Amit Gupta

• PhD
• Professor (Associate) at University of Jammu

Gymnosporia montana, a medicinal plant species, has been traditionally used by people for the treatment and cure of various infectious ailments. In this study, phytochemical profiling and biological evaluation (anti-inflammatory and antioxidant) of hydroethanolic leaves and fruit fractions (acetone, chloroform, and petroleum ether) obtained through...

Extravagant use of fluorides by taking them through water leads to various fluorosis-based diseases or may be a series of fluorosis diseases. So, the removal of excess fluoride from water is a crucial issue globally. There are various methods of defluoridation; among them, adsorption is a widely used and well-studied technology because of its minim...

Fluoride is a mineral which occurs naturally and often is ordinarily found in soil, rocks, and water. Fluoride may additionally enter water from other sources, including business operations, runoff from agriculture, and of course some natural events. Fluoride from such sources may disintegrate and find its way into ground water as well as surface w...

Cadmium (Cd) is a common element that should be taken seriously because almost all people are exposed to it through their diets and because it builds up in the human body over time. Cadmium exposure can happen when someone consumes tainted food, water, soil or dust, or when they breathe in tobacco smoke or airborne particulates. Microbial remediati...

Cadmium (Cd) contamination has grown to be a serious environmental problem in recent years due to its poisonous nature. The health of humans and other living things is negatively impacted by the buildup of Cd in the environment. Scientists have looked to the use of genetic engineering as an alternative solution for cadmium elimination in order to s...

In this study, we prepared three extracts (methanolic, ethyl acetate, and n-hexane) of Zanthoxylum armatum from respective regions of Uttarakhand (Bageshwar, Pithoragarh, and Champawat) for determining the antimicrobial activity of fruits and seed samples using the disc diffusion method. These samples were tested in vitro for their ability to inhib...

Bioactive compounds in the form of primary and secondary metabolites were isolated and purified from plant products, including fungi, microbes, etc. In the literature, these metabolites are described as having immunobiological properties on organisms that may be used in the food and pharmaceutical industries. Identification, isolation, and finding...

In the new bioeconomy, fungi play a decisive role in addressing major global challenges by upgrading resource efficiency, fabricating renewable replacements for products made from fossil fuels, upgrading waste materials to valuable food and feed ingredients, combating lifestyle diseases and antibiotic resistance by strengthening the gut biota, enha...

In recent years, the medical industry has used nanomaterials extensively in large part due to the fast advancement of nanotechnology. They are ideally suited for the target-specific and precisely controlled delivery of micro- and macromolecules in disease therapy due to their unique physical and chemical properties, which include minimized size, cu...

Nanomaterials have been widely employed in the medical profession in recent decades, thanks to the rapid development of nanotechnology. Their distinctive physical and chemical qualities, such as minimal size, functionalized surface characteristics, stable interactions with ligands, high carrier capacity, and ease of binding with both hydrophilic an...

The prevalence of heavy metals in bodies of water is connected to an increase in the quantity of industry and people. This has major implications for the well-being of humans and the environment. Because of the exceptionally toxic nature of mercury, mercury pollution is one of the major environmental challenges. This book chapter discusses the adso...

This study aims to scrutinize the phenolic secondary metabolites in the polar peel decocture of Malus domestica var Maharaji via hyphenated techniques along with the study of the antibacterial, anti- candida, and tyrosinase inhibitory potential of bioactive compound-rich fractions. Preliminary phenolics go over was performed together with thin la...

Introduction: Bacteria, being one of the most successful living forms and a result of phenotypic flexibility may be found in practically any environmental matrix. Pathogenic bacteria can also be found in water, rendering it unsafe to drink because they are responsible for a wide range of illnesses in humans, animals, plants, and other living things...

Antibiotics are antimicrobial drugs that kill germs and are crucial in the fight against bacterial infections. These medications are widely used in the prevention and treatment of diseases because they may either kill or stop bacteria from growing. Microbial resistance refers to bacteria's capacity to survive antibiotics' bacteriostatic or cytotoxi...

