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January 1989 - present
Publications
Publications (288)
Background: Circadian preference for eveningness has been linked to a higher risk of asthma and allergies, but its association with health-related quality of life (HRQL) in asthma has not been studied yet.
Objective: We aimed to investigate the associations between individual circadian preference and HRQL in asthma.
Methods: Among 691 adult asthm...
Background/Objectives: Sleep and cognitive alterations are common symptoms associated with child Post-traumatic stress disorder (PTSD) and depression (DEP). This study aims to investigate the relationship between sleep disturbances and cognitive alterations in PTSD and DEP. Methods: Using a quantitative, cross-sectional exploratory design, we exami...
Exposure to artificial light-at-night (ALAN) has been linked to cancer risk. Few meta-analyses on this topic have reviewed only breast cancer. This study aimed to systematically review and meta-analyze existing studies on ALAN exposure and cancer incidence, thoroughly evaluating exposure assessment quality. We considered observational studies (coho...
Background and Purpose
In recent years, there has been a growing interest in the study of resting neural networks in different neurological and mental disorders. While previous studies suggest that the default mode network (DMN) may be altered in dyscalculia, the study of resting‐state networks in the development of numerical skills, especially in...
Circadian typology, or "morningness" and "eveningness," is generally assessed using the Morningness-Eveningness Questionnaire (MEQ), a 19-item scale that could be burdensome in large-scale surveys. To overcome this, a 5-item version known as the reduced morningness-eveningness questionnaire (rMEQ), which is sensitive to the assessment of circadian...
Background: Allergic diseases impose a significant global disease burden, however, the influence of light at night exposure on these diseases in humans has not been comprehensively assessed. We aimed to summarize available evidence considering the association between light at night exposure and major allergic diseases through a systematic review an...
Background
The Sleep Beliefs Scale (SBS) is a well-known tool to design and monitor personalized sleep health promotion at an individual and population level. The lack of an established French version limits the development of effective interventions targeting these populations. Thus, the aim of this study was to validate the French version of the...
The aim of the present work was to compare two circadian questionnaires: the Preference Scale (PS) and the reduced version of the Morningness-Eveningness Questionnaire (rMEQ). A sample of 849 (35.10% men) university students, 421 of whom were Spanish (27.55% men; mean age 21.07 + 2.31) and 428 Italian (42.52% men; mean age 23.26 + 3.01), were admin...
Background: The explosion of information, misinformation, and disinformation (the ‘infodemic’) related to the coronavirus disease (COVID-19) pandemic on digital and social media is reported to affect mental health and quality of life. However, reports assessing the COVID-19 infodemic on health-related quality of life (HRQL) in patients with chronic...
Shift working is an inevitable part of healthcare organizations worldwide and female nurses are involved in performing rotating shifts of varying length and type which alters their preferential time for physiological activity. Shift work is linked with impaired sleep quality, irregular meal times, and imbalance dietary intakes with compromised nutr...
Unlabelled:
Major depression disorder (MDD) and bipolar disorder (BD) are usual comorbidities in patients with substance use disorders (SUD), a condition known as dual disorder (DD). MDD, BD and SUD are associated with cognitive impairment, potentially leading to a greater functional impairment in the context of DD.
Objectives:
To review the exi...
Background: The explosion of information, misinformation, and disinformation (the ‘infodemic’) related to the coronavirus disease (COVID-19) pandemic on digital and social media is reported to affect mental health and quality of life. However, reports assessing the COVID-19 infodemic on health-related quality of life (HRQL) in patients with chronic...
In clinical mental health practice, the presence of Dual Disorders (DDs), defined as the comorbidity of at least one Substance Use Disorder (SUD) and another mental disorder in the same person [...]
Background: Previous studies on health-related quality of life (HRQoL) in asthma have mainly focused on clinical and environmental determinants. Little is known about the role of social determinants on HRQoL in asthma.
Objectives: We aimed to investigate the association between social deprivation and HRQoL in asthma.
Methods: 691 adult asthmatics...
Patients with post-coronavirus disease 2019 (COVID-19) conditions typically experience cognitive problems. Some studies have linked COVID-19 severity with long-term cognitive damage, while others did not observe such associations. This discrepancy can be attributed to methodological and sample variations. We aimed to clarify the relationship betwee...
Circadian rhythmicity is associated to clinical variables that play an important role in both schizophrenia (SZ) and substance use disorders (SUD), although the characteristics of the coexistence of these two diagnoses (SZ +) remain mostly unknown. Hence, we studied a sample of 165 male patients divided in three groups each of 55, according to thei...
