Ana Jessica Pinto

Ana Jessica Pinto
University of Colorado | UCD · Division of Endocrinology, Metabolism and Diabetes

Doctor of Philosophy
Post-doctoral Fellow

About

65
Publications
9,538
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1,054
Citations
Citations since 2016
65 Research Items
1054 Citations
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Introduction
I am a Post-doctoral Fellow in the Division of Endocrinology, Metabolism and Diabetes, University of Colorado | Anschutz Medical Campus. My work integrates Clinical Exercise Physiology, Public Health and Molecular Biology to better understand how active and sedentary behaviors affect clinical symptoms, health outcomes and quality of life in clinical populations, including associated mechanisms.
Additional affiliations
May 2016 - May 2021
University of São Paulo
Position
  • PhD Student

Publications

Publications (65)
Article
BACKGROUND Physical activity (PA) is a cornerstone of type 2 diabetes mellitus (T2DM) treatment. Sex differences in PA behavior or barriers/facilitators to PA among individuals with T2DM are unclear. PURPOSE To summarize the evidence related to sex differences in participation in PA and barriers/facilitators to PA among individuals with T2DM acros...
Conference Paper
Background: To investigate the effect of 200,000IU of vitamin D3 on hospital length of stay in patients with coronavirus disease 2019 (COVID-19). Methods: This RCT was conducted in two centers in Sao Paulo, Brazil. The primary outcome was hospital length of stay (HLOS). Results: Of 240 randomized patients, 237 were assessed in the primary outcome....
Article
Full-text available
This prospective cohort study within an open‐label, single‐arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698) aimed to investigate the association between physical activity and persistent anti‐SARS‐CoV‐2 antibodies 6 months after two‐dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients (n=748). Persistent immunog...
Article
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We examined whether weight loss following HAES®-based interventions associates with changes in cardiometabolic risk factors and quality of life of women with obesity. This was an exploratory, ancillary analysis of a 7-month, mixed-method, randomized controlled trial. Fifty-five women (age: 33.0 ± 7.2; BMI: 30–39.9 kg/m ² ) were included in this stu...
Article
This randomized controlled study aimed to investigate whether a single bout of exercise prior to the homologous booster dose of a SARS-CoV-2 inactivated vaccine could enhance immunogenicity in patients with spondyloarthritis. We selected 60 consecutive patients with spondyloarthritis (SpA). Patients assigned to the intervention group performed an e...
Article
Full-text available
Background: The modulating effect of vitamin D on cytokine levels in severe coronavirus disease 2019 (COVID-19) remains unknown. Objectives: To investigate the effect of a single high-dose of vitamin D3 on cytokines, chemokines, and growth factor in hospitalized patients with moderate to severe COVID-19. Methods: This is a post-hoc, ancillary and...
Article
Full-text available
Aim: We aimed to explore how a group of classical ballet dancers perceived their eating attitudes and their bodies, with special attention to the potential presence of eating disorders (EDs) symptoms and body image (dis)satisfaction. Methods: A cross-sectional, mixed-method study was conducted on fourteen trained classical ballet dancers (18–30 yea...
Preprint
Full-text available
This study aimed to investigate the association between physical activity and persistent anti-SARS-CoV-2 antibodies 6 months after two-dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients. This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698), conducte...
Preprint
Full-text available
This study aimed to investigate whether a single bout of exercise prior to the homologous booster dose of a SARS-CoV-2 inactivated vaccine (Sinovac-CoronaVac) could enhance immunogenicity in patients with dysfunctional immune system. This was a randomized controlled trial (1:1) within a single-arm, phase 4 vaccination trial, conducted in São Paulo,...
Article
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Introduction: Among healthy adolescents, school closures and home confinement were shown to increase unhealthier eating habits and sedentary behavior. It remains unknown to which extent the pandemic has impacted the lifestyle of adolescents with chronic conditions. Thus, the aim of this study is to report on the impact of the COVID-19 outbreak on e...