Vegetables are parts of plants having several chemical families which belong to the category of antioxidants. In literature, these vegetables and fruits contain high amounts of antioxidant molecules which may directly benefit to human healthcare. The objective of our study is to determine the antioxidant potential of seed-containing fibers aqueous...

Natural products are believed to be one of the richest sources of prophylactic and therapeutic-based compounds which show a wide range of applications in the food and pharmaceutical industries. An aqueous extract of Momordica charantia was evaluated systematically for antioxidant (2,2-diphenyl-1-picrylhydrazyl, DPPH free radical assay), antimicrobi...

This book explores the latest developments in health and disease research, including new research on SARS-CoV-2, the role of cytokines in asthma, the Omicron variant, mitogen-activated protein kinases as a target for regulating connective tissue growth, deep-learning-based risk assessment of dementia, novel strategies for managing Diabetes Mellitus...

The objective of our study is to confirm and isolate the enzyme chitinase from bacterial samples that are present in different soil samples of Baramati region, Maharashtra and determined its antimicrobial activity of chitinase with protease activity against Rapither AB in virally infected human whole blood samples. In this study, soil samples of di...

Treatment of wastewater has been a hotspot of research since ages. Emerging technologies and methodologies have been postulated to resolve the issue worldwide. Almost 97.2% of our earth is covered with water bodies, out of which 12,500 water bodies are situated in India. As per the statistics, nearly 70% water bodies are polluted in Southern Asia....

Algae are a significant food source for aquatic creatures and play a vital part in the aquatic food chain or food web. Algae differ from other groups of tiny or microscopic microbes in that they have an inner green colour called chlorophyll, which can sometimes be concealed or partly disguised by other pigments and allows them to integrate water an...

Waste issues are as ancient as the human race. The term waste refers to materials that are no longer in use and have been dumped by the owner. Waste management is the management of waste from the moment it is created until it is disposed of or reused at the end of its useful life. In waste management, the main objective is to reduce the influence a...

Plants are the primary repository of the vast majority of meals, medications, and nutritional supplements. Primary and secondary metabolites are the two types of plant compounds known as phytochemicals. Primary metabolites are essential for plant survival since they are involved in tasks such as cell division, growth, reproduction, respiration, met...

Today, fossil fuel is the primary source of energy worldwide. Because of rising global population and demands, the decline of fossil energy is a problem for future supply. Aside from accessibility, pollutants created by fuel combustion are a global health and environmental issue, contributing to global climate changes, destruction of the environmen...

Water is the primary life-sustaining resource and a critical component in a country's and human civilization's social, cultural, economic, and ecological growth. One of the key factors affecting water quality is temperature, which primarily affects how chemical and biological processes in aquatic creatures occur. It is crucial for determining a num...

Plants and herbs have been used as sources of safest compounds in the management of diseases as well as in the restoration and fortification of body structures in ancient medical systems such as Ayurvedic, Unani, and traditional Chinese medicine. The major motive for incorporating herbs in healthcare is to develop a healthy relationship with the bo...

Enterococci are Gram-positive, ovoid cocci that can be found as diplococci or in short chains. These species are found in the typical microbiota of the intestine, oral cavity, vagina, and other areas. Despite being commensals with moderate virulence, these species have lately emerged as important nosocomial infections with increasing drug resistanc...

Newcastle disease virus (family Paramyxoviridae; genus Avulavirus), poultry disease isextensively spread in Asia, Africa, USA and Canada. In literature, strains of Newcastle disease virus are worldwide reported and causing a huge loss to the poultry industries. The present review discusses about Newcastle disease virus and mentioning about its clin...

Enterococci are Gram-positive, ovoid cocci that can be found as diplococci or in short chains. These species are found in the typical microbiota of the intestine, oral cavity, vagina, and other areas. Despite being commensals with moderate virulence, these species have lately emerged as important nosocomial infections with increasing drug resistanc...