Comorbidity of substance use disorders (SUD) and severe mental illness (SMI) is highly frequent in patients, the most common diagnoses being schizophrenia (SZ), bipolar disorder (BD) and major depressive disorder (MDD). Since comorbidity has its own clinical features, and neurocognitive functioning is not always similar to psychiatric symptoms the...
One of the most prevalent symptoms of post-COVID condition is cognitive impairment, which results in a significant degree of disability and low quality of life. In studies with large sample sizes, attention, memory, and executive function were reported as long-term cognitive symptoms. This study aims to describe cognitive dysfunction in large post-...
In the last years, there has been a big effort to identify risk factors for reading difficulties and to develop new methodologies to help struggling readers. It has been shown that early intervention is more successful than late intervention, and that intensive training programs can benefit children with reading difficulties. The aim of our study i...
Sleep disturbances are strongly linked with mental diseases such as substance use disorder (SUD) or schizophrenia (SZ) which can have a detrimental impact on quality of life (QOL), especially when both disorders are comorbid (dual disorder). In absence of studies about both circadian characteristics and QOL in patients with SUD and comorbid SZ (SUD...
Artificial light at night (ALAN) exposure is associated with the disruption of human circadian processes. Through numerous pathophysiological mechanisms such as melatonin dysregulation, it is hypothesised that ALAN exposure is involved in asthma and allergy, mental illness, and cancer outcomes. There are numerous existing studies considering these...
This protocol aims to characterize patients with dual disorders (DD; comorbid major depression and schizophrenia) compared with patients with only a diagnosis of substance use disorder (SUD) and those with only a diagnosis of severe mental illness (SMI; major depression and schizophrenia), evaluating clinical and personality characteristics, circad...
Universities around the world are constantly creating and upgrading undergraduate and postgraduate programs in the health sciences. Although curriculum design is a key element for the adequate functioning of academic programs, there are few articles in the scientific literature that provide recommendations and guidelines, from a global and interdis...
Abstract
Background: Misinformation related to the COVID-19 pandemic, or ‘COVID-19 infodemic,’ and the potential to adversely impact containment and clinical management strategies is a global concern. Whether the COVID-19 infodemic is associated with quality of life in patients with chronic respiratory diseases (CRDs) has not been studied.
Methods...
Aim: Although a relationship between circadian disruption and development of several psychiatric disorders, such as major depressive disorder (MDD) and substance use disorder (SUD), has been observed, knowledge on this area is scarce yet. Therefore, this study aims to analyze the circadian functioning and quality of life (QOL) in SUD patients with...
The aim was to analyze the morningness/eveningness (M/E) effect on suicidal ideation through sleep and depressive symptoms mediators with school shift (i.e., morning and afternoon) as moderator. In this study, 586 Mexican adolescents, with a mean age of 16.31 ± 0.92, from a public high school in a double-shift school system (298 from the morning sh...
Dual disorders (substance use and mental illness comorbidity) are a condition that has been strongly associated with severe symptomatology and clinical complications. The study of circadian characteristics in patients with Severe Mental Illness or Substance Use Disorder (SUD) has shown that such variables are related with mood symptoms and worse re...
The link between literacy difficulties and brain alterations has been described in depth. Resting-state fMRI (rs-fMRI) has been successfully applied to the study of intrinsic functional connectivity (iFc) both in dyslexia and typically developing children. Most related studies have focused on the stages from late childhood into adulthood using a se...
Animal Welfare Attitudes (AWA) can be defined as the attitudes of humans
towards the welfare of animals. Although AWA has been previously associated with demographic
factors as gender, one of the main limitations is that few studies applied robust psychometric
questionnaire scales. Moreover, some evidence of cross-cultural variations in AWA have bee...
An individual’s chronotype, defined as the preference for rest and activity at different times of the day, is linked to several physiological and psychological outcomes. Research on environmental determinants of chronotype has focussed mostly on geographic location, whereas other socioenvironmental determinants have been neglected. We aimed to inve...
The term “dual disorder” (DD) refers to the coexistence or concurrence of at least one substance use disorder (SUD) and another mental disorder in the same person, as the World Health Organization established in its lexicon of alcohol and drug terms [...]
Premorbid functioning has been related with several clinical features and prognosis of schizophrenia spectrum disorders. Comorbidity with substance use is highly prevalent and usually hinders clinical improvement in this kind of psychiatric disorders. This systematic review analyzes the differences in the premorbid functioning of subjects with a sc...
Objective
To determine the differences between sleep habits and circadian preference in school-aged children attending a Mexican double-shift school system.
