Amy Yen

Amy Yen
Taipei Medical University | TMU · College of Oral Medicine

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245
Publications
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Introduction
Skills and Expertise

Publications

Publications (245)
Article
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There is paucity of the statistical model that is specified for data on imported COVID-19 cases with the unique global information on infectious properties of SARS-CoV-2 variant different from local outbreak data used for estimating transmission and infectiousness parameters via the established epidemic models. To this end, a new approach with a fo...
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Background Understanding renal function state transition risk and associated factors in community residences is vital for appropriate preventive and care actions. We aim to investigate factors affecting renal function state transitions through 10-year longitudinal community screening surveys. Methods The prospective cohort study included participa...
Preprint
BACKGROUND The aging population of Baby Boomers (born between 1946-1964) in Asia was faced with a great challenge on excessive all-cause mortality during COVID-19 pandemic. However, few studies were conducted to assess whether and to what extent excess deaths were affected by Baby Boomers susceptible to various SARS-CoV-2 mutants. OBJECTIVE We aim...
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Purpose To use mammographic tumour features (imaging biomarkers) to identify and investigate breast cancers originating from the terminal ductal lobular units (TDLUs) of the breast in order to overcome the confusion arising from the current histopathology terminology, which calls cancers arising from the TDLUs either “ductal” or “lobular”. Method...
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Purpose To encourage and facilitate the recognition of ductal adenocarcinoma of the breast, DAB, as a distinct, invasive breast cancer subtype by describing the imaging biomarkers in detail. Methods Correlation of breast imaging biomarkers with the corresponding histopathological findings using large format technology, with additional evidence fro...
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Background This study is aimed at estimating the unbiased effectiveness of population-based breast cancer service screening based on case survival information alone rather than large-scale individual screening data pursuant to the intention-to-treat principle of a randomized–controlled trial. Methods A novel time-dependent switched design with two...
Preprint
Background It is important for understanding the impact of COVID-19 pandemic on the missing opportunity for the early detection of oral cancer. This study aimed to assess the impact of COVID-19 pandemic on the existing population-based oral cancer (OC) service screening program in Taiwan. Methods Before and after COVID-19 pandemic design was used...
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Purpose To call attention to a highly fatal breast cancer subtype arising from the major lactiferous ducts that is currently underdiagnosed as ductal carcinoma in situ (DCIS) with or without microinvasion. Method All breast cancers diagnosed at the Department of Mammography, Falun Central Hospital, Sweden, since 1977 have been classified according...
Preprint
We applied a four-state stochastic process to decipher the natural infectious process of SARS-CoV-2 superimposed with the disease axis of pre-symptomatic, asymptomatic, and symptomatic states. So doing provides new insights into how pre-symptomatic transmission and the proportion of asymptomatic cases have been affected by SARS-CoV-2 variants, NPIs...
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Facing the emerging COVID viral variants and the uneven distribution of vaccine worldwide, imported pre-symptomatic COVID-19 cases play a pivotal role in border control strategies. A stochastic disease process and computer simulation experiments with Bayesian underpinning was therefore developed to model pre-symptomatic disease progression during i...
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Purpose To use mammographic tumour features (imaging biomarkers) to classify breast cancer according to its apparent anatomic site of origin in the new era where tumours are found at their nonpalpable, earliest detectable phase. Method Large format, subgross, three-dimensional histopathologic images of breast cancer subtypes and their correspondin...
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The purpose of this research is to elucidate whether metabolic syndrome affects the rate of adoption of a new multiple cancer screening programme, based on the Diffusion of Innovation theory. The time to attend the screening programme, conducted in Keelung, Taiwan, within 10 years was assessed by innovativeness (innovators, early adaptors, early ma...
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The quality assurance of two-stage population-based cancer screening program is determined by arrival rate (attending screening), positive rate (determined by the criteria of screening test), the compliance and the waiting time (WT) for confirmatory diagnosis in those screened as positive. These parameters were correlated between the process of scr...
Preprint
Objectives Two kinds of epidemic surveillance models are presented for containing the spread of SARS-CoV-2 variants so as to avert and stamp out a community-acquired outbreak (CAO) with non-pharmaceutical interventions (NPIs), tests, and vaccination. Design The surveillance of domestic cluster infections transmitted from imported cases with one-we...