Plants and herbs have been used as sources of safest compounds in the management of diseases as well as in the restoration and fortification of body structures in ancient medical systems such as Ayurvedic, Unani, and traditional Chinese medicine. The major motive for incorporating herbs in healthcare is to develop a healthy relationship with the bo...

One of the family i.e. Celastraceae, consists of around 90-100 genera and 1300-1350 species of vines, shrubs, herbs and small trees. It is commonly reported and found mainly in tropical regions. According to this family, scientists reported various species which showed various medicinal uses or properties and these are already described or mentione...

Whey protein is one of the major sources of essential proteins which is being used widely now days for maintaining a healthy life style and to meet the daily protein requirement. In order to maintain a healthy body weight, regular exercise accompanied with a healthy diet is very important, and whey protein is a perfect source of fulfilling the p...

As India’s population is growing so is its water demand and corresponding water contamination. Water is a very essential element in formation of life and is an essential requirement for living organisms to thrive. Therefore, it is very important that the drinking water available must be free of any contamination and proper measures be taken in that...

Since the previous five decades, there has been a continual effort focused on renewable energy resources and their application. Solar energy, wind energy, geothermal energy, and other sustainable energy sources are available. Solar cell research is progressing rapidly throughout the world and will continue to do so in the near future. Nanotechnolog...

Access to clean, microorganism-free water is a significant concern that necessitates intensive investigation. To secure a supply of drinking water and prevent global water pollution, significant difficulties in the global water situation, mostly coming from global population expansion and climate change, necessitate unique revolutionary water solut...

A cardinal role is played by the benign immune system in our body in defending different types of infectious diseases as well as continuous surveillance of its elements actively remove malfunctioning cells that could be dangerous to the body if retained as such. The whole immune system is elegantly coordinated through complex pathways via thousands...

The term "flavonoid" is a broad term given to the collection of natural polyphenolic compounds which occur in plants (fruits, vegetables, roots, flowers, stems, bark, leaves) as their secondary metabolites. Subsequent research reveals that flavonoids possess anti-inflammatory, anti-mutagenic, anti-oxidative, anti-ageing, and anti-carcinogenic effec...

Over 100 types of arthritis have been recognized in which the dominating forms are osteoarthritis and rheumatoid arthritis. Joint stiffness, pain, swelling, lowered range of motion of joints affected, redness around joints are the main complications of almost all types of arthritis. Medications like non-steroidal anti-inflammatory drugs (NSAIDs), o...

Current research on phytochemicals is mainly focused on novel phenolic and polyphenolic compounds expressing their potential as therapeutic agents in various diseases like cancer, autoimmune diseases, cardiovascular disorders, diabetes, oxidative stress-related diseases, as well as their properties to inhibit the growth and proliferation of infecti...

In the same vein as prior advances, biotechnology tries to deliver many advantages, specifically in three major categories: environmental protection, increased yields, and advances in human health. Numerous industries are turning to biotechnology as a means of dealing with climate change and improving our everyday life to more eco-friendly approach...

Existence of life is not feasible without plants. Plants are the essential sources of food and medicine. In fact, all life forms on this planet are directly or indirectly dependent on plants for carrying on their life processes. Medicinal plants and herbs have remained the greatest sources of essential medicines and oils since times immemorial. Ev...

One of the leading causes of death worldwide is deadly metabolic disorder of uncontrolled growth of cells termed Cancer. Chemotherapy, surgery, hormonal therapy, and radiotherapy are currently available therapeutic strategies in the treatment of cancer and are known to cause significant decline in the overall mortality rate. But such conventional c...

Macrofungi mainly belong to the phylum Ascomycota and Basidiomycota. Infact the phylum Ascomycota is the largest group of Macrofungi possessing more than 64000 species. In the higher basidiomycetes, edible medicinal mushrooms mainly occur having a wide range of habitat and are almost cosmopolitan in nature. Their aerobic and saprophytic growth habi...

Aim and objective: Pollen is reported in flowers and leaves of various medicinal plants and showed its beneficial effect on human health. The objective of our study is to evaluate the antioxidant effect of flowers (Calendula officinalis and Dianthus chinensis) especially pollen protein and also determining its immunogenic effect against specific pr...

