Ana Maria Jansen

Ana Maria Jansen
Fundação Oswaldo Cruz | FIOCRUZ · Instituto Oswaldo Cruz (IOC)

PhD

About

308
Publications
42,022
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Introduction
Main project: the study of the variables that modulate the transmission cycle of Trypanosomatidae among free ranging wild mammalian fauna . Environmental conditions that favour the emergence of Chagas disease outbreaks
Additional affiliations
January 2009 - present
January 2009 - present
Fundação Oswaldo Cruz
Position
  • Variables involved in the transmission cycle of Trypaanosomatids in the wild environment
January 1991 - December 2011
Fundação Oswaldo Cruz
Education
March 1988 - January 1992
Federal University of Rio de Janeiro
Field of study
  • Parasitology

Publications

Publications (308)
Article
Full-text available
Although Leishmania transmission in nature is associated with the bite of an infected sandfly vector, other possible transmission routes are speculated to occur, such as the oral route. We evaluated the possibility of infection by this route in golden hamsters (Mesocricetus auratus) using Leishmania braziliensis (Lb) and Leishmania infantum (Li). H...
Article
Full-text available
Parasitism is a dynamic ecological phenomenon that is constantly influenced by the environment and intrinsic factors of the host. We aimed to evaluate the influence of vegetation, environmental temperature, reproductive conditions, sex, and body condition (BC) on the detection of Trypanosoma spp. in the blood of Thrichomys fosteri in the Pantanal r...
Article
Full-text available
Parasites are important components of the immense n-dimensional trophic network that connects all living beings because they, among others, forge biodiversity and deeply influence ecological evolution and host behavior. In this sense, the influence of Trypanosomatidae remains unknown. The aim of this study was to determine trypanosomatid infection...
Article
Full-text available
Canis lupus familiaris (domestic dog) represents a reliable sentinel for the occurrence of a well-established transmission cycle of Trypanosoma cruzi among wild mammals in the surroundings and, consequently, where the risk of human infection exists. Serological diagnosis is the chosen method to identify T. cruzi infection in dogs that, in Brazil, r...
Article
Full-text available
Trypanosomatids are hemoflagellate parasites that even though they have been increasingly studied, many aspects of their biology and taxonomy remain unknown. The aim of this study was to investigate the Trypanosoma sp. transmission cycle in nonflying small mammals in an area where a case of acute Chagas disease occurred in Mangaratiba municipality,...
Chapter
Full-text available
Chapter 8: Chagas Disease - In: Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Articulação Estratégica de Vigilância em Saúde. Guia de Vigilância em Saúde. 5. ed. – Brasília : Ministério da Saúde, 2021. 1.126 p.
Article
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Trypanosomatids are diverse and can infect several host species, including small mammals (rodents and marsupials). Between 2012 and 2014, 91 small mammals were surveyed for trypanosomatid infection in the Estação Biológica FIOCRUZ Mata Atlântica (EFMA), an Atlantic Forest area in Rio de Janeiro that presents different levels of conserved and degrad...
Article
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Bats are infected with several trypanosomatid species; however, assessing the diversity of this interaction remains challenging since there are species apparently unable to grow in conventional culture media. Accordingly, the ecology and biology of the Molecular Operational Taxonomic Units (MOTUs) Trypanosoma spp. Neobats are unknown. Therefore, we...
Article
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Trypanosoma rangeli is a generalist hemoflagellate that infects mammals and is transmitted by triatomines around Latin America. Due to its high genetic diversity, it can be classified into two to five lineages. In Brazil, its distribution outside the Amazon region is virtually unknown, and knowledge on the ecology of its lineages and on host specie...
Article
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Trypanosoma cruzi requires a triatomine insect vector for its life cycle, which can be complex in different enzootic scenarios, one of which is the unique transmission network in the Atlantic Forest of south-eastern Brazil. In the state of Espírito Santo, highly infected Triatoma vitticeps are frequently reported invading domiciles. However, triato...
