
Introduction: Neuroinflammation is involved in the pathophysiology of various neurological disorders, in particular Alzheimer disease (AD) and Parkinson's disease (PD). Alterations in the blood-brain barrier may allow peripheral blood lymphocytes to enter the central nervous system; these may participate in disease pathogenesis. Objective: To ev...
Article
Full-text available
Objective: The objective of this study was to estimate healthy life expectancies in eight low- and middle-income countries (LMICs), using two indicators: disability-free life expectancy (DFLE) and dependence-free life expectancy (DepFLE). Method: Using the Sullivan method, healthy life expectancy was calculated based on the prevalence of depende...
Article
Full-text available
episode among older adults and work status in low- and medium-income countries. A cross-sectional study was conducted with people 60 years of age and older from the six countries (Mexico, India, China, Russian Federation, Ghana and South Africa) included in the Study on Global Ageing and Adult Health (SAGE) and who participated in its first wave (2...
Article
Full-text available
Several neuropsychological tests have been used to assess cognitive impairment across countries, nevertheless, few of them have had mind about external validity and reliability of those assessment outcomes. It is well known that there are cross-cultural differences that might be affect those results, regarding on measuring irrelevant variance. In t...
Poster
Full-text available
Introducción: La evaluación global del funcionamiento cognitivo es una herramienta importante para el diagnóstico de demencia. Sin embargo, estas pruebas con frecuencia son multidimensionales y suelen basarse en puntajes globales, que no consideran los niveles de dificultad de cada ítem. La Teoría de Respuesta al Ítem (TRI), permite considerar la d...
Article
Full-text available
Background: While autonomy is highlighted as central to older people’s wellbeing, there has been little empirical research to inform a measurement approach, support construct validity, or establish its determinants. We aimed to study the health and economic correlates of self-perceived autonomy among community-dwelling older people in Peru, Mexico...
Article
Background: Recent epidemiological research has shown that exposure to fine particulate pollution (PM2.5) is associated with a reduction in cognitive function in older adults. However, primary evidence comes from high-income countries, and no specific studies have been conducted in low and middle-income countries where higher air pollution levels e...
Article
Full-text available
Background While links between disability and poverty are well established, there have been few longitudinal studies to clarify direction of causality, particularly among older adults in low and middle income countries. We aimed to study the effect of care dependence among older adult residents on the economic functioning of their households, in ca...
Data
Sensitivity analysis (excluding household changes, and no care households where one or more older residents have developed needs for care). Associations between redesignated household status (no care versus incident care, chronic care and care exit households) and main household economic welfare indicators (income, consumption, strain and satisfact...
Article
Full-text available
Background Adult leg length is influenced by nutrition in the first few years of life. Adult head circumference is an indicator of brain growth. Cross-sectional studies indicate inverse associations with dementia risk, but there have been few prospective studies. Methods Population-based cohort studies in urban sites in Cuba, Dominican Republic Pu...
Article
Full-text available
Background Exposure to endogenous estrogen may protect against dementia, but evidence remains equivocal. Such effects may be assessed more precisely in settings where exogenous estrogen administration is rare. We aimed to determine whether reproductive period (menarche to menopause), and other indicators of endogenous estrogen exposure are inversel...
Article
Background: There have been few cross-national studies of the prevalence of the frailty phenotype conducted among low or middle income countries. We aimed to study the variation in prevalence and correlates of frailty in rural and urban sites in Latin America, India, and China. Methods: Cross-sectional population-based catchment area surveys con...
Preprint
Full-text available
Brackground Current treatments for Alzheimer’s disease (AD) have a limited clinical response and methods, such as repetitive transcranial magnetic stimulation (rTMS), are being studied as possible treatments for the clinical symptoms with positive results. However, there is still seldom information on the type of rTMS protocols that deliver the bes...