Amit Kumar Dixit

CARI, KOLKATA

Background Rheumatoid arthritis is a chronic autoimmune disease affecting millions of people across the world. Trayodashang guggulu (TG) is a classical Ayurvedic formulation used for the treating joint diseases since decades in the Indian system of traditional medicine. The aim of the study was to evaluate anti-arthritic activity of TG against comp...

Coinfection of pathogenic bacteria and viruses is associated with multiple diseases. During the COVID-19 pandemic the co-infection of other pathogens with SARS-CoV-2 was one of the important determinants of the severity. Although primarily a respiratory virus gastric manifestation of the SARS-CoV-2 infection was widely reported. This study highligh...

A 42-year-old male patient presented with complaints of vertigo, neck pain, swallowing difficulties, and difficulty in maintaining an upright posture. The patient took allopathic consultation for the complaints and was advised to undergo MDCT scan of brain, hematological and audiological evaluations. No abnormalities were detected in the investigat...

High mortality has been reported in severe cases of COVID-19. Emerging reports suggested that the severity is not only due to SARS-CoV-2 infection, but also due to coinfections by other pathogens exhibiting symptoms like COVID-19. During the COVID-19 pandemic, simultaneous respiratory coinfections with various viral (Retroviridae, Flaviviridae, Ort...

Cancer stem cells (CSCs) are pivotal in both cancer progression and the acquisition of drug resistance. MicroRNAs (miRNAs) play a crucial role in modulating CSC properties and are being explored as potential targets for therapeutic interventions. MiR-3163 is primarily known for its tumor suppressive properties in various human malignancies, with lo...

SARS-CoV-2 Envelope protein (E) is one of the crucial components in virus assembly and pathogenesis. The current study investigated its role in the SARS-CoV-2-mediated cell death and inflammation in lung and gastrointestinal epithelium and its effect on the gastrointestinal-lung axis. We observed that transfection of E protein increases the lysosom...

Chemoresistance and tumor relapse pose significant challenges in achieving successful chemotherapy outcomes. Targeting DNA polymerase eta (Pol ƞ) mediated-mutagenic translesion DNA synthesis (TLS) has emerged as a promising strategy for improving chemotherapy. However, the identification of small molecule inhibitors specifically targeting Pol η - m...

The present study was undertaken to evaluate the Maximum Tolerated Dose and No Observed Adverse Effect Level of Trayodashang guggulu (TG), an Ayurvedic classical formulation, in Wistar rats. TG was administered orally to Wistar rats in as single dose (2000 mg/kg body weight) in an acute toxicity study. Ninety days repeated dose oral toxicity (subch...

Inflammation is a multifaceted biological and pathophysiological response to injuries, infections, toxins, and inflammatory mechanisms that plays a central role in the progression of various diseases. MicroRNAs (miRNAs) are tiny, 19–25 nucleotides long, non-coding RNAs that regulate gene expression via post-transcriptional repression. In this revie...

BACKGROUND The documentation of ethno-medicinal claims is of significant value in drug research. The present study was conducted to document and validate the information related to the traditional uses of medicinal plants used by the local health practitioners of Hassan district. METHODS In the present study, different local health traditions prev...

This volume is a comprehensive compilation of contributions on the state of art knowledge about bioactive compounds including their sources, isolation methods, biological effects, health benefits and potential applications. These bioactive compounds could serve as alternatives in the prevention or treatment of multifactorial diseases for vulnerable...

This volume is a comprehensive compilation of contributions on the state of art knowledge about bioactive compounds including their sources, isolation methods, biological effects, health benefits and potential applications. These bioactive compounds could serve as alternatives in the prevention or treatment of multifactorial diseases for vulnerable...

This volume is a comprehensive compilation of contributions on the state of art knowledge about bioactive compounds including their sources, isolation methods, biological effects, health benefits and potential applications. These bioactive compounds could serve as alternatives in the prevention or treatment of multifactorial diseases for vulnerable...

Background As per facts sheet of WHO, cancer is a leading cause of mortality worldwide accounting nearly 10 million deaths in 2020. However, breast, lung, colon and rectum, prostate, skin and stomach cancers are the six most prevailing cancer across the globe. Out of the aforesaid cancers, breast cancer is the most commonly diagnosed cancer worldwi...