Methods
This cross-sectional study consisted of 400 elementary public-school children (mean age = 10.77, SD = 0.70 y, from 4th, 5th and 6th grades) in Reynosa, Tamaulipas, in northeastern Mexi...
Background:
Recent studies with the mood rhythm instrument (MRhI) have shown that the presence of recurrent daily peaks in specific mood symptoms are significantly associated with increased risk of psychiatric disorders. Using a large sample collected in Brazil, Spain, and Canada, we aimed to analyze which MRhI items maintained good psychometric p...
Objetivos: El presente trabajo explora la influencia del trastorno mental comórbido en el funcionamiento rítmico circadiano de pacientes en fase de tratamiento de deshabituación. La ritmicidad circadiana se ha asociado, tanto en pacientes con Trastorno por Uso de Sustancias (TUS) como en trastornos mentales graves, con la severidad sintomatológica...
Health-related quality of life (HRQoL) assessment has interest as an indicator of degree of affectation and prognosis in mental disorders. HRQoL is impaired in both Substance Use Disorder (SUD) and Major Depressive Disorder (MDD), two conditions highly prevalent, although less studied when both are coexisting (SUD + MDD). Hence, we decided to explo...
With sincere satisfaction and pride, I present to you the new journal, NeuroSci, for which I am pleased to serve as editor-in-chief. To date, the world of neurology has been rapidly advancing, NeuroSci is a cross-disciplinary, open-access journal that offers an opportunity for presentation of novel data in the field of neurology and covers a broad...
Personality traits are relevant in understanding substance use disorders (SUD) and schizophrenia (SZ), but few works have also included patients with dual schizophrenia (SZ+) and personality traits. We explored personality profile in a sample of 165 male patients under treatment, using the Temperament and Character Inventory-Revised. The participan...
Background
Identification of novel genetic factors for Depressive Disorders (DD) represents a major challenge around the world. Molecular studies of endophenotypes associated with DD, such as personality traits and coping, are powerful strategies for finding genetic markers.
Objective
The main objective of this work was to confirm the potential re...
Background:
Disruption of biological rhythms has been linked to the pathophysiology of mental disorders. However, little is known regarding the rhythmicity of mood symptoms due to the lack of validated clinical questionnaires. A better understanding of the rhythmicity of mood symptoms can help identifying individuals whose severity of mood symptom...
This study aimed to validate the Morningness-Eveningness-Stability-Scale improved (MESSi) in Mexico, analyzing the factor structure and sleep habits, combined with the proposal of cutoff values for the scales, and to assess the relationship with substance use. We applied the questionnaires through an online survey to a total sample of 510 Mexicans,...
El presente trabajo explora el curso clínico y las recaídas en una muestra de 223 pacientes varones, con seguimientos a los 3, 6 y 12 meses y un diseño no estudiado previamente. Éstos se distribuyeron en tres grupos: 80 con patología dual (PD; 37 con esquizofrenia y 43 con depresión mayor), 80 con trastorno por uso de sustancias (TUS) y 63 con tras...
Las estrategias de afrontamiento tienen un impacto en los trastornos por uso de sustancias (TUS) y en los trastornos mentales severos (TMS), tanto a nivel de características clínicas como de adherencia al tratamiento. Sin embargo, el conocimiento en esta área es escaso, especialmente en los pacientes con patología dual (PD). El presente trabajo exp...
Coping strategies have an impact on substance use disorders (SUD), relapses, and clinical variables, but knowledge on this area is scarce. We explored the coping strategies used during treatment in patients with dual diagnosis (DD), SUD, and severe mental illness (SMI), and the relation with clinical course and relapses at one-year follow-up. A sam...
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Mood-related behavioral display a daily rhythmic pattern. However, most clinical instruments do not assess mood rhythm aspects. The Mood Rhythm Instrument (MRhI) intends to contribute to filling this gap. We evaluated the psychometric properties and validated the MRhI in a Spanish sample (N = 457), exploring the relationship with chronotype and soc...
Gifted children learn more rapidly and effectively than others, presumably due to neurophysiological differences that affect efficiency in neuronal communication. Identifying the topological features that support its capabilities is relevant to understanding how the brain structure is related to intelligence. We proposed the analysis of the structu...
Objective: Identification of genetic risk factors for major depressive disorder (MDD) represents a major challenge around the world. Molecular studies of endophenotypes associated with MDD, such as personality traits and coping, are useful for the identification of candidate genes. The aim of this study was to evaluate the possible association betw...