Article
Full-text available
Objectives To investigate whether physical activity is associated with enhanced immunogenicity of a SARS-CoV-2 inactivated vaccine (Coronavac) in patients with autoimmune rheumatic diseases (ARD) (n=898) and in non-ARD (n=197) individuals without pre-existing immunogenicity to SARS-CoV-2. Methods This was a prospective cohort study within an open-...
Article
Exercise is a treatment in rheumatoid arthritis but participation in moderate-to-vigorous exercise is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. We compared the acute effects of active breaks in sitting with those of moderate-to-vigorous exercise on cardiometabolic risk markers in patients wit...
Article
Full-text available
Background: Regular physical activity (PA) has been postulated to improve, or at least maintain, immunity across the life span. However, the link between physical (in)activity and coronavirus disease-2019 (COVID-19) remains to be established. This small-scale prospective cohort study is nested within a randomized controlled trial aimed to investig...
Preprint
Full-text available
Immunocompromised individuals show lower vaccine immunogenicity, which may be modulated by physical activity. This prospective cohort study within a phase-4 vaccination trial investigated whether physical activity is associated with enhanced immunogenicity of Coronavac (SARS-CoV-2 inactivated vaccine) in patients with autoimmune rheumatic diseases...
Article
Objective: To determine the dose-response relationship between prolonged sitting and vascular function in healthy individuals and those with metabolic disturbances. To investigate the acute effects, on vascular function, of interventions that target interrupting prolonged sitting. Design: Systematic review with meta-analysis. Data sources: Ovi...
Article
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Objective To examine the SARS-CoV-2 infection rate in a cohort of 6500 professional athletes and staff during the 2020 football (soccer) season in São Paulo, Brazil. Methods This retrospective cohort study included 4269 players (87% male, age: 21.7±4.2 years) and 2231 staff (87% male, age: 42.6±11.9 years) from 122 teams (women: n=16) involved in...
Article
Full-text available
Changes in emotional state due to the COVID-19 pandemic may potentially modify eating habits, which may differ as a function of body mass index (BMI). Using a self-reported, questionnaire-based survey we evaluated Brazilian women during the pandemic for: (i) the influence of BMI on changes in eating habits, food choice determinants, and psychologic...
Article
Background: Vitamin D acts as a mediator in the immune system regulating antiviral mechanisms and inflammatory processes. Vitamin D insufficiency has been suggested as a potential risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, although its impact on the prognosis of hospitalized patients with coronavirus di...
Article
Full-text available
Background: The aim of this study was to investigate possible associations between food consumption and eating habits and food choice determinants in women during COVID-19 pandemic. Methods: This is a cross-sectional survey conducted in Brazil between June and September, 2020, during which time social distancing measures were in place. Results: Par...
Preprint
Purpose To report on the impact of the COVID-19 outbreak on eating habits and sedentary behavior among adolescents with multiple chronic conditions (n=347) from a tertiary, referral hospital vs . healthy peers. Methods This observational study was conducted in Sao Paulo (Brazil) between July and October 2020, period in which a set of social distan...
Article
Full-text available
Importance: The efficacy of vitamin D3 supplementation in coronavirus disease 2019 (COVID-19) remains unclear. Objective: To investigate the effect of a single high dose of vitamin D3 on hospital length of stay in patients with COVID-19. Design, setting, and participants: This was a multicenter, double-blind, randomized, placebo-controlled tri...
Article
To assess the rheumatologists’ knowledge and willingness to prescribe physical activity, we conducted a nationwide survey. All adult and paediatric rheumatologist members of the Brazilian Rheumatology Society were invited to fulfil a questionnaire on their knowledge and willingness to promote physical activity. Four hundred twenty-eight rheumatolog...
Preprint
Full-text available
Purpose This small-scale, prospective cohort study nested within a randomized controlled trial aimed to investigate the possible associations between physical activity levels and clinical outcomes among hospitalized patients with severe COVID-19. Methods Hospitalized patients with severe COVID-19 were recruited from Clinical Hospital of the School...
