Ana Nieto

Ana Nieto
Universidad de Salamanca · Department of Statistics

About

55
Publications
8,144
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
525
Citations
Citations since 2017
38 Research Items
415 Citations
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100

Publications

Publications (55)
Article
Introduction: The acid-labile subunit (ALS) plays an important role in the endocrine effects of insulin-like growth factors (IGFs) on target tissues. Historically, it has attracted limited attention. The aim of our study was to describe the normal range of ALS in healthy children and its association with other growth factors. Patients and methods...
Article
Full-text available
Introduction: Olfactory Groove Meningiomas (OGMs) are treated by Microsurgical Transcranial Approaches (MTCAs) composed of Anterior Sub-frontal Approaches (ASFAs), Lateral Sub-frontal Approaches (LSFAs) and Superior-Interhemispheric Approach (SIHA); Minimally-Invasive (MITCAs) and Endoscopic-Endonasal Approaches (EEAs). Research Question: Determin...
Article
Human rights compliance research neglects recommendations from national human rights institutions and other domestic bodies. In particular, the implementation of recommendations issued by temporary truth commissions remains underexplored. We use data from Skaar et al. (2022a Skaar, E., Wiebelhaus-Brahm, E., & Garcia-Godos, J. (2022a). Exploring tru...
Article
Truth commissions are widely seen as important peacebuilding tools partially because they issue recommendations that seek to prompt further justice initiatives to address past abuses and promote institutional reforms that encourage non-repetition. Yet, despite growing interest in truth commissions among academics, policymakers, and activists, littl...
Article
Full-text available
In 2015, the United Nations and various countries committed to achieving the Sustainable Development Goals. The 17 goals revolve around 3 main axes: eradicating poverty, protecting the planet, and ensuring peace and prosperity for all people by 2030. These goals are integrated so that interventions in one area inevitably affect the others. Undoubte...
Article
Full-text available
In this work, a new mathematical algorithm for sparse and orthogonal constrained biplots, called C enet Biplots, is proposed. Biplots provide a joint representation of observations and variables of a multidimensional matrix in the same reference system. In this subspace the relationships between them can be interpreted in terms of geometric element...
Article
Full-text available
In this paper, we propose a new method for disjoint principal component analysis based on an intelligent search. The method consists of a principal component analysis with constraints, allowing us to determine components that are linear combinations of disjoint subsets of the original variables. The effectiveness of the proposed method contributes...
Article
Full-text available
Models implemented in statistical software for the precision analysis of diagnostic tests include random-effects modeling (bivariate model) and hierarchical regression (hierarchical summary receiver operating characteristic). However, these models do not provide an overall mean, but calculate the mean of a central study when the random effect is eq...
Article
Full-text available
The HJ biplot is a multivariate analysis technique that allows us to represent both individuals and variables in a space of reduced dimensions. To adapt this approach to massive datasets, it is necessary to implement new techniques that are capable of reducing the dimensionality of the data and improving interpretation. Because of this, we propose...
Article
Full-text available
En los últimos años, los responsables de formular políticas públicas se han nutrido cada vez más de la economía conductual o la psicología social para obtener resultados favorables en la ciudadanía. En este contexto, aparecen los nudges: instrumentos al servicio del fomento de políticas públicas caracterizados por inducir en la población una toma d...
Article
Full-text available
One of the main drawbacks of the traditional methods for computing components in the three-way Tucker model is the complex structure of the final loading matrices preventing an easy interpretation of the obtained results. In this paper, we propose a heuristic algorithm for computing disjoint orthogonal components facilitating the analysis of three-...
Article
Full-text available
Studies on the precision of diagnostic tests usually report the number of true positives, false positives, true negatives, and false negatives. There is generally a negative association between the number of true positives and true negatives, as studies that adopt less strict criteria to declare a test as positive need higher sensitivities and lowe...
Article
Full-text available