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COVID-19 pandemic has severely affected regular public health interventions including population-based cancer screening. Impacts of such screening delays on the changes in structure and screening process and the resultant long-term outcomes are unknown. It is therefore necessary to develop a systematic framework to assess theses impacts related to...
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Objectives: Whether and how the COVID-19 pandemic affected utilization of routine medical care in areas with low infection risk, such as Taiwan, has not been widely addressed. We aimed to evaluate the impact of the COVID-19 pandemic on access to medical care. Study design: Before and after exposure (COVID-19 pandemic) design with a historical co...
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Background Dental students have encountered changes in the teaching format amid the SARS CoV-2 pandemic. This study aims to evaluate the attitudes of dental students of one medical university toward online courses and compare them with those of non-dental students amid the SARS CoV-2 pandemic. Methods A cross-sectional survey with a self-report on...
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The outbreak of COVID-19 on the Diamond Princess Cruise Ship provides an unprecedented opportunity to estimate its original transmissibility with basic reproductive number (R0) and the effectiveness of containment measures. We developed an ordinary differential equation-based Susceptible-Exposed-Infected-Recovery (SEIR) model with Bayesian underpin...
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Background/Purpose A synthesis design and multistate analysis is required for assessing the clinical efficacy of antiviral therapy on dynamics of multistate disease progression and in reducing the mortality and enhancing the recovery of patients with COVID-19. A case study on remdesivir was illustrated for the clinical application of such a novel d...
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Background The surge of COVID-19 pandemic has caused severe respiratory conditions and a large number of deaths due to the shortage of intensive care unit (ICU) in many countries. Methods We developed a compartment queue model to describe the process from case confirmation, home-based isolation, hospitalization, ICU, recovery, and death. By using...
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Background Vaccine is supposed to be the most effective means to prevent COVID-19 as it may not only save lives but also reduce productivity loss due to resuming pre-pandemic activities. Providing the results of economic evaluation for mass vaccination is paramount important for all stakeholders worldwide. Methods We developed a Markov decision tr...
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The spread of the emerging pathogen, named as SARS-CoV-2, has led to a unprecedented COVID-19 pandemic since 1918 influenza pandemic. This review first sheds light om the similarity on global transmission, surges of pandemics, and the disparity of prevention between two pandemics. Such a brief comparison also provides an insight into the potential...
Preprint
BACKGROUND Pre-symptomatic imported COVID-19 cases play an important role in border control strategies for containing their further spread to community outbreaks. OBJECTIVE A pre-symptomatic incubation model was proposed to develop precision screening, quarantine, and isolation strategies for containing imported COVID-19 case. METHODS The natural...
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IntroductionEfficient evaluation with an early surrogate endpoint, taking into account the process of disease evolution, may not only clarify inconsistent or underpowered results but also provide a new insight into the exploration of a new antiviral therapy for treating COVID-19 patients.Methods We assessed the dynamics of COVID-19 disease spectrum...
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Background Previously, the risk of death from breast cancer was analyzed for women participating versus those not participating in the last screening examination before breast cancer diagnosis. Consecutive attendance patterns may further refine estimates. Purpose To estimate the effect of participation in successive mammographic screening examinati...
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Objective To evaluate the effect of the periodontal primary care (PPC) on the improvement of periodontal pocket depth based on a periodontist's 30‐year practice. Materials and Methods We enrolled a total of 2,894 patients who underwent periodontal basic treatment between 1987 and 2017 with 84.5% retention rate. The study population was composed of...
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Multistate statistical models are often used to characterize the complex multi-compartment progression of the disease such as cancer. However, the derivation of multistate transition kernels is often involved with the intractable convolution that requires intensive computation. Moreover, the estimation of parameters pertaining to transition kernel...
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Objective To measure the effects of faecal immunochemical test (FIT) for colorectal cancer (CRC) screening on overall and site-specific long-term effectiveness of population-based organised service screening. Design A prospective cohort study of Taiwanese nationwide biennial FIT screening was performed. A total of 5 417 699 eligible subjects were...
