Ana Arias

Ana Arias
University of Costa Rica | UCR · Instituto Clodomiro Picado (ICP)

About

16
Publications
2,697
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342
Citations
Citations since 2017
14 Research Items
338 Citations
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2017201820192020202120222023020406080
Introduction
Ana Arias currently works at the Instituto Clodomiro Picado (ICP), University of Costa Rica. Ana does research in Microbiology, Immunology and Biotechnology. Their current project is 'Integrative venomics and antivenomics'.

Publications

Publications (16)
Article
Full-text available
The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia due to its toxicity, which is predominantly derived from long-chain α-neurotoxins. The only specific treatment for snakebite envenoming is antivenom based on animal-derived polyclonal antibodies. Despite the lifesaving importance of these medicines, major limitatio...
Preprint
Full-text available
The monocled cobra ( Naja kaouthia ) is one of the most feared snakes in Southeast Asia. It is a highly dangerous species with a potent venom deriving its toxicity predominantly from abundant long-chain α-neurotoxins. The only specific treatment for snakebite envenoming is antivenom, which is based on animal-derived polyclonal antibodies. Despite t...
Poster
Full-text available
Snakebite envenoming is one of the world’s most neglected tropical diseases, each year resulting in tens of thousands of deaths. The only effective treatment for envenoming is antivenom derived from the plasma of animals immunized with snake venom. However, due to its heterologous nature, these antivenoms are associated with adverse reactions. The...
Article
Snakebite envenoming is a relevant public health problem in French Guiana, and Bothrops atrox is responsible for the vast majority of envenomings in this overseas French territory. The preclinical efficacy of freeze-dried antivenoms manufactured in Costa Rica (Polival-ICP®) and Mexico (Antivipmyn Tri®) was assessed against the lethal, hemorrhagic,...
Article
Full-text available
In the original version of this Article, the sixth sentence of the first paragraph of the Introduction incorrectly read ‘Particularly, elapid antivenoms often have an unbalanced antibody content with relatively low amounts of antibodies against small neurotoxic venom components that have low immunogenicity, which often leads to low immune cgqtns in...
Article
Full-text available
The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and α-neurotoxins associated with high fatality in untreated victims. Current antivenoms are both scarce on the African continent and present a number of drawbacks as they ar...
Presentation
Full-text available
Snakebite is a disease of the rural tropics, which causes death, disability, and destitution. One of the most feared venomous snakes in Africa is the infamous black mamba, Dendroaspis polylepis. D. polylepis’ venom is comprised of a multitude of toxins, the most lethal and abundant of which fall within the families of dendrotoxins and alpha-neuroto...
Article
Routine laboratory animal tests necessary to assess the toxicity of snake venoms and the preclinical neutralizing ability of antivenoms and other inhibitory substances induce significant pain and distress. This has prompted initiatives to introduce the routine use of analgesia. In this study, the analgesic effect of morphine and tramadol was assess...
Article
Bothrops lanceolatus is an endemic viperid species in the Lesser Caribbean island of Martinique. Envenomings by this species are characterized by local and systemic effects, among which the development of thrombosis in various organs is the most severe complication. An experimental toxicological characterization of this venom was performed using in...
Article
The ability of two peptidomimetic hydroxamate metalloproteinase inhibitors, Batimastat and Marimastat, to abrogate toxic and proteinase activities of the venom of Echis ocellatus from Cameroon and Ghana was assessed. Since this venom largely relies for its toxicity on the action of zinc-dependent metalloproteinases (SVMPs), the hypothesis was raise...
Article
Snakebite envenoming has a heavy burden in the public health in sub-Saharan Africa. The viperid species Echis ocellatus (carpet viper or saw-scaled viper) is the medically most important snake in the savannahs of western sub-Saharan Africa. Several antivenoms are being distributed and used in this region for the treatment of envenomings by E. ocell...
Article
The pathogenesis of dermonecrosis induced by the venom of the African spitting cobra Naja nigricollis was investigated in a mouse model. Intradermal injection of venom induced a macroscopic necrotic lesion. Histological examination revealed early edema of the dermis, followed by blistering, loss of skin appendages and reduction in cellularity. By 2...

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