Triple-negative breast cancer (TNBC) cell line MDA-MB-231 is known for Warburg metabolism and defects in mitochondria. On the other hand, dipeptidyl peptidase-IV (DPP-IV) inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis, but no study has evaluated the infl...

BACKGROUND Chickenpox is a contagious infection caused by the Varicella-zoster virus with the clinical manifestation of itchy rashes with fluid-filled blisters and fever. Although it is a self-limiting disease, to shorten the recovery period as well as to avoid complications, Ayurveda medicine could be effectively used in the management of chickenp...

Skin burn is a common health problem that needs a fast and accurate treatment; else, it can have a worse prognosis. The available treatment options pose limitations due to their adverse effects; thus there is an urgent need to find newer treatment options for burn wound healing that can provide a safer and faster treatment option. Ayurveda gives a...

BACKGROUND: Diospyros exsculpta Buch.-Ham. (DE) belongs to the genus Diospyros, is an underutilized plant and needs to explore its phytochemical and biological activities. OBJECTIVES: The Present study aimed to compare phytochemical and biological activities such as antioxidant, antimicrobial, and protein-binding assay of twig and stem bark of D...

In herbal medicine, there is a substantial amount of variety of plants have been used to treat neurodegenerative disorders including Alzheimer's (AD)as well as other memory-related issues. Dementia is a neurological condition characterised by a progressive loss in emotional and cognitive abilities. Dementia is linked to a number of conditions like...

Viola odorata Linn. (Family Violaceae) is popularly known as Sweet Violet or English Violet and Gulbanafsha in Hindi. V. odorata is used as remedy for coughs, sore throat, hoarseness and tonsillitis. It is valued as an expectorant, antioxidant, diaphoretic, antibacterial, antipyretic and diuretic. Pharmacological studies have revealed the role of V...

Thyroid disease is one of the most prevalent endocrine disorders worldwide. Hypothyroidism can result from any of a variety of abnormalities that lead to insufficient synthesis of thyroid hormones. Thyroid dysfunction prevalence is rising at an alarming rate in Indian population, more prevalent among the females. In modern science, the treatment of...

Ayurveda is the traditional, ancient Indian system of health science. Vrikshayurveda is the ancient Indian science of plant life which deals with various trees and plant species and ensures the healthy growth and productivity. One of its chapters “Chitrikarana” depicts astounding techniques to make a plant bloom throughout the year irrespective of...

Background: The outbreak of Coronavirus disease (COVID-19) has been recently declared as Public Health Emergency of International Concern (PHEIC) by World Health Organization and the virus has now spread beyond the boundaries of countries and continents. At present, no specific antiviral treatment or vaccine is available or recommended to counter t...

Thyroid disorders have been one among the most challenging and most common endocrine disorders that we confront worldwide. Major thyroid disorders include hypothyroidism, hyperthyroidism, goiter/iodine deficiency, Hashimoto’s thyroiditis, and thyroid cancer. Among these, hypothyroidism is arguably the most challenging as its multifarious clinical p...

Aim The traditional medicinal practice in India includes different aspects of health such as prevention, promotion, and healing. Since there is need for documenting this traditional medicinal practice prevalent in different parts of the country for the preservation of the knowledge, the present study was undertaken to record the traditional knowled...

The present study aimed to generate the qualitative, quantitative parameters for seeds of Argemone mexicana L. (Family: Papaveraceae) through phyto-pharmacognostical, physicochemical, phytochemical studies. Qualitative chromatographic profiling has been generated. Spectral pattern of the extract by infra-red spectroscopy has also been studied. The...

Aim: Present study was intended to investigate the physicochemical parameters, phytochemical constituents, and biochemical studies of the stem bark (STB) and small branches (SBs) of Buchanania cochinchinensis (Lour.) MR Almeida. Materials and methods: The parameters were checked in different solvent systems, viz., petroleum ether, acetone, and met...

Plants are rich sources of bioactive compounds, and have been used in traditional medicine systems for the past few millennia; even now plant-based drugs continue to provide new remedies to mankind. The medicinal plant Alstonia scholaris (L.) R. Br. (Saptaparṇa, Chhatim) is widely used in the Indian school of traditional medicine of Ayurveda. The p...

