Amit Kumar Banerjee

Indian Institute of Chemical Technology | IICT · Biology Division (IICT)

Several supervised and unsupervised methods are presently available for classification and clustering extremely nonlinear data sets. Biological data sets are known to be complex in nature due to their greater dimension, complex attribute interactions, and dynamic behavior. In this article, we present the classification of 16 organisms based on phys...

Zika, a neurotrophic virus belonging to Flaviviridae family of viruses and transmitted by vector mosquitoes of Aedes species, took the world by storm during its recent outbreak. Its spread to newer territories, unprecedented pace of transmission, lack of existing therapeutic agents and vaccines and an empty drug pipeline raised an alarm. Uncertaint...

AI can be harnessed for forecasting the spread of virus and developing early warning systems by extracting information from social media platforms, calls and news sites and provide useful information about the vulnerable regions and for prediction of morbidity and mortality.

An artificial neural network method is presented for classification and identification of Anopheles mosquito species based on the internal transcribed spacer2 (ITS2) data of ribosomal DNA string. The method is implemented in two different multi-layered feed-forward neural network model forms, namely, multi-input single-output neural network (MISONN...

Malaria, a scourge of mankind, imposes a huge socioeconomic burden in tropical countries. Emergence of multi-drug resistant malarial parasites impels us to explore novel drug targets. Thioredoxin reductase is a promising antimalarial drug target. The Thioredoxin reductase enzyme of Plasmodium falciparum was characterized in silico and protein disor...

Editor’s call for papers: “Recent Trends in Therapeutic Interventions for Neurological Disorders: Mechanistic, Clinical and Insights for the Future” Manuscript submission is now open for a new article collection I am co-editing on “Recent Trends in Therapeutic Interventions for Neurological Disorders: Mechanistic, Clinical and Insights for the Fut...

Machine learning (ML) techniques have revolutionized the way of data classification, clustering, segregation, and novel eleme nt identification. ML techniques are having tremendous impetus for biological complex data classification. A number of studies reported novel data classification methods, complex biological element classification, and cluste...

Emergence of influenza A H3N2 is alarming. Strain 2013 H3N2 has H1 subtype Haemagglutinin (HA) gene segment replaced with a H3 HA gene segment. The vulnerability of the humans to H3 may be directly proportional to the HA alterations. Therefore, we studied this strain and analyzed its sequence and structural divergence and compared it with 2009 H3N1...

The hope of controlling or eradicating the infectious diseases in the golden era of antibiotics was as short-lived as the proverbial bubble. As the emerging and reemerging diseases tend to take us by surprise by their sheer magnitude and spread, the need for accelerating the pace of discovery of newer and effective drugs and increasing our repertoi...

Graphical Abstract

Understanding structure and function of human brain remains the most intriguing region of advanced research. Neurological disorders also constitute a major proportion of ongoing brain associated research as several disorders are still not known in a comprehensive manner from a molecular, causative and functional perspective. Earlier linkage studies...

Babesia microti, the causative agent of human babesiosis which was endemic in United States and parts of Europe with sporadic cases in other regions is expanding its geographical range. Being a common transfusion threat, Babesia has become a cause of concern in researchers and epidemiologists. Human babesiosis is now recognized as an emerging disea...

Supplementary Table 1 contains the docking analysis details obtained for the target protein thioredoxin reductase of Babesia microti.

The graphical abstract is created to summarize the theme of the work in a pictorial representation.

Representation of the important region in Chromosome 17 responsible for the 5-HTTLPR polymorphism.

Structural changes in different regions of the brain have become clinically relevant and regarded as the signature phenomenon for neurological diseases. Morphological changes in brain are also associated with neuronal and neurochemical alterations. Studies have showed that minute changes in neurochemical levels may have marked impact on the psychob...

Few individuals would have heard of Zika virus prior to the current outbreak in the Americas. However, Zika virus is the most recent threat by an arbovirus after Chikungunya and dengue outbreaks in this decade. In a very short time span, Zika virus has spread to 66 countries and territories. The WHO declared Zika a public health emergency of intern...

Yersinia pestis, the causative organism of Plague, is widely recognized as a potential bioterrorism threat. Due to the absence of homologs in human, Shikimate Kinase (SK) is considered as an excellent drug target in several bacterial and protozoan parasites. Ample literature evidences confirm the suitability of this protein as a good target. Theref...

Immunology has grown as a great subject over the years and has evolved as an amalgamation of multiple disciplines and allied sub disciplines as per scientific investigation is concerned. Almost all living being responds towards the stimulation caused by their internal and external surrounding environment in a stepwise manner. Biologically, this is...

Combating viral diseases has been a challenging task since time immemorial. Available molecular approaches are limited and not much effective for this daunting task. MicroRNA based therapies have shown promise in recent times. MicroRNAs are tiny non-coding RNAs that regulate translational repression of target mRNA in highly specific manner. In this...