Article
Full-text available
Crithidia mellificae, a monoxenous trypanosomatid considered restricted to insects, was recently reported to infect a bat. Herein, C. mellificae has been demonstrated to have a wider range of vertebrate hosts and distribution in Brazilian biomes than once thought. Parasites isolated from haemocultures were characterized using V7V8 SSU rDNA and glyc...
Article
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Urbanization results in loss of natural habitats and, consequently, reduction of richness and abundance of specialist to the detriment of generalist species. We hypothesized that a greater richness of trypanosomatid in Didelphis albiventris would be found in fragments of urban forests in Campo Grande, Mato Grosso do Sul, Brazil, that presented a la...
Article
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Trypanosoma cruzi and Leishmania spp. are parasites that infect multiple hosts including canids, considered bioaccumulators of parasites. Deforestation in the Cerrado biome has resulted in the exposure of wild canids to anthropized areas, where they may establish ecological and epidemiological relationships with domestic dogs. We evaluated the infe...
Article
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Armadillos are specialist diggers and their burrows are used to find food, seek shelter and protect their pups. These burrows can also be shared with dozens of vertebrate and invertebrate species and; consequently, their parasites including the zoonotics. The aim of this study was to diagnose the presence of zoonotic parasites in four wild‐caught a...
Article
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Many previous studies have shown a great phylogenetic and biological variability of Trypanosoma cruzi using different molecular and biochemical methods. Populations of T. cruzi were initially clustered into two main lineages called TcI and TcII by the size of the mini‐exon PCR product. In the present study, 33 isolates derived from three triatomine...
Article
Trypanosoma cruzi is a widespread protozoan in Latin America causing Chagas disease in humans and able to infect several other mammal species. The objective of this study was to investigate the T. cruzi infection in triatomine fauna as well as in dogs from distinct areas of Acre, western Brazilian Amazonia, which recently reported acute cases of hu...
Article
Full-text available
Trypanosomatids are ancient parasitic eukaryotes that still maintain prokaryotic characteristics. Trypanosoma cruzi, a primarily wild mammal parasite, infected humans already long before European colonization of the Americas. T. cruzi heterogeneity remains an unsolved question, and until now, it has still not been possible to associate T. cruzi gen...
Article
Full-text available
Trypanosoma cruzi, the protozoan agent of Chagas disease in the Americas, is comprised of six genetic lineages (TcI-TcVI) and a possible seventh (TcBat, related to TcI). Identification of T. cruzi lineages infecting reservoir mammalian species is fundamental to resolving transmission cycles. However, this is hindered by the limited sensitivity and...
Article
Full-text available
Background: Arboviruses and protozoans can cause neurologic disorders in horses. In Brazilian Amazon, several horses presenting signs compatible with disorders caused by these infectious agents have been observed. Objective: To contribute to the knowledge of this epidemiological picture, we sought to construct a serological diagnostic panel for...
Article
Full-text available
We surveyed infection by Trypanosoma spp. and Leishmania spp. in small wild mammals from Cumari, Goiás State aiming to investigate the diversity of trypanosomatid in a modified landscape of the Brazilian Cerrado (and possible infection overlapping with canids from the same area). Blood, skin, spleen, and liver samples were collected for parasitolog...
Article
Full-text available
We studied infection by Trypanosomatidae in bats captured in two areas with different degradation levels in the Atlantic Forest of Rio de Janeiro state: Reserva Ecológica de Guapiaçu (REGUA) and Estação Fiocruz Mata Atlântica (EFMA). Furthermore, we evaluated whether the diversity of trypanosomatids changes according to bat diversity and the differ...
Article
Distinct species of Trypanosoma have been documented sharing the same hosts in different environments in intricate transmission networks. Knowing this, this study investigated the role of different hosts in the transmission cycles of Trypanosoma species in the Pantanal biome. The mammals were sampled from November 2015 to October 2016. We sampled a...
Article
Full-text available
Background: Dogs are considered sentinels in areas of Trypanosoma cruzi transmission risk to humans. ELISA is generally the method of choice for diagnosing T. cruzi exposure in dogs, but its performance substantially depends on the antigenic matrix employed. In previous studies, our group has developed four chimeric antigens (IBMP-8.1, 8.2, 8.3, a...
