Ana M. Ferreira

Ana M. Ferreira
Kanazawa University | Kindai

PhD in Chemical Engineering

About

33
Publications
5,044
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932
Citations
Additional affiliations
March 2019 - June 2022
University of Aveiro
Position
  • Researcher
September 2018 - February 2019
Technische Universität München
Position
  • PostDoc Position

Publications

Publications (33)
Chapter
Biocatalytic processes find increasing applications in various industries due to the high efficiency of biotransformations as well as the renewable nature of the enzymes and substrates. Enzymatic biocatalysis is an attractive alternative to conventional chemical catalysis, with corresponding advances now allowing a wide range of biotransformations....
Article
Valorisation of discarded kiwifruits is proposed by extracting bioactive compounds using sustainable solvents namely deep eutectic solvents (DES). A screening of fifteen DES and several hydrogen bonding donor solvents was carried out. Extraction efficiency was measured in terms of antioxidant activity using DPPH and FRAP tests. The influence of sol...
Article
Hansen solubility parameters (HSP) provide essential information on the nature of solvents, being a useful tool in their selection for product and process design. In this work, linear models were developed to estimate HSP based on the use of COSMO-RS (conductor-like screening model for realistic solvents) descriptors. Hansen solubility parameters f...
Article
Inspired by the recently proposed cooperative mechanism of hydrotropy, where water molecules mediate the aggregation of hydrotrope around the solute, this work studies the impact of apolar volume and polar group position on the performance of hydrotropes. To do so, the ability of two different families of alkanediols (1,2-alkanediols and 1,n-alkane...
Article
Full-text available
Ribulose-1,5-biphosphate carboxylase/oxygenase (RuBisCO) is the most abundant protein on the planet, being present in plants, algae and various species of bacteria, with application in the pharmaceutical, chemical, cosmetic and food industries. However, current extraction methods of RuBisCO do not allow high yields of extraction. Therefore, the dev...
Article
Full-text available
Plastics recycling remains a challenge due to the relatively low quality of the recycled material, since most of the developed recycling processes cannot deal with the additives present in the plastic matrix, so the recycled products end up in lower-grade applications. The application of volatile organic solvents for additives removal is the prefer...
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Full-text available
Chlorophylls and their derivatives have been extensively studied due to their unique and valuable properties, including their anti-mutagenic and anti-carcinogenic features. Nevertheless, high-purity-level chlorophylls extracted from natural sources are quite expensive because the methods used for their extraction have low selectivity and result in...
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Full-text available
Spent coffee grounds (SCGs) are a waste product with no relevant commercial value. However, SCGs are rich in extractable compounds with biological activity. To add value to this coffee byproduct, water and aqueous solutions of cholinium-based ionic liquids (ILs) were studied to extract caffeine from SCGs. In general, all IL aqueous solutions lead t...
Article
Zwitterionic compounds (ZIs) have been attracting much attention due to their properties. Unlike ionic liquids - constituted by separated ions - the ZI structures with their cations and anions covalently bonded exhibit added complexity and diversity, suggesting that their ecotoxicological behavior should probably not be extrapolated from those of i...
Article
Novel liquid supports for enzyme immobilization and reuse based on aqueous biphasic systems (ABS) constituted by cholinium‐based ionic liquids (ILs) and polymers for the degradation of dyes are here proposed. The biocatalytic reaction for dye decolorization using laccase occurs in the biphasic medium, with the enzyme being “supported” in the IL‐ric...
Article
The efficiency of an ionic hydrotrope is shown to increase with the hydrophobicity of its counterion, challenging the common view that ionic hydrotropes should possess a small, densely charged counterion such as sodium or chloride.
Chapter
Biosurfactants produced by different types of microorganisms are amphiphilic biomolecules with active surface properties. Recently, biosurfactants have emerged as promising agents for cancer therapy since a high diversity of these molecules has shown the ability to induce cytotoxicity against many cancer cell lines, thus regulating cancer progressi...
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Full-text available
The commercialization of chiral drugs is an increasing concern in the pharmacological field since the differences in the pharmacological activities of enantiomers may result in serious problems in the treatment of diseases using racemates. The resolution of chiral drugs is important for the development of safer and more active pharmaceuticals. This...
Article