Features peer-reviewed chapters written by leading experts, Analyzing and Modeling Spatial and Temporal Dynamics of Infectious Diseases sheds new light on recent research and methodology on the spread of infectious diseases. Showcasing a broad range of multi-disciplinary and state-of-the-art techniques on geo-visualization, remote sensing, metapopu...

Bioinformatics started its journey as a supportive discipline, with time which matured as an individual scientific application subject. Along with several contributions in various sectors of life sciences, it has drastically aided in gaining valuable and novel information and insight in vector biology. Application of computing technologies and deve...

Keratin protein is ubiquitous in most vertebrates and invertebrates, and has several important cellular and extracellular functions that are related to survival and protection. Keratin function has played a significant role in the natural selection of an organism. Hence, it acts as a marker of evolution. Much information about an organism and its e...

Standard molecular experimental methodologies and mathematical procedures often fail to answer many phylogeny and classification related issues. Modern artificial intelligent-based techniques, such as radial basis function, genetic algorithm, artificial neural network, and support vector machines are of ample potential in this regard. Reliance on a...

Life is not easy, it never was. With every breath, we are exposed to hundreds of infections, every passing second, a new fear of catching one infection or the other inflicts our mind. Infectious diseases claim more lives every year than all the casualties of wars since historic times. Infectious agents who live in, on and around us have emerged as...

Tuberculosis caused by Mycobacterium tuberculosis has emerged as the biggest curse of our time causing significant morbidity and mortality. Increasing resistance in mycobacterium to existing drugs calls for exploration of metabolic pathways for finding novel drug targets and also for prioritization of known drug targets. Recent advances in molecula...

Malaria continues to plague the tropical and subtropical regions causing high morbidity and mortality. Every year, millions die due to lack of affordable and effective anti-malarial drugs. Malaria poses significant threat to half of the world's population and our arsenal to combat this disease is nearly empty. Pharmaceutical companies shy away from...

The battle between human and the Human immunodeficiency virus (HIV) is on, with both of them rapidly improving their attacking and defense strategies. Many therapeutic agents for HIV infection have been designed and developed, However there are various aspects, like novel targets against HIV, which are yet to be unfolded with a goal of designing an...

Despite concerted global efforts to combat malaria, malaria elimination is still a remote dream. Fast evolution rate of malarial parasite along with its ability to respond quickly to any drug resulting in partial or complete resistance has been a cause of concern among researcher communities. Molecular modeling approach was adopted to gain insight...

Malaria remains one of the leading causes of deaths attributable to a communicable disease globally. The reemergence of drug-resistant Plasmodium falciparum, the most fatal human malarial parasite, has necessitated the exploration of different pathways to provide the urgently required novel drug targets. Aspartate carbamoyltransferase, an enzyme of...

The dominance of insects amongst all living organisms on earth, coupled with infinite wealth of knowledge so important for our own existence, is a fundamental scientific fact which is yet to be widely acknowledged. This dominance means that in numbers of species beyond our comprehension these animals permeate diverse and essential natural processes...

Understanding the protein structures is crucial, as it is involved in every cellular activity. Several experimental techniques, such as X-Ray crystallography, nuclear magnetic resonance and electron microscopy are available to gain insight about the structure and function of a protein molecule. Gigantic data on protein structural and sequential inf...

Diabetes is a metabolic disorder that has emerged recently as a major cause of global concern. Regulation of the blood glucose concentration is essential to maintain the homeostasis. GLUT2, a carrier protein, plays an important role in transporting sugar molecules across the membrane. To understand the function of this carrier molecule, knowledge o...

Shigella flexneri is a major pathogen responsible for Shigellosis causing massive morbidity among young population and imposes huge socio-economic burden. In this study, Shikimate Kinase (SK) from S. flexneri was characterized in silico and disordered regions were predicted. Motifs and domains were calculated using computational tools. A three dime...

Health has been described as one of "the most important conditions of human life and a critically significant constituent of human capabilities which we have reason to value" by the well-known economist and nobel Laureate Dr. Amartya Sen. Well-being and health of an individual not only affects him but also bears influence on national economies in t...

Biological systems are highly organized and enormously coordinated maintaining greater complexity. The increment of secondary data generation and progress of modern mining techniques provided us an opportunity to discover hidden intra and inter relations among these non linear dataset. This will help in understanding the complex biological phenomen...

Malaria has been a cause of enormous morbidity and mortality since the dawn of evolution. Control of malaria remains a farfetched dream despite numerous efforts and intervention strategies devised by research communities. Increasing drug resistance in the malarial parasite to conventional drugs has raised an alarm. This situation warrants the need...

Genomic and Proteomic database on Culex mosquito species (copy right with CSIR 2008-09

Availability of enormous number of sequences in public domain databases warrants the need for effective tools for clustering and classification of such data. AGC protein kinase family is known to contain many enzymes involved in important cellular processes. In the present study, 21 important physicochemical parameters were calculated for 115 seque...

Xylanase is an industrially important enzyme having wide range of applications especially in paper industry. It is crucial to gain an understanding about the structure and functional aspects of various xylanases produced from diverse sources. In this study, a bioinformatics and molecular modeling approach was adopted to explore properties and struc...