Medicinal plants constitute an effective source of traditional Ayurvedic system, with increasing believe and demands in Ayurvedic medicines, the adulteration in medicinal plants has also became a burning problem in the pharmaceutical industry. Adulterations is a practice of substituting original or genuine drugs with similar looking drugs which hav...

The study was performed to check the chemical, antioxidant, antimicrobial, and protein binding qualities of the hydroethanolic extract of Celastrus paniculatus (CP). Hydroethanolic extract of CP exhibited low antibacterial and antifungal activities. Excellent antioxidant activities (60–80%) were noticed for various antioxidant assays, namely, 2,2-d...

Babbula is an important traditional medicinal plant in Ayurveda and Unani systems of medicine. All parts of the plant are useful as medicine/therapeutic agents to cure various ailments. Its bark is useful in cough, bronchitis, diarrhoea, dysentery, biliousness, burning sensation, piles, leucoderma, urinary discharges, ascites etc. Levaes are useful...

The study was performed to check the chemical, antioxidant, antimicrobial and protein binding qualities of the hydro-ethanolic extract of Tinospora cordifolia (TC). In qualitative and quantitative analysis of extract, the major compounds were tinocordioside, cordifolide A, palmatine, quercetin, β-sitosterol, heptacosanol, and syringin. Hydro-ethano...

Present communication deals with the pharmacognostical standardization on the roots of Agnimantha (Premna serratifolia L. (syn. P. integrifolia L.) belong to the family Verbenaceae. It is an important medicinal plant used in many Ayurvedic formulations. According to Ayurveda the roots and leaves are most useful parts of the plant. It is one among t...

Research J. Pharm. and Tech. 11(9): Septembert 2018 1 ISSN 0974-3618 (Print) www.rjptonline.org 0974-360X (Online) RESEARCH ARTICLE A Review on Different Sources of Piper nigrum L. Adulterants Rinky Thakur1 , Ajay Kumar Meena2 , Amit Kumar Dixit1 , Suma Joshi4 1Regional Ayurveda Research Institute for Metabolic Disorder, CCRAS, Ministry of AYUSH, B...

The naming of plants is an extremely interesting topic with historical and cultural significance. Nomenclature and classification of a plant is very essential for proper identification and to distinguish a particular species from others. In Ayurveda, methodology of nomenclature is multinomial. Though the Sanskrit literature have provided accurate d...

Mukhpak (Stomatitis) is most common disease of oral cavity and can occur anywhere in the mouth, including the inside of the cheeks, gums, lips, palate and tongue. It can disrupt a person's ability to talk, eat and sleep. This is an observational study on 65 Mukhpak (stomatitis) patients with complaints of redness, ulceration in oral cavity, salivat...

Urinary calculi is one of the most common and painful urological disorder of the urinary tract affecting 10-12 % of the population. It is characterized by frequent micturition, intermittent pain occasionally radiates to flanks, sweating and restlessness during the pain. Most of the patients taking allopathic medicine but calculi was not expel or cr...

Peyronie's disease (PD) is an acquired benign disease of the penis. It is a localized connective tissue disorder, includes the presence of fibrous plaque in the penile shaft, penile curvature, penile pain and erectile dysfunction. There are numerous conventional oral drugs to treat the condition with weak scientific evidence. Due to lack of definit...

The prevalence of NAFLD is to be around 9-32% in general Indian population, with a higher incidence amongst overweight/obese and diabetic/ pre diabetic patients. There is no satisfactory patient centered clinical outcomes and evidences for NAFLD although a variety of molecules have been attempted to correct wide spectrum of NAFLD. Most of clinical...

Amlapitta is a common disorder caused by vidagdha pitta such as avipaka (indigestion), amlotkalesh or tikta amlodgara (sour or bitter belching), hridkantha daha heart throat burning sensation) and aurichi (anorexia) due to acid peptic digestion affecting more people in India. The disease was selected for clinical study to assess the efficacy of a c...

Phyto-medicines have been used traditionally by herbalists and indigenous healers worldwide for the prevention and treatment of liver diseases specially jaundice. More than sixty percent of jaundice patients of our country have the 1st choice to visit to traditional healers for their treatment. Classical text of Ayurveda vividly narrated about Kama...

In the present investigation 25 genotypes of maize collected from different sources were characterized for the soluble seed proteins using sodium dodecyl sulphate polyacrylamide gelelectrophoresis (SDS-PAGE). The total protein bands were separated on 12% polyacrylamide gel using standard protocols. Highest number of bands observed was 14 in inbred...