Article
Full-text available
Considered ecologically generalist, Didelphis albiventris is reported as reservoir for different species of parasites, especially Trypanosoma cruzi. However, the knowledge about the influence of T. cruzi on hematological parameters of free-living opossum remains scarce. The present study aimed to evaluate the influence of T. cruzi on hematological...
Article
Full-text available
Trypanosoma spp. infection in wild mammals is detected mainly through parasitological tests that usually display low sensitivity. We propose the use of DNA extracted directly from blood clots (BC), which are neglected sources of DNA for diagnosis and identification of Trypanosoma spp. This approach followed by nested PCR targeting the 18S SSU rDNA...
Article
Trypanosoma evansi (Kinetoplastea Trypanosomatidae) is the Trypanosoma species that infects the greatest variety of mammals worldwide. In 2014, a dog from Rio Branco/AC, in the Brazilian Amazon region, presented flagellates without evident kinetoplasts in blood and symptoms of T. evansi infection. Our aim was to investigate the occurrence of T. eva...
Article
Full-text available
Domestic dogs are considered reservoirs hosts for several vector-borne parasites. This study aimed to evaluate the role of domestic dogs as hosts for Trypanosoma cruzi, Trypanosoma evansi and Leishmania spp. in single and co-infections in the Urucum settlement, near the Brazil-Bolivian border. Additionally, we evaluated the involvement of wild mamm...
Article
Full-text available
Trypanosoma cruzi (Kinetoplastea: Trypanosomatidae) infects all tissues of its hosts, which along with humans, include hundreds of mammalian species in the Americas. The epidemiology of T. cruzi has been changing in that currently the majority of the cases and/or outbreaks of Chagas disease occur by the ingestion of comestibles contaminated by T. c...
Conference Paper
Full-text available
Cães domésticos são considerados hospedeiros reservatórios para várias espécies de parasitas transmitidos por vetores artrópodes. Assim, este estudo teve como objetivo avaliar o papel de cães domésticos como hospedeiros mantenedores de Trypanosoma cruzi , T. evansi e Leishmania spp. no assentamento Urucum, localizado próximo à fronteira Brasil-Bolí...
Conference Paper
Full-text available
Morcegos apresentam uma relação estreita com as espécies de Trypanosoma . Esses animais são comumente relatados com parasitas do subgênero Schizotrypanum , apresentando espécies restritas aos hospedeiros quirópteros ( Trypanosoma cruzi marinkelei , Trypanosoma dionisii e Trypanosoma erneyi ) e de importância na saúde pública ( Trypanosoma cruzi )....
Conference Paper
Full-text available
JAIREMARINHO@HOTMAIL.COM Vários gêneros de flagelados são parasitas sanguíneos de vertebrados, sendo transmitidos por vetores hematófagos. Dentro desse grupo temos os representantes do gênero Trypanosoma com mais de 500 espécies descritas. Acredita-se que os representantes da família Trypanosomatidae surgiram a partir da evolução de formas aquátic...
Article
Full-text available
The occurrence of Trypanosoma spp. in wild carnivore populations has been intensively investigated during the last decades. However, the impact of these parasites on the health of free-living infected animals has been largely neglected. The Pantanal biome is the world’s largest seasonal wetland, harboring a great diversity of species and habitats....
Data
Path analysis on immune investment against Trypanosoma evansi of ocelots (Leopardus pardalis). Results of path analysis on immune investment against Trypanosoma evansi in ocelots (Leopardus pardalis) infected with T. evansi and coinfected with T. evansi/Trypanosoma cruzi in the sub-region of Nhecolândia, Pantanal, between November 2015 and October...
