Ana Gonzalez Garnica

Ana Gonzalez Garnica
University of Granada | UGR · Department of Inorganic Chemistry

PhD Chemistry

About

19
Publications
2,520
Reads
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196
Citations
Citations since 2016
16 Research Items
196 Citations
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Additional affiliations
January 2018 - present
University of Granada
Position
  • PhD
July 2016 - October 2016
RMIT University
Position
  • Researcher
Description
  • 3 months stay at the RMIT NanoBiotechnology Research Laboratory (NBRL) of the RMIT University of Melbourne, Australia. Supervisor professor Vipul Bansal.
December 2015 - December 2015
University of Granada
Position
  • Professor
Description
  • 1 Credit Bioinorgánica. Grado en Bioquímica.
Education
November 2013 - January 2018
University of Granada
Field of study
  • Chemistry

Publications

Publications (19)
Article
Full-text available
Probiotic bacteria were used as carriers of metallic nanoparticles to develop innovative oral agents for hyperthermia cancer therapy. Two synthetic strategies were used to produce the different therapeutic agents. First, the probiotic bacterium Lactobacillus fermentum was simultaneously loaded with magnetic (MNPs) and gold nanoparticles (AuNPs) of...
Article
We show for the first time the glycosylation of recombinant metallothioneins (MTs) produced in E. coli. Interestingly, our results show that the glycosylation level of the recombinant MTs is inversely...
Article
This study describes a new strategy for real-time detection of alcohol in saliva and sweat. Phosphotungstic acid (PTA) is a colorless, photoelectrochromic heteropoly acid that can be reduced by ethanol under ultraviolet (UV) radiation to produce an intense blue color. This system has useful properties in the development of a new alcohol sensor: (1)...
Article
Full-text available
The alarming increase of antibiotic-resistant bacteria, causing conventional treatments of bacterial infections to become increasingly inefficient, is one of the biggest threats to global health. Here, we have developed probiotic cellulose, an antibiotic-free biomaterial for the treatment of severe skin infections and chronic wounds. This composite...
Article
A new concept of biomaterials for antibiotic‐free therapy of bacterial vaginosis (BV) is here proposed. These biomaterials are obtained by entrapping two probiotic biofilms, viz., Lactobacillus fermentum (Lf ) and Lactobacillus acidophilus (La ) into scaffolds of self‐assembled collagen fibers (col). An in‐depth characterization and viability assay...
Article
Full-text available
Yogurt is one of the most emblematic and popular fermented foods. It is produced by the fermentation of milk lactose by bacteria such as Streptococcus thermophilus and Lactobacillus acidophilus. Magnetic (MNPs) and gold nanoparticles (AuNPs) were incorporated into the exopolysaccharides (EPSs) of these bacteria. The functionalized bacteria were cha...
Article
Gold nanoparticles of different shapes (spherical, rods, and prisms) aggregate when deposited onto Lactobacillus fermentum's exopolysaccharide (EPS), a set of polysaccharides excreted by the bacteria. Transmission electron microscopy studies revealed that gold nanoparticles have high affinity for EPS. UV-vis spectra of aggregated gold nanoparticles...
Article
Full-text available
Spectrally-selective monitoring of ultraviolet radiations (UVR) is of paramount importance across diverse fields, including effective monitoring of excessive solar exposure. Current UV sensors cannot differentiate between UVA, B, and C, each of which has a remarkably different impact on human health. Here we show spectrally selective colorimetric m...
Article
The efficiency of maghemite nanoparticles for the treatment of anemia was sensibly higher when nanoparticles were incorporated onto the probiotic bacterium Lactobacillus fermentum (MNP-bacteria) than when administrated as uncoated nanoparticles (MNP). Plasma iron and hemoglobin, intestine expression of divalent metal transporter 1 (DMT1) and duoden...
Thesis
This doctoral thesis has addressed specific aspects relating to the chemical machinery of the probiotic bacterium Lactobacillus fermentum, which is commonly found in different floras of the human body. The work focuses particularly on exploring the bacterium's reducing activity and ability to generate biofilms through exopolysaccharide (EPS) format...
Article
Iron metabolism is an important subject of study for undergraduate students of chemistry and biochemistry. Relevant laboratory exercises are scarce in the literature but would be very helpful in assisting students grasp key concepts. The experiment described here deals with different iron release mechanisms of two protagonists in iron metabolism: s...
Poster
Full-text available
Lactobacillus fermentum es una bacteria probiótica, Gram positiva y anaerobia facultativa, que se encuentra en la microbiota intestinal con efectos positivos sobre la salud humana. Experimentos previos llevados a cabo en nuestro grupo han puesto de manifiesto que estos probióticos son también capaces de reducir químicamente a diferentes especies[1,...
Article
We have taken a vital step towards understanding why probiotic bacteria increase iron absorption in the gastrointestinal tract. We show here that Lactobacillus fermentum, one of the main probiotics of the microbiota, exhibits an extraordinary ferric-reducing activity. This activity is predominantly due to an excreted molecule: p-hydroxyphenyllactic...
Poster
Full-text available
Lactobacillus Fermentum tiene una actividad ferrireductasa extraordinaria y esta se debe a una molécula excretada por la bacteria: p-hydroxyphenyllactic acid (HPLA). La reducción de Fe(III) a Fe(II) es esencial para la absorción de hierro en el tracto intestinal. La transferencia del hierro a través de la membrana del enterocito ocurre gracias a la...
Poster
Full-text available
Lactobacillus fermentum, una bacteria de la flora intestinal, actúa como donor de electrones para el electrocrómico POM [P2MoVI18O62]6-]. Ya que la capacidad metabólica de la bacteria se relaciona con su actividad reductora, la reacción con [P2MoVI18O62]6- sirve para evaluar dicha actividad. Siguiendo esta lógica hemos querido estudiar como afectan...
Article
Full-text available
L. fermentum, a bacterium of human microbiota, acts as an electron donor to the electrochromic [P2MoVI18O62]6. Since, the reductive capacity of L. fermentum correlates with its metabolic activity, the reaction with [P2MoVI18O62]6- affords a means of evaluating its activity. Following this logic, we have concluded that vancomycin severely affects th...
Conference Paper
Full-text available
Among the different strategies to deliver drugs to specific physiological sites where pharmacological action is required, active targeting is an appealing approach that relies on the use of specific interactions with the target to direct and concentrate the drug at the site of action. The coupling of the therapeutic agent to the targeting agent and...

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Projects

Project (1)
Archived project
Identification of the mechanisms and molecules related to the reducing power of probiotic bacteria like Lactobacillus Fermentum. Materials synthesis using these mechanisms and molecules.