Compounds that act as inhibitors of the process of oxidation are termed antioxidants. These compounds exert such potential even at relatively small concentrations. Cellular activity retarding free radicals are among the end products of an oxidation chemical reaction, which react in chain reactions to cause damage to the cells of an organism which i...

According to the Asian traditional system of medicine (i.e. Ayurveda, Yunani, Siddha and Homeopathy, etc.), use plant derived products enormously for the treatment of various infectious diseases with reference to intracellular and extracellular pathogens. In general, human infections are mainly caused through ectoparasites and endoparasites (protoz...

Allium cepa (onion; Liliaceae family), herbaceous annual plant and reported Sulphur based amino acids with many minerals including vitamins. Inspite of various medicinal uses of this plant as food and also showed various beneficial effects. The antimicrobial activity of aqueous extract from Allium cepa (onion bulb) was evaluated against bacterial s...

Various studies were conducted related to its exploration of its immunopharmacological activity of medicinal plant products and understanding its mechanism related to proteomic approaches. These proteomic approaches should be applied in order to understand its medicinal plant physiology along with its immunobiological ramifications on animals. Acco...

Parkinson's disease (PD) is a chronic neurological illness that affects 50 to 328 people worldwide per lakh. Over the age of 65, PD affects more than 1% of the population, and the prevalence and incidence rates increase with age. Parkinson's disease, also known as paralysis agitans, is a common neurodegenerative ailment that causes tremor, inflexib...

SARS-CoV-2, the causative agent of COVID-19 disease belongs to the group beta-coronavirus, have infected around 120 million people so far with a 2.65 million death toll worldwide. Coronaviruses are enveloped viruses having positive sense, single-stranded RNA genome (26-32 kb size). This paper mainly reviews/focuses on the existing development on th...

Paralysis agitans, often known as idiopathic parkinsonism, is a persistent neurological disease that affects 50 to 328 persons per lakh globally. Paralysis agitans affect more than 1% of the population over the age of 65, and the prevalence and incidence rates rise with age. Tremor, inflexibility, and difficulties in standing, walking, balancing, a...

Panic attacks are unjustified anxieties and worries accompanied by a racing heart, fast breathing, and sweating. Some people acquire panic disorder, which is a form of anxiety disorder characterised by recurring panic attacks, as a result of their fear of these episodes or any other underlying pathophysiology. Heredity, thyroid gland dysfunction, l...

Antimicrobial resistance to at least one antimicrobial agent in two or more antimicrobial classes is referred to as multiple drug resistance (MDR), sometimes known as multi-resistance. Antimicrobial classes group antimicrobial substances according to their action mechanism and the target species they are effective against. Multi-drug resistant bact...

In literature, wild mushrooms are used extensively all over the world and considered them as more valuable food in terms of low calories and fat content. The objective of our study is to evaluate its antioxidant, anti-inflammatory and antimicrobial potential of protein extracted from two different species of mushroom (Oyster and button). The major...

Chemical substances that pose potential/actual harm to the environment, human health and for which no documented health standards exist are referred to as emerging contaminants. Each year, micro-pollutants from medications, personal care products, insecticides, microplastics, and other substances become more prominent due to the manufacturing of ab...

As per the literature, humans ingest a comprehensive range of food materials including drugs along with dietary supplements which are mainly derived through medicinal plant products and modifying the purpose of the central nervous system (CNS). These psychoactive based properties are mainly attributable to the existence of plant-derived secondary m...

One of the group of natural products i.e. terpenoid mainly reported and found in all classes of living things. These terpenoids belongs to the group of secondary metabolites and these are naturally occurring hydrocarbons produced through a wide variety of plants, animals including microbes. Several terpenoids extracted from medicinal plant products...

Nanomaterials may be considered as one of the most promising commodities especially in the field of healthcare, drug-gene delivery, environment, electronics, etc. One of the major investigation revealed applications of nanoparticles and its effect is totally varied with the phases, sizes, and morphologies of these particles. Thus, governed synthesi...