Although measures such as sensitivity and specificity are used in the study of diagnostic test accuracy, these are not appropriate for integrating heterogeneous studies. Therefore, it is essential to assess in detail all related aspects prior to integrating a set of studies so that the correct model can then be selected. This work describes the sch...
Article
Full-text available
Diagnosis and classification of gliomas mostly relies on histopathology and a few genetic markers. Here we interrogated microarray gene expression profiles (GEP) of 268 diffuse astrocytic gliomas—33 diffuse astrocytomas (DA), 52 anaplastic astrocytomas (AA) and 183 primary glioblastoma (GBM)—based on multivariate analysis, to identify discriminator...
Preprint
In this paper, we propose an alternative method to the disjoint principal component analysis. The method consists of a principal component analysis with constraints, which allows us to determine disjoint components that are linear combinations of disjoint subsets of the original variables. The proposed method is named constrained binary optimizatio...
Article
Full-text available
El concepto de «aporofobia» nos ayuda a reconocer, identificar y visualizar la discriminación hacia los menos visibles de nuestra sociedad (Cortina, 2000). El rechazo al pobre surge de la construcción de ideas estereotipadas y de los prejuicios hacia las personas excluidas. Aunque el concepto de aporofobia cada vez es más utilizado y su significado...
Article
Full-text available
Background: The prognostic impact of the expression profile of genes recurrently amplified in glioblastoma multiforme (GBM) remains controversial. Methods: We investigated the RNA gene expression profile of epidermal growth factor receptor (EGFR), cyclin-dependent kinase 4 (CDK4), murine doble minute 4 (MDM4), and platelet derived growth factor...
Chapter
Full-text available
In meta-analysis for diagnostic test accuracy (DTA), summary measures such as sensitivity, specificity, and odds ratio are used. However, these measures may not be adequate to integrate studies with low prevalence, which is why statistical modeling based on true positives and false positives is necessary. In this context, there are several statisti...
Article
The information contained in corporate social responsibility (CSR) reports is a controversial issue, and it has generated an important debate among academics regarding company disclosure strategies. Environmental matters are especially relevant given their impact on sustainable development. The present study has two objectives. The first is to dete...
Article
e18266 Background: Patients with cancer and their caregivers express unmet needs beyond the clinical approach to cancer. The ECO Foundation (Quality and Excellence in Oncology) and the Spanish Association Against Cancer (AECC) have promoted a qualitative research study with the objective to compare the perceptions of newly diagnosed and 2-3 years a...
Article
Full-text available
Great efforts focus on early detection of autism spectrum disorder, although some scientists and policy-makers have questioned early universal screening. The aim of this meta-analysis was to evaluate the diagnostic accuracy of the different screening tools. Several electronic databases were used to identify published studies. A Bayesian model was u...
Article
The influence of different approaches and attitude towards learning in the General Didactics is studied in few investigations. The main objective of this work is to describe in a multivariate way the relationships between attitude towards General Didactics and learning approaches of students majoring in Social Learning of the University of Salamanc...
Article
Background: Patients with cancer and their caregivers express unmet needs beyond the clinical approach to cancer. The ECO Foundation (Quality and Excellence in Oncology) and the Spanish Association Against Cancer (AECC) have promoted a qualitative research study with the objective to identify and compare the perceptions of newly diagnosed and 2–3 y...
Article
Resumen Pocos estudios investigan la influencia de la actitud y enfoques de aprendizaje en la Didáctica General. El objetivo principal de este trabajo consiste en describir, en un sentido multivariante, las relaciones entre la actitud hacia la Didáctica General y los enfoques de aprendizaje de estudiantes del grado de Educación Social de la Univers...
Article
Full-text available
Several classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be...
Article
The possible heterogeneity among individual studies constituting a meta-analysis is traditionally evaluated using Cochran Q and Higgins I² statistics. However, both indices have deficiencies: The Q statistic detects heterogeneity but does not allow its quantification, whereas the I² index allows for quantification of heterogeneity but does not indi...