Article
Objective To classify interval colorectal cancers as false negatives or newly occurring cases in a biennial Fecal immunochemical test (FIT) screening program and by various interscreening intervals. Setting Data from the Taiwanese biennial colorectal cancer screening program involving FIT from 2004 to 2014 were used to estimate the incidence rate...
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Background. Emergency department (ED) crowding and prolonged lengths of stay continue to be important medical issues. It is difficult to apply traditional methods to analyze multiple streams of the ED patient management process simultaneously. The aim of this study was to develop a statistical model to delineate the dynamic patient flow within the...
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Evaluating the performance of serum prostate-specific antigen (PSA) test in population-based screening with receiver operating characteristics (ROC) curve often neglects the time dimension. Asymptomatic cases with negative PSA test would have been missed if sojourn time is not taken into account to allow for cases surfacing into the clinical phase....
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Although the effectiveness of mass screening for colorectal cancer (CRC), stool-based tests, for example, has been demonstrated by randomized controlled trials (RCTs), whether the same benefits can be similarly observed in population-based organized service screening programs is subject to multiple factors and a complex multistate disease process....
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Objectives: We aimed to assess the effect of metabolic syndrome (MetS) on incident oral potentially malignant disorder (OPMD). Design: We conducted a prospective cohort study of the Changhua community-based integrated screening (CHCIS) programme and nationwide oral cancer screening programme during the period between 2005 and 2014. Setting: CH...
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Background: To assess the impact of treatment delay on survival of oral/oropharyngeal cancer (OSCC). Methods: We followed 5743 OSCCs between 2004 and 2009 from a population-based screening program and ascertained death until the end of 2012. Results: The hazard ratios (HRs) of mortality from OSCC were 1.46 (1.30-1.65) and 1.18 (1.04-1.33) in u...
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Objective: Subjects with a positive faecal immunochemical test (FIT) have a much higher likelihood of advanced neoplasms than the general population. Whether FIT-positive subjects with negative colonoscopy should receive subsequent FIT screening remain unclear. Design: Subjects with a negative colonoscopy after positive FIT in the first screenin...
Article
Not only were social events and public facilities closed temporarily due to the coronavirus disease 2019 (COVID‐19) pandemic, but health services also were affected greatly. In this commentary, the authors discuss how the national program of mammography screening in Taiwan was affected, even without known community‐acquired transmission.
Article
Background Implementing and lifting social distancing (LSD) is an urgent global issue during the COVID-19 pandemic, particularly when the travel ban is lifted to revive international businesses and economies. However, when and whether LSD can be considered is subject to the spread of SARS-CoV-2, the recovery rate, and the case-fatality rate. It is...
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There are few published studies that report the prevalence of intraoral anomalies for young children. The purpose of this study was to investigate the prevalence and distribution of several congenital oral and paraoral anomalies in Taiwanese children under age six. Twenty-five cities and townships were randomly sampled in different areas of Taiwan...
Preprint
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BACKGROUND Implementing and lifting social distancing (LSD) is an urgent global issue of COVID-19 pandemic particularly when the travel ban is lifted to revive international business and economics. However, when and whether LSD can be considered is subject to the spread of SARS-COV-2, the recovery rate, and case-fatality rate. It is imperative to p...
Preprint
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Background We aimed to investigate factors associated with personal self-protection in infection control among dental care workers. Methods A cross-sectional survey with self-report questionnaire was conducted between Jan and Dec, 2018. 275 dentists and 298 dental assistants were enrolled from randomly selected dental care settings. Results Complia...
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The aim was to evaluate how the inter-screening interval affected the performance of screening by mammographic appearances. This was a Swedish retrospective screening cohort study with information on screening history and mammography features in two periods (1977–1985 and 1996–2010). The pre-clinical incidence and the mean sojourn time (MST) for sm...
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Introduction: The efficacy of smoking cessation intervention has been proven with randomized controlled trials. Our study aims to elucidate the effects of the delivery method of smoking cessation advice on the process of stage of changes with transtheorectical model underpinning in a community setting. Methods: A total of 436 subjects were recru...