In literature, various medicinal plants are reported and showing various immunobiologically activities in the form of primary and secondary metabolites. So, these metabolites especially flavonoids extracted from medicinal plant products and considered them as more crucial and valuable with respect to human health care. In short, these flavonoids ex...

According to the World Health Organization, more than 80 % of the world's population totally relies on traditional forms of medicine, largely plant based to meet the primary health care needs of the people. In India, collection of medicinal plants from different regions, i.e. Western Ghats, Himalayan region etc. and processing these plant products...

The role for vaccine adjuvants in case of veterinary and human vaccines has been a matter of great interest for the last so many years. Till now, only one adjuvant i.e. alum that are approved by Food and drug administration (FDA) for human use as well as for research purpose. Now a day, researchers worked with some plant based immunostimulators per...

Today, more than two hundred countries of whole world are facing the problem of coronavirus COVID-19. This virus is communicated from one place to another by the medium of human beings. The transmission of virus is occurred by touching the contaminated surface. The contaminated surfaces may be of metal like steel, brass, copper etc., wood, plastic,...

Human beings are mainly composed of different cells / tissues / organs which carry out various physiological roles representing a complex functional system. Now a days, it is difficult to predict the interactions between organs, including cells or tissues using in vitro cell culture approaches, as a result, animal tests should be conducted, pertain...

India is considered to be one of the rich repositories of medicinal and aromatic plants, which are mainly used as starting raw materials for drug manufacturing and perfumery products. More than thirty percent of various medicinal plant species are routinely used for various medicinal purposes. In this study, our major objective is to evaluate its a...

Indian is an agriculture-based country, where more than 50% of the population is dependent on agriculture. This structures the main source of income especially for people from rural areas. The commitment of agribusiness in India is considered as backbone for Indian economy because more than 60percent of population is totally survived on agriculture...

Panic attacks are unfounded fears and concerns manifested by a racing heart, rapid breathing, and perspiration. As a result of their fear of these episodes, some individuals develop panic disorder, which is a type of anxiety illness. The main causes of panic disorder have been related to, among other things, heredity, thyroid gland malfunction, low...

Most of the microorganisms are reported in various medicinal plant products which played a major role with respect to plant’s health and development including human nutrition. In general, single plant species could possess and reported thousands of microbes recognized as epiphytes (near on plant tissue; rhizosphere and phyllosphere) or endophytes (...

5)2: 90-96 ] © 2018 IJSRST | Volume 5 | Issue 2 | Print ABSTRACT Inflammation is initiated as healing process by the tissue in response to injury by pathogens, irritants or cell damage. Anti-inflammatory drugs used today to cure the disease have serious side-effects. The focus of research is to study the bioactive compounds from medicinal plants wi...

Introduction: Over centuries, Carica papaya (papaya) has been used as a nutritious and medicinal plant. In view of its medicinal uses, our group focused on aqueous leaves extract of papaya and tried to determine its antimicrobial (using bacterial strains i.e. gram positive and gram negative ones) and anti-inflammatory (virally infected human whole...

Arthritis can lead to a person's inability to perform activities of daily living. Therapy for arthritis aims to control pain, minimize joint damage and improve or maintain quality of life. Arthritis is treated with a combination of medications, physical therapy and herbal remedies and patient's education. In other words, arthritis is a chronic, pro...

Free radicals are produced with in our immune system and these are generally attacked on normal healthy cells of our body and it will lose its cell structure and function. Most of the cells that are damaged through free radicals and is considered to be one of the major contributor with respect to aging and degenerative diseases. In this book, we me...

Introduction: In general, primary or secondary metabolites derived from medicinal plant products might be responsible for stimulating or suppressing the immune system against specific protein antigens. The objective of this study was to evaluate the adjuvant potential of aqueous leaves extract of Azadirachta indica, Butea frondosa and Ficus religio...