Trial and error remain the most common method to select the right solvent for the extraction of natural products, in particular when dealing with novel, poorly studied solvents such as deep eutectic solvents (DES). This can lead to either a lengthy or a suboptimal selection of solvents. COSMO-RS, a quantum chemistry-based thermodynamic model, was a...
Article
Phenolic acids present in industrial food waste display a broad range of biological activities and related health benefits, among which their strong antioxidant and free radical scavenger activities are the most investigated. However, food waste is still scarcely considered as an alternative source for these compounds, and volatile organic solvents...
Article
Full-text available
Herein, it is shown the effective use of aqueous biphasic systems (ABS) in Fast Centrifugal Partition Chromatography (FCPC) for the purification of PEGylated cytochrome c conjugates. High recoveries (between 88% and 100%) and purities (~100%) were obtained. Both the unreacted cytochrome c and solvents may be recovered and reused, thus allowing the...
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Full-text available
Aiming at designing effective and sustainable separation processes, herein we propose the use of carbohydrates combined with tetralkylphosphonium- and tetralkylammonium-based ionic liquids (ILs) to form aqueous biphasic systems (ABS). The formation of ABS composed of non-aromatic and non-fluorinated ILs with carbohydrates is here shown for the firs...
Article
Thermoreversible aqueous biphasic systems (ABS) composed of ammonium-based zwitterions (ZIs) and polymers are here disclosed to act as integrated bioreaction-separation processes. The biocatalytic reaction involving laccase occurs in homogeneous media, after which small changes in temperature induce the formation of two phases and the complete sepa...
Article
Chlorophylls and their derivatives are currently used in a wide range of applications. To replace the volatile organic solvents commonly applied for their extraction from biomass, aqueous solutions of non-ionic surfactants are studied herein in the extraction of chlorophylls from spinach leaves. Aqueous solutions of a wide range of non-ionic surfac...
Article
The ability of water-soluble ammonium-based zwitterions (ZIs) to form aqueous biphasic systems (ABS) in presence of salts aqueous solutions is here disclosed. These systems are thermoreversible at temperatures close to room temperature and further allow the design of their thermal behavior, from an upper critical solution temperature (UCST) to a lo...
Article
The ability to induce reversible transitions between homogeneous solutions and biphasic systems is of paramount relevance in separation processes. In this context, pH-triggered aqueous biphasic systems composed of ionic liquids and salts are here disclosed as switchable mono/biphasic systems, and their potential application further demonstrated thr...
Article
In the past few years, an increasing demand for therapeutic drugs obtained from natural products has been faced. Amongst the bioactive natural compounds with pharmacological properties, 7-hydroxymatairesinol (HMR) has been commercialized since 2006 as a nutritional supplement due to its anticarcinogenic and antioxidative properties. The extraction...
Article
Immunoglobulins G (IgG) could become widespread biopharmaceuticals if cost-efficient processes for their extraction and purification are available. In this work, aqueous biphasic systems (ABS) composed of polyethylene glycols and a buffered salt, and with ionic liquids (ILs) as adjuvants, have been studied as alternative extraction and purification...
Article
Deep eutectic solvents (DES) have emerged in the past few years as a new class of solvents with promising applications in several fields. In the present work, the application of DES (formed by binary mixtures of cholinium chloride and carboxylic acids or urea) as phase-forming components of aqueous biphasic systems (ABS) is investigated. The mechan...
Article
Full-text available
This work unveils the formation of novel aqueous biphasic systems (ABS) formed by perfluoroalkylsulfonate-based ionic liquids (ILs) and a large number of carbohydrates (monosaccharides, disaccharides and polyols) aiming at establishing more benign alternatives to the salts commonly used. The respective ternary phase diagrams were determined at 298...
Article
The extraction of caffeine from bioresources using more benign and cost-effective processes is of fundamental relevance towards the finding of alternative (bio)pesticides. Classically, the best attempts to extract caffeine from biomass have resulted in low efficiency and in a large consumption of hazardous organic solvents and/or energy requirement...
Article
Gallic acid is an interesting natural compound because of its antioxidant, anti-inflammatory, antifungal and antitumor properties. It is present in relatively high concentrations in a number of biomass sources and in industrial wastes from where it could be extracted. Aiming at developing benign and efficient extraction/purification processes for g...
Article
In this work, the ability of Na(2)SO(4) and ionic liquids to induce the formation of acidic aqueous two-phase systems (ATPS) is investigated. Ternary phase diagrams, tie lines, and tie-line lengths for several systems were determined and reported at 298 K and atmospheric pressure. It is here shown that among the ionic liquids studied only those con...

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