Preprint
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Background: The impact of remdesivir on length of stay of hospitalization, high-risk state, and death stratified by the severity of COVID-19 at enrollment is controversial. Methods: We applied a simulated two-arm controlled study design to the data on compassionate use of remdesivir as a secondary analysis. Dynamics of risk states and death from CO...
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Background: It is of paramount importance to evaluate the impact of participation in organized mammography service screening independently from changes in breast cancer treatment. This can be done by measuring the incidence of fatal breast cancer, which is based on the date of diagnosis and not on the date of death. Methods: Among 549,091 women,...
Preprint
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While the recent study on the compassionate use of remdesivir for COVID-19 patients has shown a 68% clinical improvement ⁷ it is a one-arm study that renders the evaluation of the efficacy in reducing death and the length of stay of hospitalization intractable due to a lacking of the control group. We came up with a two-arm controlled study design...
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Background: A gender difference in hepatocellular carcinoma (HCC) that men have higher incidence than women has long been noted and can be explained by the cross-talk between sex hormones and hepatitis B virus/hepatitis C virus (HBV/HCV). Whether metabolic factors yield similar sexual difference in non-HBV/HCV-HCC remains elusive. Methods: There...
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Objectives To explain apparent differences among mammography screening services in Sweden using individual data on participation in screening and with breast cancer–specific survival as an outcome. Methods We analysed breast cancer survival data from the Swedish Cancer Register on breast cancer cases from nine Swedish counties diagnosed in women e...
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Background Deep brain stimulation of subthalamic nucleus (STN-DBS) is an effective therapy for Parkinson’s disease (PD). However, cost-effectiveness analysis (CEA) is required because most patients are older adults and decision-makers must therefore consider whether the long-term effectiveness outweighs the initial cost. Method A Markov decision m...
Preprint
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Background: Little is known about how early awareness is enhanced via a community-based active detection of dementia in comparison with the passive detected dementia through routine clinical practice. Methods: To assess the extent of the awareness, the adjusted detection ratio, the ratio of prevalence to incidence was developed by a Bayesian regres...
Article
Modeling overdetection resulting from screening often uses the conventional competing risk model. This model assigns screen-detected cases dying from other causes as overdetection modeled by a one-jump process, which may not be true for the censored overdetected cases. To relax this restrictive assumption, accommodate a finite Markov process for ov...
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Normal body mass index (BMI) is associated with lower risk for cardiometabolic diseases. However, there is a subset of individuals with BMI in this range who present with this metabolic abnormality (called metabolically unhealthy normal weight, MUHNW). Here we aimed to assess the adipose characteristics of people with MUHNW using dual-energy X-ray...
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To develop personalized screening and surveillance strategies, the information required to superimpose state-specific covariates into the multi-step progression of disease natural history often relies on the entire population-based screening data, which are costly and infeasible particularly when a new biomarker is proposed. Following Prentice’s ca...
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Background: The onset of epileptic seizures is influenced by weather, which is multifactorial. It is unknown which specific weather factors affect the occurrence of seizures. Objectives: We studied the correlation between the onset of epileptic seizures and multiple weather parameters based on a population-based registry profile. Methods: We d...
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(1) Background: A simulation approach for prostate cancer (PrCa) with a prostate-specific antigen (PSA) test incorporating genetic information provides a new avenue for the development of personalized screening for PrCa. Going by the evidence-based principle, we use the simulation method to evaluate the effectiveness of mortality reduction resultin...
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Background: We aimed to assess the effect of intraocular pressure (IOP) on incident metabolic syndrome (MetS) using a longitudinal follow-up of screening cohort in contrast to most of previous studies addressing the association between both. Methods: The empirical data were derived from a community-based integrated screening program in Matsu durin...
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Background: Although fecal hemoglobin concentration (f-Hb) was highly associated with the risk of colorectal neoplasms, current studies on this subject are hampered by skewedness of the data and the ordinal property of f-Hb has not been well studied yet. Our aim was to develop a quantile-based method to estimate adjusted percentiles (median) of fe...
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Background To differentiate the risk of breast cancer death in a longitudinal cohort using imaging biomarkers of tumor extent and biology, specifically, the mammographic appearance, basal phenotype, histologic tumor distribution, and conventional tumor attributes. Methods Using a prospective cohort study design, 498 invasive breast cancer patients...