Preprint
Full-text available
Importance Patients with COVID-19 may exhibit 25-hydroxyvitamin D deficiency, but the beneficial effects of vitamin D 3 supplementation in this disease remain to be proven by randomized controlled trials. Objective To investigate the efficacy and safety of vitamin D 3 supplementation in patients with severe COVID-19. Design, Setting, and Particip...
Preprint
Full-text available
We aimed to evaluate the influence of nutritional status on eating habits and food choice determinants among Brazilian women during the COVID-19 outbreak. This cross-sectional survey was conducted between June and September, 2020, period in which social distancing measures were in place. Participants (n=1,183) were classified as normal weight (60.4...
Article
Key points: Rheumatoid arthritis (RA) patients present exacerbated blood pressure responses to exercise, but little is known regarding the underlying mechanisms involved. This study assessed autonomic and haemodynamic responses to exercise and to the isolated activation of muscle metaboreflex in post-menopausal women with RA. Participants with RA...
Article
Full-text available
We assessed physical activity using accelerometers and a questionnaire in 33 post-bariatric patients who reported to be adherent (n = 15) or not (n = 18) to social distancing due to the COVID-19 pandemic. Patients adherent to social distancing spent more time in sedentary behavior (1.1 h/day, 0.1, 2.2; p = 0.045) and less time in moderate-to-vigoro...
Preprint
Full-text available
Background: Social distancing measures designed to contain the COVID-19 pandemic can explicitly and implicitly restrict physical activity, a particular concern for high-risk patient groups. Using a within-subjects design with objective measurement (via validated accelerometers), we assessed rheumatoid arthritis patients' physical activity and seden...
Article
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The shortage of essential medical care has become a major health concern as the Covid‐19 pandemic continues to unfold. The population of Sao Paulo, Brazil, has been severely impacted due to the very‐high prevalence of Covid‐19 cases, and as the health system promptly adjusted to accommodate infected patients, the problem of access to essential care...
Preprint
Full-text available
Objectives: To assess physical activity levels in post-bariatric patients who adhered or not to social distancing measures due to the Covid-19 pandemic. Our secondary aim was to compare physical activity estimates between objectively measured and self-reported physical activity level. Methods: In this descriptive, cross-sectional study, we assessed...
Preprint
Full-text available
Background/Objectives This was an out-of-hospital screening of health status and lifestyle during the Covid-19 pandemic in post-operative bariatric patients from Sao Paulo, Brazil, prevented from face-to-face health care. Subjects/Methods In this cross-sectional study, 66 patients were remotely (via phone call) and in-person (by home visit) assess...
Article
Full-text available
Social distancing has been adopted worldwide to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. Social isolation is likely to lead to a decline in physical activity, which could result in immune system dysfunction, thereby increasing infection susceptibility and exacerbating the pathophysiology of conditions that...
Article
Physical inactivity is common during periods of self-isolation, but for patients with rheumatic diseases, there are crucial benefits to be gained from maintaining an active lifestyle throughout the COVID-19 pandemic. Patients should be provided with support to maintain physical activity and avoid prolonged periods of time spent sitting.
Article
Full-text available
Background: Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reducing sedentary time could be of novel therapeutic relevance. However, studies addressing this topic remain scarce. We aim to inve...
Article
To investigate the association between food consumption stratified by processing level and cardiovascular risk factors in rheumatoid arthritis. In this cross-sectional study, 56 patients (age: 62.5 ± 7.9 years, BMI: 28.4 ± 5.1 kg/m2) had food consumption evaluated according to the processing level (e.g., unprocessed or minimally processed foods, pr...
Article
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We investigated fat women’s perceptions of their own bodies and their experiences with weight-related discriminations, and how these situations affected their well-being. Thirty-nine obese women were interviewed, and three axes of analysis were identified: (1) repercussions of being fat, (2) living with a fat body, and (3) am I a person or just a f...