Introduction: Medicinal plants are considered to be safer, non-toxic and less harmful as compared to synthetic based drugs that are available. In this study, we focused on aqueous leaves extract of Calotropis gigantea for determining its antimicrobial activity in infected (dengue) human whole blood samples using flow cytometry. Methods: Infected de...

Introduction: Evaluation of antidiabetic studies was conducted on different medicinal plant products (Trigonella foenum-graecum, seeds; Syzygium cumini, seeds; Salavadora persica, leaves; and Terminalia chebula, seeds) on human whole blood samples. Since centuries revealed the presence of potent antidiabetic activity in primary and secondary metabo...

MicroMedicine 2017; 5 (1): 1-7 RESEARCH ARTICLE Partial purification and antidiabetic effect of bioactive compounds isolated from medicinal plants Citation: Bansode TS, Gupta A, Shinde B, Salalkar BK. Partial purification and antidiabetic effect of bioactive compounds isolated from medicinal plants. ABSTRACT Antidiabetic studies were conducted in h...

Introduction: Search for new adjuvants for human vaccines has become an expanding field of research in the last thirty years for generating stronger vaccines, capable of inducing protective and long lasting immunity in humans. The objective of this study was to investigate the immunoadjuvant activity of aqueous extract from the leaves of Calamus ro...

India ranks high for prevalence of diabetes and the treatment of diabetes without any side effects is still challenging. Though herbal remedies help reduce the side effect, proper standardization of phytochemical which prove as a bioactive compound, its proper dose and clinical trials are lacking. In our investigation, we studied the binding mechan...

Numerous metabolites present in the aqueous extract from plants are responsible for inducing adjuvant activity against rubella and hepatitis B vaccine antigen (HBsAg). One of the medicinal plants, The objective of our study is to evaluate the adjuvant potential of aqueous leaves extract of For these studies, our group evaluated the antibody (IgG) t...

Introduction: The treatment of viral infections with the available antiviral drugs is not free of side effects. Therefore, in the present study, our group focused on antiviral activity against Newcastle disease (NDV) and IBD viruses using medicinal plants especially leaves of Prosopis spicigera and Mangifera indica. Methods: Different medicinal pla...

Flow cytometry is a technology that measures simultaneously both optical and fluorescence properties of single cells or any other particle including cell organelles (i.e. nuclei, chromosome etc.), microorganisms, and latex beads. This technology also exploits bright beams of light (usually from laser) to directly disclose various aspects i.e. size,...

Biophysical tools and its techniques are in high demand for the study of molecular mechanisms underlying cell biology, immunology and biomedical research including several diagnostics techniques. Biophysical tools basically include microscopy and imaging hydrodynamics, electrophysiology, modeling and simulation, single molecule techniques and spect...

Introduction: Immunological adjuvants derived from various synthetic micro-organisms or from medicinal plant products enhance specific immune responses against vaccine antigens. Immunological studies have already done pertaining to identify compounds from medicinal plant metabolites that are suitable for vaccine formulation. In this study, aqueous...

Introduction: Medicinal plants have been used to treat various immunological diseases. Nitric oxide (NO) including proliferation and CD14 monocyte surface marker has played an important regulatory role in various types of inflammatory processes. This study was aimed to evaluate or scrutinize the effect of flavonoid extracted from the leaves of Sant...

Majority of population in developed and under developed countries totally relies on traditional forms of medicine, mainly plant based to meet the primary health care needs of the people. These medicinal plants having various chemical constituents which are bioactive and could be of the therapeutic use, known as secondary metabolites. These are the...

In the present study, our group analyzed major chemical constituents that are present in fresh aqueous leaves extracts and analyzed through HPTLC (high performance thin layer chromatography), LC-MS (liquid chromatography-mass spectrometry) and determined its immuno pharmacological (i.e. immunosuppressive) activity. During preliminary studies, phyto...

According to the WHO, above 80% of the world’s population totally relies on traditional forms of medicine, largely plant based to meet the primary health care needs of the people. Medicinal plants contain various chemical constituents which can be used as therapeutic agents. Secondary metabolites are organic compounds which are not involved in the...