Background
A functional polymorphism (5-HTTLPR, rs4795541) in the serotonin transporter ( SLC6A4 ) gene has been shown as an important candidate for several psychiatric and behavioral traits.
Objective
The objective of this study was to examine the possible interaction of this polymorphism with physical neglect in childhood on the presentation of...
While social zeitgebers are known to shape diurnal preference, little research has been devoted to determining the contribution of the familiar group chronotype as social zeitgeber on individual circadian rhythms and sleep-wake patterns in adult subjects. The current study aimed to examine the matching between perceived family chronotype and indivi...
Although major depressive disorder (MDD) is one of the main causes of global disease burden, there is little evidence about the association between personality traits and depressive symptoms in Latin America. The aim of this study was to examine the possibility that perceived stress might be a mediator of the association between neuroticism and dep...
Among the factors that contribute to the onset and maintenance of depressive disorders, rhythmicity of symptoms and consumption of caffeine have recently gained attention. The current study aimed to examine the differential rhythmicity of relevant variables in a sample of young participants, considering the presence of depressive symptomatology and...
Background: Among patients with substance use disorder (SUD), major depressive disorder (MDD) is highly prevalent. Even though, personality plays an important role in treatment outcomes for individuals with SUD and SUD + MDD, few studies have explored personality characteristics in these samples. This study aims to describe personality for patients...
Objective:
Childhood trauma and telomere length (TL) are important risk factors for major depressive disorder. We examined whether there was an association between childhood trauma and TL in a sample of Colombians who were assessed for depressive symptoms.
Methods:
We applied the Center for Epidemiologic Studies Depression scale, the Patient Hea...
Genetic studies of major depressive disorder and its associated endophenotypes are useful for the identification of candidate genes. In recent years, variations in non-coding RNA genes, such as miRNAs, have been explored as novel candidates for psychiatric disorders and related endophenotypes. The aim of the present study was to evaluate the possib...
There is evidence of the reciprocal influence between the alteration of circadian rhythms and Substance Use Disorders (SUD), and part of the success of the SUD treatment lays in the patient's rhythmic recovery. We aim to elucidate the effect of the SUD treatment in circadian rhythmicity considering, for the first time, the age of onset of substance...
Despite emerging evidence that disruption in circadian rhythms may contribute to the pathophysiology of psychiatric disorders, there is a significant knowledge gap on the rhythmicity of psychological symptoms. Here, we aimed at investigating the rhythmicity of mood symptoms in individuals at risk for psychiatric disorders. 391 Brazilian and 317 Spa...
Background:
The study of health-related quality of life (HRQOL) is an important topic in mental health around the globe. However, there is the need for more evidence about the cumulative influence of psychological variables on HRQOL. The main aim of the study was to evaluate how specific personality traits might explain scores in HRQOL and to expl...
Dyscalculia is a specific leaning disorder that profoundly impairs the acquisition of school-level arithmetic skills Kuhn (2015). It interferes
academic aims and numerical activities of daily life, and can not be
explained by any sensorial deficit, neurological disorder or medical disease. According previous studies, specific training of number
pro...
Diurnal subjective sleepiness has been associated with a large number of negative outcomes, such as increased risk of accidents and development of mental disorders as depression and anxiety. However, the role of the diurnal subjective sleepiness as a mediator is poorly understood. The goal of the present study was to examine the role of diurnal sub...
INTRODUCCIÓN La tipología circadiana o el cronotipo es una diferencia individual cuyo estudio en las últimas décadas ha aportado gran cantidad de datos de interés tanto teórico como aplicado. Los hallazgos apuntan a que la tipología circadiana influye en diversos ámbitos del funcionamiento de los individuos, pudiendo destacar entre ellos las implic...
Background:
The concept of the exposome has emerged as a new strategy for studying all environmental exposures throughout an individual’s life and their impact on human health. Nowadays, electronic devices are available to collect data about an individual’s geolocation, biological function, or exposure biomarkers. The appearance of “omic” sciences...
Background: A considerable proportion of young adults are affected by psychological distress at any time and an important fraction of them may develop mental disorders. Use of novel approaches for the analysis of data from multiple psychological scales might facilitate the identification of key indicators of mental health.
Aims: The aim of current...
The aim of this study was to provide validity for the Spanish version of the Morningness–Eveningness-Stability Scale – improved (MESSi), a novel evolved assessment of circadian typology which considers the subjective phase and amplitude by morning affect (MA), eveningness (EV) and distinctness (DI; subjective amplitude) sub-scales. Convergence vali...
