Ana Rita Araújo

i3S - Health Research and Innovation Institute - University of Porto

Integrase (IN) is one of the three fundamental enzymes for the HIV life cycle. It irreversibly inserts the viral DNA into the host DNA, infecting the host cells. Although there are 37 compounds currently used in the HIV-1 antiretroviral therapy, only three have IN as a target. Lack of structural and mechanistic information on IN greatly contributes...

The Drosophila melanogaster G protein-coupled receptor gene, methuselah (mth), has been described as a novel gene that is less than 10 million years old. Nevertheless, it shows a highly specific expression pattern in embryos, larvae, and adults, and has been implicated in larval development, stress resistance, and in the setting of adult lifespan,...

Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is short and remarkably constant. Surprisingly, there is no correlation between cell-cycle length and...

Transitions (blue diamonds) and transversions (red squares) versus genetic distance plots showing the level of nucleotide substitution saturation at different codon positions (all positions (1); 1st and 2nd codon positions (2) and 3rd codon positions (3)) using the two different alignments (ClustalW2 (A) and MUSCLE (B)). (TIF)