Article
This paper introduces a new mathematical algorithm termed Clustering Disjoint HJ-Biplot (CDBiplot), which searches for the underlying data structure in order to find the best classification of the object groups in a reduced space. To this end, disjoint factorial axes are generated, in which each variable only contributes to the formation of one fac...
Conference Paper
Full-text available
En este trabajo se analizan los factores que determinan el nivel de productividad de un país, entendiéndose que los determinantes de la productividad por sí mismos son variados y complejos. Los resultados obtenidos facilitan la descripción del entorno económico de cada nación y con ello su capacidad para conquistar niveles óptimos de prosperidad y...
Article
Full-text available
A biplot is a graphical representation of two-mode multivariate data based on markers for rows and columns often provided in a two-dimensional space. These markers define parameters that help to interpret goodness of fit, quality of the representation and variability and relationships between variables. However, such parameters are estimated as poi...
Article
Limited information exists about the impact of cytogenetic alterations on the protein expression profiles of individual meningioma cells and their association with the clinico-histopathological characteristics of the disease. The aim of this study is to investigate the potential association between the immunophenotypic profile of single meningioma...
Article
Full-text available
Meningioma was the first solid tumor shown to contain a recurrent genetic alteration e.g. monosomy 22/del(22q), NF2 being the most relevant gene involved. Although monosomy 22/del(22q) is present in half of all meningiomas, and meningiomas frequently carry NF2 mutations, no study has been reported so far in which both alterations are simultaneously...
Article
Full-text available
Meningiomas contain highly variable levels of infiltrating tissue macrophages (TiMa) and other immune cells. In this study we investigated the potential association between the number and immunophenotype of inflammatory and other immune cells infiltrating the tumor as evaluated by multiparameter flow cytometry, and the clinico-biological, cytogenet...
Article
Full-text available
Glioblastoma multiforme (GBM) displays multiple amplicons and homozygous deletions that involve relevant pathogenic genes and other genes whose role remains unknown. Single-nucleotide polymorphism (SNP)-arrays were used to determine the frequency of recurrent amplicons and homozygous deletions in GBM (n = 46), and to evaluate the impact of copy num...
Data
Number of probes analyzed with the two different types of SNP-arrays (6.0 and 500K SNP-arrays) and the GEP-array (U133 Plus 2.0), grouped according to their chromosomal localization. DNA CN alterations were assessed in all GBMs samples (n = 46) while mRNA expression levels were evaluated in a subset of 23 of these tumors. (DOC)
Data
Copy number (CN) alterations of chromosomes 7 and 9 as assessed by SNP-arrays versus iFISH analysis. (DOCX)
Data
Genes amplified in GBM tumors (n = 46). (DOC)
Data
Commercially available dual-color iFISH probes directed against specific gene locus used in the present study. (DOC)
Data
GBM (n = 46): homozygously deleted genes and their corresponding cytobands in chromosomes 1, 6, 9, 10, 12, 13, 16 and 17. (DOC)
Article
Despite recent advances in the identification of the cytogenetic profiles of meningiomas, a significant group of tumors still show normal karyotypes or few chromosomal changes. The authors analyzed the cytogenetic profile of 50 meningiomas using fluorescence in situ hybridization and high-density (500 K) single nucleotide polymorphism (SNP) arrays....
Article
Glioblastomas are cytogenetically heterogeneous tumors that frequently display alterations of chromosomes 7, 9p, and 10q. We used high-density (500K) single-nucleotide polymorphism arrays to investigate genome-wide copy number alterations and loss of heterozygosity in 35 primary glioblastomas. We focused on the identification and detailed character...
Article
Full-text available
Leukemia is one of the leading journals in hematology and oncology. It is published monthly and covers all aspects of the research and treatment of leukemia and allied diseases. Studies of normal hemopoiesis are covered because of their comparative relevance.
Article
Full-text available
Despite the increasing knowledge about the genetic alterations and molecular pathways involved in gliomas, few studies have investigated the association between the gene expression profiles (GEP) and both cytogenetics and histopathology of gliomas. Here, we analyzed the GEP (U133Plus2.0 chip) of 40 gliomas (35 astrocytic tumors, 3 oligodendroglioma...

Network

Cited By