Background
Situation awareness (SA) is defined in three levels: SA1 is the perception of the elements in a specific context, SA2 is the comprehension of their meaning, and SA3 is the projection of their status.
Purpose
To analyze the possible association of a genetic polymorphism in the serotonin transporter ( SLC6A4) gene and performance on the S...
Background
Patient-perceived health-related quality of life has become an important outcome in health care as an indicator of treatment effectiveness and recovery for patients with substance use disorder. As no study has assessed health-related quality of life among male patients with substance use disorder and co-existing severe mental illness, we...
Background
The age of onset of substance use (OSU) as well as the coping strategies (CS) influence both the development and the course of Substance Use Disorders (SUD). We aim to examine the differences in the CS applied to deal with treatment in men with SUD, considering whether the age of OSU had begun at age 16 or earlier (OSU ≤ 16) or at 17 yea...
The pattern of alcohol consumption in the form of binge drinking (BD) or heavy episodic drinking has increased notably worldwide in recent years, especially among adolescent and young people, being currently recognized as a global health problem. Although only a minority of binge drinkers will develop a substance use disorder, BD may have negative...
Background and objectives:
Young adults might engage in many risk behaviors, including alcohol and drug use, which could lead to mental health problems, such as suicide. The aim of this study was to examine specific psychosocial and clinical factors that could influence the possible relationship between polysubstance use (PSU) and suicide risk in...
Introduction: The Mood Rhythm Instrument (MRI) is a questionnaire developed to assess the circadian rhythm of mood-related behaviors. The aim of this study was to translate this instrument from Brazilian Portuguese into Spanish. Methods: The translation process consisted of forward translation, adjustment, back translation, back translation review...
Recently there is a growing interest in the interaction of schizophrenia spectrum disorders (SSD) and substance use disorders (SUD), a condition named dual schizophrenia spectrum disorders (SSD + ). While previous research has focused on clinical and cognitive aspects, little is known about the impact of comorbidity in the brain structure and funct...
Objective: The present study aimed to investigate the relationship between physical self‐efficacy and body mass index in a large sample of schoolchildren.
Methods: The Perceived Physical Ability Scale for Children was administered to 1560 children (50.4% boys; 8–12 years) from three different countries. Weight and height were also recorded to obtai...
Coping strategies exert an important influence in the development and course of both substance use disorder (SUD) and major depressive disorder (MDD) and its treatment outcomes. We examined the coping strategies related to treatment in SUD and SUD-MDD patients and their associations with clinical characteristics. Forty SUD and 40 SUD-MDD males, eac...
Background
Lifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD), known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering...
Although there have been described alterations of circadian rhythmicity both in patients with substance use disorder (SUD) and patients with major depressive disorder (MDD), the circadian characteristics of SUD patients with comorbid MDD (SUD-MDD) are unknown. Likewise, the possible influence of the different modalities of treatments (ambulatory or...
Objective:
The present study aimed to investigate the relationship between physical self-efficacy and body mass index in a large sample of schoolchildren.
Methods:
The Perceived Physical Ability Scale for Children (PPASC) was administered to 1560 children (50.4% boys; 8-12 years) from three different countries. Weight and height were also record...
Personality plays an important role in individuals with Substance Use Disorder (SUD) and co-occurring Severe Mental Illness (SMI). However, the possible personality differences in SUD patients considering their cooccurring SMI remain unknown. We explored the personality in a sample of 104 male patients with SUD and SMI: 35 had co-occurring Schizoph...
Background:
The prevalence of binge drinking (BD), found especially among young people, is increasing worldwide and has become an important social and health concern. We studied, for the first time, the personality profile, using the Alternative Five Factor Model, among university students with BD and healthy controls, taking into account the poss...
This chapter focuses on the comorbidity between Severe Mental Illness (SMI), mainly schizophrenia, bipolar disorder and major depression disorder and Substance Use Disorders (SUD). Such comorbid condition has been called Dual Diagnosis (DD). Along this manuscript major contributions of current research will be reviewed regarding the prevalence, eti...
In this chapter we revise the results currently available on the intermittent pattern of consumption of alcoholic beverages with the primary intention of reaching a marked intoxication, known as heavy episodic drinking or binge drinking (BD). We will consider some of the existing epidemiological data, in order to highlight the health and social pro...
Previous research has not considered the influence of the Comorbid Mental Disorder (CMD) among Substance Use Disorders (SUD) patients. We explored the possible differences in personality dimensions among SUD patients taking into account their CMD (Schizophrenia, SZ; Bipolar Disorder, BD; Major Depressive Disorder, MDD); and elucidated clinical fact...
Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common...