Article
Our aim was to investigate the prevalence of symptoms related to eating disorders, disordered eating and body image perception, and attitudes toward eating in a group of elite male artistic gymnastics. Seventeen athletes took part in this quali-quantitative, cross-sectional study. Presence of eating disorders symptoms, and body image perception and...
Article
Full-text available
Objective: The aim of this study was to assess the impact of a real-world, citywide intervention on physical activity and eating habits in a Latin American city with more than 50,000 inhabitants. Methods: This was a plausibility assessment of a real-life intervention. A probabilistic sample (n = 1,424) from Jaguariuna (Sao Paulo, Brazil) was ass...
Article
Full-text available
This study investigated the effect of open-placebo on cycling time-trial (TT) performance. Twenty-eight trained female cyclists completed a 1-km cycling TT following a control session or an open-placebo intervention. The intervention consisted of an individual presentation , provided by a medic, in which the concept of open-placebo was explained to...
Conference Paper
Full-text available
Background: Administration of open-placebo has shown benefits in several clinical conditions although no study has investigated its effect on exercise performance. Aim: To investigate the effect of open-placebo on exercise performance. Methods: Twenty-eight trained female cyclists completed a 1-km cycling TT following a control session or an open-p...
Article
Background Creatine supplementation could be a non-expensive, safe and effective dietary intervention to counteract bone loss. The aim of this study was to investigate whether long-term creatine supplementation can improve bone health in older, postmenopausal women. Methods A double-blind, placebo-controlled, parallel-group, randomized trial was c...
Article
Full-text available
INTRODUCTION: Health at Every Size (HAES) is a weight-neutral approach focused on promoting healthy behaviors in people with different body sizes and on enhancing pleasure derived from consuming food to achieve sustainable healthy eating outcomes. However, to the best of our knowledge, there are no studies in the literature assessing the effects of...
Article
Full-text available
Real-world interventions are fundamental to bridge the research-practice gap in healthy lifestyle promotion. This study aimed to assess the impact of a 7-month, intensive, city-wide intervention (“Life of Health”) on tackling youth inactivity and sedentary behavior in an entire Latin-American city (Jaguariuna, Brazil). For youth, a program focused...
Article
Context The growing use of interventions based on the Health at Every Size® (HAES®) in obesity management. Objective This study aimed to summarize the health‐related effects of HAES®‐based interventions on people with overweight and obesity. Data sources MEDLINE (via PubMed), EMBASE, Cochrane Library, LILACS, Google Scholar, OpenGrey and Grey Lit...
Article
Full-text available
Exercise is the treatment of choice for fibromyalgia (FM), but little is known about resistance exercise prescription to modulate pain in this condition. This study aimed to compare the effects of different resistance exercise models, comprising self-selected or prescribed intensity, on pain in FM patients. In a cross-over fashion, 32 patients unde...
Article
Full-text available
Health at Every Size® (HAES®) is a weight-neutral approach focused on promoting healthy behaviors in people with different body sizes. This study examined multiple physiological, attitudinal, nutritional, and behavioral effects of a newly developed, intensive, interdisciplinary HAES®-based intervention in obese women. This was a prospective, seven-...
Data
Baseline characteristics between participants who retained and those who dropped out, stratified by groups. Data are expressed as mean ± SD or n (%) of total sample per group. Significance level defined as p ≤ 0.05 (nonpaired t-test or chi-square test). (DOCX)
Data
A physical activity program based on the Health at Every Size® approach–an innovative proposal. (DOCX)
Article
Purpose: Cross-sectional studies suggest that training can increase muscle carnosine (MCarn), although longitudinal studies have failed to confirm this. A lack of control for dietary β-alanine intake or muscle fibre type shifting may have hampered their conclusions. The purpose of the present study was to investigate the effects of high-intensity...