Data
Path analysis on anemia indicators of coatis (Nasua nasua). Results of path analysis on anemia indicators of coatis (Nasua nasua) infected with Trypanosoma evansi and coinfected with T. evansi/Trypanosoma cruzi in the sub-region of Nhecolândia, Pantanal, between November 2015 and October 2016. (TIF)
Data
Path analysis on infection responses of crab-eating foxes (Cerdocyon thous). Results of path analysis on infection responses of crab-eating foxes (Cerdocyon thous) infected with Trypanosoma cruzi and coinfected with Trypanosoma evansi/T. cruzi in the sub-region of Nhecolândia, Pantanal, between November 2015 and October 2016. (TIF)
Data
Path analysis on immune investment against Trypanosoma cruzi of crab-eating foxes (Cerdocyon thous). Results of path analysis on immune investment against T. cruzi in crab-eating foxes (Cerdocyon thous) infected with Trypanosoma cruzi and coinfected with Trypanosoma evansi/T. cruzi in the sub-region of Nhecolândia, Pantanal, between November 2015 a...
Data
Path analysis on infection responses of coatis (Nasua nasua). Results of path analysis on infection responses of coatis (Nasua nasua) infected with Trypanosoma cruzi and coinfected with Trypanosoma evansi/T. cruzi in the sub-region of Nhecolândia, Pantanal, between November 2015 and October 2016. (TIF)
Data
Path analysis on anemia indicators in ocelots (Leopardus pardalis). Results of path analysis on anemia indicators in ocelots (Leopardus pardalis) infected with Trypanosoma evansi and coinfected with T. evansi/T. cruzi in the sub-region of Nhecolândia, Pantanal, between November 2015 and October 2016. (TIF)
Data
Path analysis on immune investment against Trypanosoma cruzi of ocelots (Leopardus pardalis). Results of path analysis on immune investment against Trypanosoma cruzi in ocelots (Leopardus pardalis) infected with T. evansi and coinfected with Trypanosoma evansi/T. cruzi in the sub-region of Nhecolândia, Pantanal, between November 2015 and October 20...
Data
Path analysis on immune investment of coatis (Nasua nasua). Results of path analysis on immune investment of coatis (Nasua nasua) infected with Trypanosoma cruzi and coinfected with Trypanosoma evansi/T. cruzi in the sub-region of Nhecolândia, Pantanal, between November 2015 and October 2016. (TIF)
Data
Path analysis on immune investment against Trypanosoma evansi of crab-eating foxes (Cerdocyon thous). Results of path analysis of immune investment against T. evansi in crab-eating foxes (Cerdocyon thous) infected with Trypanosoma cruzi and coinfected with Trypanosoma evansi/T. cruzi in the sub-region of Nhecolândia, Pantanal, between November 2015...
Data
Collection Data Set. Data of coatis (Nasua nasua), crab-eating-foxes (Cerdocyon thous) and ocelots (Leopardus pardalis) infected for Trypanosoma cruzi and Trypanosoma evansi in the Pantanal. Samples were collected from November 2015 up to October 2016. (XLSX)
Article
Full-text available
Background Trypanosoma cruzi, the causal agent of Chagas disease, is monophyletic but genetically heterogeneous. It is currently represented by six genetic lineages (Discrete Typing Units, DTUs) designated TcI-TcVI. TcI is the most geographically widespread and genetically heterogeneous lineage, this as is evidenced by a wide range of genetic marke...
Data
Haplotypic Bayesian Tree with PDH locus. (PDF)
Data
Haplotypic Bayesian Tree based on CoAR locus. (PDF)
Data
Comparison between (A) MLST and maxicircle trees (B). (PDF)
Data
Nuclear genetic clustering among 92 Brazilian sylvatic TcI strains. (PDF)
Data
Panel of microsatellite loci and primers. (PDF)
Data
Neighbor Joining tree (A) and Bayesian tree (B) based in RHO1 gene fragment. (PDF)
Data
Trees generated with individual fragments using Bayesian analysis. (A) CoAR, (B) GTP. (PDF)
Data
Topological incongruence based on the six concatenate gene markers. (PDF)
Data
Haplotypic Bayesian Tree based on RB19 locus. (PDF)
Data
Haplotypic Bayesian Tree based on LAP locus. (PDF)