Thyroid dysfunction is one of the common endocrinopathy encountered in diabetes mellitus, which affects the basal metabolic rate of the individual. Early detection and treatment of thyroid dysfunction in type-2 diabetes mellitus can prevent risk for various metabolic disorders. The rationale of this study was to study the prevalence of thyroid dysf...

Amlapitta is composed of two words i.e. Amla & Pitta. The term Amla is a special type of test similarity with sour test and pitta which is body chemical substance mainly responsible for the maintained of process of digestion, transformation. Amlapitta is a common disorder caused by vidagdha pitta such as avipaka (indigestion), amlotkalesh or tikta...

High-isoflavones soybean genotypes are desired in nutraceutical industry. Conversely, low-isoflavones soybean genotypes are preferred to regular soybean in designing soy-based infant formula and in developing soy food products with reduced astringent taste. Concentration of individual form of isoflavones viz. daidzein, glycitein and genistein was d...

Nature has produced wonderfully complex molecules that no synthetic chemist could ever dream of. It was only after the isolation of Morphine from the opium poppy plant people realized that bioactive compounds present in plants are responsible for their therapeutic properties. Thenceforth, plants are considered as a 'biosynthetic laboratory' for a m...

γ-irradiation exposure may occur during planned or unplanned situations, such as nuclear war, nuclear accidents, radiotherapy. γ-irradiation induced oxidative stress alters the antioxidant and immune system of the organisms by severely damaging biologically important molecules i.e. carbohydrates, lipids, proteins, DNA etc. In recent years, a wide r...

Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. Early detection and treatment of dyslipidemia in type-2 diabetes mellitus can prevent risk for atherogenic cardiovascular disorder. The rationale of this study was to detect the lipid abnormality in diabetic patients. Necessary data was collected from the...

Background: Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. Early detection and treatment of dyslipidemia in type-2 diabetes mellitus can prevent risk for atherogenic cardiovascular disorder. The rationale of this study was to detect the lipid abnormality in diabetic patients. Methods: Necessary data w...

Vegetable soybean is fast becoming a popular nutritious snack outside South-Eastern countries where its consumption is in vogue since ages. Reports have appeared in the literature concerning the nutritional value of green seeds; however, the information on its antioxidative properties is lacking. In the present investigation, 16 vegetable-type soyb...

Vegetable soybean is fast becoming a popular nutritious snack outside SouthEastern countries where its consumption is in vogue since ages. Reports have appeared in the literature concerning the nutritional value of green seeds; however, the information on its antioxidative properties is lacking. In the present investigation, 16 vegetable-type soybe...

Sandhi shoola refers to the joints pain where there is pain with or without inflammation and can be caused by injury or a number of autoimmune disorders such as rheumatoid arthritis and gout. Ayurveda system of medicine believes this as Sandhi shoola condition in which there is difficulty in walking and running and based on the physical examination...

The present study was undertaken to evaluate the radioprotective effect of Terminalia chebula Retzius extract against γ-irradiation-induced oxidative stress in rats. Major phenolic compounds such as total phenolics, flavonoids and triterpenoids contents of Terminalia chebula extract (TCE) were measured. Potential antioxidant activity of TCE was tes...

Indrayava (Holarrhena antidysenterica seed) has been used in bleeding piles, diarrhea, eczema, fever and colic as per Ayurveda. The folklore use of Indrayava for curing diabetes is reported as taking10 grams of Indrayava soaked overnight in 80 ml of water and then drinking the liquid. The Pharmacological study for anti-diabetic activities and acute...

The in vitro antioxidant potential and in vivo radioprotective ability of soy isoflavones was studied. Male Wistar rats were orally administered with soybean isoflavones (60mg/kg) for 21days followed by gamma irradiation exposure. Survival studies in rats exposed at 10Gy and endogenous spleen colony forming unit assay (CFU) at 6.0Gy were performed...

The seeds of three soybean genotypes with black, green, and yellow seed coat colors were treated with gamma irradiation at a dose of 0.5, 2.0, and 5.0 kGy. The ability to inhibit iron-induced lipid peroxidation, superoxide anion scavenging activity, and metal chelation activity were observed to be increased at 0.5 kGy. However, bleomycin-dependent...