Article
Background/objective: Recent studies have indicated that cardiac autonomic dysfunction is an early sign of cardiovascular impairment in rheumatoid arthritis (RA). Previous studies have mainly focused on resting assessments; however, analysis of heart rate (HR) responses to exercise might provide additional information on cardiac autonomic dysfunct...
Article
Full-text available
Background: This manuscript describes the design and rationale of a clinical trial that aims to investigate the multiple physiological, attitudinal, nutritional, and behavioral effects of a new interdisciplinary intervention based on the Health at Every Size® (HAES®) approach in obese women. Methods: This will be a prospective, 7-month, randomiz...
Article
This review aims to (1) summarize the estimates of physical inactivity and sedentary behavior in autoimmune rheumatic diseases; (2) describe the relationship between physical (in)activity levels and disease-related outcomes; (3) contextualize the estimates and impact of physical inactivity and sedentary behavior in autoimmune diseases compared to o...
Article
Objective: The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren's syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods: In this cross-sectional study, 29 women with pS...
Article
Full-text available
Objective: To compare muscle strength (i.e. lower- and upper-body strength) and function between physically inactive childhood-onset systemic lupus erythematosus patients (C-SLE) and healthy controls (CTRL). Methods: This was a cross-sectional study and the sample consisted of 19 C-SLE (age between 9 and 18 years) and 15 CTRL matched by age, sex,...
Article
Full-text available
Objective: To compare muscle strength (i.e. lower- and upper-body strength) and function between physically inactive childhood-onset systemic lupus erythematosus patients (C-SLE) and healthy controls (CTRL). Methods: This was a cross-sectional study and the sample consisted of 19 C-SLE (age between 9 to 18 years) and 15 CTRL matched by age, sex,...
Article
Objective: To examine the temporal pattern of PTH, PO4, ACa and Ca(2+) during and after exercise. Design and setting: A laboratory-based study with a cross-over design, comparing 30 min of running at 55%, 65% and 75%VO2max, followed by 2.5-h of recovery. Blood was obtained at baseline, after 2.5, 5, 7.5, 10, 15, 20, 25 and 30 min of exercise and...
Article
Objective: To compare aerobic capacity and health-related quality of life (HRQL) in physically inactive adult (A-SLE) and childhood-onset SLE (C-SLE) patients with mild/inactive disease versus healthy controls. Methods: In a cross-sectional study, 39 patients (C-SLE: n = 18; 9-18 years; and A-SLE: n = 21; 23-45 years) with inactive disease activ...
Article
To examine the agreement and association between objectively measured and indirectly assessed physical activity levels in patients with juvenile dermatomyositis (JDM) and juvenile systemic lupus erythematosus (JSLE) patients. The sample consisted of 19 JDM patients (age 8 to 22 years) and 20 JSLE patients (age 9 to 18 years). Physical activity leve...

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Projects (2)
Project
This project aims to comprehensively investigate the clinical, physiological, metabolic, and molecular effects of reducing sedentary behaviour in rheumatoid arthritis, post bariatric, and mild cognitive impairment patients. To that end, we will perform three acute laboratory studies and three randomised controlled trials. The acute laboratory studies primarily aim to better understand the potential mechanisms underlying the effects of successive active breaks in prolonged sitting (i.e., 3-minute bouts of light-intensity walking every 30 minutes for 8 hours) versus 30-minutes of exercise followed by prolonged sitting or prolonged sitting only (control condition), in a well-controlled laboratory condition. The 4-month parallel-group randomised controlled trials aim to investigate the feasibility and efficacy of a newly developed personalised intervention focused on reducing sedentary time in these populations. Measures will include: (1) Sedentary behaviour and physical activity levels; (2) Clinical parameters (specific to each condition); (3) Anthropometric parameters and body composition; (4) Aerobic fitness; (5) Muscle function; (6) Blood pressure; (7) Blood samples; (8) Insulin sensitivity surrogates; (9) Autonomic function; (10) Vascular function and structure; (11) Muscle biopsy; (12) Fatigue and health-related quality of life; and, (13) Food intake.