Ana Maria Rivas-Grajales

Massachusetts General Hospital | MGH · Department of Psychiatry

Despite the growing off-label use of ketamine for depression and other psychiatric indications, its long-term safety profile and abuse potential remain unclear. We present a case of a patient who presented with paranoia and personality changes attributed to ketamine misuse, which illustrates the need for more robust screening and systematic monitor...

Background Ketamine’s potent and rapid antidepressant properties have shown great promise to treat severe forms of major depressive disorder (MDD). A recently hypothesized antidepressant mechanism of action of ketamine is the inhibition of N-methyl-D-aspartate receptor-dependent bursting activity of the habenula (Hb), a small brain structure which...

Introduction: Generalized anxiety disorder (GAD) is a common and disabling psychiatric condition that affects 3% of the population and exacts significant costs to society if untreated. There are numerous treatment options available, but all have side effects, and none are reliably effective, hence there is a significant need for new medications. Ar...

The white matter connections between the midbrain dopamine neurons and the striatum are part of a neural system involved in reward-based learning, a process that is impaired in patients with schizophrenia. The striato-nigro-striatal (SNS) tract, which participates in this process, has not as yet been explored. The present study aimed to use diffusi...

Background The mesocorticolimbic system is particularly susceptible to the effects of chronic alcoholism. Disruption of this system has been linked to drug seeking and the development of Reward Deficiency Syndrome, a neurobiological framework for describing the development and relapsing patterns of addictions. In this study, we evaluated the associ...

Background: The white matter (WM) connections between the substantia nigra and the striatum are part of a complex neural system involved in reward-based learning, a process that is impaired in patients with schizophrenia. Most diffusion magnetic resonance imaging (dMRI) studies in schizophrenia have focused on the corticocortical and corticosubcort...

Psychosis of epilepsy (POE) is a term applied to a group of psychotic disorders with a distinct phenomenology in which potential etiopathogenic mechanisms are believed to be closely related to a seizure disorder. POE can present as interictal psychotic episodes, which may often differ semiologically from primary schizophrenic disorder. They may pre...

Ocular auscultation is a commonly neglected step of routine physical examination. An adequate ocular auscultation can be helpful in discovering an ocular bruit, which is an important diagnostic finding for a broad spectrum of pathologic conditions, some of which are potentially fatal. In this article, we present a literature review on the physical...

Objective: To find the prevalence of depressive symptoms in outpatients with epilepsy treated at the Hospital Psiquiátrico Universitario del Valle (HDPUV) and the Liga Colombiana Contra la Epilepsia (LCCE) between May and June, 2009. Method: It is a descriptive cross-sectional study which included 124 subjects over 18 years. Patients underwent Beck...

Determinar la frecuencia de depresión en pacientes con epilepsia que consultaron dos instituciones de tercer nivel de Cali, Colombia, durante los meses de mayo y junio del 2009, usando el Inventario de Depresión de Beck (BDI) y el Inventario de Depresión en Pacientes con Trastornos Neurológicos para Epilepsia (NDDI-E). Así mismo, identificar las ca...